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The map label for this gene is atoC [H]

Identifier: 197118620

GI number: 197118620

Start: 2608545

End: 2609918

Strand: Direct

Name: atoC [H]

Synonym: Gbem_2239

Alternate gene names: 197118620

Gene position: 2608545-2609918 (Clockwise)

Preceding gene: 197118614

Following gene: 197118621

Centisome position: 56.52

GC content: 61.86

Gene sequence:

>1374_bases
ATGTACAACGGCAGGGTGATCATTTGCGACGACGAGGTCGAGATTCTCAGGTATCTGAGCAAGATTCTGACGGCCAAGGG
GCTCGACCTGGAGGTGTTCAGCTCCGGCACGTCGCTGATGAGCTTCCTGGAAAATCACGGGGTCGACGCGGCGGACCTGC
TGCTTTTGGATGTCAGGATGCCGGACCTGGACGGGCTTGAGATATTGCAGCGGGTGAAGAAGATGAACCTCGAGGTCCCG
GTGGTGATGATGACCGCCTATGCCTCGATCAACTCGGCCATCGAAGCGATGAAGCTGGGGGCGTACGATTACGTCACCAA
GCCGTTCCCCAAGGAGAAGATCTTCGGGATCCTGGAGAAGGTCCTGGAGCGCAAGGAACTCCTGAAGGAGAACTCCGCGC
TGAAGGACGAGCTCGGCATCCCCTCCCCTTCCACGCCGCTCGTCTTCTCCTCCGAGAGTTTCAGGCGCGTCCACGAAATG
GCGATGCTAGTGGCGCAAAGCGAGTCCAACGTCGTCATTCTCGGTGAGTCGGGCACCGGCAAGGAGCTGGTGGCGAGCCT
GATTCATAACAACAGCCCAAGAGCCAAGGAGCGCTTTCTTACCATCAACTGCGCGGCCCTCTCGGACACCCTTTTGGAAA
GCCAGCTCTTCGGCCACGTGCGCGGAGCCTTCACCGGCGCGGTGAACGCGCAGAAGGGGCTACTCGACGCGGCCAACAAC
GGCACTCTCTTTCTGGACGAGGTGGGAGACATGAGCCCGGCCATCCAGGCGAAGCTATTGCGCGTGCTGCAGGAGGGGGA
TTTCATCCCCGTCGGCGACACCAAGGCGAGAAGCGTCGACATCAGGTTCGTGGCGGCGACCAACAAGGACCTGGAGGAAG
AAGTGCGCCAGAAGCGCTTCAGGGAGGACCTCTACTTCCGCCTCAACGTGATCTCCCTGCACCTGCCGCCGCTTAGGGAG
CGCGGCGACGACATCGAGCTTTTGGCCCGGCACTTCCTTACCAAGTACGCCGCCCGCATGAAGCGCGAGATCACCGACTT
CACCCGTGAGGCGATGCAGCTACTCACCTCCTACAACTGGCCCGGCAACATCAGGGAGCTGGAAAACGCCATTGAGCGCG
CGGCCATCCTTACCCGCGGCCACACCATCACCGCAGAGACCCTGCCGGTCTGGCGCAACCCGCAGCCGGCGGAGGCGAAG
ACGGGGGTAAGCAGGCTGGTCTCGCTGGAGACGGTGGAGCGCGAGCATATCCTGCACGTCCTCAAGGCCTCAGGGAACAA
CAAAAGCCGCGCCGCGAAGATCCTCGAGATAGCCAGGCGCACGCTGGACCGGAAGATCGAGGAGTACGGCCTGGAAGACG
GGGGCTCCCGCTGA

Upstream 100 bases:

>100_bases
AGATATTGAACCTTTGCGAAATCCGGCCCGGTGGTAAGGTGGGCAGGCCACGACGCCAGGGGTAGAACCGCGGCGCACAT
CGGCAGATAAAGGTGAGACT

Downstream 100 bases:

>100_bases
TGCTCAAGCGTTTCCCGATCAAGGCCAAGCTCACCTTCGGGGCGCTGGCGCCGCTTTTCGTCGCCTTCTTCATCTGCTCC
CTGGCCGGCCTCTACATCAT

Product: sigma-54-dependent transcriptional response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MYNGRVIICDDEVEILRYLSKILTAKGLDLEVFSSGTSLMSFLENHGVDAADLLLLDVRMPDLDGLEILQRVKKMNLEVP
VVMMTAYASINSAIEAMKLGAYDYVTKPFPKEKIFGILEKVLERKELLKENSALKDELGIPSPSTPLVFSSESFRRVHEM
AMLVAQSESNVVILGESGTGKELVASLIHNNSPRAKERFLTINCAALSDTLLESQLFGHVRGAFTGAVNAQKGLLDAANN
GTLFLDEVGDMSPAIQAKLLRVLQEGDFIPVGDTKARSVDIRFVAATNKDLEEEVRQKRFREDLYFRLNVISLHLPPLRE
RGDDIELLARHFLTKYAARMKREITDFTREAMQLLTSYNWPGNIRELENAIERAAILTRGHTITAETLPVWRNPQPAEAK
TGVSRLVSLETVEREHILHVLKASGNNKSRAAKILEIARRTLDRKIEEYGLEDGGSR

Sequences:

>Translated_457_residues
MYNGRVIICDDEVEILRYLSKILTAKGLDLEVFSSGTSLMSFLENHGVDAADLLLLDVRMPDLDGLEILQRVKKMNLEVP
VVMMTAYASINSAIEAMKLGAYDYVTKPFPKEKIFGILEKVLERKELLKENSALKDELGIPSPSTPLVFSSESFRRVHEM
AMLVAQSESNVVILGESGTGKELVASLIHNNSPRAKERFLTINCAALSDTLLESQLFGHVRGAFTGAVNAQKGLLDAANN
GTLFLDEVGDMSPAIQAKLLRVLQEGDFIPVGDTKARSVDIRFVAATNKDLEEEVRQKRFREDLYFRLNVISLHLPPLRE
RGDDIELLARHFLTKYAARMKREITDFTREAMQLLTSYNWPGNIRELENAIERAAILTRGHTITAETLPVWRNPQPAEAK
TGVSRLVSLETVEREHILHVLKASGNNKSRAAKILEIARRTLDRKIEEYGLEDGGSR
>Mature_457_residues
MYNGRVIICDDEVEILRYLSKILTAKGLDLEVFSSGTSLMSFLENHGVDAADLLLLDVRMPDLDGLEILQRVKKMNLEVP
VVMMTAYASINSAIEAMKLGAYDYVTKPFPKEKIFGILEKVLERKELLKENSALKDELGIPSPSTPLVFSSESFRRVHEM
AMLVAQSESNVVILGESGTGKELVASLIHNNSPRAKERFLTINCAALSDTLLESQLFGHVRGAFTGAVNAQKGLLDAANN
GTLFLDEVGDMSPAIQAKLLRVLQEGDFIPVGDTKARSVDIRFVAATNKDLEEEVRQKRFREDLYFRLNVISLHLPPLRE
RGDDIELLARHFLTKYAARMKREITDFTREAMQLLTSYNWPGNIRELENAIERAAILTRGHTITAETLPVWRNPQPAEAK
TGVSRLVSLETVEREHILHVLKASGNNKSRAAKILEIARRTLDRKIEEYGLEDGGSR

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=456, Percent_Identity=43.640350877193, Blast_Score=368, Evalue=1e-103,
Organism=Escherichia coli, GI1790437, Length=446, Percent_Identity=42.3766816143498, Blast_Score=349, Evalue=3e-97,
Organism=Escherichia coli, GI1790299, Length=476, Percent_Identity=36.5546218487395, Blast_Score=308, Evalue=7e-85,
Organism=Escherichia coli, GI1788905, Length=451, Percent_Identity=37.4722838137472, Blast_Score=290, Evalue=1e-79,
Organism=Escherichia coli, GI1789087, Length=334, Percent_Identity=44.9101796407186, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI87082117, Length=343, Percent_Identity=40.5247813411079, Blast_Score=252, Evalue=3e-68,
Organism=Escherichia coli, GI87082152, Length=302, Percent_Identity=46.3576158940397, Blast_Score=246, Evalue=3e-66,
Organism=Escherichia coli, GI1789233, Length=328, Percent_Identity=40.2439024390244, Blast_Score=230, Evalue=2e-61,
Organism=Escherichia coli, GI1786524, Length=315, Percent_Identity=38.0952380952381, Blast_Score=194, Evalue=8e-51,
Organism=Escherichia coli, GI87081872, Length=308, Percent_Identity=40.2597402597403, Blast_Score=191, Evalue=6e-50,
Organism=Escherichia coli, GI1787583, Length=313, Percent_Identity=36.1022364217252, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI1789828, Length=311, Percent_Identity=28.9389067524116, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI87081858, Length=307, Percent_Identity=30.6188925081433, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1788724, Length=120, Percent_Identity=31.6666666666667, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1786784, Length=120, Percent_Identity=27.5, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1789809, Length=123, Percent_Identity=26.0162601626016, Blast_Score=62, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=126, Percent_Identity=30.1587301587302, Blast_Score=63, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51128; Mature: 51128

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYNGRVIICDDEVEILRYLSKILTAKGLDLEVFSSGTSLMSFLENHGVDAADLLLLDVRM
CCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHCCCCHHHEEEEEECC
PDLDGLEILQRVKKMNLEVPVVMMTAYASINSAIEAMKLGAYDYVTKPFPKEKIFGILEK
CCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHH
VLERKELLKENSALKDELGIPSPSTPLVFSSESFRRVHEMAMLVAQSESNVVILGESGTG
HHHHHHHHHHCCCHHHHCCCCCCCCCEEECCHHHHHHHHHHHHHCCCCCCEEEEECCCCC
KELVASLIHNNSPRAKERFLTINCAALSDTLLESQLFGHVRGAFTGAVNAQKGLLDAANN
HHHHHHHHHCCCCCHHHHEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCC
GTLFLDEVGDMSPAIQAKLLRVLQEGDFIPVGDTKARSVDIRFVAATNKDLEEEVRQKRF
CEEEEECCCCCCHHHHHHHHHHHHCCCEECCCCCCCCEEEEEEEEECCCCHHHHHHHHHH
REDLYFRLNVISLHLPPLRERGDDIELLARHFLTKYAARMKREITDFTREAMQLLTSYNW
HHHHHEEEEEEEEECCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PGNIRELENAIERAAILTRGHTITAETLPVWRNPQPAEAKTGVSRLVSLETVEREHILHV
CCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LKASGNNKSRAAKILEIARRTLDRKIEEYGLEDGGSR
HHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MYNGRVIICDDEVEILRYLSKILTAKGLDLEVFSSGTSLMSFLENHGVDAADLLLLDVRM
CCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHCCCCHHHEEEEEECC
PDLDGLEILQRVKKMNLEVPVVMMTAYASINSAIEAMKLGAYDYVTKPFPKEKIFGILEK
CCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHH
VLERKELLKENSALKDELGIPSPSTPLVFSSESFRRVHEMAMLVAQSESNVVILGESGTG
HHHHHHHHHHCCCHHHHCCCCCCCCCEEECCHHHHHHHHHHHHHCCCCCCEEEEECCCCC
KELVASLIHNNSPRAKERFLTINCAALSDTLLESQLFGHVRGAFTGAVNAQKGLLDAANN
HHHHHHHHHCCCCCHHHHEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCC
GTLFLDEVGDMSPAIQAKLLRVLQEGDFIPVGDTKARSVDIRFVAATNKDLEEEVRQKRF
CEEEEECCCCCCHHHHHHHHHHHHCCCEECCCCCCCCEEEEEEEEECCCCHHHHHHHHHH
REDLYFRLNVISLHLPPLRERGDDIELLARHFLTKYAARMKREITDFTREAMQLLTSYNW
HHHHHEEEEEEEEECCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PGNIRELENAIERAAILTRGHTITAETLPVWRNPQPAEAKTGVSRLVSLETVEREHILHV
CCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LKASGNNKSRAAKILEIARRTLDRKIEEYGLEDGGSR
HHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]