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The map label for this gene is pncB [H]

Identifier: 197118347

GI number: 197118347

Start: 2268149

End: 2269603

Strand: Reverse

Name: pncB [H]

Synonym: Gbem_1964

Alternate gene names: 197118347

Gene position: 2269603-2268149 (Counterclockwise)

Preceding gene: 197118348

Following gene: 197118346

Centisome position: 49.18

GC content: 64.26

Gene sequence:

>1455_bases
ATGCGCTATTCACCGCTGCTCACCGACCTTTACGAGTTGACCATGCTGGCAGGTTACCTGGACCAAGGGATGCAAGAGCA
TCGCGCCGTCTTCGACCTGTTTTTCCGCACCCCCCCTTTCAACGGAAGCTACGCCGTCTTCGCCGGTCTGGAAAACGCGC
TTTGCTACCTGGAGGAGCTCCGCTTCAACGAGGAGGAGTTGAGCTACCTGGACGGGCTCAAGATCTTCCGCCCCGCATTT
TTGTCGTACCTGGAAACCTTCCGGTTCCGGGGGAGCGTCACCGCCCCGGCCGAGGGGAGCGTAGTCTTCTCACGCGAACC
GCTCCTTACGGTGGAGGGGAGCCTCGCCGAGGCGCAGTTCGTCGAGACGGCGCTCCTGAACATCATCAATTTTCAGACGC
TAGTCGCCACCAAGGGAGCAAGAATCACCCTCGCCGCGGCAGGCGGCACCGTGCTCGAGTTCGGGCTGCGCCGCGCCCAG
GGCCCGGACGGGGGGCTTTCCGAGGCGCGGGCCGCCTACATCGGCGGCGTGCGCTCCACCAGCAACGTCATGGCCGGCAA
GTGCTACGGCATCCCGGTCCGGGGAACCCATGCCCACAGCTGGATCATGGCGTTCCCCGACGAGCTTACCGCCTTCCGCC
ACTACGCCGGCACCTTCCCAGATTCCTGCATCCTCTTGATAGACACTTACGACACCCTTAAAAGCGGCCTTCCCAACGCG
CTCACCGTCGCCCGCGAGCTGAAGGCAAAAGGGCACGACCTGGTAGGGGTGAGGATAGATTCAGGCGACCTCGCCTACCT
CTCGCGCCAGGTTCGCGCCGCTTTCGACGCGGCCGGTTTTCCCGGGGTGAAGATAGTCGGCTCCAACGAGCTCGACGAGT
ACGTGATCGAGTCGATCCGCAGCGAAGGGGGAAAGATCGACATCTACGGCGTCGGGACCCGGCTCGCCACCTGCGCGGGC
GAAGGGGGGGGGGCTCTCGGCGGAGTCTACAAGCTGGTCCGGATAGGGGAGGAGCCCAAGCTGAAGCTGACCAGCGACCT
GTCCAAGGCGACGCTTCCCGACCGGAAAAAAGTGCTGCGAGCCGTGGCGCCGGACGGCTCCTACATACAGGACGTCATTA
CCCTGAAAGACGAGGAGCTGCAGCCGGGCGCACTGGTGTTCGATCCGGCCAACCCATTGCAGCATATCCGCCTCCCGGCG
AACGCGAGGCTCGTGGAGGTGAGAAGCCAGGTAATGCACGAGGGGGTAAGGTGCGCCCCCTCCCCCACCCTGGACGACTG
CGCCGACCGCGCAGCGCGCGAACTGACCCTGCTCCCGCAGGGGTGTCACCGGCTGGTCAACCCGCACCTCTACAAGGTAT
CCATGAGCCAGGGGCTGAACACCCTGCGGCTCAAACTCATGTCCCGGATTCAGAACCGGTATGCGGCGGGTGAAGCAGAC
GGGGATACGGCATAG

Upstream 100 bases:

>100_bases
AGGCCGAGTACCTCACACTGAAACTTGTCGACCCGGAACTGGCAGAAAAGTTGAAAAACGCTATTATCCAGAGTAGTAGT
GATTAGAATGGAGGGATTTC

Downstream 100 bases:

>100_bases
GAGGCGATAATGCAACGAAGAGGAGCACTTCTTGTTGTCGACGCGCAGGTGGATTTCTGTCCGGGCGGGGCGCTCCCCGT
CCCCCGGGGCGACCAGGTGA

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MRYSPLLTDLYELTMLAGYLDQGMQEHRAVFDLFFRTPPFNGSYAVFAGLENALCYLEELRFNEEELSYLDGLKIFRPAF
LSYLETFRFRGSVTAPAEGSVVFSREPLLTVEGSLAEAQFVETALLNIINFQTLVATKGARITLAAAGGTVLEFGLRRAQ
GPDGGLSEARAAYIGGVRSTSNVMAGKCYGIPVRGTHAHSWIMAFPDELTAFRHYAGTFPDSCILLIDTYDTLKSGLPNA
LTVARELKAKGHDLVGVRIDSGDLAYLSRQVRAAFDAAGFPGVKIVGSNELDEYVIESIRSEGGKIDIYGVGTRLATCAG
EGGGALGGVYKLVRIGEEPKLKLTSDLSKATLPDRKKVLRAVAPDGSYIQDVITLKDEELQPGALVFDPANPLQHIRLPA
NARLVEVRSQVMHEGVRCAPSPTLDDCADRAARELTLLPQGCHRLVNPHLYKVSMSQGLNTLRLKLMSRIQNRYAAGEAD
GDTA

Sequences:

>Translated_484_residues
MRYSPLLTDLYELTMLAGYLDQGMQEHRAVFDLFFRTPPFNGSYAVFAGLENALCYLEELRFNEEELSYLDGLKIFRPAF
LSYLETFRFRGSVTAPAEGSVVFSREPLLTVEGSLAEAQFVETALLNIINFQTLVATKGARITLAAAGGTVLEFGLRRAQ
GPDGGLSEARAAYIGGVRSTSNVMAGKCYGIPVRGTHAHSWIMAFPDELTAFRHYAGTFPDSCILLIDTYDTLKSGLPNA
LTVARELKAKGHDLVGVRIDSGDLAYLSRQVRAAFDAAGFPGVKIVGSNELDEYVIESIRSEGGKIDIYGVGTRLATCAG
EGGGALGGVYKLVRIGEEPKLKLTSDLSKATLPDRKKVLRAVAPDGSYIQDVITLKDEELQPGALVFDPANPLQHIRLPA
NARLVEVRSQVMHEGVRCAPSPTLDDCADRAARELTLLPQGCHRLVNPHLYKVSMSQGLNTLRLKLMSRIQNRYAAGEAD
GDTA
>Mature_484_residues
MRYSPLLTDLYELTMLAGYLDQGMQEHRAVFDLFFRTPPFNGSYAVFAGLENALCYLEELRFNEEELSYLDGLKIFRPAF
LSYLETFRFRGSVTAPAEGSVVFSREPLLTVEGSLAEAQFVETALLNIINFQTLVATKGARITLAAAGGTVLEFGLRRAQ
GPDGGLSEARAAYIGGVRSTSNVMAGKCYGIPVRGTHAHSWIMAFPDELTAFRHYAGTFPDSCILLIDTYDTLKSGLPNA
LTVARELKAKGHDLVGVRIDSGDLAYLSRQVRAAFDAAGFPGVKIVGSNELDEYVIESIRSEGGKIDIYGVGTRLATCAG
EGGGALGGVYKLVRIGEEPKLKLTSDLSKATLPDRKKVLRAVAPDGSYIQDVITLKDEELQPGALVFDPANPLQHIRLPA
NARLVEVRSQVMHEGVRCAPSPTLDDCADRAARELTLLPQGCHRLVNPHLYKVSMSQGLNTLRLKLMSRIQNRYAAGEAD
GDTA

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=521, Percent_Identity=35.8925143953935, Blast_Score=275, Evalue=8e-74,
Organism=Caenorhabditis elegans, GI71997947, Length=529, Percent_Identity=38.3742911153119, Blast_Score=337, Evalue=1e-92,
Organism=Caenorhabditis elegans, GI71997952, Length=529, Percent_Identity=38.3742911153119, Blast_Score=336, Evalue=2e-92,
Organism=Caenorhabditis elegans, GI71997955, Length=223, Percent_Identity=47.9820627802691, Blast_Score=202, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24581587, Length=521, Percent_Identity=36.468330134357, Blast_Score=288, Evalue=7e-78,
Organism=Drosophila melanogaster, GI161076680, Length=280, Percent_Identity=38.2142857142857, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24581595, Length=280, Percent_Identity=38.2142857142857, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI28574709, Length=280, Percent_Identity=38.2142857142857, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24581593, Length=280, Percent_Identity=38.2142857142857, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24581591, Length=280, Percent_Identity=38.2142857142857, Blast_Score=174, Evalue=1e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 52627; Mature: 52627

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYSPLLTDLYELTMLAGYLDQGMQEHRAVFDLFFRTPPFNGSYAVFAGLENALCYLEEL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECHHHHHHHHHHH
RFNEEELSYLDGLKIFRPAFLSYLETFRFRGSVTAPAEGSVVFSREPLLTVEGSLAEAQF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEECCCHHHHHH
VETALLNIINFQTLVATKGARITLAAAGGTVLEFGLRRAQGPDGGLSEARAAYIGGVRST
HHHHHHHHHHHHHHEECCCCEEEEEECCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCC
SNVMAGKCYGIPVRGTHAHSWIMAFPDELTAFRHYAGTFPDSCILLIDTYDTLKSGLPNA
CCCCCCEEEECCCCCCCCCCEEEECCHHHHHHHHHCCCCCCCEEEEEECHHHHHHCCCHH
LTVARELKAKGHDLVGVRIDSGDLAYLSRQVRAAFDAAGFPGVKIVGSNELDEYVIESIR
HHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHH
SEGGKIDIYGVGTRLATCAGEGGGALGGVYKLVRIGEEPKLKLTSDLSKATLPDRKKVLR
CCCCEEEEEECCCCCEEECCCCCCHHHHHHHHHHCCCCCCEEECCCCHHCCCCHHHHHHH
AVAPDGSYIQDVITLKDEELQPGALVFDPANPLQHIRLPANARLVEVRSQVMHEGVRCAP
HHCCCCHHHHHHHHHCCCCCCCCEEEECCCCCHHHEECCCCCHHHHHHHHHHHCCCCCCC
SPTLDDCADRAARELTLLPQGCHRLVNPHLYKVSMSQGLNTLRLKLMSRIQNRYAAGEAD
CCCHHHHHHHHHHHEECCHHHHHHHCCCEEEEEEHHHCHHHHHHHHHHHHHHHHCCCCCC
GDTA
CCCC
>Mature Secondary Structure
MRYSPLLTDLYELTMLAGYLDQGMQEHRAVFDLFFRTPPFNGSYAVFAGLENALCYLEEL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECHHHHHHHHHHH
RFNEEELSYLDGLKIFRPAFLSYLETFRFRGSVTAPAEGSVVFSREPLLTVEGSLAEAQF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEECCCHHHHHH
VETALLNIINFQTLVATKGARITLAAAGGTVLEFGLRRAQGPDGGLSEARAAYIGGVRST
HHHHHHHHHHHHHHEECCCCEEEEEECCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCC
SNVMAGKCYGIPVRGTHAHSWIMAFPDELTAFRHYAGTFPDSCILLIDTYDTLKSGLPNA
CCCCCCEEEECCCCCCCCCCEEEECCHHHHHHHHHCCCCCCCEEEEEECHHHHHHCCCHH
LTVARELKAKGHDLVGVRIDSGDLAYLSRQVRAAFDAAGFPGVKIVGSNELDEYVIESIR
HHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHH
SEGGKIDIYGVGTRLATCAGEGGGALGGVYKLVRIGEEPKLKLTSDLSKATLPDRKKVLR
CCCCEEEEEECCCCCEEECCCCCCHHHHHHHHHHCCCCCCEEECCCCHHCCCCHHHHHHH
AVAPDGSYIQDVITLKDEELQPGALVFDPANPLQHIRLPANARLVEVRSQVMHEGVRCAP
HHCCCCHHHHHHHHHCCCCCCCCEEEECCCCCHHHEECCCCCHHHHHHHHHHHCCCCCCC
SPTLDDCADRAARELTLLPQGCHRLVNPHLYKVSMSQGLNTLRLKLMSRIQNRYAAGEAD
CCCHHHHHHHHHHHEECCHHHHHHHCCCEEEEEEHHHCHHHHHHHHHHHHHHHHCCCCCC
GDTA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]