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The map label for this gene is htpX [H]

Identifier: 197118857

GI number: 197118857

Start: 2872613

End: 2874598

Strand: Direct

Name: htpX [H]

Synonym: Gbem_2480

Alternate gene names: 197118857

Gene position: 2872613-2874598 (Clockwise)

Preceding gene: 197118856

Following gene: 197118858

Centisome position: 62.24

GC content: 63.9

Gene sequence:

>1986_bases
ATGAACGATTTCTTCGCCAGACAGGAGAACGCCCGCCGCAATACCGGCCGGCTGCTCTTTCTCTTCGCCCTGGCCGTTAT
CGCGGTGGTGCTGGGCGTCTACCTGGTGGTCGCTTTGTCCCTTTGGTTCCACGAGTTCAAACACGGACGGAGTGCGAGCC
TCTGGCACGCGCAGGCGTTTTTCTGGAGCTCTGCTGTGTCGCTCTCCTTTATCGCGGCCATCTCCATCTGGAAGATGATG
GAACTGCGCGAAGGGGGCGCGGCCCTGGCCAAGGCCTTGGGCGCGCGGCTGGTCATTCCTCAGACAAACGAGCCGCGCGA
GCGCTTGCTTCGTAACGTGATGGAGGAAATGGCCATCGCCTCGGGGATACCTGTCCCCGACCTCTACCTCATGGAGCATG
AGCGGGGGATCAACGCCTTTGCCGCGGGTTTCGGCACCAGCGACGCGGTGATCTGCGTGACGCGCGGCGCGGTTGAACTG
CTCAGCCGCGACGAGCTGCAGGGGGTCATGGCCCACGAGTTCAGCCACATCCTCAACGGGGACATCCTTTTGAACCTCCG
CCTGCTGTGCTGGCTGGGGGGGATTCAGGCGGTGGGACAAACCGGGAGGGCGATGCTGGAGGGGATGCGCCACAACAGGG
GACGCGGCGGCGGGGCTATCCTCCTCGCCGGTTTCGCCCTCTACACCATCGGCTATCTGGGGCATTTTCTGGCGCAGCTG
ATCAAATGCGCCGTGTCGCGGCAGCGTGAGTATCTGGCTGACGCCTCTGCGGTGCAGTTCAGCAGGAACCCGGGCGGTTT
GGCAGGAGCGCTGAAAAAAATAGGGGGGCTTGCTACCGGCTCGCAACTGGTACATCCCCGCAGCGGCGAGATGAGCCACA
TGTTCTTCAGTAACGGCATCAGCGACGCTTGGCTTGCGGCACTAGACACCCATCCCCCTTTGAAAGAGCGGATCCGGCTC
CTGGAACCCCGCTTCAACGGGATTTATCCCAAGGTCACCCCTCTCCCCGTGCCAGTGGAAGAGGCGAAGCATCTGCTTAA
GCGGCCTCCTCAGCCCAAACCGGTTCAGGAGTACTCGGGAGCAGCCGTCAACGCACTGCTGAACAGCGTCGGGGAGCCGA
TGCAGCAGCACCTCGACCTGGCAGGCCGGCTGCTTTCAGAGCTCCCTGCGCCTCTTCTCGCCGCAACGCACGATCCCGTC
GCGGCACGTGCCGTCATCTACTGTCTATTGCTGAACTCCGACCAGGAAACGCGAAAGCGGCAGATGGAAGCGGTCGCGAC
ACTGGAAGGCGATCACCTGGCGCAGGAAGTCACCCGGATCGCCCCGGACCTGCAGTTCCTTCCCCCACAAGCCCGTTTGC
CGCTTCTCGACCTCTCGCTTCCGGCGCTGCGCCGCCTTAACGCCGAGGAGTTCGCACGGCTCCAAAAGACCGCCGATGCG
CTTGCCGCTGCAGACCGGCGGCTGAGCGTCTTCGAACTGGCCTTGCGCCACCTGATGCAGCGCCACCTGCAACCGCACTT
TTTCCCCTCCCCTTTGCGCACGGTCCAGATCTACGGGGTCCGCGGCGTGCAAAAAGAATGTTCCTGCATCCTTTCCACCA
TGGCGCGCGTCGGCAACAAGGACGAGGGCGCCGCGGCAGAGGCCTTCGCCAAGGGGGTCTGCCTCCTGAATGAGCCCAAA
GCCGAGTTCGCTTTCCTACCTGGAGCTGAGTGCAGCTCGAAAGCGTTGACGGCCGCCCTGTCGGCCCTCGACGGCGCCAG
TCCGCTGATCAAGCGAAAGCTTCTCGGGGCCTGCCTTGAGTGCATGGTGCACGACCAGGTGGTGAACGTGGACGAGGTCG
AGCTCTTCAGGGCCGTAGCCGACGCCATCGGCTGCCCGGTTCCCCCTTGGCTCAGCTTCCCCGTGCCGCCTGCCGGGACA
GCGCTCCAAGCGCAGTTTTCGCCTGGCGCTGAACCTCGCTCTGATTCCGCGGCGGGTGAGCCGTGA

Upstream 100 bases:

>100_bases
CATCGCCGGCTACTTCGGATTCAAGCAGGCGAGCCTTTTGGAAATAAAAGAGGCCGAGCGCGAGGCGCCGCGCGTTTCCT
TCGCCAAAGGCTAAGAAGCG

Downstream 100 bases:

>100_bases
AGATCCGGACGGGCAACGCCTACGACGCCGAGACCCACGGCACCGGCTGGTTTCTCGGCTTCAGCGACTGGACGCTGAAC
GACCCGTCGGGCCTGCTGCA

Product: peptidase M48 family peptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 661; Mature: 661

Protein sequence:

>661_residues
MNDFFARQENARRNTGRLLFLFALAVIAVVLGVYLVVALSLWFHEFKHGRSASLWHAQAFFWSSAVSLSFIAAISIWKMM
ELREGGAALAKALGARLVIPQTNEPRERLLRNVMEEMAIASGIPVPDLYLMEHERGINAFAAGFGTSDAVICVTRGAVEL
LSRDELQGVMAHEFSHILNGDILLNLRLLCWLGGIQAVGQTGRAMLEGMRHNRGRGGGAILLAGFALYTIGYLGHFLAQL
IKCAVSRQREYLADASAVQFSRNPGGLAGALKKIGGLATGSQLVHPRSGEMSHMFFSNGISDAWLAALDTHPPLKERIRL
LEPRFNGIYPKVTPLPVPVEEAKHLLKRPPQPKPVQEYSGAAVNALLNSVGEPMQQHLDLAGRLLSELPAPLLAATHDPV
AARAVIYCLLLNSDQETRKRQMEAVATLEGDHLAQEVTRIAPDLQFLPPQARLPLLDLSLPALRRLNAEEFARLQKTADA
LAAADRRLSVFELALRHLMQRHLQPHFFPSPLRTVQIYGVRGVQKECSCILSTMARVGNKDEGAAAEAFAKGVCLLNEPK
AEFAFLPGAECSSKALTAALSALDGASPLIKRKLLGACLECMVHDQVVNVDEVELFRAVADAIGCPVPPWLSFPVPPAGT
ALQAQFSPGAEPRSDSAAGEP

Sequences:

>Translated_661_residues
MNDFFARQENARRNTGRLLFLFALAVIAVVLGVYLVVALSLWFHEFKHGRSASLWHAQAFFWSSAVSLSFIAAISIWKMM
ELREGGAALAKALGARLVIPQTNEPRERLLRNVMEEMAIASGIPVPDLYLMEHERGINAFAAGFGTSDAVICVTRGAVEL
LSRDELQGVMAHEFSHILNGDILLNLRLLCWLGGIQAVGQTGRAMLEGMRHNRGRGGGAILLAGFALYTIGYLGHFLAQL
IKCAVSRQREYLADASAVQFSRNPGGLAGALKKIGGLATGSQLVHPRSGEMSHMFFSNGISDAWLAALDTHPPLKERIRL
LEPRFNGIYPKVTPLPVPVEEAKHLLKRPPQPKPVQEYSGAAVNALLNSVGEPMQQHLDLAGRLLSELPAPLLAATHDPV
AARAVIYCLLLNSDQETRKRQMEAVATLEGDHLAQEVTRIAPDLQFLPPQARLPLLDLSLPALRRLNAEEFARLQKTADA
LAAADRRLSVFELALRHLMQRHLQPHFFPSPLRTVQIYGVRGVQKECSCILSTMARVGNKDEGAAAEAFAKGVCLLNEPK
AEFAFLPGAECSSKALTAALSALDGASPLIKRKLLGACLECMVHDQVVNVDEVELFRAVADAIGCPVPPWLSFPVPPAGT
ALQAQFSPGAEPRSDSAAGEP
>Mature_661_residues
MNDFFARQENARRNTGRLLFLFALAVIAVVLGVYLVVALSLWFHEFKHGRSASLWHAQAFFWSSAVSLSFIAAISIWKMM
ELREGGAALAKALGARLVIPQTNEPRERLLRNVMEEMAIASGIPVPDLYLMEHERGINAFAAGFGTSDAVICVTRGAVEL
LSRDELQGVMAHEFSHILNGDILLNLRLLCWLGGIQAVGQTGRAMLEGMRHNRGRGGGAILLAGFALYTIGYLGHFLAQL
IKCAVSRQREYLADASAVQFSRNPGGLAGALKKIGGLATGSQLVHPRSGEMSHMFFSNGISDAWLAALDTHPPLKERIRL
LEPRFNGIYPKVTPLPVPVEEAKHLLKRPPQPKPVQEYSGAAVNALLNSVGEPMQQHLDLAGRLLSELPAPLLAATHDPV
AARAVIYCLLLNSDQETRKRQMEAVATLEGDHLAQEVTRIAPDLQFLPPQARLPLLDLSLPALRRLNAEEFARLQKTADA
LAAADRRLSVFELALRHLMQRHLQPHFFPSPLRTVQIYGVRGVQKECSCILSTMARVGNKDEGAAAEAFAKGVCLLNEPK
AEFAFLPGAECSSKALTAALSALDGASPLIKRKLLGACLECMVHDQVVNVDEVELFRAVADAIGCPVPPWLSFPVPPAGT
ALQAQFSPGAEPRSDSAAGEP

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family [H]

Homologues:

Organism=Escherichia coli, GI1788133, Length=234, Percent_Identity=30.3418803418803, Blast_Score=76, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022919
- InterPro:   IPR001915 [H]

Pfam domain/function: PF01435 Peptidase_M48 [H]

EC number: 3.4.24.- [C]

Molecular weight: Translated: 71733; Mature: 71733

Theoretical pI: Translated: 7.94; Mature: 7.94

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDFFARQENARRNTGRLLFLFALAVIAVVLGVYLVVALSLWFHEFKHGRSASLWHAQAF
CCCHHHCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
FWSSAVSLSFIAAISIWKMMELREGGAALAKALGARLVIPQTNEPRERLLRNVMEEMAIA
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHHH
SGIPVPDLYLMEHERGINAFAAGFGTSDAVICVTRGAVELLSRDELQGVMAHEFSHILNG
CCCCCCCHHHHHHHCCCHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCC
DILLNLRLLCWLGGIQAVGQTGRAMLEGMRHNRGRGGGAILLAGFALYTIGYLGHFLAQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
IKCAVSRQREYLADASAVQFSRNPGGLAGALKKIGGLATGSQLVHPRSGEMSHMFFSNGI
HHHHHHHHHHHHHCHHHHEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCCC
SDAWLAALDTHPPLKERIRLLEPRFNGIYPKVTPLPVPVEEAKHLLKRPPQPKPVQEYSG
CHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHCC
AAVNALLNSVGEPMQQHLDLAGRLLSELPAPLLAATHDPVAARAVIYCLLLNSDQETRKR
HHHHHHHHHHCHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHCCCCHHHHHH
QMEAVATLEGDHLAQEVTRIAPDLQFLPPQARLPLLDLSLPALRRLNAEEFARLQKTADA
HHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCHHHHHCCHHHHHHHHHHHHH
LAAADRRLSVFELALRHLMQRHLQPHFFPSPLRTVQIYGVRGVQKECSCILSTMARVGNK
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCC
DEGAAAEAFAKGVCLLNEPKAEFAFLPGAECSSKALTAALSALDGASPLIKRKLLGACLE
CCCHHHHHHHCCCEEECCCCCCEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
CMVHDQVVNVDEVELFRAVADAIGCPVPPWLSFPVPPAGTALQAQFSPGAEPRSDSAAGE
HHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCC
P
C
>Mature Secondary Structure
MNDFFARQENARRNTGRLLFLFALAVIAVVLGVYLVVALSLWFHEFKHGRSASLWHAQAF
CCCHHHCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
FWSSAVSLSFIAAISIWKMMELREGGAALAKALGARLVIPQTNEPRERLLRNVMEEMAIA
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHHH
SGIPVPDLYLMEHERGINAFAAGFGTSDAVICVTRGAVELLSRDELQGVMAHEFSHILNG
CCCCCCCHHHHHHHCCCHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCC
DILLNLRLLCWLGGIQAVGQTGRAMLEGMRHNRGRGGGAILLAGFALYTIGYLGHFLAQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
IKCAVSRQREYLADASAVQFSRNPGGLAGALKKIGGLATGSQLVHPRSGEMSHMFFSNGI
HHHHHHHHHHHHHCHHHHEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCCC
SDAWLAALDTHPPLKERIRLLEPRFNGIYPKVTPLPVPVEEAKHLLKRPPQPKPVQEYSG
CHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHCC
AAVNALLNSVGEPMQQHLDLAGRLLSELPAPLLAATHDPVAARAVIYCLLLNSDQETRKR
HHHHHHHHHHCHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHCCCCHHHHHH
QMEAVATLEGDHLAQEVTRIAPDLQFLPPQARLPLLDLSLPALRRLNAEEFARLQKTADA
HHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCHHHHHCCHHHHHHHHHHHHH
LAAADRRLSVFELALRHLMQRHLQPHFFPSPLRTVQIYGVRGVQKECSCILSTMARVGNK
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCC
DEGAAAEAFAKGVCLLNEPKAEFAFLPGAECSSKALTAALSALDGASPLIKRKLLGACLE
CCCHHHHHHHCCCEEECCCCCCEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
CMVHDQVVNVDEVELFRAVADAIGCPVPPWLSFPVPPAGTALQAQFSPGAEPRSDSAAGE
HHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCC
P
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA