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The map label for this gene is ppiA [H]

Identifier: 197120326

GI number: 197120326

Start: 4502429

End: 4503007

Strand: Direct

Name: ppiA [H]

Synonym: Gbem_3965

Alternate gene names: 197120326

Gene position: 4502429-4503007 (Clockwise)

Preceding gene: 197120322

Following gene: 197120336

Centisome position: 97.56

GC content: 60.45

Gene sequence:

>579_bases
ATGCTGAAAAGAATCATGCTGGTGGCGGTCCTGTTACTTTGCTTCGCCGGCAGCGCATTCGCTGCCGAAACAAAGAACCC
GGTCGTGGTCATTGAGACCAGCCAGGGGAACGTGAAGGTGGAACTGTTCGAGAAGGAAGCTCCCTTGAGCGTGAAGAACT
TCCTGGAGTACGCGAAGAGCGGGTTCTACGAGGGGACCACCTTCCACAGGGTCATTCCCGGCTTCATGATCCAGGGCGGC
GGGCTCACCAAGGACATCGCCCCCAAGGCGACCCGTGCACCCATCAAGAACGAGGCCAATAACGGCCTGAAGAACGACCG
CGGGACCCTGGCCATGGCGCGTACCGGCATGGTCGATTCGGCTACCTCGCAGTTCTTCATCAACGTCGTCAACAACGGCT
TCCTGAACCACAACCCGGCCGGCGGCCAGAGAACCTTCGGCTACGCCGTGTTCGGCAAGGTGCTGGAAGGGATGGACGTG
GTCGACAAGATCGCCGCCACCCCGACCGGGTTCAAGAACGGCATGCCGGACGTCCCCGCAACGCCGGTAGTGATCCAGAG
CGTGAAGGTAGTGAAGTAG

Upstream 100 bases:

>100_bases
TCAACCTTTACTTGCCCTAATGCAATGCGAATTGGTTGACCGCCTGTTTCGATTGGCTTATAAATGGCCAATACAAATTT
ATCTGAAAGGGAGGAACTAC

Downstream 100 bases:

>100_bases
CAAAAAGGGGCGCCTCGCGGCGCCCCTTCTCATTTCATCATCTCCCCTTGCGCTGCGCTAGCAGCATCACGTTCCCCGCC
ATGAAGAACAGCGCCCCGAG

Product: cyclophilin type peptidylprolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase A; Cyclophilin A; Rotamase A [H]

Number of amino acids: Translated: 192; Mature: 192

Protein sequence:

>192_residues
MLKRIMLVAVLLLCFAGSAFAAETKNPVVVIETSQGNVKVELFEKEAPLSVKNFLEYAKSGFYEGTTFHRVIPGFMIQGG
GLTKDIAPKATRAPIKNEANNGLKNDRGTLAMARTGMVDSATSQFFINVVNNGFLNHNPAGGQRTFGYAVFGKVLEGMDV
VDKIAATPTGFKNGMPDVPATPVVIQSVKVVK

Sequences:

>Translated_192_residues
MLKRIMLVAVLLLCFAGSAFAAETKNPVVVIETSQGNVKVELFEKEAPLSVKNFLEYAKSGFYEGTTFHRVIPGFMIQGG
GLTKDIAPKATRAPIKNEANNGLKNDRGTLAMARTGMVDSATSQFFINVVNNGFLNHNPAGGQRTFGYAVFGKVLEGMDV
VDKIAATPTGFKNGMPDVPATPVVIQSVKVVK
>Mature_192_residues
MLKRIMLVAVLLLCFAGSAFAAETKNPVVVIETSQGNVKVELFEKEAPLSVKNFLEYAKSGFYEGTTFHRVIPGFMIQGG
GLTKDIAPKATRAPIKNEANNGLKNDRGTLAMARTGMVDSATSQFFINVVNNGFLNHNPAGGQRTFGYAVFGKVLEGMDV
VDKIAATPTGFKNGMPDVPATPVVIQSVKVVK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. This protein is not essential for growth. Presumably plays a role in signal transduction [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI24308049, Length=150, Percent_Identity=36, Blast_Score=87, Evalue=7e-18,
Organism=Homo sapiens, GI7706339, Length=169, Percent_Identity=34.9112426035503, Blast_Score=84, Evalue=8e-17,
Organism=Homo sapiens, GI64276486, Length=169, Percent_Identity=32.5443786982249, Blast_Score=81, Evalue=6e-16,
Organism=Homo sapiens, GI19557636, Length=168, Percent_Identity=31.547619047619, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI5454154, Length=179, Percent_Identity=32.4022346368715, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI4758950, Length=193, Percent_Identity=34.7150259067358, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI310110104, Length=150, Percent_Identity=35.3333333333333, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI310129267, Length=150, Percent_Identity=34, Blast_Score=67, Evalue=6e-12,
Organism=Homo sapiens, GI310120620, Length=150, Percent_Identity=34, Blast_Score=67, Evalue=6e-12,
Organism=Homo sapiens, GI10863927, Length=160, Percent_Identity=35, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI22547215, Length=151, Percent_Identity=31.1258278145695, Blast_Score=64, Evalue=5e-11,
Organism=Homo sapiens, GI22547212, Length=151, Percent_Identity=31.1258278145695, Blast_Score=64, Evalue=6e-11,
Organism=Homo sapiens, GI7657473, Length=151, Percent_Identity=31.1258278145695, Blast_Score=64, Evalue=6e-11,
Organism=Escherichia coli, GI1789763, Length=185, Percent_Identity=56.7567567567568, Blast_Score=207, Evalue=4e-55,
Organism=Escherichia coli, GI1786736, Length=163, Percent_Identity=55.8282208588957, Blast_Score=178, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI71980594, Length=139, Percent_Identity=35.2517985611511, Blast_Score=83, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI71980590, Length=139, Percent_Identity=35.2517985611511, Blast_Score=83, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17506311, Length=158, Percent_Identity=34.8101265822785, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17552780, Length=195, Percent_Identity=34.8717948717949, Blast_Score=81, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71997782, Length=135, Percent_Identity=35.5555555555556, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17539496, Length=138, Percent_Identity=36.231884057971, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17506307, Length=157, Percent_Identity=36.9426751592357, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17532641, Length=173, Percent_Identity=32.3699421965318, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17532643, Length=176, Percent_Identity=34.0909090909091, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17539498, Length=143, Percent_Identity=34.2657342657343, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321848, Length=142, Percent_Identity=37.3239436619718, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323562, Length=175, Percent_Identity=32, Blast_Score=66, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320510, Length=157, Percent_Identity=34.3949044585987, Blast_Score=65, Evalue=9e-12,
Organism=Drosophila melanogaster, GI17986117, Length=167, Percent_Identity=37.125748502994, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI19922912, Length=151, Percent_Identity=37.0860927152318, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17136360, Length=199, Percent_Identity=31.6582914572864, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24586038, Length=174, Percent_Identity=31.6091954022989, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24652460, Length=153, Percent_Identity=31.3725490196078, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI20130249, Length=156, Percent_Identity=35.2564102564103, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17647301, Length=182, Percent_Identity=32.4175824175824, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21357249, Length=101, Percent_Identity=34.6534653465347, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 20553; Mature: 20553

Theoretical pI: Translated: 10.11; Mature: 10.11

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKRIMLVAVLLLCFAGSAFAAETKNPVVVIETSQGNVKVELFEKEAPLSVKNFLEYAKS
CHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHC
GFYEGTTFHRVIPGFMIQGGGLTKDIAPKATRAPIKNEANNGLKNDRGTLAMARTGMVDS
CCCCCCHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCH
ATSQFFINVVNNGFLNHNPAGGQRTFGYAVFGKVLEGMDVVDKIAATPTGFKNGMPDVPA
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
TPVVIQSVKVVK
CHHHHHCEEECC
>Mature Secondary Structure
MLKRIMLVAVLLLCFAGSAFAAETKNPVVVIETSQGNVKVELFEKEAPLSVKNFLEYAKS
CHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHC
GFYEGTTFHRVIPGFMIQGGGLTKDIAPKATRAPIKNEANNGLKNDRGTLAMARTGMVDS
CCCCCCHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCH
ATSQFFINVVNNGFLNHNPAGGQRTFGYAVFGKVLEGMDVVDKIAATPTGFKNGMPDVPA
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
TPVVIQSVKVVK
CHHHHHCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 8581173 [H]