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The map label for this gene is prsA [H]

Identifier: 197118895

GI number: 197118895

Start: 2919097

End: 2920152

Strand: Direct

Name: prsA [H]

Synonym: Gbem_2518

Alternate gene names: 197118895

Gene position: 2919097-2920152 (Clockwise)

Preceding gene: 197118893

Following gene: 197118898

Centisome position: 63.25

GC content: 57.39

Gene sequence:

>1056_bases
ATGTTTTCGTTGAAGAAAAAGCACCTTTTAGTGATCGCCTCGCTGCTGACGGCCATGCTGCTCCCGGCCGGTTCCTTCGC
GGAAGAATCCGCCGCCACCCCTCAAGAAAAACCAGCCGGCCAGCCAGCCGCGAAAAAGGCGGCCAACGAGCCGGCGGCGG
CTCAGAAAAGCCCAGCCGTGGTCCGGGTTAACGGCACGCCCATCACCAAGCTGGACGTCGAGCGCGCGGTCAAGGTGATG
CTCGCGCAAAACAAGGTAGACCAGCCGATTCCACCGGAGCTGCAAAAGCAGGCGGAGAGCGCCGCGCTGGAGCAGTTGAC
CTCCGCCGAACTGCTCTACCAGGAAGCCTCGAAGAGCAAGATCCCCGATTTGGACAAGATGATTGAACAGAAGGTGTCGC
AGAACCGGCAGAAGTTCAAGACCGAAGCGGAACTGGTCGAGGCGCTGAGCGCGCTGGAAATGACCCTACCGGATCTGGAG
GAGTTCACCCGCAAGGAGATCGTCCTCAGTACCTACATCGCCGAACATTTCCAGAACAAGGCTAGTGTCAGCGACGAAGA
GGTAAAAAAGTTCTACGACGACAACCTGAACCAGTATTTCAAGAAGCCGGAGTCGGTGAAAGCGAGCCACATCCTGGTCG
GGACCGATGAGAAGTCAACGCCGGAGGACAAGAAAAAGGCGAAGGAGAAGGCCGAGGCACTCCTGAAGCGGCTGCAGGCT
GGCGAGGATTTCGCAGCGGTTGCCAAGGGTGAGTCGACCTGCCCGAGCGCGAGCGAGGGAGGCGACCTGGGCGAATTCGG
TCGCGGGCAAATGGTCCCCGAATTCGAAGAGGCAGCGTTCAAGCTTAAGCCGGGCGAGATGAGCGGCGTGGTCGAGACCA
AGTTCGGCTACCATATCATCAAGGTAACCGGGAAGCAGGAAGCGGCAGCGGAGAAGCTGGAAAACGTGAAAGAGACAATT
GTCGAATTCCTGAAAAAACAGAAGGAGCAGCAGGAGCTCTCCAATTTCATCGATGAGTTGAAGAAAAAGGCGAAGATAGA
AAAGGTCGAGCTGTAA

Upstream 100 bases:

>100_bases
AAAACCCCCAACGTTTACGTCTGCCGTTATTTTCTGCTTAGCATTCACCGTGGTTAAATGATACTATCGCCGGCATCAAA
AAAATCTGAAGGAGATATGC

Downstream 100 bases:

>100_bases
CCAAACAGAAAGCAAAAGGGGACAGGCAACTTTTTGATCTCAAAAAGTAGCCTGTCCCCCTTTCTTTTTTGTGGTCTCCT
CCCCTCTTCCTTTCAGGGAG

Product: PpiC-type peptidylprolyl cis-trans isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MFSLKKKHLLVIASLLTAMLLPAGSFAEESAATPQEKPAGQPAAKKAANEPAAAQKSPAVVRVNGTPITKLDVERAVKVM
LAQNKVDQPIPPELQKQAESAALEQLTSAELLYQEASKSKIPDLDKMIEQKVSQNRQKFKTEAELVEALSALEMTLPDLE
EFTRKEIVLSTYIAEHFQNKASVSDEEVKKFYDDNLNQYFKKPESVKASHILVGTDEKSTPEDKKKAKEKAEALLKRLQA
GEDFAAVAKGESTCPSASEGGDLGEFGRGQMVPEFEEAAFKLKPGEMSGVVETKFGYHIIKVTGKQEAAAEKLENVKETI
VEFLKKQKEQQELSNFIDELKKKAKIEKVEL

Sequences:

>Translated_351_residues
MFSLKKKHLLVIASLLTAMLLPAGSFAEESAATPQEKPAGQPAAKKAANEPAAAQKSPAVVRVNGTPITKLDVERAVKVM
LAQNKVDQPIPPELQKQAESAALEQLTSAELLYQEASKSKIPDLDKMIEQKVSQNRQKFKTEAELVEALSALEMTLPDLE
EFTRKEIVLSTYIAEHFQNKASVSDEEVKKFYDDNLNQYFKKPESVKASHILVGTDEKSTPEDKKKAKEKAEALLKRLQA
GEDFAAVAKGESTCPSASEGGDLGEFGRGQMVPEFEEAAFKLKPGEMSGVVETKFGYHIIKVTGKQEAAAEKLENVKETI
VEFLKKQKEQQELSNFIDELKKKAKIEKVEL
>Mature_351_residues
MFSLKKKHLLVIASLLTAMLLPAGSFAEESAATPQEKPAGQPAAKKAANEPAAAQKSPAVVRVNGTPITKLDVERAVKVM
LAQNKVDQPIPPELQKQAESAALEQLTSAELLYQEASKSKIPDLDKMIEQKVSQNRQKFKTEAELVEALSALEMTLPDLE
EFTRKEIVLSTYIAEHFQNKASVSDEEVKKFYDDNLNQYFKKPESVKASHILVGTDEKSTPEDKKKAKEKAEALLKRLQA
GEDFAAVAKGESTCPSASEGGDLGEFGRGQMVPEFEEAAFKLKPGEMSGVVETKFGYHIIKVTGKQEAAAEKLENVKETI
VEFLKKQKEQQELSNFIDELKKKAKIEKVEL

Specific function: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Homo sapiens, GI5453898, Length=111, Percent_Identity=41.4414414414414, Blast_Score=75, Evalue=9e-14,
Organism=Escherichia coli, GI1790211, Length=69, Percent_Identity=52.1739130434783, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786645, Length=147, Percent_Identity=31.2925170068027, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1786238, Length=231, Percent_Identity=24.6753246753247, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322478, Length=124, Percent_Identity=38.7096774193548, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17647355, Length=108, Percent_Identity=41.6666666666667, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023059
- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR015391
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 38732; Mature: 38732

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00068 MDH ; PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSLKKKHLLVIASLLTAMLLPAGSFAEESAATPQEKPAGQPAAKKAANEPAAAQKSPAV
CCCCHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCHHHHHCCCCCCCCCCCCE
VRVNGTPITKLDVERAVKVMLAQNKVDQPIPPELQKQAESAALEQLTSAELLYQEASKSK
EEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IPDLDKMIEQKVSQNRQKFKTEAELVEALSALEMTLPDLEEFTRKEIVLSTYIAEHFQNK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
ASVSDEEVKKFYDDNLNQYFKKPESVKASHILVGTDEKSTPEDKKKAKEKAEALLKRLQA
CCCCHHHHHHHHHCCHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHC
GEDFAAVAKGESTCPSASEGGDLGEFGRGQMVPEFEEAAFKLKPGEMSGVVETKFGYHII
CCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHEECCCCCCCCCEEECCCEEEE
KVTGKQEAAAEKLENVKETIVEFLKKQKEQQELSNFIDELKKKAKIEKVEL
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFSLKKKHLLVIASLLTAMLLPAGSFAEESAATPQEKPAGQPAAKKAANEPAAAQKSPAV
CCCCHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCHHHHHCCCCCCCCCCCCE
VRVNGTPITKLDVERAVKVMLAQNKVDQPIPPELQKQAESAALEQLTSAELLYQEASKSK
EEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IPDLDKMIEQKVSQNRQKFKTEAELVEALSALEMTLPDLEEFTRKEIVLSTYIAEHFQNK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
ASVSDEEVKKFYDDNLNQYFKKPESVKASHILVGTDEKSTPEDKKKAKEKAEALLKRLQA
CCCCHHHHHHHHHCCHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHC
GEDFAAVAKGESTCPSASEGGDLGEFGRGQMVPEFEEAAFKLKPGEMSGVVETKFGYHII
CCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHEECCCCCCCCCEEECCCEEEE
KVTGKQEAAAEKLENVKETIVEFLKKQKEQQELSNFIDELKKKAKIEKVEL
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]