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The map label for this gene is atoC [H]

Identifier: 197119035

GI number: 197119035

Start: 3077532

End: 3078908

Strand: Direct

Name: atoC [H]

Synonym: Gbem_2658

Alternate gene names: 197119035

Gene position: 3077532-3078908 (Clockwise)

Preceding gene: 197119034

Following gene: 197119036

Centisome position: 66.68

GC content: 62.75

Gene sequence:

>1377_bases
ATGGAAAAGATACTGATAATAGACGACGAGGCCTTCATCTGCGAGAACGTGCAGCGCATCCTTTCCGGCGAAGGGTTCCT
GGTCTGCGCCGCCGGGTCCGGAAAAGAGGCGCGCGACATCGTGGCCGGCGAAGAGATCGACCTGGCCCTGCTCGACCTGA
ACCTCGGCTCCGAGGACGGCATCGAGGTCCTCAAATCGCTCAAGGAGACGGACCCGGAACTGCTGGTGATCATCATCACC
GGGTACGGCTCGGTCGAGAGCGCCGTCGAGTCCCTGCAACTGGGCGCCTTCCACTACATGAAGAAGCCCTTCAAGGCAGA
CGCGCTCAGGCTGATCGTCAAGCTCGCCCTGAAGACGCAGACCTTGAAGCGCGAGGTCCGCAAGCTAAAGCGCAACGACT
CCCCACTCCCCGGGCGCTCCCCCATCATCGGCAAGAGCGAGGCATTTCAGGAGATGGCGGCCCAGGTGCGTGAGATCGCC
CGCATCCCCTCCACCGTGCTCATCACCGGCGAATCAGGTACCGGCAAAGAGGTGGTAGCCCGCGCCATCCATGACCTCTC
CGACCGCAAGGAACAAGCTTTCATTGCCATCAACTGCGCCTCCATCCCGGCCCCTCTCTTGGAGAGCGAGCTCTTCGGGC
ACGAGAAGGGGGCCTTCACCGGCGCCAGCGGACGTAAGAAGGGGCTCTTCGAGGAGGCGCACCACGGCACCATCTTCCTG
GACGAAATCGGGGAGATGGACATGGCGATGCAGGTGAAGCTTTTGCGCGTGCTGCAGGAGAGGACCATCAGGCGAGTGGG
CGCCGTCAAGGACATCGAGATAGACGCGCGGGTCATAGCCGCCACCAACCGCAACCTCGCCAAGCGGATCGAGGAGAAGA
GTTTCCGCGAAGACCTCTTCTACCGCCTCAACGTGTTTCCCATCAACATACCTCCGCTTAGGGAGCGCCCCGCAGACATA
GCCGCCCTCGCCGTCTACTTCCTGGACAGCTTCAGCCGCTCCTTCGGCCGCGACTTCCGCGACGTCTCACCCGAGGCGGA
GCAACTGATGGCGCAGTACGCCTGGCCCGGCAACGTCAGGGAGTTGAGGAACGTGATAGAACGGATCTGCATCATGCGCA
GCGGCCCAACCCTGCTCCCGGAACATCTGCCGCAGGAGATCAGGAGCACCGTGGCTCCCCCCCCCTTGCCGGCAGAGCTC
CCCATCAGCATCGCTGCCGATCTCGGGCTCGAAGAGGCGGTGAGCGCCATCGAGAAATCGCTCATCCAGCAGGCCCTCCA
GAAGACGGGGTGGAACGTGCTGCAGACGGCGGCCAACCTGAAGATCCCCCGTGGCACCCTGCGCTACAAGATGGAGAAGT
ACGGCCTGATTCAATAG

Upstream 100 bases:

>100_bases
CCAGATTAGTGACCATCTTCCGCCAGTCCCCTCTCCCAGAGGGAGAGGGGACTGTGGACGGAGGGGGAGTAACCAACCAG
CAGCAGCGGGAACGGGAACC

Downstream 100 bases:

>100_bases
CCCCCCCCTGCATCCTCATCCCCTGGCAACTATTCGCCACCTCGGTGGCGGATTTCAGCCACCCGTCTACCTTAAACCGA
TATTTCATTGTCGGCCTACC

Product: sigma-54-dependent transcriptional response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MEKILIIDDEAFICENVQRILSGEGFLVCAAGSGKEARDIVAGEEIDLALLDLNLGSEDGIEVLKSLKETDPELLVIIIT
GYGSVESAVESLQLGAFHYMKKPFKADALRLIVKLALKTQTLKREVRKLKRNDSPLPGRSPIIGKSEAFQEMAAQVREIA
RIPSTVLITGESGTGKEVVARAIHDLSDRKEQAFIAINCASIPAPLLESELFGHEKGAFTGASGRKKGLFEEAHHGTIFL
DEIGEMDMAMQVKLLRVLQERTIRRVGAVKDIEIDARVIAATNRNLAKRIEEKSFREDLFYRLNVFPINIPPLRERPADI
AALAVYFLDSFSRSFGRDFRDVSPEAEQLMAQYAWPGNVRELRNVIERICIMRSGPTLLPEHLPQEIRSTVAPPPLPAEL
PISIAADLGLEEAVSAIEKSLIQQALQKTGWNVLQTAANLKIPRGTLRYKMEKYGLIQ

Sequences:

>Translated_458_residues
MEKILIIDDEAFICENVQRILSGEGFLVCAAGSGKEARDIVAGEEIDLALLDLNLGSEDGIEVLKSLKETDPELLVIIIT
GYGSVESAVESLQLGAFHYMKKPFKADALRLIVKLALKTQTLKREVRKLKRNDSPLPGRSPIIGKSEAFQEMAAQVREIA
RIPSTVLITGESGTGKEVVARAIHDLSDRKEQAFIAINCASIPAPLLESELFGHEKGAFTGASGRKKGLFEEAHHGTIFL
DEIGEMDMAMQVKLLRVLQERTIRRVGAVKDIEIDARVIAATNRNLAKRIEEKSFREDLFYRLNVFPINIPPLRERPADI
AALAVYFLDSFSRSFGRDFRDVSPEAEQLMAQYAWPGNVRELRNVIERICIMRSGPTLLPEHLPQEIRSTVAPPPLPAEL
PISIAADLGLEEAVSAIEKSLIQQALQKTGWNVLQTAANLKIPRGTLRYKMEKYGLIQ
>Mature_458_residues
MEKILIIDDEAFICENVQRILSGEGFLVCAAGSGKEARDIVAGEEIDLALLDLNLGSEDGIEVLKSLKETDPELLVIIIT
GYGSVESAVESLQLGAFHYMKKPFKADALRLIVKLALKTQTLKREVRKLKRNDSPLPGRSPIIGKSEAFQEMAAQVREIA
RIPSTVLITGESGTGKEVVARAIHDLSDRKEQAFIAINCASIPAPLLESELFGHEKGAFTGASGRKKGLFEEAHHGTIFL
DEIGEMDMAMQVKLLRVLQERTIRRVGAVKDIEIDARVIAATNRNLAKRIEEKSFREDLFYRLNVFPINIPPLRERPADI
AALAVYFLDSFSRSFGRDFRDVSPEAEQLMAQYAWPGNVRELRNVIERICIMRSGPTLLPEHLPQEIRSTVAPPPLPAEL
PISIAADLGLEEAVSAIEKSLIQQALQKTGWNVLQTAANLKIPRGTLRYKMEKYGLIQ

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=460, Percent_Identity=45, Blast_Score=390, Evalue=1e-109,
Organism=Escherichia coli, GI1790437, Length=451, Percent_Identity=42.1286031042129, Blast_Score=340, Evalue=1e-94,
Organism=Escherichia coli, GI1790299, Length=467, Percent_Identity=38.1156316916488, Blast_Score=314, Evalue=7e-87,
Organism=Escherichia coli, GI1788905, Length=454, Percent_Identity=37.6651982378855, Blast_Score=287, Evalue=9e-79,
Organism=Escherichia coli, GI87082117, Length=378, Percent_Identity=42.0634920634921, Blast_Score=272, Evalue=4e-74,
Organism=Escherichia coli, GI1789087, Length=318, Percent_Identity=45.9119496855346, Blast_Score=262, Evalue=3e-71,
Organism=Escherichia coli, GI1789233, Length=339, Percent_Identity=44.2477876106195, Blast_Score=260, Evalue=1e-70,
Organism=Escherichia coli, GI87082152, Length=322, Percent_Identity=40.6832298136646, Blast_Score=230, Evalue=2e-61,
Organism=Escherichia coli, GI1786524, Length=273, Percent_Identity=42.8571428571429, Blast_Score=214, Evalue=9e-57,
Organism=Escherichia coli, GI1787583, Length=321, Percent_Identity=38.6292834890966, Blast_Score=214, Evalue=1e-56,
Organism=Escherichia coli, GI87081872, Length=327, Percent_Identity=37.6146788990826, Blast_Score=204, Evalue=7e-54,
Organism=Escherichia coli, GI87081858, Length=300, Percent_Identity=33.6666666666667, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1789828, Length=245, Percent_Identity=34.2857142857143, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1787229, Length=124, Percent_Identity=30.6451612903226, Blast_Score=63, Evalue=5e-11,
Organism=Escherichia coli, GI1789809, Length=118, Percent_Identity=27.9661016949153, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50782; Mature: 50782

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKILIIDDEAFICENVQRILSGEGFLVCAAGSGKEARDIVAGEEIDLALLDLNLGSEDG
CCEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHCCCCCCEEEEEECCCCCHH
IEVLKSLKETDPELLVIIITGYGSVESAVESLQLGAFHYMKKPFKADALRLIVKLALKTQ
HHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
TLKREVRKLKRNDSPLPGRSPIIGKSEAFQEMAAQVREIARIPSTVLITGESGTGKEVVA
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHH
RAIHDLSDRKEQAFIAINCASIPAPLLESELFGHEKGAFTGASGRKKGLFEEAHHGTIFL
HHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCEEEE
DEIGEMDMAMQVKLLRVLQERTIRRVGAVKDIEIDARVIAATNRNLAKRIEEKSFREDLF
ECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEEEEECCHHHHHHHHHHHHHHHHH
YRLNVFPINIPPLRERPADIAALAVYFLDSFSRSFGRDFRDVSPEAEQLMAQYAWPGNVR
EEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHCCCCCHH
ELRNVIERICIMRSGPTLLPEHLPQEIRSTVAPPPLPAELPISIAADLGLEEAVSAIEKS
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCHHHHHHHHHHH
LIQQALQKTGWNVLQTAANLKIPRGTLRYKMEKYGLIQ
HHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MEKILIIDDEAFICENVQRILSGEGFLVCAAGSGKEARDIVAGEEIDLALLDLNLGSEDG
CCEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHCCCCCCEEEEEECCCCCHH
IEVLKSLKETDPELLVIIITGYGSVESAVESLQLGAFHYMKKPFKADALRLIVKLALKTQ
HHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
TLKREVRKLKRNDSPLPGRSPIIGKSEAFQEMAAQVREIARIPSTVLITGESGTGKEVVA
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHH
RAIHDLSDRKEQAFIAINCASIPAPLLESELFGHEKGAFTGASGRKKGLFEEAHHGTIFL
HHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCEEEE
DEIGEMDMAMQVKLLRVLQERTIRRVGAVKDIEIDARVIAATNRNLAKRIEEKSFREDLF
ECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEEEEECCHHHHHHHHHHHHHHHHH
YRLNVFPINIPPLRERPADIAALAVYFLDSFSRSFGRDFRDVSPEAEQLMAQYAWPGNVR
EEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHCCCCCHH
ELRNVIERICIMRSGPTLLPEHLPQEIRSTVAPPPLPAELPISIAADLGLEEAVSAIEKS
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCHHHHHHHHHHH
LIQQALQKTGWNVLQTAANLKIPRGTLRYKMEKYGLIQ
HHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]