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The map label for this gene is uppS [H]

Identifier: 203284045

GI number: 203284045

Start: 129316

End: 130008

Strand: Reverse

Name: uppS [H]

Synonym: BDU_123

Alternate gene names: 203284045

Gene position: 130008-129316 (Counterclockwise)

Preceding gene: 203284046

Following gene: 203284044

Centisome position: 13.95

GC content: 29.29

Gene sequence:

>693_bases
ATGAGTAGTAATTCTCTTCCAAGTCATGTTGGGATCATTATGGATGGAAATAGGAGATGGGCATTAAAAAAAGGTTTGTC
ATTTTTTGAAGGACATAAAGAGGGTTTAAAGAGAGCTAAAGAAATAGTGAAACATTCTTGTGAATTGGGTATAAAGTGTT
TATCTCTTTATGTTTTTTCTACAGAAAATTGGAATAGAACAAATTCTGAAATAGAACATTTGATGTTTTTAATTGCCGAT
TATCTAAGTTCTGAGTTTAAATTTTATGCTGAAAACAATATAAGGGTAGTGGTTTCAGGCGATATTGAAACTTTAAGTCA
AAAAGTTAAAAAGTCGATTGAAGATGCTACTAATTATACAAAGAATTTTGATGGACTTATATTAAATTTGGCTATTAATT
ATGGCGGCAGAAATGAAATAGTTAGAGCTATTAAGAAAGTTTTAGCAAAAGGGTTATCAGTTGAAACTTTAAATGAGGTT
GAATTTGCTAAGTTTTTAGATAATCAAGAACTTGGTGATCTTGATCTCTTAATTCGAACAGGTGGAGATATGAGAGTAAG
TAATTTTCTTTTATGGAGACTTGCTTATTGTGAATTTATTTTTTCAAATGTTTTATGGCCAGATTATTTTGTTTTTCATT
ATGAGAGAGATTTGGAATGTTTTAAGAATAGGAAGAGAAACTTTGGGAGATAA

Upstream 100 bases:

>100_bases
CGAATTTTAGATGATATTCAACGAGATACCAATTTTTATATTAAAAAAATAGATGGGATTTTTGATTTAAAAGCAAAAGA
GATAATGGAAGTTTAAGTTT

Downstream 100 bases:

>100_bases
AGGTTTATTTAGTATTAGGTCTAAAAAGTTGACATTTGTTGCTAGACTTGGAACATTTTTATTTTTTGTTCCTTTGGTCT
TGCTTTTAATATTTTTAGAG

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 230; Mature: 229

Protein sequence:

>230_residues
MSSNSLPSHVGIIMDGNRRWALKKGLSFFEGHKEGLKRAKEIVKHSCELGIKCLSLYVFSTENWNRTNSEIEHLMFLIAD
YLSSEFKFYAENNIRVVVSGDIETLSQKVKKSIEDATNYTKNFDGLILNLAINYGGRNEIVRAIKKVLAKGLSVETLNEV
EFAKFLDNQELGDLDLLIRTGGDMRVSNFLLWRLAYCEFIFSNVLWPDYFVFHYERDLECFKNRKRNFGR

Sequences:

>Translated_230_residues
MSSNSLPSHVGIIMDGNRRWALKKGLSFFEGHKEGLKRAKEIVKHSCELGIKCLSLYVFSTENWNRTNSEIEHLMFLIAD
YLSSEFKFYAENNIRVVVSGDIETLSQKVKKSIEDATNYTKNFDGLILNLAINYGGRNEIVRAIKKVLAKGLSVETLNEV
EFAKFLDNQELGDLDLLIRTGGDMRVSNFLLWRLAYCEFIFSNVLWPDYFVFHYERDLECFKNRKRNFGR
>Mature_229_residues
SSNSLPSHVGIIMDGNRRWALKKGLSFFEGHKEGLKRAKEIVKHSCELGIKCLSLYVFSTENWNRTNSEIEHLMFLIADY
LSSEFKFYAENNIRVVVSGDIETLSQKVKKSIEDATNYTKNFDGLILNLAINYGGRNEIVRAIKKVLAKGLSVETLNEVE
FAKFLDNQELGDLDLLIRTGGDMRVSNFLLWRLAYCEFIFSNVLWPDYFVFHYERDLECFKNRKRNFGR

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=216, Percent_Identity=32.8703703703704, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI45580738, Length=216, Percent_Identity=32.8703703703704, Blast_Score=125, Evalue=3e-29,
Organism=Escherichia coli, GI1786371, Length=235, Percent_Identity=41.2765957446808, Blast_Score=181, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI71993029, Length=222, Percent_Identity=33.7837837837838, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6319474, Length=213, Percent_Identity=31.924882629108, Blast_Score=115, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6323748, Length=221, Percent_Identity=32.579185520362, Blast_Score=108, Evalue=8e-25,
Organism=Drosophila melanogaster, GI18857969, Length=215, Percent_Identity=33.0232558139535, Blast_Score=133, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 26659; Mature: 26528

Theoretical pI: Translated: 8.30; Mature: 8.30

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSNSLPSHVGIIMDGNRRWALKKGLSFFEGHKEGLKRAKEIVKHSCELGIKCLSLYVFS
CCCCCCCCCEEEEEECCCEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEE
TENWNRTNSEIEHLMFLIADYLSSEFKFYAENNIRVVVSGDIETLSQKVKKSIEDATNYT
CCCCCCCHHHHHHHHHHHHHHHHHHCEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHC
KNFDGLILNLAINYGGRNEIVRAIKKVLAKGLSVETLNEVEFAKFLDNQELGDLDLLIRT
CCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEC
GGDMRVSNFLLWRLAYCEFIFSNVLWPDYFVFHYERDLECFKNRKRNFGR
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SSNSLPSHVGIIMDGNRRWALKKGLSFFEGHKEGLKRAKEIVKHSCELGIKCLSLYVFS
CCCCCCCCEEEEEECCCEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEE
TENWNRTNSEIEHLMFLIADYLSSEFKFYAENNIRVVVSGDIETLSQKVKKSIEDATNYT
CCCCCCCHHHHHHHHHHHHHHHHHHCEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHC
KNFDGLILNLAINYGGRNEIVRAIKKVLAKGLSVETLNEVEFAKFLDNQELGDLDLLIRT
CCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEC
GGDMRVSNFLLWRLAYCEFIFSNVLWPDYFVFHYERDLECFKNRKRNFGR
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9403685 [H]