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The map label for this gene is mtaD

Identifier: 20093804

GI number: 20093804

Start: 353673

End: 354968

Strand: Direct

Name: mtaD

Synonym: MK0366

Alternate gene names: 20093804

Gene position: 353673-354968 (Clockwise)

Preceding gene: 20093802

Following gene: 20093806

Centisome position: 20.87

GC content: 54.4

Gene sequence:

>1296_bases
TTGAGGCTCGCGATACTAGGAGGCATCGCGGTAACTCCGGAGCGCGTGATCGAAGACGCCGGAATTCTGATCGACGAAGA
CGGCCGGATCTCGTTCGTGGACACCCGAGAACAGCTCGAGGAGTGTGAAGACTGGGAGGACGAAATAGAGCTCGGAGAGA
AGGACGTTATCATGCCGGGCTTGATCAACACTCACACACACGGTCCCATGACGCTGTTTCGAGGCGTCGCCGATGATATG
CCACTGATGAAGTGGTTGAGGGAAGAGATATGGCCACTAGAGGAGCGCCTCGACGCCGAGAAGTGCCGATGGGGAGCGGC
GCTCGCGGCTATGGAGGCCCTCAAGTCCGGCACTACCTGTCTCGCCGACATGTACTTCTTCATGGACGCCGTAGCCGAGG
CCTACGCCGAAGTCGGCATCCGCGCGGTGATCTCCCACGGCATGATTGACCTCGGCGAGGAGGATAAGCGGGAGGAGGAG
CTGAAAGAGTCGAAACGCGTGTACCGCAAGTGCCAAGGGATGGAAGGACTCATCGAGTTCTCGCTAGGACCGCATGCCCC
CTACACATGCTCGGAGGAGTTGCTCAAGGAGGTCCGGCGCTTAGCGGACGAGTGGGGCGTTAAAATTCAGATCCACGTGG
CCGAAACTGAGGACGAGGTAAAAGAGGTGAAACGGAAGCACGGGAAGCGACCGGTAGAGTACCTGGACGAAATCGGACTG
CTTGGTGACGACGTTATAGCCGCCCACTGCGTGTGGCTCGATGATAAAGAAATTGAAATATTATCGAAGAGAGGAGTAAT
AGTCTCACACAATCCAATCAGTAACATGAAGTTGGCTTCAGGTATCAGCCCCGTACCTGAAATGCTCGAGAGAGGCGTCA
ACGTCACTATAGGTACAGACGGGTGTGCTAGCAACAACAACCTCGATATGTTGGAGGAGATCAAAGTAGCAGCTCTGTTA
CATAAAGTGAATAAGATGGATCCGTCGGCCACGGAAATGTTGGAGATCCTGAGGATGGCGACGGTGAGGGCGGGTACGGT
CTTCTCGAGCGAGAAGATAGGAGCCATCGAGGAAGGTTACGCGGCAGACCTAGTAGTTTTAGACGGTAGTTCTCCCAGAC
TGAATCCCAATCACAACCCGATCTCAAACATTGTATACTCAGCCTCAGGATCGGACGTGAAGCATGTGTTCGTGGCAGGA
GAACTCGTAGTGAAGAACGGAAAACTCGTTAAAGCAGACGAGCAAGAAATACTGGAAAACTCCACCGAGTGCGCAGAACA
ACTCACCTCCTCATGA

Upstream 100 bases:

>100_bases
CTCGTGTAGGCGTCCTTTGTTGGGTACCGCTACGGTTATCACTTGCGCCCTCCGTCGACGTCCCAGCCGCAGGATATAAC
GGTACCCGGGGACCTCGGAC

Downstream 100 bases:

>100_bases
GTCTAACTCCCAGGTAAATCGCCGCTCCCGCTAGCACTACTACTAGAAGCGCCACTAACACCCACGCTGCGGACTTCGAC
GACAACCTCTTAAGTTTCTT

Product: metal-dependent hydrolase related to cytosine deaminase

Products: NA

Alternate protein names: MTA/SAH deaminase

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MRLAILGGIAVTPERVIEDAGILIDEDGRISFVDTREQLEECEDWEDEIELGEKDVIMPGLINTHTHGPMTLFRGVADDM
PLMKWLREEIWPLEERLDAEKCRWGAALAAMEALKSGTTCLADMYFFMDAVAEAYAEVGIRAVISHGMIDLGEEDKREEE
LKESKRVYRKCQGMEGLIEFSLGPHAPYTCSEELLKEVRRLADEWGVKIQIHVAETEDEVKEVKRKHGKRPVEYLDEIGL
LGDDVIAAHCVWLDDKEIEILSKRGVIVSHNPISNMKLASGISPVPEMLERGVNVTIGTDGCASNNNLDMLEEIKVAALL
HKVNKMDPSATEMLEILRMATVRAGTVFSSEKIGAIEEGYAADLVVLDGSSPRLNPNHNPISNIVYSASGSDVKHVFVAG
ELVVKNGKLVKADEQEILENSTECAEQLTSS

Sequences:

>Translated_431_residues
MRLAILGGIAVTPERVIEDAGILIDEDGRISFVDTREQLEECEDWEDEIELGEKDVIMPGLINTHTHGPMTLFRGVADDM
PLMKWLREEIWPLEERLDAEKCRWGAALAAMEALKSGTTCLADMYFFMDAVAEAYAEVGIRAVISHGMIDLGEEDKREEE
LKESKRVYRKCQGMEGLIEFSLGPHAPYTCSEELLKEVRRLADEWGVKIQIHVAETEDEVKEVKRKHGKRPVEYLDEIGL
LGDDVIAAHCVWLDDKEIEILSKRGVIVSHNPISNMKLASGISPVPEMLERGVNVTIGTDGCASNNNLDMLEEIKVAALL
HKVNKMDPSATEMLEILRMATVRAGTVFSSEKIGAIEEGYAADLVVLDGSSPRLNPNHNPISNIVYSASGSDVKHVFVAG
ELVVKNGKLVKADEQEILENSTECAEQLTSS
>Mature_431_residues
MRLAILGGIAVTPERVIEDAGILIDEDGRISFVDTREQLEECEDWEDEIELGEKDVIMPGLINTHTHGPMTLFRGVADDM
PLMKWLREEIWPLEERLDAEKCRWGAALAAMEALKSGTTCLADMYFFMDAVAEAYAEVGIRAVISHGMIDLGEEDKREEE
LKESKRVYRKCQGMEGLIEFSLGPHAPYTCSEELLKEVRRLADEWGVKIQIHVAETEDEVKEVKRKHGKRPVEYLDEIGL
LGDDVIAAHCVWLDDKEIEILSKRGVIVSHNPISNMKLASGISPVPEMLERGVNVTIGTDGCASNNNLDMLEEIKVAALL
HKVNKMDPSATEMLEILRMATVRAGTVFSSEKIGAIEEGYAADLVVLDGSSPRLNPNHNPISNIVYSASGSDVKHVFVAG
ELVVKNGKLVKADEQEILENSTECAEQLTSS

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family

Homologues:

Organism=Homo sapiens, GI4758426, Length=380, Percent_Identity=28.1578947368421, Blast_Score=138, Evalue=1e-32,
Organism=Escherichia coli, GI87082177, Length=422, Percent_Identity=25.3554502369668, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1789249, Length=406, Percent_Identity=27.0935960591133, Blast_Score=114, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6319963, Length=412, Percent_Identity=25, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24643849, Length=390, Percent_Identity=26.1538461538462, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTAD_METKA (Q8TYD4)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_613651.1
- ProteinModelPortal:   Q8TYD4
- SMR:   Q8TYD4
- GeneID:   1477669
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0366
- NMPDR:   fig|190192.1.peg.364
- HOGENOM:   HBG668170
- OMA:   KENIESH
- BioCyc:   MKAN190192:MK0366-MONOMER
- BRENDA:   3.5.4.28
- HAMAP:   MF_01281
- InterPro:   IPR006680
- InterPro:   IPR011059

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.4.28

Molecular weight: Translated: 47753; Mature: 47753

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: NA

Important sites: BINDING 94-94 BINDING 185-185 BINDING 215-215 BINDING 300-300

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLAILGGIAVTPERVIEDAGILIDEDGRISFVDTREQLEECEDWEDEIELGEKDVIMPG
CEEEEECCCCCCHHHHHHCCCCEEECCCCEEEECCHHHHHHHHCCHHHHHCCCCCEECCC
LINTHTHGPMTLFRGVADDMPLMKWLREEIWPLEERLDAEKCRWGAALAAMEALKSGTTC
CCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHCCCHH
LADMYFFMDAVAEAYAEVGIRAVISHGMIDLGEEDKREEELKESKRVYRKCQGMEGLIEF
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHEEE
SLGPHAPYTCSEELLKEVRRLADEWGVKIQIHVAETEDEVKEVKRKHGKRPVEYLDEIGL
CCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHCCCHHHHHHHCCC
LGDDVIAAHCVWLDDKEIEILSKRGVIVSHNPISNMKLASGISPVPEMLERGVNVTIGTD
CCCHHHEEEEEEECCCCHHHHHHCCEEEECCCCCCCCHHCCCCHHHHHHHCCCEEEECCC
GCASNNNLDMLEEIKVAALLHKVNKMDPSATEMLEILRMATVRAGTVFSSEKIGAIEEGY
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCEECCCCCCCCCCCC
AADLVVLDGSSPRLNPNHNPISNIVYSASGSDVKHVFVAGELVVKNGKLVKADEQEILEN
CEEEEEECCCCCCCCCCCCCHHHEEEECCCCCCEEEEEEEEEEEECCCEEECCHHHHHCC
STECAEQLTSS
HHHHHHHHHCC
>Mature Secondary Structure
MRLAILGGIAVTPERVIEDAGILIDEDGRISFVDTREQLEECEDWEDEIELGEKDVIMPG
CEEEEECCCCCCHHHHHHCCCCEEECCCCEEEECCHHHHHHHHCCHHHHHCCCCCEECCC
LINTHTHGPMTLFRGVADDMPLMKWLREEIWPLEERLDAEKCRWGAALAAMEALKSGTTC
CCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHCCCHH
LADMYFFMDAVAEAYAEVGIRAVISHGMIDLGEEDKREEELKESKRVYRKCQGMEGLIEF
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHEEE
SLGPHAPYTCSEELLKEVRRLADEWGVKIQIHVAETEDEVKEVKRKHGKRPVEYLDEIGL
CCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHCCCHHHHHHHCCC
LGDDVIAAHCVWLDDKEIEILSKRGVIVSHNPISNMKLASGISPVPEMLERGVNVTIGTD
CCCHHHEEEEEEECCCCHHHHHHCCEEEECCCCCCCCHHCCCCHHHHHHHCCCEEEECCC
GCASNNNLDMLEEIKVAALLHKVNKMDPSATEMLEILRMATVRAGTVFSSEKIGAIEEGY
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCEECCCCCCCCCCCC
AADLVVLDGSSPRLNPNHNPISNIVYSASGSDVKHVFVAGELVVKNGKLVKADEQEILEN
CEEEEEECCCCCCCCCCCCCHHHEEEECCCCCCEEEEEEEEEEEECCCEEECCHHHHHCC
STECAEQLTSS
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11930014