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The map label for this gene is Asd [H]

Identifier: 20094825

GI number: 20094825

Start: 1415734

End: 1416798

Strand: Direct

Name: Asd [H]

Synonym: MK1389

Alternate gene names: 20094825

Gene position: 1415734-1416798 (Clockwise)

Preceding gene: 20094824

Following gene: 20094827

Centisome position: 83.53

GC content: 66.01

Gene sequence:

>1065_bases
TTGGCGAAGGTTCGGGTCGGAGTCCTGGGCGCCACGGGTATCGTAGGTCAGCGGTTCATCAGCCTGCTGGCCGACCATCC
GTGGTTCGAGCTCGAGGCCGTGACGGCGTCGCCGCGCTCTGCCGGGAAGACCTACGCCGAGGCCGCTAAGTGGTACCTCG
AGGAGCCGATGCCGGAGGACGTGGCGGAGCTTACCGTTCTGGAGACCGACCCGAAGGAGGTGGAGCGCGAGGCGGACGTG
GACCTGGTGTTCTCCGCGCTACCGTCGGACGTGGCGCGCGACGTCGAGCCGGCGTTCGCGGAGGCTGGCTTCGCCGTCGC
CAGTAACGCCAGCGCGTACCGCATGGAGGAGGACGTCCCCCTGGTGGTGCCCGAGGTCAACCCGGACCATCTGGGACTGA
TCGACGTGCAGCGGGACGAGCGGGACTGGGACGGTTTCATCGTGACTAATCCCAACTGCTCGACGATCCAGATGGTCCTG
ACCCTCAAGCCGCTGATGGACGAGTACGGGATCGAGAGCGTAGTAGTCTCAACGATGCAGGCGGTCTCCGGCGCCGGTTA
CGCGGGCGTACCCTCGATGGCTATCATCGACAACGTGATTCCCTACATCGAGGGCGAGGAGGAGAAGATGGAGACCGAGA
CCCTGAAGATCCTGGGCGAGCTGGACGGCGACCGTGTCGAGTTCGCGGACGTCAAGGTCTCTGCATCGTGTCACCGAGTG
CCCGTGCTGGACGGTCACACCGAGGCGATCTTCGTGGCGACCGAGAAGGAGGCTGACCCGGAGGAGGCGGCGGAGGTTCT
GGCCGGGTTCCGGGGAGTCCCGCAGGAGAAGGGTCTACCGAGTGCACCGGAGCGTCCCGTCGTGGTCAGGGAGGAAGAGG
ACAGACCGCAGCCGAGGTTCGACCGCGACGTCGACGGCGGCATGGCCGTGGTCGTCGGCAGGATCCGTAAGGACCCGGTG
TTCGGCGGTCTGAAGTACGTGTGCGTCGGTCACAACGCGGTGAGGGGTGCTGCGGGCGCTTCCGTGCTGAACGCCGAGCT
CCTCGTTGAGGAAGGCTACCTGTAA

Upstream 100 bases:

>100_bases
GCGGCCCTCGGGAGAGGGCGCGGATGGTCACGGCCCGGCCGGTCCGGCTGCGGTCCTTTTTTTAACGGTGTCCCCTGTCC
GCGATGGGGGGTCGCGAAGG

Downstream 100 bases:

>100_bases
CCGGCTAGCAGCTCCGCCTTCTCCACGGCCTCCTCGGGTGATTCCGCCCCCTCGATCTCACCGCGCCTCGCCAGCTCCTC
GGCCCATCCTCCCGATGACG

Product: aspartate-semialdehyde dehydrogenase

Products: NA

Alternate protein names: ASA dehydrogenase; ASADH [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MAKVRVGVLGATGIVGQRFISLLADHPWFELEAVTASPRSAGKTYAEAAKWYLEEPMPEDVAELTVLETDPKEVEREADV
DLVFSALPSDVARDVEPAFAEAGFAVASNASAYRMEEDVPLVVPEVNPDHLGLIDVQRDERDWDGFIVTNPNCSTIQMVL
TLKPLMDEYGIESVVVSTMQAVSGAGYAGVPSMAIIDNVIPYIEGEEEKMETETLKILGELDGDRVEFADVKVSASCHRV
PVLDGHTEAIFVATEKEADPEEAAEVLAGFRGVPQEKGLPSAPERPVVVREEEDRPQPRFDRDVDGGMAVVVGRIRKDPV
FGGLKYVCVGHNAVRGAAGASVLNAELLVEEGYL

Sequences:

>Translated_354_residues
MAKVRVGVLGATGIVGQRFISLLADHPWFELEAVTASPRSAGKTYAEAAKWYLEEPMPEDVAELTVLETDPKEVEREADV
DLVFSALPSDVARDVEPAFAEAGFAVASNASAYRMEEDVPLVVPEVNPDHLGLIDVQRDERDWDGFIVTNPNCSTIQMVL
TLKPLMDEYGIESVVVSTMQAVSGAGYAGVPSMAIIDNVIPYIEGEEEKMETETLKILGELDGDRVEFADVKVSASCHRV
PVLDGHTEAIFVATEKEADPEEAAEVLAGFRGVPQEKGLPSAPERPVVVREEEDRPQPRFDRDVDGGMAVVVGRIRKDPV
FGGLKYVCVGHNAVRGAAGASVLNAELLVEEGYL
>Mature_353_residues
AKVRVGVLGATGIVGQRFISLLADHPWFELEAVTASPRSAGKTYAEAAKWYLEEPMPEDVAELTVLETDPKEVEREADVD
LVFSALPSDVARDVEPAFAEAGFAVASNASAYRMEEDVPLVVPEVNPDHLGLIDVQRDERDWDGFIVTNPNCSTIQMVLT
LKPLMDEYGIESVVVSTMQAVSGAGYAGVPSMAIIDNVIPYIEGEEEKMETETLKILGELDGDRVEFADVKVSASCHRVP
VLDGHTEAIFVATEKEADPEEAAEVLAGFRGVPQEKGLPSAPERPVVVREEEDRPQPRFDRDVDGGMAVVVGRIRKDPVF
GGLKYVCVGHNAVRGAAGASVLNAELLVEEGYL

Specific function: This enzyme catalyzes the second step in the common metabolic pathway to synthesize Thr and Met from Asp [H]

COG id: COG0136

COG function: function code E; Aspartate-semialdehyde dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aspartate-semialdehyde dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788658, Length=382, Percent_Identity=26.7015706806283, Blast_Score=65, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320362, Length=362, Percent_Identity=45.5801104972376, Blast_Score=293, Evalue=3e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000319
- InterPro:   IPR005676
- InterPro:   IPR012080
- InterPro:   IPR016040
- InterPro:   IPR000534
- InterPro:   IPR012280 [H]

Pfam domain/function: PF01118 Semialdhyde_dh; PF02774 Semialdhyde_dhC [H]

EC number: =1.2.1.11 [H]

Molecular weight: Translated: 38305; Mature: 38173

Theoretical pI: Translated: 4.11; Mature: 4.11

Prosite motif: PS01103 ASD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKVRVGVLGATGIVGQRFISLLADHPWFELEAVTASPRSAGKTYAEAAKWYLEEPMPED
CCEEEEEEECCCHHHHHHHHHHHHCCCCEEEEEEECCCHHCCHHHHHHHHHHHCCCCCCC
VAELTVLETDPKEVEREADVDLVFSALPSDVARDVEPAFAEAGFAVASNASAYRMEEDVP
HHHEEEEECCHHHHHHHCCHHHHHHHCCHHHHHHCCHHHHHCCCEEECCCCCEEECCCCC
LVVPEVNPDHLGLIDVQRDERDWDGFIVTNPNCSTIQMVLTLKPLMDEYGIESVVVSTMQ
EEECCCCCCCEEEEEEECCCCCCCCEEEECCCCCEEEEEEHHHHHHHHHCHHHHHHHHHH
AVSGAGYAGVPSMAIIDNVIPYIEGEEEKMETETLKILGELDGDRVEFADVKVSASCHRV
HHCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCEE
PVLDGHTEAIFVATEKEADPEEAAEVLAGFRGVPQEKGLPSAPERPVVVREEEDRPQPRF
EEECCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCC
DRDVDGGMAVVVGRIRKDPVFGGLKYVCVGHNAVRGAAGASVLNAELLVEEGYL
CCCCCCCCEEEEEHHHCCCCCCCEEEEEECCCHHCCCCCCHHHHHEEEEECCCC
>Mature Secondary Structure 
AKVRVGVLGATGIVGQRFISLLADHPWFELEAVTASPRSAGKTYAEAAKWYLEEPMPED
CEEEEEEECCCHHHHHHHHHHHHCCCCEEEEEEECCCHHCCHHHHHHHHHHHCCCCCCC
VAELTVLETDPKEVEREADVDLVFSALPSDVARDVEPAFAEAGFAVASNASAYRMEEDVP
HHHEEEEECCHHHHHHHCCHHHHHHHCCHHHHHHCCHHHHHCCCEEECCCCCEEECCCCC
LVVPEVNPDHLGLIDVQRDERDWDGFIVTNPNCSTIQMVLTLKPLMDEYGIESVVVSTMQ
EEECCCCCCCEEEEEEECCCCCCCCEEEECCCCCEEEEEEHHHHHHHHHCHHHHHHHHHH
AVSGAGYAGVPSMAIIDNVIPYIEGEEEKMETETLKILGELDGDRVEFADVKVSASCHRV
HHCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCEE
PVLDGHTEAIFVATEKEADPEEAAEVLAGFRGVPQEKGLPSAPERPVVVREEEDRPQPRF
EEECCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCC
DRDVDGGMAVVVGRIRKDPVFGGLKYVCVGHNAVRGAAGASVLNAELLVEEGYL
CCCCCCCCEEEEEHHHCCCCCCCEEEEEECCCHHCCCCCCHHHHHEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]