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The map label for this gene is ahcY

Identifier: 20093806

GI number: 20093806

Start: 356998

End: 358272

Strand: Direct

Name: ahcY

Synonym: MK0368

Alternate gene names: 20093806

Gene position: 356998-358272 (Clockwise)

Preceding gene: 20093804

Following gene: 20093807

Centisome position: 21.06

GC content: 59.29

Gene sequence:

>1275_bases
TTGGTCGTAGTTAAGGAGGGTGAGTACGCTATTCGGGACCCCTCCCTGGCTCCGAAAGGTCGAGACATGATTGAGTGGGC
TCGGGACCACATGCCGGTATTAGGGGCCATCCGTGAGCGGTTCGAAGAAGAACGGCCGCTCGAAGGTATAACCGTGGGAA
TGACCCTGCATCTCGAGGCCAAGACGGCCGTTCTGGTCGAAACGCTGATGGCCGGTGGCGCCGAGGTAGCCATCACCGGA
TGCAATCCACTTTCGACGAAAGATGAAGTTGCGGCGGCACTCGTGGAGGAAGGAGTGCACGTATACGCCTGGCGCGGGGA
GACGGAGGAAGAGTACTACCAGAACATCGACCGGGTGCTCTCCCACGAGCCCGACATCATAGTCGACGACGGTGCCGACT
GTATCGCGCGCGTGCACACCGAGTTCCCGGACCTAGCGGAGCGCGTGATCGGGGCCACCGAGGAGACCACGACGGGCGTT
AACAGACTGCACGCGATGCACAGGGAGGGCGTCCTGAAGTTCCCGGTCATCGCCGTGAACGACGCTAAGACGAAATACCT
CATGGACAACCGTTACGGGACCGGACAGAGCGCGCTGGACGGATTGATGCGGGCCACCAACATCCTCCTAGCGGGCAAGA
CCGTAGTGGTAGTCGGGTACGGGTGGTGCGGTCGCGGCATTGCACGTCGAGCGCGGGGCTTGGGCGCCAACGTCATAGTA
GTGGAGGTAGACCCGATCAAGGCCATGGAGGCTATCTTCGACGGATTCCGAGTGATGCCGATGGACCGCGCCGCCGAGGA
AGGTGACATCTTCATCACCGCTACCGGGAATCGGGATGTGATCCGTGGCGAACACATCGAAAAGATGAAGGACGGCGTCA
TTTTAGCCAACGCGGGTCACTTCGACGTGGAGATCGACAAGGAGTATCTCGAGGAACATTGCGAGGAAAAGATCGACCGC
AGGGGTGGCCTGGTCACCGAATACCGGATGCCAGACGGTAAGAGGGTCTACCTGATCGCAGAGGGGAGACTAGTGAACCT
GGCGGCCGGCGAGGGACACCCTATTGAGATCATGGACATCAGCTTCGCACTCCAAGCGCTTTCCGTCGAGGTGTTGGCGA
AAGAAGGGAAGGAGATGGAACCCGGAGTGTACAAGGTACCGAAAGACGTTGACAAGCGCGTCGCTGAACTGAAGCTAGAA
TCCATGGGGATCGAGTTGGAGGAACTGACACCGGAACAGCGCGAGTACATGAAGAGCTGGGAAGAAGGTACATAG

Upstream 100 bases:

>100_bases
ACCGCGGGGATCACCGCCGGGAGACTCCCGTCTCCCCCCGTCGGGGGCCCGGCGTGGACACTCGATCACCCTCATTACCA
TTTTCGGGGGATGCTCGACG

Downstream 100 bases:

>100_bases
CGTCGAGGATCGGGCTCCGAAAAGTTATTTTGCCAGCAATTAACAGGACCTCTCGGCGCGCGCCTTTTCAACCGAATAAC
GGGAGGGAACGTGATGAAAC

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MVVVKEGEYAIRDPSLAPKGRDMIEWARDHMPVLGAIRERFEEERPLEGITVGMTLHLEAKTAVLVETLMAGGAEVAITG
CNPLSTKDEVAAALVEEGVHVYAWRGETEEEYYQNIDRVLSHEPDIIVDDGADCIARVHTEFPDLAERVIGATEETTTGV
NRLHAMHREGVLKFPVIAVNDAKTKYLMDNRYGTGQSALDGLMRATNILLAGKTVVVVGYGWCGRGIARRARGLGANVIV
VEVDPIKAMEAIFDGFRVMPMDRAAEEGDIFITATGNRDVIRGEHIEKMKDGVILANAGHFDVEIDKEYLEEHCEEKIDR
RGGLVTEYRMPDGKRVYLIAEGRLVNLAAGEGHPIEIMDISFALQALSVEVLAKEGKEMEPGVYKVPKDVDKRVAELKLE
SMGIELEELTPEQREYMKSWEEGT

Sequences:

>Translated_424_residues
MVVVKEGEYAIRDPSLAPKGRDMIEWARDHMPVLGAIRERFEEERPLEGITVGMTLHLEAKTAVLVETLMAGGAEVAITG
CNPLSTKDEVAAALVEEGVHVYAWRGETEEEYYQNIDRVLSHEPDIIVDDGADCIARVHTEFPDLAERVIGATEETTTGV
NRLHAMHREGVLKFPVIAVNDAKTKYLMDNRYGTGQSALDGLMRATNILLAGKTVVVVGYGWCGRGIARRARGLGANVIV
VEVDPIKAMEAIFDGFRVMPMDRAAEEGDIFITATGNRDVIRGEHIEKMKDGVILANAGHFDVEIDKEYLEEHCEEKIDR
RGGLVTEYRMPDGKRVYLIAEGRLVNLAAGEGHPIEIMDISFALQALSVEVLAKEGKEMEPGVYKVPKDVDKRVAELKLE
SMGIELEELTPEQREYMKSWEEGT
>Mature_424_residues
MVVVKEGEYAIRDPSLAPKGRDMIEWARDHMPVLGAIRERFEEERPLEGITVGMTLHLEAKTAVLVETLMAGGAEVAITG
CNPLSTKDEVAAALVEEGVHVYAWRGETEEEYYQNIDRVLSHEPDIIVDDGADCIARVHTEFPDLAERVIGATEETTTGV
NRLHAMHREGVLKFPVIAVNDAKTKYLMDNRYGTGQSALDGLMRATNILLAGKTVVVVGYGWCGRGIARRARGLGANVIV
VEVDPIKAMEAIFDGFRVMPMDRAAEEGDIFITATGNRDVIRGEHIEKMKDGVILANAGHFDVEIDKEYLEEHCEEKIDR
RGGLVTEYRMPDGKRVYLIAEGRLVNLAAGEGHPIEIMDISFALQALSVEVLAKEGKEMEPGVYKVPKDVDKRVAELKLE
SMGIELEELTPEQREYMKSWEEGT

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family

Homologues:

Organism=Homo sapiens, GI9951915, Length=412, Percent_Identity=44.1747572815534, Blast_Score=349, Evalue=2e-96,
Organism=Homo sapiens, GI239937451, Length=390, Percent_Identity=44.8717948717949, Blast_Score=338, Evalue=6e-93,
Organism=Homo sapiens, GI298286489, Length=417, Percent_Identity=40.0479616306954, Blast_Score=306, Evalue=3e-83,
Organism=Homo sapiens, GI195539349, Length=417, Percent_Identity=40.0479616306954, Blast_Score=306, Evalue=3e-83,
Organism=Homo sapiens, GI195539337, Length=417, Percent_Identity=40.0479616306954, Blast_Score=305, Evalue=6e-83,
Organism=Homo sapiens, GI24308043, Length=417, Percent_Identity=40.0479616306954, Blast_Score=305, Evalue=7e-83,
Organism=Homo sapiens, GI21361647, Length=417, Percent_Identity=40.0479616306954, Blast_Score=285, Evalue=5e-77,
Organism=Caenorhabditis elegans, GI17506425, Length=416, Percent_Identity=42.5480769230769, Blast_Score=327, Evalue=8e-90,
Organism=Saccharomyces cerevisiae, GI6320882, Length=435, Percent_Identity=42.9885057471264, Blast_Score=334, Evalue=2e-92,
Organism=Drosophila melanogaster, GI24642172, Length=415, Percent_Identity=43.6144578313253, Blast_Score=340, Evalue=1e-93,
Organism=Drosophila melanogaster, GI24656245, Length=404, Percent_Identity=41.0891089108911, Blast_Score=296, Evalue=1e-80,
Organism=Drosophila melanogaster, GI45553385, Length=414, Percent_Identity=39.8550724637681, Blast_Score=283, Evalue=2e-76,
Organism=Drosophila melanogaster, GI45553387, Length=414, Percent_Identity=39.8550724637681, Blast_Score=283, Evalue=2e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SAHH_METKA (P58855)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_613653.1
- ProteinModelPortal:   P58855
- SMR:   P58855
- GeneID:   1477671
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0368
- NMPDR:   fig|190192.1.peg.366
- HOGENOM:   HBG352029
- OMA:   KMEWARN
- ProtClustDB:   PRK05476
- BioCyc:   MKAN190192:MK0368-MONOMER
- BRENDA:   3.3.1.1
- GO:   GO:0005737
- GO:   GO:0005488
- HAMAP:   MF_00563
- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082
- PANTHER:   PTHR23420
- PIRSF:   PIRSF001109
- TIGRFAMs:   TIGR00936

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD

EC number: =3.3.1.1

Molecular weight: Translated: 47016; Mature: 47016

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS00738 ADOHCYASE_1; PS00739 ADOHCYASE_2

Important sites: BINDING 130-130 BINDING 155-155 BINDING 185-185 BINDING 189-189 BINDING 190-190 BINDING 242-242 BINDING 277-277 BINDING 346-346

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVVKEGEYAIRDPSLAPKGRDMIEWARDHMPVLGAIRERFEEERPLEGITVGMTLHLEA
CEEEECCCEEECCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEEEEECC
KTAVLVETLMAGGAEVAITGCNPLSTKDEVAAALVEEGVHVYAWRGETEEEYYQNIDRVL
HHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHH
SHEPDIIVDDGADCIARVHTEFPDLAERVIGATEETTTGVNRLHAMHREGVLKFPVIAVN
CCCCCEEEECCHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEECCEEEEC
DAKTKYLMDNRYGTGQSALDGLMRATNILLAGKTVVVVGYGWCGRGIARRARGLGANVIV
CCCEEEEECCCCCCCHHHHHHHHHHHHEEEECCEEEEEECCCCCHHHHHHHHCCCCEEEE
VEVDPIKAMEAIFDGFRVMPMDRAAEEGDIFITATGNRDVIRGEHIEKMKDGVILANAGH
EEECCHHHHHHHHCCEEEEECCCCCCCCCEEEEECCCCCCCCCHHHHHHHCCEEEEECCC
FDVEIDKEYLEEHCEEKIDRRGGLVTEYRMPDGKRVYLIAEGRLVNLAAGEGHPIEIMDI
EEEEECHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEECCEEEEEECCCCCCEEEEEH
SFALQALSVEVLAKEGKEMEPGVYKVPKDVDKRVAELKLESMGIELEELTPEQREYMKSW
HHHHHHHHHHHHHHCCCCCCCCCEECCHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHC
EEGT
CCCC
>Mature Secondary Structure
MVVVKEGEYAIRDPSLAPKGRDMIEWARDHMPVLGAIRERFEEERPLEGITVGMTLHLEA
CEEEECCCEEECCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEEEEECC
KTAVLVETLMAGGAEVAITGCNPLSTKDEVAAALVEEGVHVYAWRGETEEEYYQNIDRVL
HHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHH
SHEPDIIVDDGADCIARVHTEFPDLAERVIGATEETTTGVNRLHAMHREGVLKFPVIAVN
CCCCCEEEECCHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEECCEEEEC
DAKTKYLMDNRYGTGQSALDGLMRATNILLAGKTVVVVGYGWCGRGIARRARGLGANVIV
CCCEEEEECCCCCCCHHHHHHHHHHHHEEEECCEEEEEECCCCCHHHHHHHHCCCCEEEE
VEVDPIKAMEAIFDGFRVMPMDRAAEEGDIFITATGNRDVIRGEHIEKMKDGVILANAGH
EEECCHHHHHHHHCCEEEEECCCCCCCCCEEEEECCCCCCCCCHHHHHHHCCEEEEECCC
FDVEIDKEYLEEHCEEKIDRRGGLVTEYRMPDGKRVYLIAEGRLVNLAAGEGHPIEIMDI
EEEEECHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEECCEEEEEECCCCCCEEEEEH
SFALQALSVEVLAKEGKEMEPGVYKVPKDVDKRVAELKLESMGIELEELTPEQREYMKSW
HHHHHHHHHHHHHHCCCCCCCCCEECCHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHC
EEGT
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11930014