Click here to switch to the map view.

The map label for this gene is ugd [H]

Identifier: 197118668

GI number: 197118668

Start: 2656418

End: 2657770

Strand: Reverse

Name: ugd [H]

Synonym: Gbem_2287

Alternate gene names: 197118668

Gene position: 2657770-2656418 (Counterclockwise)

Preceding gene: 197118669

Following gene: 197118667

Centisome position: 57.59

GC content: 60.24

Gene sequence:

>1353_bases
ATGAAAGTATGTGTGGTCGGATCAGGCTACGTGGGTCTCGTAGCCGGCACCTGTTTTGCCGAAAGCGGTAACGACGTCAT
CTGCGTCGACGTCGATAAAGATAAGATAGACGGCCTGAAGCGCGGCGTCATACCCATTTACGAGCCCGGCTTGAAGGAAA
TGGTCTTAAGGAACTGCGAGGAGGGGAGGCTTAACTTCACTACCGACCTCGACCTGGCCGTGAAGGAGTCGTTGGTCTGC
TTCATCGCAGTCGGCACCCCCCCCGGCGCCGACGGCTCAGCCGACCTGCAGTACGTCCTCTCCGTTGCCCGCTCCATCGG
CCGTGCCATGGAGAGCTTCAAGATCATCGTCGACAAGTCCACCGTCCCCGTAGGGACCGCCGACAAGGTGCGCGCTGCCG
TGAACGACGAGCTCGGCAAACGCGGGACGCATATAGAATTCGACGTGGTGTCCAACCCCGAGTTCTTAAAGGAAGGGGCG
GCAATCGACGACTTCATGAAACCCGACCGCGTCGTCATCGGTACCGACAACGTGAGGACCGCCGAGATCATGAAGGAGCT
CTACTCGGCCTTCATGCGCAAGTCTAACCGCCTGCTGGTGATGGACATCAGAAGCGCCGAGATGACCAAGTACGCCGCCA
ACGCCATGCTCGCCACCCGCATCACGTTCATGAACCAGATCGCAAACCTCTGCGAGGTGATGGGCGCGGACGTCATGGCG
GTCAGAGAAGGGATCGGCTCCGACTCCCGCATCGGTTACGACTTCCTCTTCCCCGGCGTCGGCTACGGCGGCTCCTGCTT
CCCCAAGGACGTCAAGGCCCTGGTGAAGACGGCGGACGAGTGCAGCTACGACTTCGTCCTCTTGAAAGCGGTAGAAACCG
CCAACGAGCGGCAGAAGGCGATCCTCTCCGACAAGATACTGCGCCGGCTGGGAAGCGCCGGGGACAAGCCTCTGGCGGGC
AAGCGTTTCGCCATCTGGGGGCTCTCCTTCAAGCCCCGCACCGACGACATGAGGGACGCCCCATCGCTCACCATCATCAA
CAGGCTTCTGGAAATGGGAGCCAGCGTGCACGCCCACGACCCTGAGGCGATGAACGAGGCGAAGAAGCATTTCGGCGACC
GCATCAGCTACAGCGTGAACAAGTACGACCTGATGAGAGGGGCCGATGCGCTGGTCATCATCACCGAGTGGAACGAGTAC
AGAAACCCCGATTTCGACCGCATCAAGGAACTCCTGATCAACCCGATCATCTTCGACGGCCGGAACCTCTACCACCCTGC
CCGCATGAAGGAGGCCGGGTTCGAGTACCTCCCCATCGGCAGAAACGGCAACGTCGTCTGCGAAATGAACTAA

Upstream 100 bases:

>100_bases
CTCACCAGGGAACTTTCGGCCGGGAAAACTCTGGCGTAACCCCACTGGTGTGTGCTATATAAGAACGCTAATTTTTTATC
TCCATGGAGGATGACGCAAC

Downstream 100 bases:

>100_bases
AAAGGCTGTTTTAGAGGCTGTTCTACGTTCTATGTTCTACGTTGAACACCGAACCCGGTCACACCTCTTGAATCGCGACA
ATGCTGAAACGAACATATAA

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MKVCVVGSGYVGLVAGTCFAESGNDVICVDVDKDKIDGLKRGVIPIYEPGLKEMVLRNCEEGRLNFTTDLDLAVKESLVC
FIAVGTPPGADGSADLQYVLSVARSIGRAMESFKIIVDKSTVPVGTADKVRAAVNDELGKRGTHIEFDVVSNPEFLKEGA
AIDDFMKPDRVVIGTDNVRTAEIMKELYSAFMRKSNRLLVMDIRSAEMTKYAANAMLATRITFMNQIANLCEVMGADVMA
VREGIGSDSRIGYDFLFPGVGYGGSCFPKDVKALVKTADECSYDFVLLKAVETANERQKAILSDKILRRLGSAGDKPLAG
KRFAIWGLSFKPRTDDMRDAPSLTIINRLLEMGASVHAHDPEAMNEAKKHFGDRISYSVNKYDLMRGADALVIITEWNEY
RNPDFDRIKELLINPIIFDGRNLYHPARMKEAGFEYLPIGRNGNVVCEMN

Sequences:

>Translated_450_residues
MKVCVVGSGYVGLVAGTCFAESGNDVICVDVDKDKIDGLKRGVIPIYEPGLKEMVLRNCEEGRLNFTTDLDLAVKESLVC
FIAVGTPPGADGSADLQYVLSVARSIGRAMESFKIIVDKSTVPVGTADKVRAAVNDELGKRGTHIEFDVVSNPEFLKEGA
AIDDFMKPDRVVIGTDNVRTAEIMKELYSAFMRKSNRLLVMDIRSAEMTKYAANAMLATRITFMNQIANLCEVMGADVMA
VREGIGSDSRIGYDFLFPGVGYGGSCFPKDVKALVKTADECSYDFVLLKAVETANERQKAILSDKILRRLGSAGDKPLAG
KRFAIWGLSFKPRTDDMRDAPSLTIINRLLEMGASVHAHDPEAMNEAKKHFGDRISYSVNKYDLMRGADALVIITEWNEY
RNPDFDRIKELLINPIIFDGRNLYHPARMKEAGFEYLPIGRNGNVVCEMN
>Mature_450_residues
MKVCVVGSGYVGLVAGTCFAESGNDVICVDVDKDKIDGLKRGVIPIYEPGLKEMVLRNCEEGRLNFTTDLDLAVKESLVC
FIAVGTPPGADGSADLQYVLSVARSIGRAMESFKIIVDKSTVPVGTADKVRAAVNDELGKRGTHIEFDVVSNPEFLKEGA
AIDDFMKPDRVVIGTDNVRTAEIMKELYSAFMRKSNRLLVMDIRSAEMTKYAANAMLATRITFMNQIANLCEVMGADVMA
VREGIGSDSRIGYDFLFPGVGYGGSCFPKDVKALVKTADECSYDFVLLKAVETANERQKAILSDKILRRLGSAGDKPLAG
KRFAIWGLSFKPRTDDMRDAPSLTIINRLLEMGASVHAHDPEAMNEAKKHFGDRISYSVNKYDLMRGADALVIITEWNEY
RNPDFDRIKELLINPIIFDGRNLYHPARMKEAGFEYLPIGRNGNVVCEMN

Specific function: Unknown

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=468, Percent_Identity=35.8974358974359, Blast_Score=258, Evalue=8e-69,
Organism=Homo sapiens, GI296040438, Length=374, Percent_Identity=35.2941176470588, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI296040443, Length=327, Percent_Identity=35.474006116208, Blast_Score=174, Evalue=1e-43,
Organism=Escherichia coli, GI1788340, Length=363, Percent_Identity=28.099173553719, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI48994968, Length=420, Percent_Identity=26.6666666666667, Blast_Score=138, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17560350, Length=468, Percent_Identity=34.6153846153846, Blast_Score=248, Evalue=4e-66,
Organism=Drosophila melanogaster, GI17136908, Length=468, Percent_Identity=37.1794871794872, Blast_Score=282, Evalue=3e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 49618; Mature: 49618

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVCVVGSGYVGLVAGTCFAESGNDVICVDVDKDKIDGLKRGVIPIYEPGLKEMVLRNCE
CEEEEEECCCHHHHHHEEEECCCCEEEEEECCHHHHHHHHHCCCCCCCCCHHHHHHHCCC
EGRLNFTTDLDLAVKESLVCFIAVGTPPGADGSADLQYVLSVARSIGRAMESFKIIVDKS
CCCEEEEECCCHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEECC
TVPVGTADKVRAAVNDELGKRGTHIEFDVVSNPEFLKEGAAIDDFMKPDRVVIGTDNVRT
CCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHCCCCHHHHCCCCEEEEECCCCCH
AEIMKELYSAFMRKSNRLLVMDIRSAEMTKYAANAMLATRITFMNQIANLCEVMGADVMA
HHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
VREGIGSDSRIGYDFLFPGVGYGGSCFPKDVKALVKTADECSYDFVLLKAVETANERQKA
HHHCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHH
ILSDKILRRLGSAGDKPLAGKRFAIWGLSFKPRTDDMRDAPSLTIINRLLEMGASVHAHD
HHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCC
PEAMNEAKKHFGDRISYSVNKYDLMRGADALVIITEWNEYRNPDFDRIKELLINPIIFDG
HHHHHHHHHHCCCCEEECCCHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHCCEEECC
RNLYHPARMKEAGFEYLPIGRNGNVVCEMN
CCCCCCHHHHHCCCCEEEECCCCCEEEEEC
>Mature Secondary Structure
MKVCVVGSGYVGLVAGTCFAESGNDVICVDVDKDKIDGLKRGVIPIYEPGLKEMVLRNCE
CEEEEEECCCHHHHHHEEEECCCCEEEEEECCHHHHHHHHHCCCCCCCCCHHHHHHHCCC
EGRLNFTTDLDLAVKESLVCFIAVGTPPGADGSADLQYVLSVARSIGRAMESFKIIVDKS
CCCEEEEECCCHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEECC
TVPVGTADKVRAAVNDELGKRGTHIEFDVVSNPEFLKEGAAIDDFMKPDRVVIGTDNVRT
CCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHCCCCHHHHCCCCEEEEECCCCCH
AEIMKELYSAFMRKSNRLLVMDIRSAEMTKYAANAMLATRITFMNQIANLCEVMGADVMA
HHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
VREGIGSDSRIGYDFLFPGVGYGGSCFPKDVKALVKTADECSYDFVLLKAVETANERQKA
HHHCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHH
ILSDKILRRLGSAGDKPLAGKRFAIWGLSFKPRTDDMRDAPSLTIINRLLEMGASVHAHD
HHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCC
PEAMNEAKKHFGDRISYSVNKYDLMRGADALVIITEWNEYRNPDFDRIKELLINPIIFDG
HHHHHHHHHHCCCCEEECCCHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHCCEEECC
RNLYHPARMKEAGFEYLPIGRNGNVVCEMN
CCCCCCHHHHHCCCCEEEECCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]