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The map label for this gene is fadA [H]

Identifier: 203284034

GI number: 203284034

Start: 117988

End: 119181

Strand: Reverse

Name: fadA [H]

Synonym: BDU_112

Alternate gene names: 203284034

Gene position: 119181-117988 (Counterclockwise)

Preceding gene: 203284036

Following gene: 203284033

Centisome position: 12.79

GC content: 32.66

Gene sequence:

>1194_bases
ATGAAAAAAATAGCGATTATTGGTGGCCTTAGATCTCCTATTACTAGGTTTGGCGGAACATTAAAGGGAATGAATATTGT
TGATGTGTCTGCTGATATTGTTAAGGTTTTGCTTGAGAGGAATAGTATTGATAAAGTAGATGAAGTTATTGTTGGAAATG
TAATCTCATCGGGACTTGGTCAAAATATTGCCAGACAGATTACTTTGAAAGCTGGTTTAGGAGAAGCTATTCCTGCTTTT
AGCGTAAATAAAGTGTGTGGTTCGGGGCTTAAGTCTTTGGAACTTGCATTTAATTCTATATCTCTTGGTGAGAGTGAGGT
TATTGTTGCAGGTGGAGTAGAAGATTTGAGTAATGCACCTTATTTATTACCAAGAAATGTCAGATTTGATGGTTTAAAAT
TTGGAGACTTTAAAATAGAAGATTCAATATATAAAGATGCTTTAGTTGATACTCCAAGTTCTACTGTGATGGGTATTACA
GCAGAGAATTTAGCAGAAATGTATAAAATTACAAGAGAAATGCAAGATCAATTTGCATATAATTCTCATATGAAGGCAAA
AGTTGCAAGAGATAGTGGGTATTTTAATGATGAGATATATCCTCTATCGATTTTTGATAAAAAGACAAAACTTAAAAATG
TTGTGTCTAGTGATGAAGAAATACGTGATAATTTAAGTTTAGAAAAGCTTGCTTCTTTAAAACCTATCTTTAAAGAAAAT
GGGACTATTACTGCTGGCAATTCTTCTAGTTTAGATGATGGAGCTTGTTTTTTAATATTGGCAAGTGGAGATTTTGTTCA
TAAAATGAATGTAAAACCTTTGGCTTATATTGGTGGTTTTAAAAGTGTAGGGTTAAATCCTTTGCATATGGGATTTGGGG
CTTTTCTTGCTATTGAGGGCATTATAGAAAAGTTTAGTTTAAATTCAAATGAAATTGATTTTATTGAAACAAATGAAGCT
TTTGCAGCACAATCTTTGAGTGTTCTTAAAGCTTTACGTGAAAAGTATGGTATTAAGGATGATATTGTTAATGTTAATGG
AGGAGCTATTGCATTGGGTCATCCATTTTCAGTTAGTGGTTCAAGGATTTTATTGACTCTTGCACGTCTTATGAGTATGA
ATAATAAGTCAAAAGGAATTGCTTCTCTTTGTATTGGGGGTGGTCAAGGTATAGCAGCCTTTTTATATAGATAG

Upstream 100 bases:

>100_bases
TGATAATTTTTATTAAATCATTTATAATTATTAAATATATTGTGTCAAATTGTGGTTTGCTTGTTAATAGTTAAGTTATT
GTTATTGTTTGGAGTGATTT

Downstream 100 bases:

>100_bases
ATAATATTGTTTTGAAGCTAGATTTAAGTTTAATGTTTTGTTAAAATTTTATGAAGCGATTTAGTTTAATTTGATATAAG
GGTAATTTTTATGGGTAATT

Product: acetyl-CoA C-acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MKKIAIIGGLRSPITRFGGTLKGMNIVDVSADIVKVLLERNSIDKVDEVIVGNVISSGLGQNIARQITLKAGLGEAIPAF
SVNKVCGSGLKSLELAFNSISLGESEVIVAGGVEDLSNAPYLLPRNVRFDGLKFGDFKIEDSIYKDALVDTPSSTVMGIT
AENLAEMYKITREMQDQFAYNSHMKAKVARDSGYFNDEIYPLSIFDKKTKLKNVVSSDEEIRDNLSLEKLASLKPIFKEN
GTITAGNSSSLDDGACFLILASGDFVHKMNVKPLAYIGGFKSVGLNPLHMGFGAFLAIEGIIEKFSLNSNEIDFIETNEA
FAAQSLSVLKALREKYGIKDDIVNVNGGAIALGHPFSVSGSRILLTLARLMSMNNKSKGIASLCIGGGQGIAAFLYR

Sequences:

>Translated_397_residues
MKKIAIIGGLRSPITRFGGTLKGMNIVDVSADIVKVLLERNSIDKVDEVIVGNVISSGLGQNIARQITLKAGLGEAIPAF
SVNKVCGSGLKSLELAFNSISLGESEVIVAGGVEDLSNAPYLLPRNVRFDGLKFGDFKIEDSIYKDALVDTPSSTVMGIT
AENLAEMYKITREMQDQFAYNSHMKAKVARDSGYFNDEIYPLSIFDKKTKLKNVVSSDEEIRDNLSLEKLASLKPIFKEN
GTITAGNSSSLDDGACFLILASGDFVHKMNVKPLAYIGGFKSVGLNPLHMGFGAFLAIEGIIEKFSLNSNEIDFIETNEA
FAAQSLSVLKALREKYGIKDDIVNVNGGAIALGHPFSVSGSRILLTLARLMSMNNKSKGIASLCIGGGQGIAAFLYR
>Mature_397_residues
MKKIAIIGGLRSPITRFGGTLKGMNIVDVSADIVKVLLERNSIDKVDEVIVGNVISSGLGQNIARQITLKAGLGEAIPAF
SVNKVCGSGLKSLELAFNSISLGESEVIVAGGVEDLSNAPYLLPRNVRFDGLKFGDFKIEDSIYKDALVDTPSSTVMGIT
AENLAEMYKITREMQDQFAYNSHMKAKVARDSGYFNDEIYPLSIFDKKTKLKNVVSSDEEIRDNLSLEKLASLKPIFKEN
GTITAGNSSSLDDGACFLILASGDFVHKMNVKPLAYIGGFKSVGLNPLHMGFGAFLAIEGIIEKFSLNSNEIDFIETNEA
FAAQSLSVLKALREKYGIKDDIVNVNGGAIALGHPFSVSGSRILLTLARLMSMNNKSKGIASLCIGGGQGIAAFLYR

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=399, Percent_Identity=41.6040100250627, Blast_Score=288, Evalue=6e-78,
Organism=Homo sapiens, GI148539872, Length=398, Percent_Identity=38.4422110552764, Blast_Score=281, Evalue=7e-76,
Organism=Homo sapiens, GI4557237, Length=400, Percent_Identity=36.5, Blast_Score=244, Evalue=9e-65,
Organism=Homo sapiens, GI4501853, Length=401, Percent_Identity=35.1620947630923, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI4504327, Length=423, Percent_Identity=32.1513002364066, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI194353979, Length=250, Percent_Identity=31.6, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI87082165, Length=399, Percent_Identity=44.1102756892231, Blast_Score=325, Evalue=2e-90,
Organism=Escherichia coli, GI1788554, Length=399, Percent_Identity=46.1152882205514, Blast_Score=321, Evalue=7e-89,
Organism=Escherichia coli, GI1787663, Length=414, Percent_Identity=37.1980676328502, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI48994986, Length=406, Percent_Identity=37.192118226601, Blast_Score=238, Evalue=4e-64,
Organism=Escherichia coli, GI1788683, Length=393, Percent_Identity=30.2798982188295, Blast_Score=168, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI133906874, Length=394, Percent_Identity=39.5939086294416, Blast_Score=268, Evalue=5e-72,
Organism=Caenorhabditis elegans, GI17535921, Length=400, Percent_Identity=36.5, Blast_Score=234, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI25147385, Length=385, Percent_Identity=33.5064935064935, Blast_Score=226, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI17551802, Length=422, Percent_Identity=30.0947867298578, Blast_Score=181, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI17535917, Length=390, Percent_Identity=26.6666666666667, Blast_Score=130, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6325229, Length=393, Percent_Identity=38.1679389312977, Blast_Score=254, Evalue=1e-68,
Organism=Saccharomyces cerevisiae, GI6322031, Length=359, Percent_Identity=36.2116991643454, Blast_Score=204, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24655093, Length=399, Percent_Identity=43.1077694235589, Blast_Score=320, Evalue=7e-88,
Organism=Drosophila melanogaster, GI17648125, Length=398, Percent_Identity=39.4472361809045, Blast_Score=252, Evalue=3e-67,
Organism=Drosophila melanogaster, GI24640423, Length=391, Percent_Identity=36.8286445012788, Blast_Score=244, Evalue=9e-65,
Organism=Drosophila melanogaster, GI17137578, Length=427, Percent_Identity=31.1475409836066, Blast_Score=184, Evalue=7e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 42666; Mature: 42666

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00098 THIOLASE_1 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIAIIGGLRSPITRFGGTLKGMNIVDVSADIVKVLLERNSIDKVDEVIVGNVISSGLG
CCEEEEECCCHHHHHHHCCCCCCCEEEECHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
QNIARQITLKAGLGEAIPAFSVNKVCGSGLKSLELAFNSISLGESEVIVAGGVEDLSNAP
HHHHHHEEEECCCCCCCCCCCHHHHHHCCHHHHHHHHHHCCCCCCCEEEECCHHHHCCCC
YLLPRNVRFDGLKFGDFKIEDSIYKDALVDTPSSTVMGITAENLAEMYKITREMQDQFAY
EEEECCCCCCCEEECCEEECHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHH
NSHMKAKVARDSGYFNDEIYPLSIFDKKTKLKNVVSSDEEIRDNLSLEKLASLKPIFKEN
CCCCEEEEECCCCCCCCCEEEEEEECHHHHHHHHHCCCHHHHHCCCHHHHHHHCHHHHCC
GTITAGNSSSLDDGACFLILASGDFVHKMNVKPLAYIGGFKSVGLNPLHMGFGAFLAIEG
CEEEECCCCCCCCCEEEEEEECCCEEEECCCCEEEEECCHHHCCCCHHHHHHHHHHHHHH
IIEKFSLNSNEIDFIETNEAFAAQSLSVLKALREKYGIKDDIVNVNGGAIALGHPFSVSG
HHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEECCCCCCCC
SRILLTLARLMSMNNKSKGIASLCIGGGQGIAAFLYR
CHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHEECC
>Mature Secondary Structure
MKKIAIIGGLRSPITRFGGTLKGMNIVDVSADIVKVLLERNSIDKVDEVIVGNVISSGLG
CCEEEEECCCHHHHHHHCCCCCCCEEEECHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
QNIARQITLKAGLGEAIPAFSVNKVCGSGLKSLELAFNSISLGESEVIVAGGVEDLSNAP
HHHHHHEEEECCCCCCCCCCCHHHHHHCCHHHHHHHHHHCCCCCCCEEEECCHHHHCCCC
YLLPRNVRFDGLKFGDFKIEDSIYKDALVDTPSSTVMGITAENLAEMYKITREMQDQFAY
EEEECCCCCCCEEECCEEECHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHH
NSHMKAKVARDSGYFNDEIYPLSIFDKKTKLKNVVSSDEEIRDNLSLEKLASLKPIFKEN
CCCCEEEEECCCCCCCCCEEEEEEECHHHHHHHHHCCCHHHHHCCCHHHHHHHCHHHHCC
GTITAGNSSSLDDGACFLILASGDFVHKMNVKPLAYIGGFKSVGLNPLHMGFGAFLAIEG
CEEEECCCCCCCCCEEEEEEECCCEEEECCCCEEEEECCHHHCCCCHHHHHHHHHHHHHH
IIEKFSLNSNEIDFIETNEAFAAQSLSVLKALREKYGIKDDIVNVNGGAIALGHPFSVSG
HHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEECCCCCCCC
SRILLTLARLMSMNNKSKGIASLCIGGGQGIAAFLYR
CHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]