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The map label for this gene is PurE [H]

Identifier: 20094631

GI number: 20094631

Start: 1189569

End: 1190054

Strand: Direct

Name: PurE [H]

Synonym: MK1195

Alternate gene names: 20094631

Gene position: 1189569-1190054 (Clockwise)

Preceding gene: 20094630

Following gene: 20094634

Centisome position: 70.18

GC content: 66.05

Gene sequence:

>486_bases
ATGGTCGACGTTCTGATCGTTCTGGGAAGTAGGAGCGATCGAGACGTCGCCGAGAAGGCCGCGAAGGTGCTCGACCGAGC
CGGCGTCGACTACAACGTGCGGGTGGCCTCCGCCCACCGGACGCCGGAGCGTATCGACGAGCTGATCGAGGAGTACGAGC
CCGACGTGAAGGTGTACATCGCGATCGCGGGTCTGGCCGCTCACCTCCCGGGTGTGATCGCCGCCAAGACCCTGAAGCCC
GTGATCGCCGTGCCGGTGGAGGCGAAGCTGTGTGGTCTGGACGCGCTCCTCTCGACCGTGCAGATGCCCCCGGGTGTACC
GGTGGCGGTTGTCGGCGTGGATCGCGGGGAGAACGCGGCGCTCTTGGCCTTGCAGATCCTGGCACTGGAGGACGAGGACG
TCCGGTCCTTCCTGGAGGAGTACCGGGAGGAGATGAAGAAGCAGGTGGCCCGGGACGACGACACGATCAAGGAGCGTTTC
CGGTGA

Upstream 100 bases:

>100_bases
CTTGGGGTACGTGGCCCAGTCCGAGACCGTCCGCAACTGGATCTCCTACTACCTGGGGCCTAAGGCCCTGAAGATGCTCA
TGAGTACGGGGTGACCTGGA

Downstream 100 bases:

>100_bases
CGCAGTCCGCCAGGGCGTTGAACGCCGCCACCGCGAGCGGTGTCCCACCGCGGACCGAGACGTTCGTCACCACCGGGATT
CCGGCGTCCATCGCGGCTCG

Product: phosphoribosylaminoimidazole carboxylase catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 161; Mature: 161

Protein sequence:

>161_residues
MVDVLIVLGSRSDRDVAEKAAKVLDRAGVDYNVRVASAHRTPERIDELIEEYEPDVKVYIAIAGLAAHLPGVIAAKTLKP
VIAVPVEAKLCGLDALLSTVQMPPGVPVAVVGVDRGENAALLALQILALEDEDVRSFLEEYREEMKKQVARDDDTIKERF
R

Sequences:

>Translated_161_residues
MVDVLIVLGSRSDRDVAEKAAKVLDRAGVDYNVRVASAHRTPERIDELIEEYEPDVKVYIAIAGLAAHLPGVIAAKTLKP
VIAVPVEAKLCGLDALLSTVQMPPGVPVAVVGVDRGENAALLALQILALEDEDVRSFLEEYREEMKKQVARDDDTIKERF
R
>Mature_161_residues
MVDVLIVLGSRSDRDVAEKAAKVLDRAGVDYNVRVASAHRTPERIDELIEEYEPDVKVYIAIAGLAAHLPGVIAAKTLKP
VIAVPVEAKLCGLDALLSTVQMPPGVPVAVVGVDRGENAALLALQILALEDEDVRSFLEEYREEMKKQVARDDDTIKERF
R

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=110, Percent_Identity=50, Blast_Score=99, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6324702, Length=148, Percent_Identity=44.5945945945946, Blast_Score=110, Evalue=9e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17614; Mature: 17614

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDVLIVLGSRSDRDVAEKAAKVLDRAGVDYNVRVASAHRTPERIDELIEEYEPDVKVYI
CEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEE
AIAGLAAHLPGVIAAKTLKPVIAVPVEAKLCGLDALLSTVQMPPGVPVAVVGVDRGENAA
EEEHHHHHCCHHHHHHHHCCEEECCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHH
LLALQILALEDEDVRSFLEEYREEMKKQVARDDDTIKERFR
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCC
>Mature Secondary Structure
MVDVLIVLGSRSDRDVAEKAAKVLDRAGVDYNVRVASAHRTPERIDELIEEYEPDVKVYI
CEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEE
AIAGLAAHLPGVIAAKTLKPVIAVPVEAKLCGLDALLSTVQMPPGVPVAVVGVDRGENAA
EEEHHHHHCCHHHHHHHHCCEEECCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHH
LLALQILALEDEDVRSFLEEYREEMKKQVARDDDTIKERFR
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]