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The map label for this gene is uvrC [H]

Identifier: 197120322

GI number: 197120322

Start: 4497671

End: 4499542

Strand: Direct

Name: uvrC [H]

Synonym: Gbem_3961

Alternate gene names: 197120322

Gene position: 4497671-4499542 (Clockwise)

Preceding gene: 197120321

Following gene: 197120326

Centisome position: 97.45

GC content: 63.89

Gene sequence:

>1872_bases
ATGATTACTCAGGCGATGATCGAGAACTTCCCCCCCTCCCCCGGCGTCTACCTCATGAAGAGCGCCGACGACACCGTCAT
CTACGTCGGCAAAGCGCGCAACCTCAAGAAAAGGGTCCGCTCCTACGCGGGAGACACCCGCGACTCCCGGATACACATCC
GCTTCATGGTGCAACTGGTCCATTCGGTCGACTACCTGGTCACCGACACGGAGAAGGAAGCGCTCATCCTCGAAAACACG
CTGATCAAGCAGCACCGCCCCAAGTACAACATCAACCTGCGCGACGACAAGACCTACTTCTCGCTGCGCATGGACATGAA
GGAACAGTTCCCGCGCCTCTCCATCGTCCGGAAGATCCCCTCCGATGGCGCTCGCTACTTCGGCCCCTACGCCTCTGCCA
CCGCCGCCAAAGAGGTGCTGAAACAGCTCTACAAGATGTTCCCGCTGCGCCACTACCCCCTTGCCACCTGCATGGCCAGA
AAGCGCCCCTGCCTGTACCACCAGATCAAGCAGTGCTCCGCACCTTGCTGCGGCCTCATCTCCGCCGCGGAGTATGCGGC
GCTGGCCCATGGGGCCGCACTCTTCCTGGAGGGGAAGAACACCGAGGTGGCGCGGCTCTACCGGTCCAAGATGAACCTGG
CCGCCGAGCAGATGCGCTACGAGGACGCGGCCCGCTACCGGGACCTGCTGCGCGCCATCGAGGTGACGGTCGAGCGGCAG
AAGATGGTGGCACAAAGCGACGACAGCGACGTTTTCGGCTTGCACCGCGAGGCGGACCGGATGCAGATCGCCCTTTTGCA
CATCCGCGGCGGGACCCTGACCGGCGGGCGCAGCTTCCTCTTCGACTGGGAACTGGAGACCGAGGAGGGACTCGCCTCCT
TCCTGAACGAGTACTACGACCTGGACGCGCCTATCCCCCCCCAGGTGCTGATACCGGTTCCCATAGCCGAGCCCGCCGCG
CTGGAGGAGCTTCTTTCCGAAAAAGCAGGGAAGAAGGTGACCATCGCAGTGCCGCAGCGCGGCCCGAAACTCGAGATGGT
GAAACTTGCCGGGAAGAACGCCGAGACCGCTGCCCAGGAACGCTTGGCGCGGGAGAGTTCCTCCGCGACGCTTCTGACCG
AACTGGCCGAGAAACTGAACCTGCCGCACCCCCCGAGAAGGATCGAGTGCTACGACATCTCCAACATCCAAGGGGAGATG
GCGGTCGGGAGCCGGGTGGTCTTCATCGACGGCAGGGCCGACAAGTCCCTGTACCGGCGCTACCGGATCAAAGGGGTGCT
GCAGTCGGACGACTTCGCCATGATGCGCGAGGTGCTCTCGCGCAGGTTCAAGGCCGAAAGCAGCGAAGAGAAGCCGGACC
TGATCGTGGTCGACGGGGGTCTCGGGCAGCTGGGCGTCTTGAACGCGGTGCTCGACGAGCTTGAGGTCACCGGGGTCGAG
GCTGCGGGGCTCGCCAAAAGCCGCGTGGCCCGCGACATGGAGAGCGAAGAGATCGAGCGCAGCGACGAGCGCGTGTTCCG
CCCCGGCCGGAAGAATGCGATTGCCCTCAGGCAGAGTTCCGCCCCGCTACTGCTCCTGGTGCGCATCAGAGACGAGGCGC
ACCGCTTCGCCGTCACCTACCACAAGGACGTGCGCAGCAAGGTCCTGACCGGTTCCGAGCTGGACGGAGTCGCGGGTATC
GGCGAGAAGAGGAAGAAGGCGCTGTTGAAGCATTTCGGGAGTCTAAAACGGGTGAAAGAGGCGACGCTGGAAGAGCTGAA
GGGCGCGCCGGGGATGACCGAAAGTGCGGCGAAGGCGTTGGTGGAACGTCTGCATGGCAGCCCCCTCCCCAACCCTCCCC
CTCCTGGGGAGGGAGCCATGGACCGCAAATAA

Upstream 100 bases:

>100_bases
AACCCAAATCTCCCTCCCCCTCCGGGGGGAGGAGTATTGCCTCCCTTCCTTAAAACAACCCACCTTCCCTTCTAACCAGC
TTCAGTCTATACTACGCCTC

Downstream 100 bases:

>100_bases
GAAGGGGGCGCCGGTTTTTTCGGCGCCCCCTTCTTCGTTCGATCTCTTAAGCCTTCTTCCCACTTCCCTTCTTGGATCCT
ACTTCCCTTTCTTCAGATCG

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 623; Mature: 623

Protein sequence:

>623_residues
MITQAMIENFPPSPGVYLMKSADDTVIYVGKARNLKKRVRSYAGDTRDSRIHIRFMVQLVHSVDYLVTDTEKEALILENT
LIKQHRPKYNINLRDDKTYFSLRMDMKEQFPRLSIVRKIPSDGARYFGPYASATAAKEVLKQLYKMFPLRHYPLATCMAR
KRPCLYHQIKQCSAPCCGLISAAEYAALAHGAALFLEGKNTEVARLYRSKMNLAAEQMRYEDAARYRDLLRAIEVTVERQ
KMVAQSDDSDVFGLHREADRMQIALLHIRGGTLTGGRSFLFDWELETEEGLASFLNEYYDLDAPIPPQVLIPVPIAEPAA
LEELLSEKAGKKVTIAVPQRGPKLEMVKLAGKNAETAAQERLARESSSATLLTELAEKLNLPHPPRRIECYDISNIQGEM
AVGSRVVFIDGRADKSLYRRYRIKGVLQSDDFAMMREVLSRRFKAESSEEKPDLIVVDGGLGQLGVLNAVLDELEVTGVE
AAGLAKSRVARDMESEEIERSDERVFRPGRKNAIALRQSSAPLLLLVRIRDEAHRFAVTYHKDVRSKVLTGSELDGVAGI
GEKRKKALLKHFGSLKRVKEATLEELKGAPGMTESAAKALVERLHGSPLPNPPPPGEGAMDRK

Sequences:

>Translated_623_residues
MITQAMIENFPPSPGVYLMKSADDTVIYVGKARNLKKRVRSYAGDTRDSRIHIRFMVQLVHSVDYLVTDTEKEALILENT
LIKQHRPKYNINLRDDKTYFSLRMDMKEQFPRLSIVRKIPSDGARYFGPYASATAAKEVLKQLYKMFPLRHYPLATCMAR
KRPCLYHQIKQCSAPCCGLISAAEYAALAHGAALFLEGKNTEVARLYRSKMNLAAEQMRYEDAARYRDLLRAIEVTVERQ
KMVAQSDDSDVFGLHREADRMQIALLHIRGGTLTGGRSFLFDWELETEEGLASFLNEYYDLDAPIPPQVLIPVPIAEPAA
LEELLSEKAGKKVTIAVPQRGPKLEMVKLAGKNAETAAQERLARESSSATLLTELAEKLNLPHPPRRIECYDISNIQGEM
AVGSRVVFIDGRADKSLYRRYRIKGVLQSDDFAMMREVLSRRFKAESSEEKPDLIVVDGGLGQLGVLNAVLDELEVTGVE
AAGLAKSRVARDMESEEIERSDERVFRPGRKNAIALRQSSAPLLLLVRIRDEAHRFAVTYHKDVRSKVLTGSELDGVAGI
GEKRKKALLKHFGSLKRVKEATLEELKGAPGMTESAAKALVERLHGSPLPNPPPPGEGAMDRK
>Mature_623_residues
MITQAMIENFPPSPGVYLMKSADDTVIYVGKARNLKKRVRSYAGDTRDSRIHIRFMVQLVHSVDYLVTDTEKEALILENT
LIKQHRPKYNINLRDDKTYFSLRMDMKEQFPRLSIVRKIPSDGARYFGPYASATAAKEVLKQLYKMFPLRHYPLATCMAR
KRPCLYHQIKQCSAPCCGLISAAEYAALAHGAALFLEGKNTEVARLYRSKMNLAAEQMRYEDAARYRDLLRAIEVTVERQ
KMVAQSDDSDVFGLHREADRMQIALLHIRGGTLTGGRSFLFDWELETEEGLASFLNEYYDLDAPIPPQVLIPVPIAEPAA
LEELLSEKAGKKVTIAVPQRGPKLEMVKLAGKNAETAAQERLARESSSATLLTELAEKLNLPHPPRRIECYDISNIQGEM
AVGSRVVFIDGRADKSLYRRYRIKGVLQSDDFAMMREVLSRRFKAESSEEKPDLIVVDGGLGQLGVLNAVLDELEVTGVE
AAGLAKSRVARDMESEEIERSDERVFRPGRKNAIALRQSSAPLLLLVRIRDEAHRFAVTYHKDVRSKVLTGSELDGVAGI
GEKRKKALLKHFGSLKRVKEATLEELKGAPGMTESAAKALVERLHGSPLPNPPPPGEGAMDRK

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=608, Percent_Identity=35.6907894736842, Blast_Score=349, Evalue=2e-97,
Organism=Escherichia coli, GI1788037, Length=188, Percent_Identity=28.7234042553192, Blast_Score=76, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 69759; Mature: 69759

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITQAMIENFPPSPGVYLMKSADDTVIYVGKARNLKKRVRSYAGDTRDSRIHIRFMVQLV
CCCHHHHHCCCCCCCEEEEECCCCCEEEEECCHHHHHHHHHHCCCCCCCEEHHHHHHHHH
HSVDYLVTDTEKEALILENTLIKQHRPKYNINLRDDKTYFSLRMDMKEQFPRLSIVRKIP
HHHHHEEECCCCCCHHHHHHHHHHCCCCEEEEECCCCEEEEEEECHHHCCCHHHHHHHCC
SDGARYFGPYASATAAKEVLKQLYKMFPLRHYPLATCMARKRPCLYHQIKQCSAPCCGLI
CCCCHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHCCCHHHHH
SAAEYAALAHGAALFLEGKNTEVARLYRSKMNLAAEQMRYEDAARYRDLLRAIEVTVERQ
HHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KMVAQSDDSDVFGLHREADRMQIALLHIRGGTLTGGRSFLFDWELETEEGLASFLNEYYD
HHHHCCCCCCEECCCCCCCCEEEEEEEEECCCCCCCCEEEEEEECCCHHHHHHHHHHHHC
LDAPIPPQVLIPVPIAEPAALEELLSEKAGKKVTIAVPQRGPKLEMVKLAGKNAETAAQE
CCCCCCCCEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCHHHHHHH
RLARESSSATLLTELAEKLNLPHPPRRIECYDISNIQGEMAVGSRVVFIDGRADKSLYRR
HHHHHCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCEECCCEEEEEECCCCHHHHHH
YRIKGVLQSDDFAMMREVLSRRFKAESSEEKPDLIVVDGGLGQLGVLNAVLDELEVTGVE
HHHHHEECCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCC
AAGLAKSRVARDMESEEIERSDERVFRPGRKNAIALRQSSAPLLLLVRIRDEAHRFAVTY
HHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEEECCCCHHEEEEE
HKDVRSKVLTGSELDGVAGIGEKRKKALLKHFGSLKRVKEATLEELKGAPGMTESAAKAL
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
VERLHGSPLPNPPPPGEGAMDRK
HHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MITQAMIENFPPSPGVYLMKSADDTVIYVGKARNLKKRVRSYAGDTRDSRIHIRFMVQLV
CCCHHHHHCCCCCCCEEEEECCCCCEEEEECCHHHHHHHHHHCCCCCCCEEHHHHHHHHH
HSVDYLVTDTEKEALILENTLIKQHRPKYNINLRDDKTYFSLRMDMKEQFPRLSIVRKIP
HHHHHEEECCCCCCHHHHHHHHHHCCCCEEEEECCCCEEEEEEECHHHCCCHHHHHHHCC
SDGARYFGPYASATAAKEVLKQLYKMFPLRHYPLATCMARKRPCLYHQIKQCSAPCCGLI
CCCCHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHCCCHHHHH
SAAEYAALAHGAALFLEGKNTEVARLYRSKMNLAAEQMRYEDAARYRDLLRAIEVTVERQ
HHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KMVAQSDDSDVFGLHREADRMQIALLHIRGGTLTGGRSFLFDWELETEEGLASFLNEYYD
HHHHCCCCCCEECCCCCCCCEEEEEEEEECCCCCCCCEEEEEEECCCHHHHHHHHHHHHC
LDAPIPPQVLIPVPIAEPAALEELLSEKAGKKVTIAVPQRGPKLEMVKLAGKNAETAAQE
CCCCCCCCEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCHHHHHHH
RLARESSSATLLTELAEKLNLPHPPRRIECYDISNIQGEMAVGSRVVFIDGRADKSLYRR
HHHHHCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCEECCCEEEEEECCCCHHHHHH
YRIKGVLQSDDFAMMREVLSRRFKAESSEEKPDLIVVDGGLGQLGVLNAVLDELEVTGVE
HHHHHEECCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCC
AAGLAKSRVARDMESEEIERSDERVFRPGRKNAIALRQSSAPLLLLVRIRDEAHRFAVTY
HHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEEECCCCHHEEEEE
HKDVRSKVLTGSELDGVAGIGEKRKKALLKHFGSLKRVKEATLEELKGAPGMTESAAKAL
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
VERLHGSPLPNPPPPGEGAMDRK
HHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA