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The map label for this gene is trxA [H]

Identifier: 203283987

GI number: 203283987

Start: 67732

End: 68085

Strand: Reverse

Name: trxA [H]

Synonym: BDU_65

Alternate gene names: 203283987

Gene position: 68085-67732 (Counterclockwise)

Preceding gene: 203283989

Following gene: 203283986

Centisome position: 7.31

GC content: 29.66

Gene sequence:

>354_bases
ATGGCAATTAGTTTAACTAAGCAGGAATTTATTGATAAGGTTTTTGATTATAAAAACAATCAAGAATGGAATTTTAAGGG
TATAAAACCTGCAATAATTGATTTTTATGCTGATTGGTGTGGTCCATGTAAAATGCTTGCTCCGATTTATGACGAACTTT
CTGAGGAATATGGAGATAAAATTGATTTTTATAAAGTGAATACTGATAAGGAGCAAGAAGTTTCTATGGTGCTTGGTGTA
CAAAGTCTTCCTACCATTATTTTTGTTCCTGTTGGAGATAAACCAAGAGTTTCTGTTGGATTTATTGAAAAAAATTCTTT
GAAAGATGCAATTAAAGATTTGTTTAAAGTTTAA

Upstream 100 bases:

>100_bases
GTATTTATTAATATCAAATTCATTGTCTATATGATTTATTTCCTTATTAATTATATTATATTTATGTTATAATGAAAAAT
CTATTGATTTAGGAGAAAAT

Downstream 100 bases:

>100_bases
TAAGGGTTTTAATTATAAAAAATTGAACTCTTGTCTGTTTATATAATGTTCTTTTTAAGTTATAATTAATTTTAGGATAT
AGTGAATTGATAAAAGAGGA

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 117; Mature: 116

Protein sequence:

>117_residues
MAISLTKQEFIDKVFDYKNNQEWNFKGIKPAIIDFYADWCGPCKMLAPIYDELSEEYGDKIDFYKVNTDKEQEVSMVLGV
QSLPTIIFVPVGDKPRVSVGFIEKNSLKDAIKDLFKV

Sequences:

>Translated_117_residues
MAISLTKQEFIDKVFDYKNNQEWNFKGIKPAIIDFYADWCGPCKMLAPIYDELSEEYGDKIDFYKVNTDKEQEVSMVLGV
QSLPTIIFVPVGDKPRVSVGFIEKNSLKDAIKDLFKV
>Mature_116_residues
AISLTKQEFIDKVFDYKNNQEWNFKGIKPAIIDFYADWCGPCKMLAPIYDELSEEYGDKIDFYKVNTDKEQEVSMVLGVQ
SLPTIIFVPVGDKPRVSVGFIEKNSLKDAIKDLFKV

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI87082331, Length=78, Percent_Identity=38.4615384615385, Blast_Score=74, Evalue=2e-15,
Organism=Escherichia coli, GI1788936, Length=63, Percent_Identity=46.031746031746, Blast_Score=74, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17507705, Length=58, Percent_Identity=44.8275862068966, Blast_Score=68, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=106, Percent_Identity=31.1320754716981, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71980562, Length=72, Percent_Identity=41.6666666666667, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71980565, Length=72, Percent_Identity=41.6666666666667, Blast_Score=62, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=74, Percent_Identity=41.8918918918919, Blast_Score=68, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6323072, Length=72, Percent_Identity=40.2777777777778, Blast_Score=63, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24639826, Length=72, Percent_Identity=44.4444444444444, Blast_Score=79, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17648013, Length=84, Percent_Identity=38.0952380952381, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24583090, Length=84, Percent_Identity=38.0952380952381, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24658597, Length=75, Percent_Identity=41.3333333333333, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 13451; Mature: 13319

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAISLTKQEFIDKVFDYKNNQEWNFKGIKPAIIDFYADWCGPCKMLAPIYDELSEEYGDK
CCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCC
IDFYKVNTDKEQEVSMVLGVQSLPTIIFVPVGDKPRVSVGFIEKNSLKDAIKDLFKV
EEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEECHHHHHHHHHHHHCC
>Mature Secondary Structure 
AISLTKQEFIDKVFDYKNNQEWNFKGIKPAIIDFYADWCGPCKMLAPIYDELSEEYGDK
CCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCC
IDFYKVNTDKEQEVSMVLGVQSLPTIIFVPVGDKPRVSVGFIEKNSLKDAIKDLFKV
EEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEECHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9403685 [H]