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The map label for this gene is pyrC [H]

Identifier: 197118280

GI number: 197118280

Start: 2196360

End: 2197634

Strand: Direct

Name: pyrC [H]

Synonym: Gbem_1897

Alternate gene names: 197118280

Gene position: 2196360-2197634 (Clockwise)

Preceding gene: 197118279

Following gene: 197118281

Centisome position: 47.59

GC content: 64.0

Gene sequence:

>1275_bases
ATGAATCTTTTGATAAAAGGCGGGCGTGTGATTGATCCCTCTCAGGGGATAGATGCGAACCTCGATGTCCTGATCGCCGA
CGGCGTCGTGCTCGAACTGGGGCAGGGGCTTGCCGCGCCGGAGGGAACTCCGGCCATCGACGCCAGCGGGCTGATCGTGA
CGCCTGGGCTCATCGACATGCACGTGCACCTGCGCGACCCGGGCCTGGAGTACAAGGAAGACATCGCCACCGGTAGCCGC
TCCGCTGCGGCGGGGGGCTTCACCTCGGTTGCCTGCATGCCGAACACCTCGCCGGTCATCGACAGCAAGGCCATCGCTTC
CTACATCATCAACAAGGCCAAAAGCGAGGCGCTGGTCAACGTCTTCCCGATCGGCTGCATCACCAAGGGGGGCAAGGGTG
AGAGCCTCGCCGAAATGGGCGAGCTCAAGGAAGCTGGTTGCGTCGCGGTTTCCGACGACGGCAAGCCGGTCTGCAACTCC
GAGCTGATGCGCCGCGCCCTCGAGTACGCCAAAGGGATCGGCATCGCCGTTATCTCGCACTCCGAGGATCTGGCTCTCGT
GGGCGAAGGGGTCATGAACGAAGGGTTCGTCTCCACCGAGCTGGGACTGAAGGGAATCCCCTGGGCTGCCGAAGACATCG
CAGTGGCCCGCGAGGTGTACCTGGCCGAGTTCGCAGGAGCACCGGTGCACATAGCGCACATCTCCACCGTGGGATCGGCC
CGCATCATCCGCAACGCTAAGGCGCGCGGCGTCAAGGTCACCTGCGAGACCGCGCCGCACTACTTCACCCTGACCGACGA
GGCGGTGCGCGGCTATGAAACCAACGCCAAGATGAACCCGCCTTTGAGAAGCGCCGCAGACGTCGAGGCCATGAAGGCCG
GCCTTGCCGACGGCACCATCGACGCCATCGCCACGGATCATGCGCCGCACCACCCGGACGAGAAGGACGTGGAATTCAAC
GTCGCCCTGAACGGCATCGTAGGCCTTGAGACCTCGCTTTCCCTCTCGCTCAAGCTCGTCGAAGAGGGGCGCCTGGACCT
GAACCAGCTGGTGTCGCTCATGTCCTGCACCCCGGCGAAGATCCTCGGTCTCGACCGCGGCACCTTGAAGGTCGGGGCCG
TGGGCGACGTCACCATCATCGACCCGGCCAAGGAGTGGCAGGTAGAGGCGGCGAAGCTGGAGTCGAAGTCCAAGAACTCC
CCCTTCCTTGGCTGGAAGATGAAGGGGAGGGCGGTCTACACCGTCGTGAAGGGGCAGGTGGTGTACCAGGCGTAA

Upstream 100 bases:

>100_bases
TTTACTGGATGGAGGAGCCGTCCCGGTTCGGGTGCCACAGACAGAACCGTCAGTTGAACCTTGAACGTTGAACGTTGAAC
CTTTTTTAGGGGGGTAAGAG

Downstream 100 bases:

>100_bases
GATTGACTCGCGCCACATGCTCCCCCTCCCTTGACGGGAGGGGGAAGTTAAAACGAAATTTGCGCTTTTTTGCGCGGCAG
AAATATAACGGACTTGGGAG

Product: dihydroorotase, multifunctional complex type

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MNLLIKGGRVIDPSQGIDANLDVLIADGVVLELGQGLAAPEGTPAIDASGLIVTPGLIDMHVHLRDPGLEYKEDIATGSR
SAAAGGFTSVACMPNTSPVIDSKAIASYIINKAKSEALVNVFPIGCITKGGKGESLAEMGELKEAGCVAVSDDGKPVCNS
ELMRRALEYAKGIGIAVISHSEDLALVGEGVMNEGFVSTELGLKGIPWAAEDIAVAREVYLAEFAGAPVHIAHISTVGSA
RIIRNAKARGVKVTCETAPHYFTLTDEAVRGYETNAKMNPPLRSAADVEAMKAGLADGTIDAIATDHAPHHPDEKDVEFN
VALNGIVGLETSLSLSLKLVEEGRLDLNQLVSLMSCTPAKILGLDRGTLKVGAVGDVTIIDPAKEWQVEAAKLESKSKNS
PFLGWKMKGRAVYTVVKGQVVYQA

Sequences:

>Translated_424_residues
MNLLIKGGRVIDPSQGIDANLDVLIADGVVLELGQGLAAPEGTPAIDASGLIVTPGLIDMHVHLRDPGLEYKEDIATGSR
SAAAGGFTSVACMPNTSPVIDSKAIASYIINKAKSEALVNVFPIGCITKGGKGESLAEMGELKEAGCVAVSDDGKPVCNS
ELMRRALEYAKGIGIAVISHSEDLALVGEGVMNEGFVSTELGLKGIPWAAEDIAVAREVYLAEFAGAPVHIAHISTVGSA
RIIRNAKARGVKVTCETAPHYFTLTDEAVRGYETNAKMNPPLRSAADVEAMKAGLADGTIDAIATDHAPHHPDEKDVEFN
VALNGIVGLETSLSLSLKLVEEGRLDLNQLVSLMSCTPAKILGLDRGTLKVGAVGDVTIIDPAKEWQVEAAKLESKSKNS
PFLGWKMKGRAVYTVVKGQVVYQA
>Mature_424_residues
MNLLIKGGRVIDPSQGIDANLDVLIADGVVLELGQGLAAPEGTPAIDASGLIVTPGLIDMHVHLRDPGLEYKEDIATGSR
SAAAGGFTSVACMPNTSPVIDSKAIASYIINKAKSEALVNVFPIGCITKGGKGESLAEMGELKEAGCVAVSDDGKPVCNS
ELMRRALEYAKGIGIAVISHSEDLALVGEGVMNEGFVSTELGLKGIPWAAEDIAVAREVYLAEFAGAPVHIAHISTVGSA
RIIRNAKARGVKVTCETAPHYFTLTDEAVRGYETNAKMNPPLRSAADVEAMKAGLADGTIDAIATDHAPHHPDEKDVEFN
VALNGIVGLETSLSLSLKLVEEGRLDLNQLVSLMSCTPAKILGLDRGTLKVGAVGDVTIIDPAKEWQVEAAKLESKSKNS
PFLGWKMKGRAVYTVVKGQVVYQA

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=408, Percent_Identity=32.843137254902, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI4503051, Length=447, Percent_Identity=25.9507829977629, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI62422571, Length=447, Percent_Identity=25.9507829977629, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI190194363, Length=453, Percent_Identity=26.7108167770419, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI4503375, Length=460, Percent_Identity=26.7391304347826, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI19923821, Length=454, Percent_Identity=25.7709251101322, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI4503379, Length=453, Percent_Identity=24.5033112582781, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI4503377, Length=448, Percent_Identity=23.6607142857143, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1786722, Length=440, Percent_Identity=28.8636363636364, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI87082175, Length=456, Percent_Identity=28.0701754385965, Blast_Score=146, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI193204318, Length=381, Percent_Identity=28.8713910761155, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI71989490, Length=452, Percent_Identity=27.4336283185841, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI86575075, Length=438, Percent_Identity=24.2009132420091, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6322218, Length=197, Percent_Identity=28.9340101522843, Blast_Score=96, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24642586, Length=382, Percent_Identity=30.8900523560209, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI18859883, Length=450, Percent_Identity=28.6666666666667, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 44440; Mature: 44440

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLLIKGGRVIDPSQGIDANLDVLIADGVVLELGQGLAAPEGTPAIDASGLIVTPGLIDM
CCEEEECCEEECCCCCCCCCCEEEEECCEEEECCCCCCCCCCCCCCCCCCEEECCCEEEE
HVHLRDPGLEYKEDIATGSRSAAAGGFTSVACMPNTSPVIDSKAIASYIINKAKSEALVN
EEEEECCCCCHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEE
VFPIGCITKGGKGESLAEMGELKEAGCVAVSDDGKPVCNSELMRRALEYAKGIGIAVISH
EEEEEEEECCCCCCHHHHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHCCCEEEEEEC
SEDLALVGEGVMNEGFVSTELGLKGIPWAAEDIAVAREVYLAEFAGAPVHIAHISTVGSA
CCCEEEECCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCH
RIIRNAKARGVKVTCETAPHYFTLTDEAVRGYETNAKMNPPLRSAADVEAMKAGLADGTI
HHHHCCCCCCEEEEEECCCCEEEECHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCC
DAIATDHAPHHPDEKDVEFNVALNGIVGLETSLSLSLKLVEEGRLDLNQLVSLMSCTPAK
CEEECCCCCCCCCCCCEEEEEEEEEEEECCCCEEEEEEEEECCCCCHHHHHHHHCCCCHH
ILGLDRGTLKVGAVGDVTIIDPAKEWQVEAAKLESKSKNSPFLGWKMKGRAVYTVVKGQV
EEECCCCCEEECCCCCEEEECCHHHHHHHHHHHHCCCCCCCEEEEEECCCEEEEEEECEE
VYQA
EEEC
>Mature Secondary Structure
MNLLIKGGRVIDPSQGIDANLDVLIADGVVLELGQGLAAPEGTPAIDASGLIVTPGLIDM
CCEEEECCEEECCCCCCCCCCEEEEECCEEEECCCCCCCCCCCCCCCCCCEEECCCEEEE
HVHLRDPGLEYKEDIATGSRSAAAGGFTSVACMPNTSPVIDSKAIASYIINKAKSEALVN
EEEEECCCCCHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEE
VFPIGCITKGGKGESLAEMGELKEAGCVAVSDDGKPVCNSELMRRALEYAKGIGIAVISH
EEEEEEEECCCCCCHHHHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHCCCEEEEEEC
SEDLALVGEGVMNEGFVSTELGLKGIPWAAEDIAVAREVYLAEFAGAPVHIAHISTVGSA
CCCEEEECCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCH
RIIRNAKARGVKVTCETAPHYFTLTDEAVRGYETNAKMNPPLRSAADVEAMKAGLADGTI
HHHHCCCCCCEEEEEECCCCEEEECHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCC
DAIATDHAPHHPDEKDVEFNVALNGIVGLETSLSLSLKLVEEGRLDLNQLVSLMSCTPAK
CEEECCCCCCCCCCCCEEEEEEEEEEEECCCCEEEEEEEEECCCCCHHHHHHHHCCCCHH
ILGLDRGTLKVGAVGDVTIIDPAKEWQVEAAKLESKSKNSPFLGWKMKGRAVYTVVKGQV
EEECCCCCEEECCCCCEEEECCHHHHHHHHHHHHCCCCCCCEEEEEECCCEEEEEEECEE
VYQA
EEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA