Click here to switch to the map view.

The map label for this gene is ppx [H]

Identifier: 197118614

GI number: 197118614

Start: 2597648

End: 2599183

Strand: Direct

Name: ppx [H]

Synonym: Gbem_2233

Alternate gene names: 197118614

Gene position: 2597648-2599183 (Clockwise)

Preceding gene: 197118613

Following gene: 197118620

Centisome position: 56.29

GC content: 62.17

Gene sequence:

>1536_bases
TTGAAGCAGACCCGGCTTGCCGCCATCGACATCGGCACCAACTCAATCCGAAGCATAATCATCGAGACCTCCGGAAACGG
CAAATACAAGATCCTAGACGACGAGAAGGTGCTGGTGCGGCTGGGCGAGGGCCTGCACCAAAGCGGCGCCATCTCCCCCG
CTGCCTGCAGCCGCGCGCTGGAAGCCCTTTCCCGACAAAAGAAAATCATAGACGGCTACGGGGTAGCCTCCATCGAGGCG
GTTGCCACCAGCGCGATGCGCAAGGCGAGTAATGGTCCCGCCCTGGTGCAGGCCATCAATGACGCCACCGGCGTCGAGGT
GGAAGTCATCAGCGGCGAGGAGGAGGCCGAGCTTGCGGCCTTAAGCGCCGCGCACAATTTCGAGCTGGAAGGGGTCAGGC
ACCTTATCTTCGACATCGGCGGCGGGAGCATGGAGCTGATTGCCGCGCTCGGTTCCCATACCGAGGAGATGATCTCCCTG
GAACTGGGAGCGGTTTTCCTCACCGAGAGTTTCCTCAAGGGAGACCCGGTGCACCCCTCCGAGCACGAAAAGCTGCGCAA
GCACGTCCGCAAGACGCTGAAGCGAGCCTATACCGGTGAGCGCAGTGGCATGCAGTGCCTGGTAGGCTCCGGCGGAACCG
TCACCACGATCGCGGCCATGGTTGCCGCCACCAGGAAGGAGAAGTACGACTCCGTGCACGGCTACGAGCTCCTCCGCTCG
GAGGTGGTTCACCTTCTGGCCATGCTGGTCAGAAAGAACGACAAGGAACGGCGCACCATCCCCGGGCTCAACCCGGATCG
TTCCGACATCATTGTGGCCGGGGTCACCGTAGTCGACGAACTGATGGATTTTTTCCAGGTGAACCTGCTCAAGGTGAACG
AGCGCGGCATCAGGGAAGGACTGATATTGAGGGGGCTGCGGCGGCAGAACCTGCTCCCCCACGAGAAAAGGACCCGCTCC
TGGCGCAACTCCGCGCAGGAGTTCGGCCATTCCTGCCATTTCGACCAGGATCATGCGGAGCACGTGGCCAAACTGGCGCA
GCAGGTGGCGAAGGCGCTAGCGCCCAAATTCCAGCTGGCGGAACGGGAGCTGCGGCTACTGGAAGCCGCGGCGCTTTTGC
ATGACGTCGGCTACTTCATCAACTATTCCAGCCACCACAAGCACTCCTACCACCTGATCCGCCATGCCGACCTCTTCGGC
TTCACCCCGCGCGAACGGGAATTGATCGCCAACGTCGCGCGCTACCACCGCAAATCGATCCCCAAGAAAAAGCACGACCA
GTTCGTGCGGCTTCCGGCAGCCGACCAGTTGCTGGTTTCGCGCCTGGGGGGGATACTGCGGCTTTGCGACGGGCTGGACC
GACGCCGAAACGGCGTGGTGCGAGAGCTTGTCTGCCGGCTTGCGCCGGACGACACGCTGCGCGTGACCCTGGTAGGCGAT
GAGGACATGTCGGTGGAGTTGTACGGCGCGAAGGCCAAGGGAGACCTGCTGCAGGAGGCTTTCCATCTGAAGCTTGCGCT
ACAGACAGCTGAATGA

Upstream 100 bases:

>100_bases
TCTTGGTACAATCCCTGCCATCCTGTCATCTAAGAGACCCAATAGCATCTGGTGCCACTGCCCGGCGCAAAGGGTGCGGG
GCAGGCACGAGGAGAACCCC

Downstream 100 bases:

>100_bases
AAAAAGGACCCGGCAGGCGCCGGGTCCTTTTTTTTGCTGTATTGGCTAACGGTGTTGAAGGGACAGGCTCCTTTAGGTGC
CTGTCCCTCTATCGGAACGT

Product: exopolyphosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 511; Mature: 511

Protein sequence:

>511_residues
MKQTRLAAIDIGTNSIRSIIIETSGNGKYKILDDEKVLVRLGEGLHQSGAISPAACSRALEALSRQKKIIDGYGVASIEA
VATSAMRKASNGPALVQAINDATGVEVEVISGEEEAELAALSAAHNFELEGVRHLIFDIGGGSMELIAALGSHTEEMISL
ELGAVFLTESFLKGDPVHPSEHEKLRKHVRKTLKRAYTGERSGMQCLVGSGGTVTTIAAMVAATRKEKYDSVHGYELLRS
EVVHLLAMLVRKNDKERRTIPGLNPDRSDIIVAGVTVVDELMDFFQVNLLKVNERGIREGLILRGLRRQNLLPHEKRTRS
WRNSAQEFGHSCHFDQDHAEHVAKLAQQVAKALAPKFQLAERELRLLEAAALLHDVGYFINYSSHHKHSYHLIRHADLFG
FTPRERELIANVARYHRKSIPKKKHDQFVRLPAADQLLVSRLGGILRLCDGLDRRRNGVVRELVCRLAPDDTLRVTLVGD
EDMSVELYGAKAKGDLLQEAFHLKLALQTAE

Sequences:

>Translated_511_residues
MKQTRLAAIDIGTNSIRSIIIETSGNGKYKILDDEKVLVRLGEGLHQSGAISPAACSRALEALSRQKKIIDGYGVASIEA
VATSAMRKASNGPALVQAINDATGVEVEVISGEEEAELAALSAAHNFELEGVRHLIFDIGGGSMELIAALGSHTEEMISL
ELGAVFLTESFLKGDPVHPSEHEKLRKHVRKTLKRAYTGERSGMQCLVGSGGTVTTIAAMVAATRKEKYDSVHGYELLRS
EVVHLLAMLVRKNDKERRTIPGLNPDRSDIIVAGVTVVDELMDFFQVNLLKVNERGIREGLILRGLRRQNLLPHEKRTRS
WRNSAQEFGHSCHFDQDHAEHVAKLAQQVAKALAPKFQLAERELRLLEAAALLHDVGYFINYSSHHKHSYHLIRHADLFG
FTPRERELIANVARYHRKSIPKKKHDQFVRLPAADQLLVSRLGGILRLCDGLDRRRNGVVRELVCRLAPDDTLRVTLVGD
EDMSVELYGAKAKGDLLQEAFHLKLALQTAE
>Mature_511_residues
MKQTRLAAIDIGTNSIRSIIIETSGNGKYKILDDEKVLVRLGEGLHQSGAISPAACSRALEALSRQKKIIDGYGVASIEA
VATSAMRKASNGPALVQAINDATGVEVEVISGEEEAELAALSAAHNFELEGVRHLIFDIGGGSMELIAALGSHTEEMISL
ELGAVFLTESFLKGDPVHPSEHEKLRKHVRKTLKRAYTGERSGMQCLVGSGGTVTTIAAMVAATRKEKYDSVHGYELLRS
EVVHLLAMLVRKNDKERRTIPGLNPDRSDIIVAGVTVVDELMDFFQVNLLKVNERGIREGLILRGLRRQNLLPHEKRTRS
WRNSAQEFGHSCHFDQDHAEHVAKLAQQVAKALAPKFQLAERELRLLEAAALLHDVGYFINYSSHHKHSYHLIRHADLFG
FTPRERELIANVARYHRKSIPKKKHDQFVRLPAADQLLVSRLGGILRLCDGLDRRRNGVVRELVCRLAPDDTLRVTLVGD
EDMSVELYGAKAKGDLLQEAFHLKLALQTAE

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=477, Percent_Identity=27.8825995807128, Blast_Score=148, Evalue=7e-37,
Organism=Escherichia coli, GI48994966, Length=437, Percent_Identity=26.0869565217391, Blast_Score=144, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 56576; Mature: 56576

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQTRLAAIDIGTNSIRSIIIETSGNGKYKILDDEKVLVRLGEGLHQSGAISPAACSRAL
CCCCEEEEEECCCCCEEEEEEEECCCCEEEEECCHHHHHHHHCCCCCCCCCCHHHHHHHH
EALSRQKKIIDGYGVASIEAVATSAMRKASNGPALVQAINDATGVEVEVISGEEEAELAA
HHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCEEEEECCCCHHHHHH
LSAAHNFELEGVRHLIFDIGGGSMELIAALGSHTEEMISLELGAVFLTESFLKGDPVHPS
HHHHCCCCHHHHHHHHEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
EHEKLRKHVRKTLKRAYTGERSGMQCLVGSGGTVTTIAAMVAATRKEKYDSVHGYELLRS
HHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHH
EVVHLLAMLVRKNDKERRTIPGLNPDRSDIIVAGVTVVDELMDFFQVNLLKVNERGIREG
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHEEECCHHHHHH
LILRGLRRQNLLPHEKRTRSWRNSAQEFGHSCHFDQDHAEHVAKLAQQVAKALAPKFQLA
HHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHH
ERELRLLEAAALLHDVGYFINYSSHHKHSYHLIRHADLFGFTPRERELIANVARYHRKSI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHEEECHHCCCCCHHHHHHHHHHHHHHHCC
PKKKHDQFVRLPAADQLLVSRLGGILRLCDGLDRRRNGVVRELVCRLAPDDTLRVTLVGD
CCHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEEEEEECC
EDMSVELYGAKAKGDLLQEAFHLKLALQTAE
CCCEEEEECCCCHHHHHHHHHHHHEEEEECC
>Mature Secondary Structure
MKQTRLAAIDIGTNSIRSIIIETSGNGKYKILDDEKVLVRLGEGLHQSGAISPAACSRAL
CCCCEEEEEECCCCCEEEEEEEECCCCEEEEECCHHHHHHHHCCCCCCCCCCHHHHHHHH
EALSRQKKIIDGYGVASIEAVATSAMRKASNGPALVQAINDATGVEVEVISGEEEAELAA
HHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCEEEEECCCCHHHHHH
LSAAHNFELEGVRHLIFDIGGGSMELIAALGSHTEEMISLELGAVFLTESFLKGDPVHPS
HHHHCCCCHHHHHHHHEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
EHEKLRKHVRKTLKRAYTGERSGMQCLVGSGGTVTTIAAMVAATRKEKYDSVHGYELLRS
HHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHH
EVVHLLAMLVRKNDKERRTIPGLNPDRSDIIVAGVTVVDELMDFFQVNLLKVNERGIREG
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHEEECCHHHHHH
LILRGLRRQNLLPHEKRTRSWRNSAQEFGHSCHFDQDHAEHVAKLAQQVAKALAPKFQLA
HHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHH
ERELRLLEAAALLHDVGYFINYSSHHKHSYHLIRHADLFGFTPRERELIANVARYHRKSI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHEEECHHCCCCCHHHHHHHHHHHHHHHCC
PKKKHDQFVRLPAADQLLVSRLGGILRLCDGLDRRRNGVVRELVCRLAPDDTLRVTLVGD
CCHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEEEEEECC
EDMSVELYGAKAKGDLLQEAFHLKLALQTAE
CCCEEEEECCCCHHHHHHHHHHHHEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10382967; 10984043 [H]