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The map label for this gene is manA [H]

Identifier: 203284317

GI number: 203284317

Start: 430267

End: 431388

Strand: Reverse

Name: manA [H]

Synonym: BDU_401

Alternate gene names: 203284317

Gene position: 431388-430267 (Counterclockwise)

Preceding gene: 203284318

Following gene: 203284314

Centisome position: 46.3

GC content: 28.52

Gene sequence:

>1122_bases
ATGAGTGTTGATAATATATTTTTGATGAAAAATGAGATTAAGGAGTATGATTGGGGTGGATATGGTTTCATCCCTTCCCT
TTTGGGACAAAAAAAAGACGGTTTGCCAAAAGCTGAAATGTGGCTTGGTGCACATAAAACATTTTCTAGTAAAATATTAG
TTGATGGTCAATATGTTTCTCTTTTTAATTTTTTAGAAATACATAAAGAGCTTTTAGGTTTTGGGAGTGAATTGTCGTTT
TTATTTAAAATTCTTTCAGTGCATAAACCTTTGTCACTGCAGATACATCCTTCAAAAGATATTGCTTTAAAAGGCTTTGC
GCTTGAAAATAATAAAAAAATAGTTATTGATGATTCTAAGAGAATTTATAAGGATGAAAATCCTAAAGTAGAGCTTGTTT
ATGCTTTGAGTGATTTTTATGCTCTTAAAGGTTTTTTGCCACTTGATGGCATTAACCATATTTATAGAAGTTTAGGATTG
GATTTTAATTTTATGACACATGAATCGTTTGTAAAAACCTTATTTGATTTACACGAATTTGAAATTGAGAATATTATTTA
TAAAGTGTTAGATAATTTAAATTTTATAGATGAATTTAGAGCTTTTTGGTTTAATGAAATTTATAAAATGTATGGTATTG
ATATTGGTCTTTTGGTATTTTTGGGAATGTATATTTTTAAATTAAAAACAGGTGAAGTTTTTTATACTGAAAGTCGAGAA
GTTCATGCTTATCTTAAAGGTGAATGCATTGAACTTATGACTAATTCTGATAATGTCATTAGAGCAGGTTTTACAACTAA
ACATATTGACAAAGATGAAATGTTGAAGGTTGGAAAATTTGAGGAGGGAGTTTTTTCATTGTTAAAGAGTGAAAATATTG
ATGGTTGTGATGTATTTAAGTTGCCAGGTACCAATTTAAGTTTGTTTCACAAATGTATAGGTGGAGAGAGCTACTTTGAA
AGAGTTGGTGTTATGATATTATTAGTTATAAAAGGAAAAGTTCAGCTTAATAATAGAATTTCTCTTAAGATGGGAGATAG
TGTGTTTATAGGGAATTGTGATTGTAATAAGGAATTGTCAATTTGTGGTAATGGAGAAATTTTTATTGCGCTTTCTTTAT
AG

Upstream 100 bases:

>100_bases
TTGATCATAAATTTGGATTTCTTGTTGCAATAGCTGTTGGTGTTGCGGTGGCAACAAGTGTAGTTATTTTTTTGAAATCT
TTAAAGGTTAAGGTATCTAA

Downstream 100 bases:

>100_bases
TTAAGATATTGATTTTTAATTTTTAATTTTAAGAAAAGATATTTAATAATTTATATAAACATTTTAATAAATCCAATTGC
AAAAAATTTAAATCTCATGC

Product: mannose-6-phosphate isomerase

Products: NA

Alternate protein names: Phosphohexomutase; Phosphomannose isomerase; PMI [H]

Number of amino acids: Translated: 373; Mature: 372

Protein sequence:

>373_residues
MSVDNIFLMKNEIKEYDWGGYGFIPSLLGQKKDGLPKAEMWLGAHKTFSSKILVDGQYVSLFNFLEIHKELLGFGSELSF
LFKILSVHKPLSLQIHPSKDIALKGFALENNKKIVIDDSKRIYKDENPKVELVYALSDFYALKGFLPLDGINHIYRSLGL
DFNFMTHESFVKTLFDLHEFEIENIIYKVLDNLNFIDEFRAFWFNEIYKMYGIDIGLLVFLGMYIFKLKTGEVFYTESRE
VHAYLKGECIELMTNSDNVIRAGFTTKHIDKDEMLKVGKFEEGVFSLLKSENIDGCDVFKLPGTNLSLFHKCIGGESYFE
RVGVMILLVIKGKVQLNNRISLKMGDSVFIGNCDCNKELSICGNGEIFIALSL

Sequences:

>Translated_373_residues
MSVDNIFLMKNEIKEYDWGGYGFIPSLLGQKKDGLPKAEMWLGAHKTFSSKILVDGQYVSLFNFLEIHKELLGFGSELSF
LFKILSVHKPLSLQIHPSKDIALKGFALENNKKIVIDDSKRIYKDENPKVELVYALSDFYALKGFLPLDGINHIYRSLGL
DFNFMTHESFVKTLFDLHEFEIENIIYKVLDNLNFIDEFRAFWFNEIYKMYGIDIGLLVFLGMYIFKLKTGEVFYTESRE
VHAYLKGECIELMTNSDNVIRAGFTTKHIDKDEMLKVGKFEEGVFSLLKSENIDGCDVFKLPGTNLSLFHKCIGGESYFE
RVGVMILLVIKGKVQLNNRISLKMGDSVFIGNCDCNKELSICGNGEIFIALSL
>Mature_372_residues
SVDNIFLMKNEIKEYDWGGYGFIPSLLGQKKDGLPKAEMWLGAHKTFSSKILVDGQYVSLFNFLEIHKELLGFGSELSFL
FKILSVHKPLSLQIHPSKDIALKGFALENNKKIVIDDSKRIYKDENPKVELVYALSDFYALKGFLPLDGINHIYRSLGLD
FNFMTHESFVKTLFDLHEFEIENIIYKVLDNLNFIDEFRAFWFNEIYKMYGIDIGLLVFLGMYIFKLKTGEVFYTESREV
HAYLKGECIELMTNSDNVIRAGFTTKHIDKDEMLKVGKFEEGVFSLLKSENIDGCDVFKLPGTNLSLFHKCIGGESYFER
VGVMILLVIKGKVQLNNRISLKMGDSVFIGNCDCNKELSICGNGEIFIALSL

Specific function: Involved in the conversion of glucose to GDP-L-fucose, which can be converted to L-fucose, a capsular polysaccharide [H]

COG id: COG1482

COG function: function code G; Phosphomannose isomerase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 1 family [H]

Homologues:

Organism=Homo sapiens, GI4505235, Length=413, Percent_Identity=27.3607748184019, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI1787899, Length=388, Percent_Identity=30.9278350515464, Blast_Score=161, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI71997620, Length=392, Percent_Identity=28.0612244897959, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI21356061, Length=295, Percent_Identity=29.1525423728814, Blast_Score=113, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR001250
- InterPro:   IPR016305
- InterPro:   IPR018050
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01238 PMI_typeI [H]

EC number: =5.3.1.8 [H]

Molecular weight: Translated: 42655; Mature: 42524

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVDNIFLMKNEIKEYDWGGYGFIPSLLGQKKDGLPKAEMWLGAHKTFSSKILVDGQYVS
CCCCCEEEEEHHHHHCCCCCCCHHHHHHCCCCCCCCHHHHHHCCCCCCCCEEEECCHHHH
LFNFLEIHKELLGFGSELSFLFKILSVHKPLSLQIHPSKDIALKGFALENNKKIVIDDSK
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEECCCCCEEEEEEEEECCCEEEEECCH
RIYKDENPKVELVYALSDFYALKGFLPLDGINHIYRSLGLDFNFMTHESFVKTLFDLHEF
HHCCCCCCCEEEEEEEHHHHHHHCCCCCCHHHHHHHHHCCCEEEECHHHHHHHHHHHHHH
EIENIIYKVLDNLNFIDEFRAFWFNEIYKMYGIDIGLLVFLGMYIFKLKTGEVFYTESRE
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEECCCEEEECCCE
VHAYLKGECIELMTNSDNVIRAGFTTKHIDKDEMLKVGKFEEGVFSLLKSENIDGCDVFK
EEEEECCCEEEEEECCCCEEEECCCCCCCCHHHHHCCCCHHHHHHHHHHCCCCCCCEEEE
LPGTNLSLFHKCIGGESYFERVGVMILLVIKGKVQLNNRISLKMGDSVFIGNCDCNKELS
ECCCCHHHHHHHHCCHHHHHHHHHEEEEEEECEEEECCEEEEEECCEEEEECCCCCCCEE
ICGNGEIFIALSL
EECCCCEEEEEEC
>Mature Secondary Structure 
SVDNIFLMKNEIKEYDWGGYGFIPSLLGQKKDGLPKAEMWLGAHKTFSSKILVDGQYVS
CCCCEEEEEHHHHHCCCCCCCHHHHHHCCCCCCCCHHHHHHCCCCCCCCEEEECCHHHH
LFNFLEIHKELLGFGSELSFLFKILSVHKPLSLQIHPSKDIALKGFALENNKKIVIDDSK
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEECCCCCEEEEEEEEECCCEEEEECCH
RIYKDENPKVELVYALSDFYALKGFLPLDGINHIYRSLGLDFNFMTHESFVKTLFDLHEF
HHCCCCCCCEEEEEEEHHHHHHHCCCCCCHHHHHHHHHCCCEEEECHHHHHHHHHHHHHH
EIENIIYKVLDNLNFIDEFRAFWFNEIYKMYGIDIGLLVFLGMYIFKLKTGEVFYTESRE
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEECCCEEEECCCE
VHAYLKGECIELMTNSDNVIRAGFTTKHIDKDEMLKVGKFEEGVFSLLKSENIDGCDVFK
EEEEECCCEEEEEECCCCEEEECCCCCCCCHHHHHCCCCHHHHHHHHHHCCCCCCCEEEE
LPGTNLSLFHKCIGGESYFERVGVMILLVIKGKVQLNNRISLKMGDSVFIGNCDCNKELS
ECCCCHHHHHHHHCCHHHHHHHHHEEEEEEECEEEECCEEEEEECCEEEEECCCCCCCEE
ICGNGEIFIALSL
EECCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1879695; 11677609 [H]