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The map label for this gene is TrpC

Identifier: 20094827

GI number: 20094827

Start: 1417522

End: 1418286

Strand: Direct

Name: TrpC

Synonym: MK1391

Alternate gene names: 20094827

Gene position: 1417522-1418286 (Clockwise)

Preceding gene: 20094825

Following gene: 20094828

Centisome position: 83.63

GC content: 65.23

Gene sequence:

>765_bases
CTGGACGAGATCCTGGAGCGCGTGAGGGAAAGGGTTGAGGAGATTCGCGACCGCACGTTCACGCCGAGAGCGGGAGGAAG
ATCGCTACGGAAGGCACTTTCGGGCCCCGGCGTGTCGGTGATCGCCGAGGTGAAACCCACCTCCCCCTCCCAGGGCAGAC
TACGCGACGTGGACGCGGAAGACGTCGCCGAGCGGGCCCGTGCGTACGAGCGAGGTGGTGCGGCGGGTATCTCCGTGTTG
ACCGAGCCCGAGTTCTTCGACGGTCGGCCTGAGTACGTCGAGGTCGTCCGGGAGGCCGTGGACGTTCCGGTACTCCGCAA
GGACTTCATAATCGACCCGGTGCAGGTGGAGGAGAGCGCGCACTACGGGGCCGACGCCGTACTGATCATTGCCGCGGCCG
TAGGTAGAGAGGCTCCCGAACTAATCGATCTGGCACACGAACACGGTATGGAGGTTCTACTGGAGATCGACCGATGGGAG
CACCTCGAACTGCTGAGCGAGTGCGATCCCGACGTCGTAGGGGTGAACAACCGGGACCTCCGCACGCTCGAGGTGGACCT
GAACCGGACGCTCGAGCTGGGTCCCGAGGTTAAAGACCTCACGAACGCCCCCCTGGTCGCCGAATCCGGTGTTTCCGGAC
CCGAGGACGTCGTCCTGTTGGGTGAGGTGGCCGACGCGGTGCTGGTCGGTACGTACCTGATGCGTGCCCCCGACCCGAGC
GAAGCGGTAAGGAAGCTCGTGGAAGCGGGGCGGTCGACGGAGTGA

Upstream 100 bases:

>100_bases
TCATCCGTTTCCTCATCTCCCTGGCTCGGTCGGGGCGCAGCCACCCCATCCGGACGTCGGACCAAGCCGATGTCGTCATC
GCCGGGGGTGTTCCGAGCTG

Downstream 100 bases:

>100_bases
TCGAACCGTACAAGCTGGCGTGGTCGGTTGTTTTCGGTATCTCCAGGGGTCTCTACGTGTTTGCGGGGTCGTTCATAGCG
GCGGCCCTGTACCGGTACGT

Product: indole-3-glycerol phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MDEILERVRERVEEIRDRTFTPRAGGRSLRKALSGPGVSVIAEVKPTSPSQGRLRDVDAEDVAERARAYERGGAAGISVL
TEPEFFDGRPEYVEVVREAVDVPVLRKDFIIDPVQVEESAHYGADAVLIIAAAVGREAPELIDLAHEHGMEVLLEIDRWE
HLELLSECDPDVVGVNNRDLRTLEVDLNRTLELGPEVKDLTNAPLVAESGVSGPEDVVLLGEVADAVLVGTYLMRAPDPS
EAVRKLVEAGRSTE

Sequences:

>Translated_254_residues
MDEILERVRERVEEIRDRTFTPRAGGRSLRKALSGPGVSVIAEVKPTSPSQGRLRDVDAEDVAERARAYERGGAAGISVL
TEPEFFDGRPEYVEVVREAVDVPVLRKDFIIDPVQVEESAHYGADAVLIIAAAVGREAPELIDLAHEHGMEVLLEIDRWE
HLELLSECDPDVVGVNNRDLRTLEVDLNRTLELGPEVKDLTNAPLVAESGVSGPEDVVLLGEVADAVLVGTYLMRAPDPS
EAVRKLVEAGRSTE
>Mature_254_residues
MDEILERVRERVEEIRDRTFTPRAGGRSLRKALSGPGVSVIAEVKPTSPSQGRLRDVDAEDVAERARAYERGGAAGISVL
TEPEFFDGRPEYVEVVREAVDVPVLRKDFIIDPVQVEESAHYGADAVLIIAAAVGREAPELIDLAHEHGMEVLLEIDRWE
HLELLSECDPDVVGVNNRDLRTLEVDLNRTLELGPEVKDLTNAPLVAESGVSGPEDVVLLGEVADAVLVGTYLMRAPDPS
EAVRKLVEAGRSTE

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=223, Percent_Identity=36.7713004484305, Blast_Score=130, Evalue=8e-32,
Organism=Saccharomyces cerevisiae, GI6322638, Length=222, Percent_Identity=37.3873873873874, Blast_Score=105, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_METKA (Q8TVJ8)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_614674.1
- ProteinModelPortal:   Q8TVJ8
- SMR:   Q8TVJ8
- GeneID:   1477986
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK1391
- NMPDR:   fig|190192.1.peg.1387
- HOGENOM:   HBG540956
- OMA:   KRASPRG
- BioCyc:   MKAN190192:MK1391-MONOMER
- BRENDA:   4.1.1.48
- HAMAP:   MF_00134_A
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 27774; Mature: 27774

Theoretical pI: Translated: 4.25; Mature: 4.25

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEILERVRERVEEIRDRTFTPRAGGRSLRKALSGPGVSVIAEVKPTSPSQGRLRDVDAE
CHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCHH
DVAERARAYERGGAAGISVLTEPEFFDGRPEYVEVVREAVDVPVLRKDFIIDPVQVEESA
HHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHCCCCHHHCCCC
HYGADAVLIIAAAVGREAPELIDLAHEHGMEVLLEIDRWEHLELLSECDPDVVGVNNRDL
CCCCCHHHHHHHHHCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHCCCCEECCCCCCC
RTLEVDLNRTLELGPEVKDLTNAPLVAESGVSGPEDVVLLGEVADAVLVGTYLMRAPDPS
EEEEECCCCCCCCCCCHHHHCCCCCEECCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCHH
EAVRKLVEAGRSTE
HHHHHHHHCCCCCC
>Mature Secondary Structure
MDEILERVRERVEEIRDRTFTPRAGGRSLRKALSGPGVSVIAEVKPTSPSQGRLRDVDAE
CHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCHH
DVAERARAYERGGAAGISVLTEPEFFDGRPEYVEVVREAVDVPVLRKDFIIDPVQVEESA
HHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHCCCCHHHCCCC
HYGADAVLIIAAAVGREAPELIDLAHEHGMEVLLEIDRWEHLELLSECDPDVVGVNNRDL
CCCCCHHHHHHHHHCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHCCCCEECCCCCCC
RTLEVDLNRTLELGPEVKDLTNAPLVAESGVSGPEDVVLLGEVADAVLVGTYLMRAPDPS
EEEEECCCCCCCCCCCHHHHCCCCCEECCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCHH
EAVRKLVEAGRSTE
HHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014