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The map label for this gene is loN-2 [H]

Identifier: 197117662

GI number: 197117662

Start: 1471254

End: 1473674

Strand: Direct

Name: loN-2 [H]

Synonym: Gbem_1274

Alternate gene names: 197117662

Gene position: 1471254-1473674 (Clockwise)

Preceding gene: 197117661

Following gene: 197117663

Centisome position: 31.88

GC content: 64.68

Gene sequence:

>2421_bases
ATGACTGAGAAAGCCAGAACCAGAGGTAAAAGGAGGGGGAATCCGGAAAGATTCCCTCTCTTTCCATTAAGGGACATAGT
TATCTTCCCGCACATGGTGATTCCCCTCTTCGTAGGGAGGGAGAAGTCGGTGCTCGCCCTAGAGGCGGCCATGGCGCAAA
ACGACAAGCTGATCCTTTTGGCCACGCAGAAAAACGCCAAGACCGAGGACCCCGAGCCTGGAGACATCTACACGGTCGGG
ACCCTTTGCCAGGTGATCCAGCTCCTGAAGCTCCCCGACGGGACCGTGAAGGTGCTGGTGGAAGGGAAGCGGCGCGGCTC
CATCGCCTCCTTCTCCGACAACAGCGAATACTTCGAGGTCGAGGTCGAGGTGCTCGAGGAGCAAAGCGGCAACGACAGCG
AGAACGAGGCGCTGAAGCGCGGGGTGCTTGCCTCCTTCGAAAGCTACGTCGAGCTGAACAGCTCGGTGCCGTCCGAGATC
CTGCAGTCGGTGCAGGCGATCGCGGACCCCTCGCGCCTGGCCGATTCCATTGCCCCGCACCTGAACCTTAAGGTGGCACA
GAAGCAGGAGCTTCTGGCCGCGGTGCAGCCCGCGCGCCGCATGGAGCGACTCTTGTCGCTCATGGGGGCGGAGATCGAGA
TCCTGCAGATCGAGAAGAAGATCCATGCCCGGGTCAAGAAGCAGATGGAGAAGACCCAGAAGGATTACTACCTGAACGAG
CAGATCAGGGCGATCCAGAAGGAGCTGGGGGGGAAAGACGAGTTCAAGCAGGAGCTGCGCGCCCTGGAGGCGAAGGCGGC
CAAGCTGCCGCTGTCGCCCGAGGCCAAGCAGAAGGTGCAAAGCGAGATCAAGAAGCTTAAGTTCATGTCCCCCATGTCCG
CCGAGGCCTCGGTGGTGCGCAACTACGTGGAGTGGCTCCTGGCGCTTCCCTGGGGCGCCTACGCCGAGGAAAACCGGGAG
TTGAAGGTAGCCCGGGAGCGGCTGGACGCCGACCACTACGGCCTGGAGAAGGTGAAGCTCAGGATCCTCGAATTCCTGGC
GGTGAGCGCGCTCGCCCCGGGGATGAAGGGCCCCATCCTCTGCCTGGTGGGCCCTCCCGGGGTCGGCAAGACCTCGCTCG
CCCGCTCGGTCGCGAAGGCCACCGGCCGCGACTTCGTGAAGATCTCGCTGGGCGGGGTGCGCGACGAGGCGGAGATCAGG
GGGCACCGGCGCACCTACGTCGGGGCCATGCCCGGCCGGATCATCCAGTCGCTCAAGAAGTGCGGCTCCTCGAACCCGGT
CTTTCTTTTGGACGAGATCGACAAGATGAGCTCCGACTTCCGCGGCGATCCCGCCTCGGCACTTCTGGAGGTGCTCGACC
CGGAGCAGAACAACTGCTTCAACGACCATTTCCTCGACCTCGACTACGACCTCTCGCAGGTGATGTTCATCACCACCGCC
AACTCGAGCCACACCATACCGAGGCCGCTTCTGGACCGCATGGAGGTGGTGCGGCTGGACGGCTACACCGAGCACGAAAA
GCTTGCCATCGCGCGCGAGTACCTGGTCCCCAAACAAGCGGCGGGAAACGGGCTCGCTGGGAAGGGGATCAGCTTCACCG
ATGCCGCCGTCCTTGAGTTGGTCCGCCGCTACACCCGCGAGGCAGGCGTCAGGAACCTGGAGCGGGAGATCGGCGCCGTA
TGCCGCAAGATCGCCTTCGCCGTCGCCGGCGGCGGAAAGCTGCGTCGCACCGTGCAGCCGCGCCAGATAGCCGGCTTCCT
GGGTGCGCCGCGGTTCAAGTACGGAGAGGCGGGGCTCGAAGACGCGGTGGGGCTCGTGACCGGTCTCGCCTGGACCGAGG
TCGGGGGAGAACTCCTGAACATCGAGGTGGTGTCGCTGCCGGGCAAGGGGAAGCTGACCGTGACCGGCAAGCTGGGCGAG
GTGATGCAGGAATCGGCGCAGGCCGCCATGACCTACGTCCGTTCCCGCGGCGAGCTTCTGGGGTTTGCCAAGGACTTCTA
CCAGCATCTGGACATCCACATCCACGTCCCGGAGGGGGCCATACCGAAGGACGGTCCCTCGGCCGGGATAGCCATGGCCT
GCGCGCTCACCTCGGCGCTTACCAGGAGGCCGGTGAGACGCGATATCGCCATGACCGGCGAGGTGACCCTGCGCGGCACG
GTGCTCCCCATCGGCGGCCTCAAGGAGAAACTCCTGGCGGCAGGGCGGGGGGGTATCCGCACCGTGCTGATCCCCAAGGA
GAACGAGAAGGACCTGGCCGAGATCCCCAAGGAGATCCGCGCCGGCATCACGGTGCACCCGGTGGCCCACATGGACGAGG
TGCTGGGGTACGCGCTCCTCGCGCCGGTGGGGCTTGCTCCGGCGGCGATCTACGGTGATGCTGCCGTCGCCGCGACCGAA
AATTCGGTTGTGCCACATTAG

Upstream 100 bases:

>100_bases
TGAAGGAAGTGGTCATCAACGAAGAGGTGATCTACAGCAAGGAAAAGCCGATCATCGTCTACGAGAACGTGGCGGAAAGC
GCCTGAGCATACAGGAAAAC

Downstream 100 bases:

>100_bases
AAAAAAAGCCGCAGAAAAAAGGTTGACAGTCGAGACGGCGCTCTGGTATAAGATGTCTTCACTTTGCGATGCAAACCGGG
AGGATCAATGAATAAGGCAG

Product: ATP-dependent Lon protease

Products: NA

Alternate protein names: ATP-dependent protease La 1 [H]

Number of amino acids: Translated: 806; Mature: 805

Protein sequence:

>806_residues
MTEKARTRGKRRGNPERFPLFPLRDIVIFPHMVIPLFVGREKSVLALEAAMAQNDKLILLATQKNAKTEDPEPGDIYTVG
TLCQVIQLLKLPDGTVKVLVEGKRRGSIASFSDNSEYFEVEVEVLEEQSGNDSENEALKRGVLASFESYVELNSSVPSEI
LQSVQAIADPSRLADSIAPHLNLKVAQKQELLAAVQPARRMERLLSLMGAEIEILQIEKKIHARVKKQMEKTQKDYYLNE
QIRAIQKELGGKDEFKQELRALEAKAAKLPLSPEAKQKVQSEIKKLKFMSPMSAEASVVRNYVEWLLALPWGAYAEENRE
LKVARERLDADHYGLEKVKLRILEFLAVSALAPGMKGPILCLVGPPGVGKTSLARSVAKATGRDFVKISLGGVRDEAEIR
GHRRTYVGAMPGRIIQSLKKCGSSNPVFLLDEIDKMSSDFRGDPASALLEVLDPEQNNCFNDHFLDLDYDLSQVMFITTA
NSSHTIPRPLLDRMEVVRLDGYTEHEKLAIAREYLVPKQAAGNGLAGKGISFTDAAVLELVRRYTREAGVRNLEREIGAV
CRKIAFAVAGGGKLRRTVQPRQIAGFLGAPRFKYGEAGLEDAVGLVTGLAWTEVGGELLNIEVVSLPGKGKLTVTGKLGE
VMQESAQAAMTYVRSRGELLGFAKDFYQHLDIHIHVPEGAIPKDGPSAGIAMACALTSALTRRPVRRDIAMTGEVTLRGT
VLPIGGLKEKLLAAGRGGIRTVLIPKENEKDLAEIPKEIRAGITVHPVAHMDEVLGYALLAPVGLAPAAIYGDAAVAATE
NSVVPH

Sequences:

>Translated_806_residues
MTEKARTRGKRRGNPERFPLFPLRDIVIFPHMVIPLFVGREKSVLALEAAMAQNDKLILLATQKNAKTEDPEPGDIYTVG
TLCQVIQLLKLPDGTVKVLVEGKRRGSIASFSDNSEYFEVEVEVLEEQSGNDSENEALKRGVLASFESYVELNSSVPSEI
LQSVQAIADPSRLADSIAPHLNLKVAQKQELLAAVQPARRMERLLSLMGAEIEILQIEKKIHARVKKQMEKTQKDYYLNE
QIRAIQKELGGKDEFKQELRALEAKAAKLPLSPEAKQKVQSEIKKLKFMSPMSAEASVVRNYVEWLLALPWGAYAEENRE
LKVARERLDADHYGLEKVKLRILEFLAVSALAPGMKGPILCLVGPPGVGKTSLARSVAKATGRDFVKISLGGVRDEAEIR
GHRRTYVGAMPGRIIQSLKKCGSSNPVFLLDEIDKMSSDFRGDPASALLEVLDPEQNNCFNDHFLDLDYDLSQVMFITTA
NSSHTIPRPLLDRMEVVRLDGYTEHEKLAIAREYLVPKQAAGNGLAGKGISFTDAAVLELVRRYTREAGVRNLEREIGAV
CRKIAFAVAGGGKLRRTVQPRQIAGFLGAPRFKYGEAGLEDAVGLVTGLAWTEVGGELLNIEVVSLPGKGKLTVTGKLGE
VMQESAQAAMTYVRSRGELLGFAKDFYQHLDIHIHVPEGAIPKDGPSAGIAMACALTSALTRRPVRRDIAMTGEVTLRGT
VLPIGGLKEKLLAAGRGGIRTVLIPKENEKDLAEIPKEIRAGITVHPVAHMDEVLGYALLAPVGLAPAAIYGDAAVAATE
NSVVPH
>Mature_805_residues
TEKARTRGKRRGNPERFPLFPLRDIVIFPHMVIPLFVGREKSVLALEAAMAQNDKLILLATQKNAKTEDPEPGDIYTVGT
LCQVIQLLKLPDGTVKVLVEGKRRGSIASFSDNSEYFEVEVEVLEEQSGNDSENEALKRGVLASFESYVELNSSVPSEIL
QSVQAIADPSRLADSIAPHLNLKVAQKQELLAAVQPARRMERLLSLMGAEIEILQIEKKIHARVKKQMEKTQKDYYLNEQ
IRAIQKELGGKDEFKQELRALEAKAAKLPLSPEAKQKVQSEIKKLKFMSPMSAEASVVRNYVEWLLALPWGAYAEENREL
KVARERLDADHYGLEKVKLRILEFLAVSALAPGMKGPILCLVGPPGVGKTSLARSVAKATGRDFVKISLGGVRDEAEIRG
HRRTYVGAMPGRIIQSLKKCGSSNPVFLLDEIDKMSSDFRGDPASALLEVLDPEQNNCFNDHFLDLDYDLSQVMFITTAN
SSHTIPRPLLDRMEVVRLDGYTEHEKLAIAREYLVPKQAAGNGLAGKGISFTDAAVLELVRRYTREAGVRNLEREIGAVC
RKIAFAVAGGGKLRRTVQPRQIAGFLGAPRFKYGEAGLEDAVGLVTGLAWTEVGGELLNIEVVSLPGKGKLTVTGKLGEV
MQESAQAAMTYVRSRGELLGFAKDFYQHLDIHIHVPEGAIPKDGPSAGIAMACALTSALTRRPVRRDIAMTGEVTLRGTV
LPIGGLKEKLLAAGRGGIRTVLIPKENEKDLAEIPKEIRAGITVHPVAHMDEVLGYALLAPVGLAPAAIYGDAAVAATEN
SVVPH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=835, Percent_Identity=38.2035928143713, Blast_Score=531, Evalue=1e-151,
Organism=Homo sapiens, GI31377667, Length=836, Percent_Identity=37.5598086124402, Blast_Score=514, Evalue=1e-146,
Organism=Escherichia coli, GI1786643, Length=774, Percent_Identity=59.1731266149871, Blast_Score=919, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=728, Percent_Identity=38.3241758241758, Blast_Score=493, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI17556486, Length=536, Percent_Identity=41.6044776119403, Blast_Score=437, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6319449, Length=696, Percent_Identity=37.9310344827586, Blast_Score=474, Evalue=1e-134,
Organism=Drosophila melanogaster, GI221513036, Length=677, Percent_Identity=42.8360413589365, Blast_Score=521, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24666867, Length=677, Percent_Identity=42.8360413589365, Blast_Score=520, Evalue=1e-147,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 88100; Mature: 87969

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEKARTRGKRRGNPERFPLFPLRDIVIFPHMVIPLFVGREKSVLALEAAMAQNDKLILL
CCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEE
ATQKNAKTEDPEPGDIYTVGTLCQVIQLLKLPDGTVKVLVEGKRRGSIASFSDNSEYFEV
EECCCCCCCCCCCCCEEEHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCEEEE
EVEVLEEQSGNDSENEALKRGVLASFESYVELNSSVPSEILQSVQAIADPSRLADSIAPH
EEEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHCCC
LNLKVAQKQELLAAVQPARRMERLLSLMGAEIEILQIEKKIHARVKKQMEKTQKDYYLNE
CCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHH
QIRAIQKELGGKDEFKQELRALEAKAAKLPLSPEAKQKVQSEIKKLKFMSPMSAEASVVR
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHH
NYVEWLLALPWGAYAEENRELKVARERLDADHYGLEKVKLRILEFLAVSALAPGMKGPIL
HHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEE
CLVGPPGVGKTSLARSVAKATGRDFVKISLGGVRDEAEIRGHRRTYVGAMPGRIIQSLKK
EEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHHHCCCCCEEECCCCHHHHHHHHH
CGSSNPVFLLDEIDKMSSDFRGDPASALLEVLDPEQNNCFNDHFLDLDYDLSQVMFITTA
CCCCCCEEEEECHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEEC
NSSHTIPRPLLDRMEVVRLDGYTEHEKLAIAREYLVPKQAAGNGLAGKGISFTDAAVLEL
CCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHH
VRRYTREAGVRNLEREIGAVCRKIAFAVAGGGKLRRTVQPRQIAGFLGAPRFKYGEAGLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHCCCCCCCCCCCHH
DAVGLVTGLAWTEVGGELLNIEVVSLPGKGKLTVTGKLGEVMQESAQAAMTYVRSRGELL
HHHHHHHHHHHHHCCCEEEEEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHH
GFAKDFYQHLDIHIHVPEGAIPKDGPSAGIAMACALTSALTRRPVRRDIAMTGEVTLRGT
HHHHHHHHHCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHEECCCEEEEEE
VLPIGGLKEKLLAAGRGGIRTVLIPKENEKDLAEIPKEIRAGITVHPVAHMDEVLGYALL
EEECCCHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHCCCEECCHHHHHHHHHHHHH
APVGLAPAAIYGDAAVAATENSVVPH
HHCCCCCHHHCCCCEEEECCCCCCCC
>Mature Secondary Structure 
TEKARTRGKRRGNPERFPLFPLRDIVIFPHMVIPLFVGREKSVLALEAAMAQNDKLILL
CCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEE
ATQKNAKTEDPEPGDIYTVGTLCQVIQLLKLPDGTVKVLVEGKRRGSIASFSDNSEYFEV
EECCCCCCCCCCCCCEEEHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCEEEE
EVEVLEEQSGNDSENEALKRGVLASFESYVELNSSVPSEILQSVQAIADPSRLADSIAPH
EEEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHCCC
LNLKVAQKQELLAAVQPARRMERLLSLMGAEIEILQIEKKIHARVKKQMEKTQKDYYLNE
CCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHH
QIRAIQKELGGKDEFKQELRALEAKAAKLPLSPEAKQKVQSEIKKLKFMSPMSAEASVVR
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHH
NYVEWLLALPWGAYAEENRELKVARERLDADHYGLEKVKLRILEFLAVSALAPGMKGPIL
HHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEE
CLVGPPGVGKTSLARSVAKATGRDFVKISLGGVRDEAEIRGHRRTYVGAMPGRIIQSLKK
EEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHHHCCCCCEEECCCCHHHHHHHHH
CGSSNPVFLLDEIDKMSSDFRGDPASALLEVLDPEQNNCFNDHFLDLDYDLSQVMFITTA
CCCCCCEEEEECHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEEC
NSSHTIPRPLLDRMEVVRLDGYTEHEKLAIAREYLVPKQAAGNGLAGKGISFTDAAVLEL
CCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHH
VRRYTREAGVRNLEREIGAVCRKIAFAVAGGGKLRRTVQPRQIAGFLGAPRFKYGEAGLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHCCCCCCCCCCCHH
DAVGLVTGLAWTEVGGELLNIEVVSLPGKGKLTVTGKLGEVMQESAQAAMTYVRSRGELL
HHHHHHHHHHHHHCCCEEEEEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHH
GFAKDFYQHLDIHIHVPEGAIPKDGPSAGIAMACALTSALTRRPVRRDIAMTGEVTLRGT
HHHHHHHHHCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHEECCCEEEEEE
VLPIGGLKEKLLAAGRGGIRTVLIPKENEKDLAEIPKEIRAGITVHPVAHMDEVLGYALL
EEECCCHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHCCCEECCHHHHHHHHHHHHH
APVGLAPAAIYGDAAVAATENSVVPH
HHCCCCCHHHCCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8468287 [H]