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The map label for this gene is HisC

Identifier: 20094862

GI number: 20094862

Start: 1455566

End: 1456741

Strand: Direct

Name: HisC

Synonym: MK1426

Alternate gene names: 20094862

Gene position: 1455566-1456741 (Clockwise)

Preceding gene: 20094861

Following gene: 20094864

Centisome position: 85.88

GC content: 62.93

Gene sequence:

>1176_bases
GTGGATCGCGTACGTCCTCTCGCCGGGGGCCGGAACGTGAGGATCCGGGAAGCCGTGCTGAACATCGACCCGTACGTTCC
CGGCAAGTCGAAGGAAGAGATCGCTCGGGAATACGGTATCGAACCGGACGAGATAGTGAAGCTGGGATCAAACGAGAACC
CGCTGGGCCCTTCACCCAAGGCCGTGAAGGCCGCGAAGCGTGAGCTGGAACGCCTTCACGAGTACCCGGAACCCCTGGCA
CCTCCGTCCCTGTACGAGGCCATTATCGATTACCTGGCGGATCCTCCTTATCCCGCCGGAGAACCCGTGGAGATCACACG
GGAGCACCTAGTCGTCGGTGGGGACGGCGCCGACGAGATCATCGACGTGCTGACGCGCGTGCTCGTCGACCCGGGCGACC
CCGTGGTAATCCCCGTGCCCACCTTCTCGCAGTACGGCATCTCCGCACGGGCGTGCGGTGCCGAGGTCAGGAAGCCTCGC
TTCGACCCGGAGCGCGGGTTCGAGCTGGACGAGGACTCACTGTTCGAGGCCCTCGACCGGGAAGTGCGTCTAGTGTACCT
CTGTACCCCGAACAACCCTACGGGTAACCGGATCCGGGAGCGGGTCGTGAGGGACGTCGTGGAGGAGTGCCGCGGGGTCG
TCCTGATCGACCACGCCTACGTCGAGTTCGCCGACCACGACTACACACCGCTGGCGCTCGAGTACGACAACGTCCTCGTA
CTGCGCACGTGCTCCAAGGCGCTGGGTCTGGCCGGGGCCCGGGTCGGTTACGGGATAGCGAACCCCGAGCTGATCGAGCA
CCTACACCGGATCAAACCCGTGTTCAGCCTGACGAGACCCAGCGCGGCCGCCGCCGAGGCCACGTTCCGCGATCGGGACT
ACATCGAGAAGTCCGTACGGTTGATGATCGAGAGCCGAAAGTACCTGTACCGAGAGCTCCGGAAGTTGGATCGGTTAACA
CCGTTCCCCTCGGAGGCCAACTACCTCTTGGTGGATGTCTCCAACACTGGAATGAACGCGTCGGAGTTCACGGAGGAGCT
CCTGAAGCGCGGCGTCATAGTACGCGACTGCTCCAGCTTCGAGGGTATAGAGCCATTTTACGTCCGGGTATCTACCGGCA
CGCTCGAGGAGGATCGCAAGTTCATAGAGGTCGTGAAAGATGTGCTCGAGGTGTGA

Upstream 100 bases:

>100_bases
TCAACCTGAGGAAGGCCGTGAATTGGGGCAGTGCGCCGGTCCTCAGTATCGGGGGTGCCGGCACGTTCGACGCTGTGTTC
GTGACGGGTCTCACCGCCGT

Downstream 100 bases:

>100_bases
ACGCAACACGCCGTAGTAAGCGACGCCACGGTTCGTGCACGCCGCCGTTACAGCGCTACAGCGCTCCGAGTGAACTTAGC
GCACTAGTTCGTCGAGCAGC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MDRVRPLAGGRNVRIREAVLNIDPYVPGKSKEEIAREYGIEPDEIVKLGSNENPLGPSPKAVKAAKRELERLHEYPEPLA
PPSLYEAIIDYLADPPYPAGEPVEITREHLVVGGDGADEIIDVLTRVLVDPGDPVVIPVPTFSQYGISARACGAEVRKPR
FDPERGFELDEDSLFEALDREVRLVYLCTPNNPTGNRIRERVVRDVVEECRGVVLIDHAYVEFADHDYTPLALEYDNVLV
LRTCSKALGLAGARVGYGIANPELIEHLHRIKPVFSLTRPSAAAAEATFRDRDYIEKSVRLMIESRKYLYRELRKLDRLT
PFPSEANYLLVDVSNTGMNASEFTEELLKRGVIVRDCSSFEGIEPFYVRVSTGTLEEDRKFIEVVKDVLEV

Sequences:

>Translated_391_residues
MDRVRPLAGGRNVRIREAVLNIDPYVPGKSKEEIAREYGIEPDEIVKLGSNENPLGPSPKAVKAAKRELERLHEYPEPLA
PPSLYEAIIDYLADPPYPAGEPVEITREHLVVGGDGADEIIDVLTRVLVDPGDPVVIPVPTFSQYGISARACGAEVRKPR
FDPERGFELDEDSLFEALDREVRLVYLCTPNNPTGNRIRERVVRDVVEECRGVVLIDHAYVEFADHDYTPLALEYDNVLV
LRTCSKALGLAGARVGYGIANPELIEHLHRIKPVFSLTRPSAAAAEATFRDRDYIEKSVRLMIESRKYLYRELRKLDRLT
PFPSEANYLLVDVSNTGMNASEFTEELLKRGVIVRDCSSFEGIEPFYVRVSTGTLEEDRKFIEVVKDVLEV
>Mature_391_residues
MDRVRPLAGGRNVRIREAVLNIDPYVPGKSKEEIAREYGIEPDEIVKLGSNENPLGPSPKAVKAAKRELERLHEYPEPLA
PPSLYEAIIDYLADPPYPAGEPVEITREHLVVGGDGADEIIDVLTRVLVDPGDPVVIPVPTFSQYGISARACGAEVRKPR
FDPERGFELDEDSLFEALDREVRLVYLCTPNNPTGNRIRERVVRDVVEECRGVVLIDHAYVEFADHDYTPLALEYDNVLV
LRTCSKALGLAGARVGYGIANPELIEHLHRIKPVFSLTRPSAAAAEATFRDRDYIEKSVRLMIESRKYLYRELRKLDRLT
PFPSEANYLLVDVSNTGMNASEFTEELLKRGVIVRDCSSFEGIEPFYVRVSTGTLEEDRKFIEVVKDVLEV

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=382, Percent_Identity=31.413612565445, Blast_Score=139, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6322075, Length=393, Percent_Identity=29.2620865139949, Blast_Score=135, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_METKA (Q8TVG3)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_614709.1
- ProteinModelPortal:   Q8TVG3
- SMR:   Q8TVG3
- GeneID:   1478021
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK1426
- NMPDR:   fig|190192.1.peg.1422
- HOGENOM:   HBG646350
- OMA:   MSARYHH
- ProtClustDB:   PRK00950
- BioCyc:   MKAN190192:MK1426-MONOMER
- BRENDA:   2.6.1.9
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 43960; Mature: 43960

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRVRPLAGGRNVRIREAVLNIDPYVPGKSKEEIAREYGIEPDEIVKLGSNENPLGPSPK
CCCCCCCCCCCCEEEEHHHHCCCCCCCCCCHHHHHHHHCCCHHHHEECCCCCCCCCCCHH
AVKAAKRELERLHEYPEPLAPPSLYEAIIDYLADPPYPAGEPVEITREHLVVGGDGADEI
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHEEEEEEEECCCCHHHH
IDVLTRVLVDPGDPVVIPVPTFSQYGISARACGAEVRKPRFDPERGFELDEDSLFEALDR
HHHHHHHHCCCCCCEEEECCCCHHHCCCHHHCCHHHCCCCCCCCCCCCCCHHHHHHHHCC
EVRLVYLCTPNNPTGNRIRERVVRDVVEECRGVVLIDHAYVEFADHDYTPLALEYDNVLV
CEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEEHEEEECCCCCCCEEEECCCEEE
LRTCSKALGLAGARVGYGIANPELIEHLHRIKPVFSLTRPSAAAAEATFRDRDYIEKSVR
EEHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
LMIESRKYLYRELRKLDRLTPFPSEANYLLVDVSNTGMNASEFTEELLKRGVIVRDCSSF
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEECCCC
EGIEPFYVRVSTGTLEEDRKFIEVVKDVLEV
CCCCCEEEEEECCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDRVRPLAGGRNVRIREAVLNIDPYVPGKSKEEIAREYGIEPDEIVKLGSNENPLGPSPK
CCCCCCCCCCCCEEEEHHHHCCCCCCCCCCHHHHHHHHCCCHHHHEECCCCCCCCCCCHH
AVKAAKRELERLHEYPEPLAPPSLYEAIIDYLADPPYPAGEPVEITREHLVVGGDGADEI
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHEEEEEEEECCCCHHHH
IDVLTRVLVDPGDPVVIPVPTFSQYGISARACGAEVRKPRFDPERGFELDEDSLFEALDR
HHHHHHHHCCCCCCEEEECCCCHHHCCCHHHCCHHHCCCCCCCCCCCCCCHHHHHHHHCC
EVRLVYLCTPNNPTGNRIRERVVRDVVEECRGVVLIDHAYVEFADHDYTPLALEYDNVLV
CEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEEHEEEECCCCCCCEEEECCCEEE
LRTCSKALGLAGARVGYGIANPELIEHLHRIKPVFSLTRPSAAAAEATFRDRDYIEKSVR
EEHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
LMIESRKYLYRELRKLDRLTPFPSEANYLLVDVSNTGMNASEFTEELLKRGVIVRDCSSF
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEECCCC
EGIEPFYVRVSTGTLEEDRKFIEVVKDVLEV
CCCCCEEEEEECCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11930014