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The map label for this gene is fadA [C]

Identifier: 20094814

GI number: 20094814

Start: 1404635

End: 1405819

Strand: Reverse

Name: fadA [C]

Synonym: MK1378

Alternate gene names: 20094814

Gene position: 1405819-1404635 (Counterclockwise)

Preceding gene: 20094815

Following gene: 20094813

Centisome position: 82.94

GC content: 66.08

Gene sequence:

>1185_bases
ATGGTGTGCGTGCGTTTCCGTCGGGACGTCGCCATCGTCGGCGTGGGTATGACGAGGTTCGGAGAGCTGTGGGAGCGGTC
CTTCGACGACCTGTTCGTGGAGGCCGGGTTGGAGGCCCTCGAGGACGCGGGCATGGGAGGCGACGAGATCGAGGCGATGT
ACGTCGGGAACATGAGCGCAGGTCGCTTCATCGACCAGGAGCACGTGGCCTCGTTGATCGCGGACCGGTCCGGTCTGACA
CCTATCCCGTGTACGCGGGTCGAGGCGGCCTGTGCCTCCGGCGGCCTGGCCGTGCGTCAGGCCATCCTTGCGGTGGCCTC
CGGGATGTACGACATCGTGCTAGCCGGCGGCGTCGAGAAGATGACCGACGTGACCACGGAGGAGGCGACCGCGACGTTAG
CCACGGCGGCGGACCAGGAGTGGGAGGCGTTCCACGGGGTCACGTTCCCCGCCCTTTACGCGATGATCGCCAGGAGGCAC
ATGTACGAGTACGGAACTACCCGGGAGCACCTGGCGCTTCCGCCGGTGAAGAACCATCGCAACGCCACCAAGAACCCGAA
GGCTCAGTTCCAGTTCGAGATCACGGTCGAGCAGGTAATCGAGAGCCCGCTCGTCGCCGACCCGCTCCGGTTACTCGACT
GTTCTCCGGTGTCGGACGGTGCCGCCGCCGTGATAGTCTGCCCACTCGAGATGGCCAAGGAGTTCACGGACACGCCGATC
GTGGTGCGCGCGACGGCCCAGGCCTCAGACTCCATCGCGCTGCACGACCGCGAGGACATCACCACGCTGAAGGCCACGGT
CGAGGCCGCGAAGACCGTGTACAAGCAGGCGGGTGTGGAGCCCGAGGAAGTGGACGTGGCCGAGGTGCACGACTGCTTCT
CGATCGCGGAGCTCGTGGCCGTCGAGGACCTGGGCTTCGTCGAGAAGGGAGAGGCCGGTGAAGCGTACCACGAGGGGATG
TTCGAGATCGACTCCGATTACGTCGCGGTGAACCCGAGCGGTGGGCTGAAGGCGAAGGGACACCCGGTGGGCGCGTCGGG
CGTCGCCCAGGTGGTCGAGATCGTGGAGCAACTGAGAGGAGAAGCCGGGAAGCGCCAGGTCGACGGCGCCGAGATCGGGC
TCACTCACAACGTTGGAGGTTCGGGAGGTACCGTGGTCGTCCATATCTTCGAGCGGGCCGATTAG

Upstream 100 bases:

>100_bases
CGGGAGAAGGCCCCGCTGCTGGAGGAGTACCTGGAGGATCGCGTGTACGTGACGTATGGAGAGTACGCGAAGATGAAGAA
GAAGCTCAAGTTCTGAGGGG

Downstream 100 bases:

>100_bases
GGGGGATCCGTCGTGGGTGGCGTACCCCGCTTCTGGCGGAGCATCGACAACAGGTACCGGTTGGTCGGGACGAGGTGCAA
GAACTGCGGGGAGGTGTTCT

Product: acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MVCVRFRRDVAIVGVGMTRFGELWERSFDDLFVEAGLEALEDAGMGGDEIEAMYVGNMSAGRFIDQEHVASLIADRSGLT
PIPCTRVEAACASGGLAVRQAILAVASGMYDIVLAGGVEKMTDVTTEEATATLATAADQEWEAFHGVTFPALYAMIARRH
MYEYGTTREHLALPPVKNHRNATKNPKAQFQFEITVEQVIESPLVADPLRLLDCSPVSDGAAAVIVCPLEMAKEFTDTPI
VVRATAQASDSIALHDREDITTLKATVEAAKTVYKQAGVEPEEVDVAEVHDCFSIAELVAVEDLGFVEKGEAGEAYHEGM
FEIDSDYVAVNPSGGLKAKGHPVGASGVAQVVEIVEQLRGEAGKRQVDGAEIGLTHNVGGSGGTVVVHIFERAD

Sequences:

>Translated_394_residues
MVCVRFRRDVAIVGVGMTRFGELWERSFDDLFVEAGLEALEDAGMGGDEIEAMYVGNMSAGRFIDQEHVASLIADRSGLT
PIPCTRVEAACASGGLAVRQAILAVASGMYDIVLAGGVEKMTDVTTEEATATLATAADQEWEAFHGVTFPALYAMIARRH
MYEYGTTREHLALPPVKNHRNATKNPKAQFQFEITVEQVIESPLVADPLRLLDCSPVSDGAAAVIVCPLEMAKEFTDTPI
VVRATAQASDSIALHDREDITTLKATVEAAKTVYKQAGVEPEEVDVAEVHDCFSIAELVAVEDLGFVEKGEAGEAYHEGM
FEIDSDYVAVNPSGGLKAKGHPVGASGVAQVVEIVEQLRGEAGKRQVDGAEIGLTHNVGGSGGTVVVHIFERAD
>Mature_394_residues
MVCVRFRRDVAIVGVGMTRFGELWERSFDDLFVEAGLEALEDAGMGGDEIEAMYVGNMSAGRFIDQEHVASLIADRSGLT
PIPCTRVEAACASGGLAVRQAILAVASGMYDIVLAGGVEKMTDVTTEEATATLATAADQEWEAFHGVTFPALYAMIARRH
MYEYGTTREHLALPPVKNHRNATKNPKAQFQFEITVEQVIESPLVADPLRLLDCSPVSDGAAAVIVCPLEMAKEFTDTPI
VVRATAQASDSIALHDREDITTLKATVEAAKTVYKQAGVEPEEVDVAEVHDCFSIAELVAVEDLGFVEKGEAGEAYHEGM
FEIDSDYVAVNPSGGLKAKGHPVGASGVAQVVEIVEQLRGEAGKRQVDGAEIGLTHNVGGSGGTVVVHIFERAD

Specific function: Subunit Of The Multifunctional Enzyme Complex Of The Fatty Acid Degradation Cycle. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI19923233, Length=399, Percent_Identity=35.8395989974937, Blast_Score=212, Evalue=6e-55,
Organism=Homo sapiens, GI302344760, Length=399, Percent_Identity=34.0852130325814, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI302344767, Length=325, Percent_Identity=36, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI302344762, Length=399, Percent_Identity=33.3333333333333, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI55956775, Length=355, Percent_Identity=30.4225352112676, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17537653, Length=400, Percent_Identity=34.25, Blast_Score=197, Evalue=7e-51,
Organism=Drosophila melanogaster, GI24585051, Length=397, Percent_Identity=34.5088161209068, Blast_Score=198, Evalue=7e-51,
Organism=Drosophila melanogaster, GI19921506, Length=400, Percent_Identity=33.75, Blast_Score=196, Evalue=3e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 42064; Mature: 42064

Theoretical pI: Translated: 4.33; Mature: 4.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVCVRFRRDVAIVGVGMTRFGELWERSFDDLFVEAGLEALEDAGMGGDEIEAMYVGNMSA
CEEEEEECCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCC
GRFIDQEHVASLIADRSGLTPIPCTRVEAACASGGLAVRQAILAVASGMYDIVLAGGVEK
CCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCHHEEEEECCHHH
MTDVTTEEATATLATAADQEWEAFHGVTFPALYAMIARRHMYEYGTTREHLALPPVKNHR
HHHCCHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCC
NATKNPKAQFQFEITVEQVIESPLVADPLRLLDCSPVSDGAAAVIVCPLEMAKEFTDTPI
CCCCCCCCEEEEEEEHHHHHCCCCCCCCHHHHCCCCCCCCCCEEEEECHHHHHHCCCCCE
VVRATAQASDSIALHDREDITTLKATVEAAKTVYKQAGVEPEEVDVAEVHDCFSIAELVA
EEEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHH
VEDLGFVEKGEAGEAYHEGMFEIDSDYVAVNPSGGLKAKGHPVGASGVAQVVEIVEQLRG
HHHCCCCCCCCCCCHHHCCCEEECCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
EAGKRQVDGAEIGLTHNVGGSGGTVVVHIFERAD
CCCCCCCCCCEEEEEECCCCCCCEEEEEEEECCC
>Mature Secondary Structure
MVCVRFRRDVAIVGVGMTRFGELWERSFDDLFVEAGLEALEDAGMGGDEIEAMYVGNMSA
CEEEEEECCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCC
GRFIDQEHVASLIADRSGLTPIPCTRVEAACASGGLAVRQAILAVASGMYDIVLAGGVEK
CCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCHHEEEEECCHHH
MTDVTTEEATATLATAADQEWEAFHGVTFPALYAMIARRHMYEYGTTREHLALPPVKNHR
HHHCCHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCC
NATKNPKAQFQFEITVEQVIESPLVADPLRLLDCSPVSDGAAAVIVCPLEMAKEFTDTPI
CCCCCCCCEEEEEEEHHHHHCCCCCCCCHHHHCCCCCCCCCCEEEEECHHHHHHCCCCCE
VVRATAQASDSIALHDREDITTLKATVEAAKTVYKQAGVEPEEVDVAEVHDCFSIAELVA
EEEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHH
VEDLGFVEKGEAGEAYHEGMFEIDSDYVAVNPSGGLKAKGHPVGASGVAQVVEIVEQLRG
HHHCCCCCCCCCCCHHHCCCEEECCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
EAGKRQVDGAEIGLTHNVGGSGGTVVVHIFERAD
CCCCCCCCCCEEEEEECCCCCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: Acyl group transfer; Claisen condensation [C]

Inhibitor: Tris (hydroxy methyl) aminomethane [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]