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The map label for this gene is xseA

Identifier: 197117643

GI number: 197117643

Start: 1451681

End: 1453057

Strand: Direct

Name: xseA

Synonym: Gbem_1255

Alternate gene names: 197117643

Gene position: 1451681-1453057 (Clockwise)

Preceding gene: 197117641

Following gene: 197117644

Centisome position: 31.45

GC content: 66.74

Gene sequence:

>1377_bases
GTGCAACTTTTCAAGGAGCGGCGGGTCCTCACCGTGAGCGCGCTCACGGCGCTGGTGCGCGGACTTTTGGAGGAGAATTT
CGAGCAGGTCTGGGTCGAGGGGGAGATCTCCAATCTCGCCTGCCCCCAGTCGGGGCACTGCTACTTCACCTTGAAGGACG
TCGGCGCCCAGATCCGCTGCGTCATGTTCCGCGGCGCCTTCCGCTCCCTCAAATTCACCCCCCGCGACGGCATGCGCATC
CTCACCCGCGGCAGGCTCACCCTCTTCGAGCCGCGCGGCGAATACCAGCTGGTGGCCGACTACCTGGAGCCGCAGGGGAT
CGGCGGGCTGCAGATGGCCTTCATCCAGCTCAAGGAGAAGCTCGCCAAGGAGGGGCTTTTCTCGGAGCTGCACAAAAGGG
AGATACCGAAGCTGCCGCGCCGCATCGGTGTGGTTACCTCGCCCACCGGCGCCGCCATCAGGGACATCCTCACCGTTTTA
AACCGCCGCTTCACCAACGTGGAGCTGCTGATCTCGCCGGTCCGGGTGCAGGGGGATGGGGCGGCGCGTGAGATTGCCGA
CGCCATCGACGACCTGAACCGGGTGGGGAATCTCGACGTCATGATCGTCGGCCGTGGCGGTGGCTCTCTTGAAGACCTCT
GGGCCTTCAACGAGGAGGTGGTGGCCCGCGCCATCCACCGCTCGAAGGTTCCGGTGATCTCGGCGGTGGGGCACGAGATC
GACTTCACCATCGCGGATTTTGTCGCAGACTTACGGGCGGCGACGCCGTCGGCCGCGGCGGAGATCGTCGTCGCCAGCAA
GAAGGAGCTGACCGCGGAGGTGGAGGCGCTCACCCACAGGCTCCATGTCTCGCAGCAGCGCCGCCTGGAGCGCTCGCGCG
CCCTGGTCACCGCCTTGAGCCGCGCCATCACCGACCCGAGCCGGTTCCTAGGGCACCTGGCGCAGCGGGTCGACTCGCTC
GACGCCCGGCTCACGCGCGAGGCGGGGCTCATCCTGGACGACGCTTCCGAGAGGATAGTGACTCTCACCGCGCGGCTGTC
GCGGCAAACCCCGGCGCTCACGCTAAAGCGTTGGGAGGAGCGACTTGCCACGCTTTCGCTGCGCCTGGACCACGCCATGA
CCCGGCGCCTCGCCGTGGCCGCGGAAAGCATAGGGCTTGCCACCGGCACGCTGAACGCCGTTTCCCCCCTGGCCACCCTT
TCCCGTGGCTACAGCATCACCAGGAAACTCCCCGCCCGTTCGGTGGTCACCAGCAGCCGCCAGTTGGCCCCCGGCGACCG
CGTAGAAGTGAGCTTCGCCGCGGGTTCGGCGCTTTGTACCGTGGAGCAGGCGCACAAGGATAGTGATTCCTTGACGGCAC
CCCCACGATCAGTATAA

Upstream 100 bases:

>100_bases
GGGGGACCAAGCAAGCCCCGGAATTCCCCGATGAACTTTCGGCAAAGGGGGAGGTTCACATCACAGCTTGATCAGATTTC
CCGCAGTCCCGGAGGTTTCA

Downstream 100 bases:

>100_bases
TAGGCGATCTCTTTTTAATAATTCCCGGCGCCTGCGGCGTTAATCTTCGCTAAAGGCACGGCTAGAGGGACGAGAGGGTT
ATTCATGGCAGTGGAGAAGT

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MQLFKERRVLTVSALTALVRGLLEENFEQVWVEGEISNLACPQSGHCYFTLKDVGAQIRCVMFRGAFRSLKFTPRDGMRI
LTRGRLTLFEPRGEYQLVADYLEPQGIGGLQMAFIQLKEKLAKEGLFSELHKREIPKLPRRIGVVTSPTGAAIRDILTVL
NRRFTNVELLISPVRVQGDGAAREIADAIDDLNRVGNLDVMIVGRGGGSLEDLWAFNEEVVARAIHRSKVPVISAVGHEI
DFTIADFVADLRAATPSAAAEIVVASKKELTAEVEALTHRLHVSQQRRLERSRALVTALSRAITDPSRFLGHLAQRVDSL
DARLTREAGLILDDASERIVTLTARLSRQTPALTLKRWEERLATLSLRLDHAMTRRLAVAAESIGLATGTLNAVSPLATL
SRGYSITRKLPARSVVTSSRQLAPGDRVEVSFAAGSALCTVEQAHKDSDSLTAPPRSV

Sequences:

>Translated_458_residues
MQLFKERRVLTVSALTALVRGLLEENFEQVWVEGEISNLACPQSGHCYFTLKDVGAQIRCVMFRGAFRSLKFTPRDGMRI
LTRGRLTLFEPRGEYQLVADYLEPQGIGGLQMAFIQLKEKLAKEGLFSELHKREIPKLPRRIGVVTSPTGAAIRDILTVL
NRRFTNVELLISPVRVQGDGAAREIADAIDDLNRVGNLDVMIVGRGGGSLEDLWAFNEEVVARAIHRSKVPVISAVGHEI
DFTIADFVADLRAATPSAAAEIVVASKKELTAEVEALTHRLHVSQQRRLERSRALVTALSRAITDPSRFLGHLAQRVDSL
DARLTREAGLILDDASERIVTLTARLSRQTPALTLKRWEERLATLSLRLDHAMTRRLAVAAESIGLATGTLNAVSPLATL
SRGYSITRKLPARSVVTSSRQLAPGDRVEVSFAAGSALCTVEQAHKDSDSLTAPPRSV
>Mature_458_residues
MQLFKERRVLTVSALTALVRGLLEENFEQVWVEGEISNLACPQSGHCYFTLKDVGAQIRCVMFRGAFRSLKFTPRDGMRI
LTRGRLTLFEPRGEYQLVADYLEPQGIGGLQMAFIQLKEKLAKEGLFSELHKREIPKLPRRIGVVTSPTGAAIRDILTVL
NRRFTNVELLISPVRVQGDGAAREIADAIDDLNRVGNLDVMIVGRGGGSLEDLWAFNEEVVARAIHRSKVPVISAVGHEI
DFTIADFVADLRAATPSAAAEIVVASKKELTAEVEALTHRLHVSQQRRLERSRALVTALSRAITDPSRFLGHLAQRVDSL
DARLTREAGLILDDASERIVTLTARLSRQTPALTLKRWEERLATLSLRLDHAMTRRLAVAAESIGLATGTLNAVSPLATL
SRGYSITRKLPARSVVTSSRQLAPGDRVEVSFAAGSALCTVEQAHKDSDSLTAPPRSV

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=404, Percent_Identity=46.039603960396, Blast_Score=334, Evalue=6e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_GEOBB (B5EI10)

Other databases:

- EMBL:   CP001124
- RefSeq:   YP_002138070.1
- GeneID:   6781239
- GenomeReviews:   CP001124_GR
- KEGG:   gbm:Gbem_1255
- HOGENOM:   HBG634411
- OMA:   RLLIANM
- ProtClustDB:   PRK00286
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 50287; Mature: 50287

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLFKERRVLTVSALTALVRGLLEENFEQVWVEGEISNLACPQSGHCYFTLKDVGAQIRC
CCCHHHCCHHHHHHHHHHHHHHHHCCHHHEEEECCCCCCCCCCCCCEEEEEECCCCEEEE
VMFRGAFRSLKFTPRDGMRILTRGRLTLFEPRGEYQLVADYLEPQGIGGLQMAFIQLKEK
EEEHHHHHCCCCCCCCCCEEEECCCEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHHH
LAKEGLFSELHKREIPKLPRRIGVVTSPTGAAIRDILTVLNRRFTNVELLISPVRVQGDG
HHHHHHHHHHHHHHCCCHHHHCCCEECCCHHHHHHHHHHHHCCCCCEEEEEEEEEECCCC
AAREIADAIDDLNRVGNLDVMIVGRGGGSLEDLWAFNEEVVARAIHRSKVPVISAVGHEI
HHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHCCHHHHHHHHHHCCCCEEECCCCCC
DFTIADFVADLRAATPSAAAEIVVASKKELTAEVEALTHRLHVSQQRRLERSRALVTALS
CHHHHHHHHHHHHCCCCHHHHEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAITDPSRFLGHLAQRVDSLDARLTREAGLILDDASERIVTLTARLSRQTPALTLKRWEE
HHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEHHHHHCCCCCHHHHHHHHH
RLATLSLRLDHAMTRRLAVAAESIGLATGTLNAVSPLATLSRGYSITRKLPARSVVTSSR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHCCCCHHHHHCCC
QLAPGDRVEVSFAAGSALCTVEQAHKDSDSLTAPPRSV
CCCCCCCEEEEEECCCEEEEHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MQLFKERRVLTVSALTALVRGLLEENFEQVWVEGEISNLACPQSGHCYFTLKDVGAQIRC
CCCHHHCCHHHHHHHHHHHHHHHHCCHHHEEEECCCCCCCCCCCCCEEEEEECCCCEEEE
VMFRGAFRSLKFTPRDGMRILTRGRLTLFEPRGEYQLVADYLEPQGIGGLQMAFIQLKEK
EEEHHHHHCCCCCCCCCCEEEECCCEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHHH
LAKEGLFSELHKREIPKLPRRIGVVTSPTGAAIRDILTVLNRRFTNVELLISPVRVQGDG
HHHHHHHHHHHHHHCCCHHHHCCCEECCCHHHHHHHHHHHHCCCCCEEEEEEEEEECCCC
AAREIADAIDDLNRVGNLDVMIVGRGGGSLEDLWAFNEEVVARAIHRSKVPVISAVGHEI
HHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHCCHHHHHHHHHHCCCCEEECCCCCC
DFTIADFVADLRAATPSAAAEIVVASKKELTAEVEALTHRLHVSQQRRLERSRALVTALS
CHHHHHHHHHHHHCCCCHHHHEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAITDPSRFLGHLAQRVDSLDARLTREAGLILDDASERIVTLTARLSRQTPALTLKRWEE
HHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEHHHHHCCCCCHHHHHHHHH
RLATLSLRLDHAMTRRLAVAAESIGLATGTLNAVSPLATLSRGYSITRKLPARSVVTSSR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHCCCCHHHHHCCC
QLAPGDRVEVSFAAGSALCTVEQAHKDSDSLTAPPRSV
CCCCCCCEEEEEECCCEEEEHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA