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The map label for this gene is sucD-2 [H]

Identifier: 197117852

GI number: 197117852

Start: 1696243

End: 1697169

Strand: Direct

Name: sucD-2 [H]

Synonym: Gbem_1465

Alternate gene names: 197117852

Gene position: 1696243-1697169 (Clockwise)

Preceding gene: 197117851

Following gene: 197117853

Centisome position: 36.75

GC content: 64.51

Gene sequence:

>927_bases
ATGAGCATCTTAGTCGACAAGAACACCAAGGTCATCACCCAGGGCATCACCGGTGCCACCGGTCTCTTCCACGCGCAGGG
CGCGCGCGAGTACGGCACCCAGATGGTAGGCGGGGTAACCCCCGGCAAGGGAGGGTCCAACGTCGACGGCTTCCCCGTCT
TCAACACCGTCGCTGAGGCGGTAGAAAAGACCGGCGCCAACGCGAGCGTCATCTACGTGCCGCCGCCGTTTGCCGCAGAC
TCCATCATGGAGGCCATCGATGCCGGCCTCGATCTCGTCTGCTGCATCACCGAGGGGATTCCGGTCCTCGACATGGTCAA
GGTGAAGCAATACATGCAGGGCAAGAAGACCCGCCTGATCGGCCCCAACTGTCCCGGCGTGATCACCCCCGGCCAGTGCA
AGATAGGCATCATGCCCGGCTACATCCACCGTCCGGGCAAGGTCGGCGTCGTCTCCCGCAGCGGCACCCTCACCTACGAA
GCGGTCTGGCAGCTGACCGGTTACGGCCTGGGGCAATCCACCTGCGTCGGCATCGGCGGCGACCCCGTCAACGGCACCAG
CCATCTGGACTGCCTGAAGATGTTCGAAGAAGACCCCGACACCGAAGCCGTCATCATGATCGGCGAGATCGGCGGCAGTG
CCGAAGAAGAAGCCGCCTATTTCGTCAAGGAGCACATGACCAAGCCGGTGGCAGGCTACATCGCCGGGCGCACCGCCCCT
CCGGGAAAAAGGATGGGCCATGCCGGCGCCATCATCTCCGGCGGCAAGGGGACCGCGGCCGAGAAAGTAGCCATCTTGGA
ATCCTGCGGCATCAGCGTAGCGGCCACCCCCGCCGAGATGGCCCAGGCTCTGATGAAGGTGTACCGCCCCGATTCCAAGG
TGAGTCACCACTACGTCAACGCCCCCGCCGCAGCCGCGGCGTCGTAA

Upstream 100 bases:

>100_bases
AGCTCCTGGCCCAAAGCGGGCTCGACATAGTCGCCGCCGACGGGATGGCCGACGCCGCCCAGAAAATCGTGATGGCCGTT
TCTGCCAAAGGGGGGAGAGC

Downstream 100 bases:

>100_bases
ATGAAGTAAGGGGGGGGACTGGCTCCGAAGGTGCCTGTCCCCCTTAGCCAAAGCTGAGCAAAGCAACTCCCCCTAAATCC
CCCTTCGCAAAGGGGGACTT

Product: succinyl-CoA synthetase subunit alpha

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha; Vegetative protein 239; VEG239 [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MSILVDKNTKVITQGITGATGLFHAQGAREYGTQMVGGVTPGKGGSNVDGFPVFNTVAEAVEKTGANASVIYVPPPFAAD
SIMEAIDAGLDLVCCITEGIPVLDMVKVKQYMQGKKTRLIGPNCPGVITPGQCKIGIMPGYIHRPGKVGVVSRSGTLTYE
AVWQLTGYGLGQSTCVGIGGDPVNGTSHLDCLKMFEEDPDTEAVIMIGEIGGSAEEEAAYFVKEHMTKPVAGYIAGRTAP
PGKRMGHAGAIISGGKGTAAEKVAILESCGISVAATPAEMAQALMKVYRPDSKVSHHYVNAPAAAAAS

Sequences:

>Translated_308_residues
MSILVDKNTKVITQGITGATGLFHAQGAREYGTQMVGGVTPGKGGSNVDGFPVFNTVAEAVEKTGANASVIYVPPPFAAD
SIMEAIDAGLDLVCCITEGIPVLDMVKVKQYMQGKKTRLIGPNCPGVITPGQCKIGIMPGYIHRPGKVGVVSRSGTLTYE
AVWQLTGYGLGQSTCVGIGGDPVNGTSHLDCLKMFEEDPDTEAVIMIGEIGGSAEEEAAYFVKEHMTKPVAGYIAGRTAP
PGKRMGHAGAIISGGKGTAAEKVAILESCGISVAATPAEMAQALMKVYRPDSKVSHHYVNAPAAAAAS
>Mature_307_residues
SILVDKNTKVITQGITGATGLFHAQGAREYGTQMVGGVTPGKGGSNVDGFPVFNTVAEAVEKTGANASVIYVPPPFAADS
IMEAIDAGLDLVCCITEGIPVLDMVKVKQYMQGKKTRLIGPNCPGVITPGQCKIGIMPGYIHRPGKVGVVSRSGTLTYEA
VWQLTGYGLGQSTCVGIGGDPVNGTSHLDCLKMFEEDPDTEAVIMIGEIGGSAEEEAAYFVKEHMTKPVAGYIAGRTAPP
GKRMGHAGAIISGGKGTAAEKVAILESCGISVAATPAEMAQALMKVYRPDSKVSHHYVNAPAAAAAS

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=291, Percent_Identity=63.9175257731959, Blast_Score=321, Evalue=7e-88,
Organism=Homo sapiens, GI38569423, Length=251, Percent_Identity=30.2788844621514, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI38569421, Length=251, Percent_Identity=30.2788844621514, Blast_Score=95, Evalue=7e-20,
Organism=Escherichia coli, GI1786949, Length=289, Percent_Identity=68.5121107266436, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI1786513, Length=148, Percent_Identity=30.4054054054054, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17550194, Length=292, Percent_Identity=58.2191780821918, Blast_Score=327, Evalue=6e-90,
Organism=Caenorhabditis elegans, GI17553126, Length=290, Percent_Identity=56.2068965517241, Blast_Score=315, Evalue=2e-86,
Organism=Caenorhabditis elegans, GI17557344, Length=251, Percent_Identity=27.4900398406374, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17551266, Length=266, Percent_Identity=27.0676691729323, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324716, Length=296, Percent_Identity=50, Blast_Score=276, Evalue=3e-75,
Organism=Drosophila melanogaster, GI21356559, Length=290, Percent_Identity=57.2413793103448, Blast_Score=335, Evalue=2e-92,
Organism=Drosophila melanogaster, GI28574296, Length=290, Percent_Identity=58.2758620689655, Blast_Score=307, Evalue=7e-84,
Organism=Drosophila melanogaster, GI281363477, Length=251, Percent_Identity=27.4900398406374, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI281363475, Length=251, Percent_Identity=27.4900398406374, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI281363473, Length=251, Percent_Identity=27.4900398406374, Blast_Score=85, Evalue=5e-17,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 31783; Mature: 31652

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSILVDKNTKVITQGITGATGLFHAQGAREYGTQMVGGVTPGKGGSNVDGFPVFNTVAEA
CEEEEECCCEEEECCCCCCCHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHH
VEKTGANASVIYVPPPFAADSIMEAIDAGLDLVCCITEGIPVLDMVKVKQYMQGKKTRLI
HHHCCCCCEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEE
GPNCPGVITPGQCKIGIMPGYIHRPGKVGVVSRSGTLTYEAVWQLTGYGLGQSTCVGIGG
CCCCCCEECCCCEEEEECCCCEECCCCEEEEECCCCEEHEEHHHHHCCCCCCCEEEECCC
DPVNGTSHLDCLKMFEEDPDTEAVIMIGEIGGSAEEEAAYFVKEHMTKPVAGYIAGRTAP
CCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHCCCCCC
PGKRMGHAGAIISGGKGTAAEKVAILESCGISVAATPAEMAQALMKVYRPDSKVSHHYVN
CCCCCCCCCEEEECCCCCHHHHHHHHHHCCCEEEECHHHHHHHHHHHHCCCCCCCCEECC
APAAAAAS
CCHHHCCC
>Mature Secondary Structure 
SILVDKNTKVITQGITGATGLFHAQGAREYGTQMVGGVTPGKGGSNVDGFPVFNTVAEA
EEEEECCCEEEECCCCCCCHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHH
VEKTGANASVIYVPPPFAADSIMEAIDAGLDLVCCITEGIPVLDMVKVKQYMQGKKTRLI
HHHCCCCCEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEE
GPNCPGVITPGQCKIGIMPGYIHRPGKVGVVSRSGTLTYEAVWQLTGYGLGQSTCVGIGG
CCCCCCEECCCCEEEEECCCCEECCCCEEEEECCCCEEHEEHHHHHCCCCCCCEEEECCC
DPVNGTSHLDCLKMFEEDPDTEAVIMIGEIGGSAEEEAAYFVKEHMTKPVAGYIAGRTAP
CCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHCCCCCC
PGKRMGHAGAIISGGKGTAAEKVAILESCGISVAATPAEMAQALMKVYRPDSKVSHHYVN
CCCCCCCCCEEEECCCCCHHHHHHHHHHCCCEEEECHHHHHHHHHHHHCCCCCCCCEECC
APAAAAAS
CCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 9298659 [H]