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The map label for this gene is atoC [H]

Identifier: 197120180

GI number: 197120180

Start: 4358638

End: 4360005

Strand: Direct

Name: atoC [H]

Synonym: Gbem_3819

Alternate gene names: 197120180

Gene position: 4358638-4360005 (Clockwise)

Preceding gene: 197120179

Following gene: 197120181

Centisome position: 94.44

GC content: 61.26

Gene sequence:

>1368_bases
ATGATCGGCAGCATCCTGATAGTAGACGACGAGAAGGGGCAGCGGGACATACTCACTGCCATACTCACCAAGATGGGGTA
CAACATCCAAACCGCCTCGGGCGGTGAAGAGGCGCTGCAGCAACTGCAGCAGGAAGAATTCGACCTCCTCCTCACCGACC
TCAAGATGCAGGGAATTTCAGGGATGGAACTCATGGAGCGGGTGCTGGCCGACAACCCCTCCCAGTGCGTGGTGATGATG
ACCGCCCACGGCACCATCGACTCGGCCGTGGAGGCAATGAAGAAAGGGGCTTTCGACTACCTGGAAAAGCCCCTGGAGCG
CGAGGACTTGATCCTCACCGTGCAGCGTGCCTTCGAGCGGATTGGGCTTTTGCAGGAAAACAAGGCGCTGCACAAGAAGC
TCGCCGAGACGAAAAGGCTTCCCAACATGATCGGAGAGCACCCGAAGATGCACGAGGTGGTCCGGATCATCAACAAGATA
GCCCCAACCTCCACGACGGTCCTCATCTACGGTGAGTCGGGGACGGGGAAGGAACTGGTGGCGCGCGCCATCCACGACGG
GAGCCCGCGCAGGGACAAGGCCTTTTTCGCCATCAACTGCGCGGCGATTCCCGACTCGCTGATGGAAAGCGAGCTCTTCG
GGCACGAGAAGGGGGCCTTCACCGGCGCGGGGACACGGGAGATCGGCCTTTTCGAGGCAGCCGAGGCGGGAACCGTCTTC
CTCGACGAGATCGGCGAGATGAACATCGCCATGCAGGCGAAGCTCTTGCGCGCCATACAGGAGAAGGAGATCCGCAGGGT
CGGGGGGAAGGTGAACATCCCCGTCGACGTCAGGATCATCTCCGCCACCAACAAGGACCTGGAGCAGGAGACCCGGCGCG
GCAACTTCCGCGAGGACCTCTTCTACAGGCTCAACGTGATCAGGATACCCCTCCCTCCCCTGAGGGAGCGCGGCAACGAC
ATCGTGACGCTGGCCGACTTCTTCCTGAGGAAGTACAGCGCCTCCTGCGGCATTCCCCTGAAAGGGATCGCCAAACCGGC
GCTGAAGATCCTGCTCGACTACAACTGGCCCGGCAACGTGCGGCAACTGGAATCGGTCATCGAGCGCGGCGTGCTCATGG
CCGAAAGCGAATACATCCAGCCCGAGGACCTGCCGGCCGAGGTGCACCACGAGGCCTCCCCTGCGGGAAGCCTCCCCTTC
GACTTCCCGGCCGAGGGGATATCCATCGACAACCTGGAACGGGACCTGATCGTCAAGGCGATGCAGAGAACCGACTGGGT
CATCGCCAAAGCGGCACCACTACTCGGTATGAGCTACAAGACGCTGCAATACCGGTTGGAAAAATTCGGCATCGGCAAAC
CGGAGTAG

Upstream 100 bases:

>100_bases
AAGGGGAAGGGACCACCTTCTCGGTCACCCTCCCGGCGGCAACGGCATAAAGCACCGCCCGGCTCCCAGGGCACGGGAGC
AAAAAGAGCAAGGAGTAGCA

Downstream 100 bases:

>100_bases
CCTCAAGTAGCCAGGAGCGCGGTATGAACCTGAGCTCAACGCTGCACAGATTTACCGTCGTCCCCTCGCTTCCCAAGGAG
CTTGCCGGGCTGCAGCGCAT

Product: sigma-54-dependent transcriptional response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MIGSILIVDDEKGQRDILTAILTKMGYNIQTASGGEEALQQLQQEEFDLLLTDLKMQGISGMELMERVLADNPSQCVVMM
TAHGTIDSAVEAMKKGAFDYLEKPLEREDLILTVQRAFERIGLLQENKALHKKLAETKRLPNMIGEHPKMHEVVRIINKI
APTSTTVLIYGESGTGKELVARAIHDGSPRRDKAFFAINCAAIPDSLMESELFGHEKGAFTGAGTREIGLFEAAEAGTVF
LDEIGEMNIAMQAKLLRAIQEKEIRRVGGKVNIPVDVRIISATNKDLEQETRRGNFREDLFYRLNVIRIPLPPLRERGND
IVTLADFFLRKYSASCGIPLKGIAKPALKILLDYNWPGNVRQLESVIERGVLMAESEYIQPEDLPAEVHHEASPAGSLPF
DFPAEGISIDNLERDLIVKAMQRTDWVIAKAAPLLGMSYKTLQYRLEKFGIGKPE

Sequences:

>Translated_455_residues
MIGSILIVDDEKGQRDILTAILTKMGYNIQTASGGEEALQQLQQEEFDLLLTDLKMQGISGMELMERVLADNPSQCVVMM
TAHGTIDSAVEAMKKGAFDYLEKPLEREDLILTVQRAFERIGLLQENKALHKKLAETKRLPNMIGEHPKMHEVVRIINKI
APTSTTVLIYGESGTGKELVARAIHDGSPRRDKAFFAINCAAIPDSLMESELFGHEKGAFTGAGTREIGLFEAAEAGTVF
LDEIGEMNIAMQAKLLRAIQEKEIRRVGGKVNIPVDVRIISATNKDLEQETRRGNFREDLFYRLNVIRIPLPPLRERGND
IVTLADFFLRKYSASCGIPLKGIAKPALKILLDYNWPGNVRQLESVIERGVLMAESEYIQPEDLPAEVHHEASPAGSLPF
DFPAEGISIDNLERDLIVKAMQRTDWVIAKAAPLLGMSYKTLQYRLEKFGIGKPE
>Mature_455_residues
MIGSILIVDDEKGQRDILTAILTKMGYNIQTASGGEEALQQLQQEEFDLLLTDLKMQGISGMELMERVLADNPSQCVVMM
TAHGTIDSAVEAMKKGAFDYLEKPLEREDLILTVQRAFERIGLLQENKALHKKLAETKRLPNMIGEHPKMHEVVRIINKI
APTSTTVLIYGESGTGKELVARAIHDGSPRRDKAFFAINCAAIPDSLMESELFGHEKGAFTGAGTREIGLFEAAEAGTVF
LDEIGEMNIAMQAKLLRAIQEKEIRRVGGKVNIPVDVRIISATNKDLEQETRRGNFREDLFYRLNVIRIPLPPLRERGND
IVTLADFFLRKYSASCGIPLKGIAKPALKILLDYNWPGNVRQLESVIERGVLMAESEYIQPEDLPAEVHHEASPAGSLPF
DFPAEGISIDNLERDLIVKAMQRTDWVIAKAAPLLGMSYKTLQYRLEKFGIGKPE

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=453, Percent_Identity=42.3841059602649, Blast_Score=367, Evalue=1e-102,
Organism=Escherichia coli, GI1790437, Length=448, Percent_Identity=42.8571428571429, Blast_Score=362, Evalue=1e-101,
Organism=Escherichia coli, GI1790299, Length=470, Percent_Identity=40.8510638297872, Blast_Score=332, Evalue=4e-92,
Organism=Escherichia coli, GI1788905, Length=375, Percent_Identity=42.9333333333333, Blast_Score=303, Evalue=1e-83,
Organism=Escherichia coli, GI87082117, Length=344, Percent_Identity=44.1860465116279, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1789233, Length=318, Percent_Identity=45.9119496855346, Blast_Score=257, Evalue=1e-69,
Organism=Escherichia coli, GI1789087, Length=349, Percent_Identity=42.9799426934097, Blast_Score=251, Evalue=6e-68,
Organism=Escherichia coli, GI87082152, Length=324, Percent_Identity=41.358024691358, Blast_Score=238, Evalue=5e-64,
Organism=Escherichia coli, GI1786524, Length=252, Percent_Identity=48.8095238095238, Blast_Score=232, Evalue=3e-62,
Organism=Escherichia coli, GI87081872, Length=324, Percent_Identity=39.5061728395062, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI1787583, Length=312, Percent_Identity=38.7820512820513, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI87081858, Length=312, Percent_Identity=30.1282051282051, Blast_Score=141, Evalue=7e-35,
Organism=Escherichia coli, GI1789828, Length=284, Percent_Identity=33.0985915492958, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1788191, Length=122, Percent_Identity=29.5081967213115, Blast_Score=63, Evalue=5e-11,
Organism=Escherichia coli, GI1789809, Length=116, Percent_Identity=27.5862068965517, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI1786784, Length=116, Percent_Identity=29.3103448275862, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50680; Mature: 50680

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGSILIVDDEKGQRDILTAILTKMGYNIQTASGGEEALQQLQQEEFDLLLTDLKMQGIS
CCCCEEEEECCCCHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCC
GMELMERVLADNPSQCVVMMTAHGTIDSAVEAMKKGAFDYLEKPLEREDLILTVQRAFER
HHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHH
IGLLQENKALHKKLAETKRLPNMIGEHPKMHEVVRIINKIAPTSTTVLIYGESGTGKELV
HCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHH
ARAIHDGSPRRDKAFFAINCAAIPDSLMESELFGHEKGAFTGAGTREIGLFEAAEAGTVF
HHHHHCCCCCCCCEEEEEEEHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCCCEEE
LDEIGEMNIAMQAKLLRAIQEKEIRRVGGKVNIPVDVRIISATNKDLEQETRRGNFREDL
HHHHCCCCHHHHHHHHHHHHHHHHHHCCCEECCCEEEEEEECCCCHHHHHHHCCCHHHHH
FYRLNVIRIPLPPLRERGNDIVTLADFFLRKYSASCGIPLKGIAKPALKILLDYNWPGNV
HHEEEEEEECCCHHHHCCCCEEHHHHHHHHHHCCCCCCCHHHHHHHHHEEEEECCCCCCH
RQLESVIERGVLMAESEYIQPEDLPAEVHHEASPAGSLPFDFPAEGISIDNLERDLIVKA
HHHHHHHHCCEEEECCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
MQRTDWVIAKAAPLLGMSYKTLQYRLEKFGIGKPE
HHHHCEEHHHHCHHHCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MIGSILIVDDEKGQRDILTAILTKMGYNIQTASGGEEALQQLQQEEFDLLLTDLKMQGIS
CCCCEEEEECCCCHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCC
GMELMERVLADNPSQCVVMMTAHGTIDSAVEAMKKGAFDYLEKPLEREDLILTVQRAFER
HHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHH
IGLLQENKALHKKLAETKRLPNMIGEHPKMHEVVRIINKIAPTSTTVLIYGESGTGKELV
HCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHH
ARAIHDGSPRRDKAFFAINCAAIPDSLMESELFGHEKGAFTGAGTREIGLFEAAEAGTVF
HHHHHCCCCCCCCEEEEEEEHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCCCEEE
LDEIGEMNIAMQAKLLRAIQEKEIRRVGGKVNIPVDVRIISATNKDLEQETRRGNFREDL
HHHHCCCCHHHHHHHHHHHHHHHHHHCCCEECCCEEEEEEECCCCHHHHHHHCCCHHHHH
FYRLNVIRIPLPPLRERGNDIVTLADFFLRKYSASCGIPLKGIAKPALKILLDYNWPGNV
HHEEEEEEECCCHHHHCCCCEEHHHHHHHHHHCCCCCCCHHHHHHHHHEEEEECCCCCCH
RQLESVIERGVLMAESEYIQPEDLPAEVHHEASPAGSLPFDFPAEGISIDNLERDLIVKA
HHHHHHHHCCEEEECCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
MQRTDWVIAKAAPLLGMSYKTLQYRLEKFGIGKPE
HHHHCEEHHHHCHHHCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]