Click here to switch to the map view.

The map label for this gene is rsmA [H]

Identifier: 197118669

GI number: 197118669

Start: 2657832

End: 2658659

Strand: Reverse

Name: rsmA [H]

Synonym: Gbem_2288

Alternate gene names: 197118669

Gene position: 2658659-2657832 (Counterclockwise)

Preceding gene: 197118670

Following gene: 197118668

Centisome position: 57.61

GC content: 61.84

Gene sequence:

>828_bases
ATGGAGAAGATCCGCGCCAAGAAGGAGTTCGGCCAGAATTTCCTGGTCGACGACAGCGTACTGACCCGCATCGTCGCCTG
CGTCGCCCCCACGAAAGACGACTGCATCCTCGAGGTGGGACCGGGGCGGGGCGCGCTCTCGCGGCTTCTGGCGGAAAGCG
GCGCCAGGTTTCTGGCCGTGGAATGGGACCGCGAGCTCTTGCCGCTTTTAAAGGCGGAGTTTGCCACCAATCCCAACGTG
GAAATAGGCCACGGCGACATCCTCAGGGTCGACCTCCCGCTTTTGCTCGGATCCCGCGCAGAAGGGAAGAAATGGAAGGT
GGCGGCGAACCTCCCCTACAACATCTCGTCGCAGGTCCTTTTCCGTTTCATGGAGCACAGCGAGCTCTTCGAAAAGCTGG
TGCTCATGCTGCAAAAGGAGGTGGGGGACCGGCTGACCGCCCCCCCCGCCTGCAAGGAATACGGCGCGCTCACCGTACTT
CTTAGGCTGCACTTCGACATCCGCCGGGAGTTCATAGTGAAGCCCGGCTCTTTCCGGCCGGTCCCTAAGGTCGACTCGGC
GGTGCTGAGTTTTCTCCCACTGTCCGGGCCGAGGGTGGAGGTAGGTGACGAGGAACTTTTCCGCCGCGTGGTGAAAGGGG
CGTTTTTACAACGCAGGAAAACCCTCCTTAACTCGTTGCGCTCCTCCGGTTTCGACGATGCCGACGGCTTTCTTTCCGCA
GCCCTCTCAAGAAGCGGCATCGACGGCGGCAGGCGCGGCGAGACCCTGTCGCTGGAGGAGTTTGCCTGCCTCACCAGGGA
ACTTTCGGCCGGGAAAACTCTGGCGTAA

Upstream 100 bases:

>100_bases
ACTACTATCTGGGCCTCGGGATGAAGAGCGGTTTCGATCTCGACGCGCTTCCGGTGTGGCCCCTGGACAAGCTGGCCGCA
CGGCTGAAGGAGCATTGCTG

Downstream 100 bases:

>100_bases
CCCCACTGGTGTGTGCTATATAAGAACGCTAATTTTTTATCTCCATGGAGGATGACGCAACATGAAAGTATGTGTGGTCG
GATCAGGCTACGTGGGTCTC

Product: dimethyladenosine transferase

Products: NA

Alternate protein names: 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase; 16S rRNA dimethyladenosine transferase; 16S rRNA dimethylase; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase [H]

Number of amino acids: Translated: 275; Mature: 275

Protein sequence:

>275_residues
MEKIRAKKEFGQNFLVDDSVLTRIVACVAPTKDDCILEVGPGRGALSRLLAESGARFLAVEWDRELLPLLKAEFATNPNV
EIGHGDILRVDLPLLLGSRAEGKKWKVAANLPYNISSQVLFRFMEHSELFEKLVLMLQKEVGDRLTAPPACKEYGALTVL
LRLHFDIRREFIVKPGSFRPVPKVDSAVLSFLPLSGPRVEVGDEELFRRVVKGAFLQRRKTLLNSLRSSGFDDADGFLSA
ALSRSGIDGGRRGETLSLEEFACLTRELSAGKTLA

Sequences:

>Translated_275_residues
MEKIRAKKEFGQNFLVDDSVLTRIVACVAPTKDDCILEVGPGRGALSRLLAESGARFLAVEWDRELLPLLKAEFATNPNV
EIGHGDILRVDLPLLLGSRAEGKKWKVAANLPYNISSQVLFRFMEHSELFEKLVLMLQKEVGDRLTAPPACKEYGALTVL
LRLHFDIRREFIVKPGSFRPVPKVDSAVLSFLPLSGPRVEVGDEELFRRVVKGAFLQRRKTLLNSLRSSGFDDADGFLSA
ALSRSGIDGGRRGETLSLEEFACLTRELSAGKTLA
>Mature_275_residues
MEKIRAKKEFGQNFLVDDSVLTRIVACVAPTKDDCILEVGPGRGALSRLLAESGARFLAVEWDRELLPLLKAEFATNPNV
EIGHGDILRVDLPLLLGSRAEGKKWKVAANLPYNISSQVLFRFMEHSELFEKLVLMLQKEVGDRLTAPPACKEYGALTVL
LRLHFDIRREFIVKPGSFRPVPKVDSAVLSFLPLSGPRVEVGDEELFRRVVKGAFLQRRKTLLNSLRSSGFDDADGFLSA
ALSRSGIDGGRRGETLSLEEFACLTRELSAGKTLA

Specific function: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits [H]

COG id: COG0030

COG function: function code J; Dimethyladenosine transferase (rRNA methylation)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily [H]

Homologues:

Organism=Homo sapiens, GI156415992, Length=281, Percent_Identity=28.8256227758007, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI7657198, Length=223, Percent_Identity=30.9417040358744, Blast_Score=98, Evalue=8e-21,
Organism=Escherichia coli, GI1786236, Length=271, Percent_Identity=33.9483394833948, Blast_Score=152, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI25141369, Length=287, Percent_Identity=28.2229965156794, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI25146882, Length=224, Percent_Identity=33.0357142857143, Blast_Score=101, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6324989, Length=228, Percent_Identity=27.1929824561404, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21358017, Length=227, Percent_Identity=30.8370044052863, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21357273, Length=235, Percent_Identity=29.3617021276596, Blast_Score=87, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023165
- InterPro:   IPR020596
- InterPro:   IPR001737
- InterPro:   IPR020598
- InterPro:   IPR011530 [H]

Pfam domain/function: PF00398 RrnaAD [H]

EC number: =2.1.1.182 [H]

Molecular weight: Translated: 30423; Mature: 30423

Theoretical pI: Translated: 8.64; Mature: 8.64

Prosite motif: PS01131 RRNA_A_DIMETH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKIRAKKEFGQNFLVDDSVLTRIVACVAPTKDDCILEVGPGRGALSRLLAESGARFLAV
CCCCHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCCEEEEE
EWDRELLPLLKAEFATNPNVEIGHGDILRVDLPLLLGSRAEGKKWKVAANLPYNISSQVL
ECCHHHHHHHHHHHCCCCCEEECCCCEEEEEHHHHHCCCCCCCEEEEEECCCCCCHHHHH
FRFMEHSELFEKLVLMLQKEVGDRLTAPPACKEYGALTVLLRLHFDIRREFIVKPGSFRP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCC
VPKVDSAVLSFLPLSGPRVEVGDEELFRRVVKGAFLQRRKTLLNSLRSSGFDDADGFLSA
CCCHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
ALSRSGIDGGRRGETLSLEEFACLTRELSAGKTLA
HHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MEKIRAKKEFGQNFLVDDSVLTRIVACVAPTKDDCILEVGPGRGALSRLLAESGARFLAV
CCCCHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCCEEEEE
EWDRELLPLLKAEFATNPNVEIGHGDILRVDLPLLLGSRAEGKKWKVAANLPYNISSQVL
ECCHHHHHHHHHHHCCCCCEEECCCCEEEEEHHHHHCCCCCCCEEEEEECCCCCCHHHHH
FRFMEHSELFEKLVLMLQKEVGDRLTAPPACKEYGALTVLLRLHFDIRREFIVKPGSFRP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCC
VPKVDSAVLSFLPLSGPRVEVGDEELFRRVVKGAFLQRRKTLLNSLRSSGFDDADGFLSA
CCCHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
ALSRSGIDGGRRGETLSLEEFACLTRELSAGKTLA
HHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA