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The map label for this gene is hbdA [H]

Identifier: 197117848

GI number: 197117848

Start: 1690871

End: 1691719

Strand: Direct

Name: hbdA [H]

Synonym: Gbem_1461

Alternate gene names: 197117848

Gene position: 1690871-1691719 (Clockwise)

Preceding gene: 197117847

Following gene: 197117849

Centisome position: 36.64

GC content: 62.54

Gene sequence:

>849_bases
ATGATCAAGAAGGTCGGAGTACTCGGCGCGGGGCAGATGGGAAGCGGTATCGCACAGGTCTTGGCCCAGCGCGAAACGGA
AGTCTACCTCTACGACATAGCGGAGGCCCAGCTTTCCAAGGCCCATGCCGGTATCGCCAAGAACCTGGAGCGCCAGGTGC
AGAAGGGGCAGCTGGACGCGGCCTCGGTGAGCCAGGTGATGGGAATGATCCGCACCACCCGCTCGCTGAACGACCTGGCC
GGCTGCGATCTCGCCATCGAGGCGGTCACCGAGAAGGAGACGCTCAAACTGGAGATCTTCAAAAAGCTCGACGAGACGCT
GAAGCCGGAGGCCATCCTCGCCTCCAACACCTCGTCCATCCCCATCACCCGCATAGCGGCGGTGACCGGGAGACCGGACC
GCGTCATCGGCATGCACTTCATGAACCCGGTGCCGGTGATGAAGCTGGTCGAGGTGATCCGCGGGCTTGCCACCAGCGAG
GAAACCTTCCAGGCGATCTCGCAGCTCGTGACGCGGCTCGACAAGGAGATGGCGGTCTCCGCCGACTACCCTGGCTTCAT
CGTGAACCGCATCCTCATCCCCATGATCAACGAGGCCGCCTTCGCCCTCTTCGAGGGGATCGCCACCGCGGAGGACATCG
ACAAGGCCATGAAACTCGGTACCAATCAGCCCATGGGTCCGCTCACCCTGGCCGACTTCATCGGCCTCGACACCTGCCTC
GCCATCATGGAGGTGCTCTACCAGGGGTTCAAGGATCCCAAGTACCGTCCCTGCCCGCTGCTGGCCAAGATGGTCGAAGC
GGGCTACCTGGGCAAAAAGAGCGGCAGAGGGTTCTACAACTACGCGTAA

Upstream 100 bases:

>100_bases
GGGAACTTCACAAACGCAAACAACGCTACGGTCTCGCCACCCTCTGCATAGGCGGCGGCGAGGCGGTCGCGGTAATCCTG
GAAAGGGTTTAGGAGGGGTC

Downstream 100 bases:

>100_bases
AAGAGGTGTGCCATGTACGAAGATCTGCTGCTGGAAAAAAAGGACGGGATCGCGCTGCTTCAGATCAACCGTCCCAAGGC
GATGAACAGCCTGAACGACG

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MIKKVGVLGAGQMGSGIAQVLAQRETEVYLYDIAEAQLSKAHAGIAKNLERQVQKGQLDAASVSQVMGMIRTTRSLNDLA
GCDLAIEAVTEKETLKLEIFKKLDETLKPEAILASNTSSIPITRIAAVTGRPDRVIGMHFMNPVPVMKLVEVIRGLATSE
ETFQAISQLVTRLDKEMAVSADYPGFIVNRILIPMINEAAFALFEGIATAEDIDKAMKLGTNQPMGPLTLADFIGLDTCL
AIMEVLYQGFKDPKYRPCPLLAKMVEAGYLGKKSGRGFYNYA

Sequences:

>Translated_282_residues
MIKKVGVLGAGQMGSGIAQVLAQRETEVYLYDIAEAQLSKAHAGIAKNLERQVQKGQLDAASVSQVMGMIRTTRSLNDLA
GCDLAIEAVTEKETLKLEIFKKLDETLKPEAILASNTSSIPITRIAAVTGRPDRVIGMHFMNPVPVMKLVEVIRGLATSE
ETFQAISQLVTRLDKEMAVSADYPGFIVNRILIPMINEAAFALFEGIATAEDIDKAMKLGTNQPMGPLTLADFIGLDTCL
AIMEVLYQGFKDPKYRPCPLLAKMVEAGYLGKKSGRGFYNYA
>Mature_282_residues
MIKKVGVLGAGQMGSGIAQVLAQRETEVYLYDIAEAQLSKAHAGIAKNLERQVQKGQLDAASVSQVMGMIRTTRSLNDLA
GCDLAIEAVTEKETLKLEIFKKLDETLKPEAILASNTSSIPITRIAAVTGRPDRVIGMHFMNPVPVMKLVEVIRGLATSE
ETFQAISQLVTRLDKEMAVSADYPGFIVNRILIPMINEAAFALFEGIATAEDIDKAMKLGTNQPMGPLTLADFIGLDTCL
AIMEVLYQGFKDPKYRPCPLLAKMVEAGYLGKKSGRGFYNYA

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=288, Percent_Identity=42.3611111111111, Blast_Score=213, Evalue=1e-55,
Organism=Homo sapiens, GI296179427, Length=306, Percent_Identity=40.5228758169935, Blast_Score=207, Evalue=9e-54,
Organism=Homo sapiens, GI68989263, Length=293, Percent_Identity=35.4948805460751, Blast_Score=156, Evalue=2e-38,
Organism=Homo sapiens, GI261878539, Length=293, Percent_Identity=35.4948805460751, Blast_Score=156, Evalue=2e-38,
Organism=Homo sapiens, GI20127408, Length=283, Percent_Identity=35.3356890459364, Blast_Score=155, Evalue=4e-38,
Organism=Homo sapiens, GI115430219, Length=219, Percent_Identity=28.7671232876712, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1787661, Length=281, Percent_Identity=40.5693950177936, Blast_Score=211, Evalue=5e-56,
Organism=Escherichia coli, GI1790281, Length=266, Percent_Identity=34.2105263157895, Blast_Score=151, Evalue=4e-38,
Organism=Escherichia coli, GI1788682, Length=255, Percent_Identity=36.8627450980392, Blast_Score=143, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17549919, Length=287, Percent_Identity=40.418118466899, Blast_Score=211, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17553560, Length=286, Percent_Identity=41.6083916083916, Blast_Score=204, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI17563036, Length=287, Percent_Identity=39.0243902439024, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI25144276, Length=284, Percent_Identity=35.9154929577465, Blast_Score=165, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17508951, Length=284, Percent_Identity=35.9154929577465, Blast_Score=165, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17508953, Length=284, Percent_Identity=35.9154929577465, Blast_Score=165, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17558304, Length=284, Percent_Identity=34.1549295774648, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI71985923, Length=284, Percent_Identity=31.6901408450704, Blast_Score=137, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI71985930, Length=282, Percent_Identity=28.3687943262411, Blast_Score=124, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI115533614, Length=204, Percent_Identity=27.9411764705882, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI193203623, Length=204, Percent_Identity=27.9411764705882, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI19921000, Length=283, Percent_Identity=36.3957597173145, Blast_Score=165, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24583077, Length=283, Percent_Identity=36.3957597173145, Blast_Score=165, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24583079, Length=283, Percent_Identity=36.3957597173145, Blast_Score=165, Evalue=3e-41,
Organism=Drosophila melanogaster, GI45549573, Length=228, Percent_Identity=29.8245614035088, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI20129993, Length=221, Percent_Identity=27.6018099547511, Blast_Score=81, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 30659; Mature: 30659

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKVGVLGAGQMGSGIAQVLAQRETEVYLYDIAEAQLSKAHAGIAKNLERQVQKGQLDA
CCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCH
ASVSQVMGMIRTTRSLNDLAGCDLAIEAVTEKETLKLEIFKKLDETLKPEAILASNTSSI
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEECCCCCC
PITRIAAVTGRPDRVIGMHFMNPVPVMKLVEVIRGLATSEETFQAISQLVTRLDKEMAVS
CHHHEEEECCCCCCEEEHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
ADYPGFIVNRILIPMINEAAFALFEGIATAEDIDKAMKLGTNQPMGPLTLADFIGLDTCL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
AIMEVLYQGFKDPKYRPCPLLAKMVEAGYLGKKSGRGFYNYA
HHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIKKVGVLGAGQMGSGIAQVLAQRETEVYLYDIAEAQLSKAHAGIAKNLERQVQKGQLDA
CCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCH
ASVSQVMGMIRTTRSLNDLAGCDLAIEAVTEKETLKLEIFKKLDETLKPEAILASNTSSI
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEECCCCCC
PITRIAAVTGRPDRVIGMHFMNPVPVMKLVEVIRGLATSEETFQAISQLVTRLDKEMAVS
CHHHEEEECCCCCCEEEHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
ADYPGFIVNRILIPMINEAAFALFEGIATAEDIDKAMKLGTNQPMGPLTLADFIGLDTCL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
AIMEVLYQGFKDPKYRPCPLLAKMVEAGYLGKKSGRGFYNYA
HHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]