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The map label for this gene is ppa [H]

Identifier: 197294646

GI number: 197294646

Start: 596233

End: 596763

Strand: Direct

Name: ppa [H]

Synonym: PAa_0602

Alternate gene names: 197294646

Gene position: 596233-596763 (Clockwise)

Preceding gene: 197294645

Following gene: 197294647

Centisome position: 67.76

GC content: 29.57

Gene sequence:

>531_bases
ATGAATATATTACATGACATTAAACCTAAAAGAATCACTAAGGAAGAATTTATAGCAGTGATTGAAATTCCCCAAGGAAG
CAAAAAAAAATACGAAATCGATAAAGAAACAGGGATGTTGATATTAGACCGTTTTTTGACAACTTCTTTTCGTTATCCTG
TTAATTATGGCTTTATTCCTTTGACTCATTGTCAAGATAATGATCCGATGGATGTATTAGTTTTGGCTCAAGAAAATTTA
GCTCCTTTGACTCTAGTAAAATGCCGTCCTTTAGCAGTGATTAAGATGATTGATGATAATGAATTGGATGAAAAAATTAT
TGCCGTTCCTGTGTCGGATGCTGCTTTTAAAAATTTTCATGATTTATCAGATATTTCTGTTTCATTGTTGTCAGAAATAA
AGCATTTTTTTCTTAATTATAAAGCTTTAGAGAAAAAAAGTGTGATTATAGAAGGAATTCAAGGCAAAAACGAAGCTTAT
CAAGCAATTGAAAAAAGCATTATCGCTTATAGAAAATTAAAAAAAGATTAA

Upstream 100 bases:

>100_bases
TATAGTCGCTTCAATTAAATTTCAAGATAATCAACTAAAAAATCATTTGGTCTTTGATTCATTTAGAAAAAATTAAACTA
AAGAAAGAAAGGTTTTAAAA

Downstream 100 bases:

>100_bases
TTATTATGAAGAAGAAAGAGTTAAATATTTTGGTTTTTTGTTTAAGATTTTAAAATTTCAAACTCATTCGTGTTGAAGAA
CCAATTTTTTGGTTGTTTTT

Product: Inorganic pyrophosphatase

Products: NA

Alternate protein names: Pyrophosphate phospho-hydrolase; PPase [H]

Number of amino acids: Translated: 176; Mature: 176

Protein sequence:

>176_residues
MNILHDIKPKRITKEEFIAVIEIPQGSKKKYEIDKETGMLILDRFLTTSFRYPVNYGFIPLTHCQDNDPMDVLVLAQENL
APLTLVKCRPLAVIKMIDDNELDEKIIAVPVSDAAFKNFHDLSDISVSLLSEIKHFFLNYKALEKKSVIIEGIQGKNEAY
QAIEKSIIAYRKLKKD

Sequences:

>Translated_176_residues
MNILHDIKPKRITKEEFIAVIEIPQGSKKKYEIDKETGMLILDRFLTTSFRYPVNYGFIPLTHCQDNDPMDVLVLAQENL
APLTLVKCRPLAVIKMIDDNELDEKIIAVPVSDAAFKNFHDLSDISVSLLSEIKHFFLNYKALEKKSVIIEGIQGKNEAY
QAIEKSIIAYRKLKKD
>Mature_176_residues
MNILHDIKPKRITKEEFIAVIEIPQGSKKKYEIDKETGMLILDRFLTTSFRYPVNYGFIPLTHCQDNDPMDVLVLAQENL
APLTLVKCRPLAVIKMIDDNELDEKIIAVPVSDAAFKNFHDLSDISVSLLSEIKHFFLNYKALEKKSVIIEGIQGKNEAY
QAIEKSIIAYRKLKKD

Specific function: Unknown

COG id: COG0221

COG function: function code C; Inorganic pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PPase family [H]

Homologues:

Organism=Homo sapiens, GI11056044, Length=172, Percent_Identity=30.2325581395349, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI1790673, Length=156, Percent_Identity=42.9487179487179, Blast_Score=118, Evalue=2e-28,

Paralogues:

None

Copy number: 5480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 200 Molecules/Cell In: Early Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008162 [H]

Pfam domain/function: PF00719 Pyrophosphatase [H]

EC number: =3.6.1.1 [H]

Molecular weight: Translated: 20166; Mature: 20166

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00387 PPASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILHDIKPKRITKEEFIAVIEIPQGSKKKYEIDKETGMLILDRFLTTSFRYPVNYGFIP
CCCCCCCCCCCCCHHHEEEEEECCCCCCCCEEECCCCCHHHHHHHHHHCCCCCCCCCCEE
LTHCQDNDPMDVLVLAQENLAPLTLVKCRPLAVIKMIDDNELDEKIIAVPVSDAAFKNFH
EECCCCCCCCEEEEEECCCCCCEEEEEECCEEEEEEECCCCCCCEEEEEECCHHHHHHHC
DLSDISVSLLSEIKHFFLNYKALEKKSVIIEGIQGKNEAYQAIEKSIIAYRKLKKD
CHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNILHDIKPKRITKEEFIAVIEIPQGSKKKYEIDKETGMLILDRFLTTSFRYPVNYGFIP
CCCCCCCCCCCCCHHHEEEEEECCCCCCCCEEECCCCCHHHHHHHHHHCCCCCCCCCCEE
LTHCQDNDPMDVLVLAQENLAPLTLVKCRPLAVIKMIDDNELDEKIIAVPVSDAAFKNFH
EECCCCCCCCEEEEEECCCCCCEEEEEECCEEEEEEECCCCCCCEEEEEECCHHHHHHHC
DLSDISVSLLSEIKHFFLNYKALEKKSVIIEGIQGKNEAYQAIEKSIIAYRKLKKD
CHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]