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The map label for this gene is atoC [H]

Identifier: 197118898

GI number: 197118898

Start: 2921792

End: 2923165

Strand: Direct

Name: atoC [H]

Synonym: Gbem_2521

Alternate gene names: 197118898

Gene position: 2921792-2923165 (Clockwise)

Preceding gene: 197118895

Following gene: 197118900

Centisome position: 63.31

GC content: 58.22

Gene sequence:

>1374_bases
ATGAAACAGAACATCAAGATACTGGTTATTGAAGATGACGACAGCAGCCGCGAGGCGCTGCTCATCCTTTTGAAGTCGAT
CGGCTTCACGGTCAAGGGATGCAGCAGCGGTCAGGACGGTTTGGGCGTCCTGTCGGGCGAGCCGTTCGACATCGTCATCA
CCGACCTTTTTCTCCCCGACCTGAACGGGATCGATATCCTGACCCGGGTAAAGGAGAGTTCCCCCCGCACCGAGGTCATC
CTGGTCACCGGGTACGGCTCCGCCGAGACCGCGGTGCAGGCGATGAAGAAAGGGGCCTACGATTACATCACCAAGCCCCT
CAACATAGAAGAACTCCGCATCATCATCGACAAGGCCCTTGAGAAGGGGCAGCTCGTCAGTGAAAACGTCTACCTGAAAA
AGCAGCTCAGGGATAAGTACGAGTTCGCCAACATCATCGGCAACTCCCAGGCGATGCAGCAGCTCTTCTCGAGGATGAAG
CGGATCATCAAGACCGACTCCACCGTCCTCATCCTGGGCGAATCGGGAACCGGCAAGGAGCTCGTCGCCAAGGCGATCCA
CTTCAACGGCAACCGCAAGGACAAGCCGTTCATAGCCGTCAACTGCTCCGCCATACCCGAGAACCTTCTGGAGAGCGAAC
TCTTCGGGCACGTCAAGGGGGCCTTCACCGGCGCGGTGAAGGAAAAGGTGGGCAAATTCGAGGCAGCCAACTACGGCACC
ATCTTTCTCGACGAGATCGGCACCCTCCCCATGCATCTGCAGACCAAGCTCTTGCGCGTGCTGCAGGAGCAGGAACTGGA
GCGGGTCGGCTCCAACAAGCAGATCAAGCTCGACGTGCGCGTAGTCTCCGCCACCAACGTGAACCTTGAGGAAGAAGTCG
CGCGCGGCAATTTCCGCGAGGATCTATTTTACCGGCTCAACGTCATCCCCATCCTGATTCCCCCCTTACGGGAGCGAATC
GAAGACCTGCTTCCCCTCACCAAGCACTTCCTGGATAAGAACTGCCGTTCCATGCAGCGTCCCATCATGCACATAGACAA
GGAGGCGTTGGAAGCGCTGGAGGCGTATCCCTGGAACGGGAACGTGCGCGAGCTTGAGAACATCATCGAGCGGATTGTGG
CGCTGACCGAGGGAGACCTGATCACCTTGCGGGACCTGCCGGCGAACATAGTGAAGAGCTACGTAGAAGGGACCCCCACC
AGCGTCACCCCCGCCGGCATAGACATGGTAGCCGCCATCAACGAGATAGAAAAGCGGATGATAGGCGAGGCGTTGCAGCT
AGCAGGCGGAGTGAAAGCCCGCGCCGCCGTCATGCTCAACATAAACAGGACCACCCTCGTGGAGAAGATGCGCAGATTGG
GGATTCCGCTATAG

Upstream 100 bases:

>100_bases
CCGCCAAAGTATAACTAAGCAACAGTCTCAGTCAATTGCTGGCTTGCCAAAACTCTTCATCCATGTTATTGAAGAAACCT
CTAACAATGGGAACTGGCGC

Downstream 100 bases:

>100_bases
CGCGGCGCCCAGAAGACGTCTTCTCCACCGGTCGTCGCCCCCCCCTCTCCTTGCCGCCCCCGCCCCCCAAAAAACCAGCA
TCAACTTCTAGCAGCCAAAA

Product: sigma-54-dependent transcriptional response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MKQNIKILVIEDDDSSREALLILLKSIGFTVKGCSSGQDGLGVLSGEPFDIVITDLFLPDLNGIDILTRVKESSPRTEVI
LVTGYGSAETAVQAMKKGAYDYITKPLNIEELRIIIDKALEKGQLVSENVYLKKQLRDKYEFANIIGNSQAMQQLFSRMK
RIIKTDSTVLILGESGTGKELVAKAIHFNGNRKDKPFIAVNCSAIPENLLESELFGHVKGAFTGAVKEKVGKFEAANYGT
IFLDEIGTLPMHLQTKLLRVLQEQELERVGSNKQIKLDVRVVSATNVNLEEEVARGNFREDLFYRLNVIPILIPPLRERI
EDLLPLTKHFLDKNCRSMQRPIMHIDKEALEALEAYPWNGNVRELENIIERIVALTEGDLITLRDLPANIVKSYVEGTPT
SVTPAGIDMVAAINEIEKRMIGEALQLAGGVKARAAVMLNINRTTLVEKMRRLGIPL

Sequences:

>Translated_457_residues
MKQNIKILVIEDDDSSREALLILLKSIGFTVKGCSSGQDGLGVLSGEPFDIVITDLFLPDLNGIDILTRVKESSPRTEVI
LVTGYGSAETAVQAMKKGAYDYITKPLNIEELRIIIDKALEKGQLVSENVYLKKQLRDKYEFANIIGNSQAMQQLFSRMK
RIIKTDSTVLILGESGTGKELVAKAIHFNGNRKDKPFIAVNCSAIPENLLESELFGHVKGAFTGAVKEKVGKFEAANYGT
IFLDEIGTLPMHLQTKLLRVLQEQELERVGSNKQIKLDVRVVSATNVNLEEEVARGNFREDLFYRLNVIPILIPPLRERI
EDLLPLTKHFLDKNCRSMQRPIMHIDKEALEALEAYPWNGNVRELENIIERIVALTEGDLITLRDLPANIVKSYVEGTPT
SVTPAGIDMVAAINEIEKRMIGEALQLAGGVKARAAVMLNINRTTLVEKMRRLGIPL
>Mature_457_residues
MKQNIKILVIEDDDSSREALLILLKSIGFTVKGCSSGQDGLGVLSGEPFDIVITDLFLPDLNGIDILTRVKESSPRTEVI
LVTGYGSAETAVQAMKKGAYDYITKPLNIEELRIIIDKALEKGQLVSENVYLKKQLRDKYEFANIIGNSQAMQQLFSRMK
RIIKTDSTVLILGESGTGKELVAKAIHFNGNRKDKPFIAVNCSAIPENLLESELFGHVKGAFTGAVKEKVGKFEAANYGT
IFLDEIGTLPMHLQTKLLRVLQEQELERVGSNKQIKLDVRVVSATNVNLEEEVARGNFREDLFYRLNVIPILIPPLRERI
EDLLPLTKHFLDKNCRSMQRPIMHIDKEALEALEAYPWNGNVRELENIIERIVALTEGDLITLRDLPANIVKSYVEGTPT
SVTPAGIDMVAAINEIEKRMIGEALQLAGGVKARAAVMLNINRTTLVEKMRRLGIPL

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=451, Percent_Identity=43.6807095343681, Blast_Score=393, Evalue=1e-110,
Organism=Escherichia coli, GI1790437, Length=450, Percent_Identity=42, Blast_Score=349, Evalue=2e-97,
Organism=Escherichia coli, GI1790299, Length=477, Percent_Identity=38.3647798742138, Blast_Score=328, Evalue=5e-91,
Organism=Escherichia coli, GI1788905, Length=446, Percent_Identity=39.4618834080717, Blast_Score=314, Evalue=9e-87,
Organism=Escherichia coli, GI1789087, Length=370, Percent_Identity=46.7567567567568, Blast_Score=298, Evalue=3e-82,
Organism=Escherichia coli, GI87082117, Length=345, Percent_Identity=48.1159420289855, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI1789233, Length=323, Percent_Identity=44.8916408668731, Blast_Score=261, Evalue=8e-71,
Organism=Escherichia coli, GI1786524, Length=342, Percent_Identity=39.4736842105263, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI87082152, Length=326, Percent_Identity=42.638036809816, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI87081872, Length=309, Percent_Identity=38.8349514563107, Blast_Score=214, Evalue=7e-57,
Organism=Escherichia coli, GI1787583, Length=325, Percent_Identity=37.5384615384615, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI87081858, Length=320, Percent_Identity=30.625, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1789828, Length=270, Percent_Identity=32.962962962963, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1786784, Length=122, Percent_Identity=31.1475409836066, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789809, Length=112, Percent_Identity=34.8214285714286, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789402, Length=108, Percent_Identity=34.2592592592593, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI87082012, Length=108, Percent_Identity=32.4074074074074, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50887; Mature: 50887

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQNIKILVIEDDDSSREALLILLKSIGFTVKGCSSGQDGLGVLSGEPFDIVITDLFLPD
CCCCEEEEEEECCCCCHHHHHHHHHHHCCEEECCCCCCCCCEECCCCCCEEEEEEECCCC
LNGIDILTRVKESSPRTEVILVTGYGSAETAVQAMKKGAYDYITKPLNIEELRIIIDKAL
CCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHH
EKGQLVSENVYLKKQLRDKYEFANIIGNSQAMQQLFSRMKRIIKTDSTVLILGESGTGKE
HCCCEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHH
LVAKAIHFNGNRKDKPFIAVNCSAIPENLLESELFGHVKGAFTGAVKEKVGKFEAANYGT
HHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCE
IFLDEIGTLPMHLQTKLLRVLQEQELERVGSNKQIKLDVRVVSATNVNLEEEVARGNFRE
EEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCHHHHHHCCCHHH
DLFYRLNVIPILIPPLRERIEDLLPLTKHFLDKNCRSMQRPIMHIDKEALEALEAYPWNG
HHHHHEEEHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCC
NVRELENIIERIVALTEGDLITLRDLPANIVKSYVEGTPTSVTPAGIDMVAAINEIEKRM
CHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
IGEALQLAGGVKARAAVMLNINRTTLVEKMRRLGIPL
HHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKQNIKILVIEDDDSSREALLILLKSIGFTVKGCSSGQDGLGVLSGEPFDIVITDLFLPD
CCCCEEEEEEECCCCCHHHHHHHHHHHCCEEECCCCCCCCCEECCCCCCEEEEEEECCCC
LNGIDILTRVKESSPRTEVILVTGYGSAETAVQAMKKGAYDYITKPLNIEELRIIIDKAL
CCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHH
EKGQLVSENVYLKKQLRDKYEFANIIGNSQAMQQLFSRMKRIIKTDSTVLILGESGTGKE
HCCCEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHH
LVAKAIHFNGNRKDKPFIAVNCSAIPENLLESELFGHVKGAFTGAVKEKVGKFEAANYGT
HHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCE
IFLDEIGTLPMHLQTKLLRVLQEQELERVGSNKQIKLDVRVVSATNVNLEEEVARGNFRE
EEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCHHHHHHCCCHHH
DLFYRLNVIPILIPPLRERIEDLLPLTKHFLDKNCRSMQRPIMHIDKEALEALEAYPWNG
HHHHHEEEHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCC
NVRELENIIERIVALTEGDLITLRDLPANIVKSYVEGTPTSVTPAGIDMVAAINEIEKRM
CHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
IGEALQLAGGVKARAAVMLNINRTTLVEKMRRLGIPL
HHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]