BacMap

Definition	Methanopyrus kandleri AV19, complete genome.
Accession	NC_003551
Length	1,694,969

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The map label for this gene is HslV_1

Identifier: 20093823

GI number: 20093823

Start: 369855

End: 370595

Strand: Reverse

Name: HslV_1

Synonym: MK0385

Alternate gene names: 20093823

Gene position: 370595-369855 (Counterclockwise)

Preceding gene: 20093824

Following gene: 20093822

Centisome position: 21.86

GC content: 60.19

Gene sequence:

>741_bases
GTGGCCGTGCAACCCGCTCAGACGGCGTATGACCGGGCCATCACCGTCTTCAGCCCGGACGGTCGACTGTTCCAGGTCGA
GTACGCGCGCGAGGCCGTCAAGCGTGGCACTACGGCTCTGGGGATTAAAGTGGAAGAGGGTGTCGTCCTCGGGGTCGATA
AGCGCGTCACCTCCAAGCTGATCGAGCCCGAGTCCATAGAGAAAGTCTACCAGATCGACACTCACATTGGAGCGGCTACG
GCGGGGCTCGTCGCGGACGCTCGTGTGTTAGTCGAGCGCGCCAGGATCGAGGCACAGACGTATCGGTACACTTACGGTGA
GCCGATCGATGTGGACGTGCTCGTGAAGGCTATCTGCGACCTCAAGCAGGTGTACACGCAGCATGGAGGAGTTCGACCCT
TCGGAACCGCGCTTTTGATCGCCGGGGTGGACACGAAGGGATGTCGCCTGTTCGAGACCGATCCCAGCGGTGCTCTGACC
GAACACAAAGCCACGGCGATCGGTGAGGGTCGACAGGAAGCGTTGGACGTGTTCGAAGAGGAATACCGGGAGGACATGAC
CCTTCAAGAGGCCATCGAGCTCGCGGTGCGGGCGCTGTACGAAGCCTCACGGGAAGAGACTACCGCTGACAACCTCGAGA
TCGCCGTCGTCGATAAACAAGGGTTCCGGAAGTTGGAGCGGAAGAAGATCGAGGAGATGTTTGAACGTGTAGTCGGTTCG
GAGGAAGACGAGGGTGAATGA

Upstream 100 bases:

>100_bases
TCGTGTTGTACGAGAACGGTGAAGTCGACGTCGTGGAGGATGGTCGTATAGTGGCGTTCGCTAGCTTCGAATGTCCACTG
CCTGAGGAGAATCGGGGGTA

Downstream 100 bases:

>100_bases
CGATGGCCCGAGTCAGTCTAGAAGACGCCGTGGTAGCGCGTCTGGAGAAGGGAGGCGAGCGCTTCGAGGTACTCGTAGAC
CCCGAAGGGGCCCGTAAATT

Product: proteasome subunit alpha

Products: NA

Alternate protein names: 20S proteasome alpha subunit; Proteasome core protein PsmA

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MAVQPAQTAYDRAITVFSPDGRLFQVEYAREAVKRGTTALGIKVEEGVVLGVDKRVTSKLIEPESIEKVYQIDTHIGAAT
AGLVADARVLVERARIEAQTYRYTYGEPIDVDVLVKAICDLKQVYTQHGGVRPFGTALLIAGVDTKGCRLFETDPSGALT
EHKATAIGEGRQEALDVFEEEYREDMTLQEAIELAVRALYEASREETTADNLEIAVVDKQGFRKLERKKIEEMFERVVGS
EEDEGE

Sequences:

>Translated_246_residues
MAVQPAQTAYDRAITVFSPDGRLFQVEYAREAVKRGTTALGIKVEEGVVLGVDKRVTSKLIEPESIEKVYQIDTHIGAAT
AGLVADARVLVERARIEAQTYRYTYGEPIDVDVLVKAICDLKQVYTQHGGVRPFGTALLIAGVDTKGCRLFETDPSGALT
EHKATAIGEGRQEALDVFEEEYREDMTLQEAIELAVRALYEASREETTADNLEIAVVDKQGFRKLERKKIEEMFERVVGS
EEDEGE
>Mature_245_residues
AVQPAQTAYDRAITVFSPDGRLFQVEYAREAVKRGTTALGIKVEEGVVLGVDKRVTSKLIEPESIEKVYQIDTHIGAATA
GLVADARVLVERARIEAQTYRYTYGEPIDVDVLVKAICDLKQVYTQHGGVRPFGTALLIAGVDTKGCRLFETDPSGALTE
HKATAIGEGRQEALDVFEEEYREDMTLQEAIELAVRALYEASREETTADNLEIAVVDKQGFRKLERKKIEEMFERVVGSE
EDEGE

Specific function: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation

COG id: COG0638

COG function: function code O; 20S proteasome, alpha and beta subunits

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase T1A family

Homologues:

Organism=Homo sapiens, GI23110942, Length=234, Percent_Identity=44.017094017094, Blast_Score=209, Evalue=2e-54,
Organism=Homo sapiens, GI68303563, Length=226, Percent_Identity=45.575221238938, Blast_Score=193, Evalue=1e-49,
Organism=Homo sapiens, GI68303561, Length=232, Percent_Identity=44.3965517241379, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI4506189, Length=228, Percent_Identity=43.859649122807, Blast_Score=185, Evalue=3e-47,
Organism=Homo sapiens, GI4506181, Length=227, Percent_Identity=41.8502202643172, Blast_Score=181, Evalue=5e-46,
Organism=Homo sapiens, GI156713442, Length=232, Percent_Identity=39.6551724137931, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI4506185, Length=232, Percent_Identity=39.6551724137931, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI68303565, Length=226, Percent_Identity=39.8230088495575, Blast_Score=153, Evalue=1e-37,
Organism=Homo sapiens, GI23110944, Length=232, Percent_Identity=34.051724137931, Blast_Score=151, Evalue=6e-37,
Organism=Homo sapiens, GI4506183, Length=194, Percent_Identity=39.1752577319588, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI23110939, Length=193, Percent_Identity=39.3782383419689, Blast_Score=145, Evalue=3e-35,
Organism=Homo sapiens, GI23110935, Length=217, Percent_Identity=38.2488479262673, Blast_Score=141, Evalue=5e-34,
Organism=Homo sapiens, GI4506179, Length=217, Percent_Identity=38.2488479262673, Blast_Score=141, Evalue=6e-34,
Organism=Homo sapiens, GI156713444, Length=166, Percent_Identity=37.9518072289157, Blast_Score=118, Evalue=5e-27,
Organism=Homo sapiens, GI221316716, Length=109, Percent_Identity=42.2018348623853, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI4506191, Length=204, Percent_Identity=28.4313725490196, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4506201, Length=212, Percent_Identity=27.3584905660377, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI73747875, Length=217, Percent_Identity=24.8847926267281, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI4758970, Length=217, Percent_Identity=24.8847926267281, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI4506203, Length=189, Percent_Identity=27.5132275132275, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17508491, Length=239, Percent_Identity=45.1882845188285, Blast_Score=194, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17508493, Length=212, Percent_Identity=43.8679245283019, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI25143215, Length=213, Percent_Identity=40.8450704225352, Blast_Score=173, Evalue=9e-44,
Organism=Caenorhabditis elegans, GI17562790, Length=225, Percent_Identity=40, Blast_Score=159, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17562788, Length=238, Percent_Identity=34.0336134453782, Blast_Score=142, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17562792, Length=236, Percent_Identity=36.0169491525424, Blast_Score=136, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI71998965, Length=208, Percent_Identity=33.6538461538462, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17508495, Length=192, Percent_Identity=27.6041666666667, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6321692, Length=239, Percent_Identity=42.6778242677824, Blast_Score=193, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6321574, Length=213, Percent_Identity=44.131455399061, Blast_Score=189, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6324535, Length=219, Percent_Identity=44.2922374429224, Blast_Score=181, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6324938, Length=212, Percent_Identity=40.0943396226415, Blast_Score=164, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6323547, Length=244, Percent_Identity=38.1147540983607, Blast_Score=162, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6321427, Length=232, Percent_Identity=34.4827586206897, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6323974, Length=221, Percent_Identity=38.0090497737557, Blast_Score=127, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6324731, Length=192, Percent_Identity=29.6875, Blast_Score=76, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6325360, Length=217, Percent_Identity=23.963133640553, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24654391, Length=236, Percent_Identity=40.2542372881356, Blast_Score=197, Evalue=6e-51,
Organism=Drosophila melanogaster, GI24654389, Length=236, Percent_Identity=40.2542372881356, Blast_Score=197, Evalue=6e-51,
Organism=Drosophila melanogaster, GI17933602, Length=213, Percent_Identity=43.6619718309859, Blast_Score=190, Evalue=8e-49,
Organism=Drosophila melanogaster, GI17737927, Length=228, Percent_Identity=41.6666666666667, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI21356137, Length=235, Percent_Identity=42.5531914893617, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI19922898, Length=243, Percent_Identity=40.7407407407407, Blast_Score=177, Evalue=6e-45,
Organism=Drosophila melanogaster, GI17136420, Length=238, Percent_Identity=38.2352941176471, Blast_Score=170, Evalue=7e-43,
Organism=Drosophila melanogaster, GI281360341, Length=236, Percent_Identity=36.4406779661017, Blast_Score=166, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24586406, Length=236, Percent_Identity=36.4406779661017, Blast_Score=166, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24586400, Length=236, Percent_Identity=36.4406779661017, Blast_Score=166, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24586402, Length=236, Percent_Identity=36.4406779661017, Blast_Score=166, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24651571, Length=237, Percent_Identity=35.0210970464135, Blast_Score=157, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24652204, Length=199, Percent_Identity=37.1859296482412, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI17737405, Length=192, Percent_Identity=38.0208333333333, Blast_Score=124, Evalue=5e-29,
Organism=Drosophila melanogaster, GI19921232, Length=210, Percent_Identity=38.0952380952381, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24584895, Length=252, Percent_Identity=27.3809523809524, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI20130281, Length=228, Percent_Identity=28.0701754385965, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24639979, Length=196, Percent_Identity=25.5102040816327, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21355573, Length=205, Percent_Identity=27.3170731707317, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24652553, Length=205, Percent_Identity=27.3170731707317, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28573221, Length=189, Percent_Identity=26.4550264550265, Blast_Score=71, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PSA_METKA (Q8TYB7)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_613670.1
- ProteinModelPortal:   Q8TYB7
- SMR:   Q8TYB7
- GeneID:   1477688
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0385
- NMPDR:   fig|190192.1.peg.383
- HOGENOM:   HBG499923
- OMA:   IFQIDDH
- ProtClustDB:   PRK03996
- BioCyc:   MKAN190192:MK0385-MONOMER
- BRENDA:   3.4.25.1
- GO:   GO:0005737
- HAMAP:   MF_00289_A
- InterPro:   IPR019982
- InterPro:   IPR000426
- InterPro:   IPR001353
- SMART:   SM00948
- TIGRFAMs:   TIGR03633

Pfam domain/function: PF00227 Proteasome; PF10584 Proteasome_A_N

EC number: =3.4.25.1

Molecular weight: Translated: 27287; Mature: 27156

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: PS00388 PROTEASOME_A_1; PS51475 PROTEASOME_A_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVQPAQTAYDRAITVFSPDGRLFQVEYAREAVKRGTTALGIKVEEGVVLGVDKRVTSKL
CCCCCCCHHHHCEEEEECCCCCEEEEHHHHHHHHCCCEEEEEEECCCEEEECCHHHHHHC
IEPESIEKVYQIDTHIGAATAGLVADARVLVERARIEAQTYRYTYGEPIDVDVLVKAICD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHH
LKQVYTQHGGVRPFGTALLIAGVDTKGCRLFETDPSGALTEHKATAIGEGRQEALDVFEE
HHHHHHHCCCCCCCCCEEEEECCCCCCCEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHH
EYREDMTLQEAIELAVRALYEASREETTADNLEIAVVDKQGFRKLERKKIEEMFERVVGS
HHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCC
EEDEGE
CCCCCC
>Mature Secondary Structure 
AVQPAQTAYDRAITVFSPDGRLFQVEYAREAVKRGTTALGIKVEEGVVLGVDKRVTSKL
CCCCCCHHHHCEEEEECCCCCEEEEHHHHHHHHCCCEEEEEEECCCEEEECCHHHHHHC
IEPESIEKVYQIDTHIGAATAGLVADARVLVERARIEAQTYRYTYGEPIDVDVLVKAICD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHH
LKQVYTQHGGVRPFGTALLIAGVDTKGCRLFETDPSGALTEHKATAIGEGRQEALDVFEE
HHHHHHHCCCCCCCCCEEEEECCCCCCCEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHH
EYREDMTLQEAIELAVRALYEASREETTADNLEIAVVDKQGFRKLERKKIEEMFERVVGS
HHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCC
EEDEGE
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014