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The map label for this gene is adk

Identifier: 197117344

GI number: 197117344

Start: 1108060

End: 1108704

Strand: Direct

Name: adk

Synonym: Gbem_0954

Alternate gene names: 197117344

Gene position: 1108060-1108704 (Clockwise)

Preceding gene: 197117343

Following gene: 308535202

Centisome position: 24.01

GC content: 62.33

Gene sequence:

>645_bases
ATGAATCTCATCCTCCTCGGACCCCCGGGCGTCGGCAAGGGGACCCAGGCAAAACTTCTCATAGATAGATTTGGTATCCC
GCAGATATCGACAGGTGATATACTGCGGGCTGCCGTTAAAGAGCTGACTCCCATGGGAGCCAAGGCCAAGGGATATATGG
ACTCCGGCGCGCTGGTTCCGGACGAAGTCGTGATCGGCATCGTCGAGGAGCGGCTGGCGCAGGCGGACTGCCAGAAGGGA
TTCATCCTGGACGGTTTCCCCCGCACGGTACCCCAGGCGGACGCATTGGGTCAGGTCCTCTCCGGCATGGGGAAGTCGAT
CGATCATGTGGTCTCGCTTTCGGTGGACAAGGGAGAGCTTCTGAAGCGGCTTACCGGGCGTCGCGCCTGTGCCAATTGCG
GCGCCGGCTACCACGTCGACTTCGCCCCCTCCAAAGTGGCAGGCGTCTGCGATGCCTGCTCCGGCCAACTGGTCCAGCGT
GAGGACGACAAGGAAGAAACCATCCTGAACCGCCTGGCGGTTTACGAAGCGCAGACCGCGCCTTTGATCGCCTACTATCA
GGCGGCAGGGTTGCTCCGCTCCGTCGATGGCCTCGGGACCGTAGAAGGGGTCCAGTCGGGCATCCTCGCGGCGATACGGG
CCTAG

Upstream 100 bases:

>100_bases
CATGGACACTCTGTCGCAGATAGAGGCGCACCTGATTACCCGAAGCTACGAAGGGTTCATGAAGGGCGTGCGCATCCAGG
GCAGAAGGTAAGGGGTTATC

Downstream 100 bases:

>100_bases
CGGTGATCGTACTAAAGTCCCCGGCTGAGATCGAGAAGATGGCGGCTGCCGGAAGGATCGTAGCGGAGATCCTGGCCGGG
CTCAGGGAAAAAGTGGTGCC

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MNLILLGPPGVGKGTQAKLLIDRFGIPQISTGDILRAAVKELTPMGAKAKGYMDSGALVPDEVVIGIVEERLAQADCQKG
FILDGFPRTVPQADALGQVLSGMGKSIDHVVSLSVDKGELLKRLTGRRACANCGAGYHVDFAPSKVAGVCDACSGQLVQR
EDDKEETILNRLAVYEAQTAPLIAYYQAAGLLRSVDGLGTVEGVQSGILAAIRA

Sequences:

>Translated_214_residues
MNLILLGPPGVGKGTQAKLLIDRFGIPQISTGDILRAAVKELTPMGAKAKGYMDSGALVPDEVVIGIVEERLAQADCQKG
FILDGFPRTVPQADALGQVLSGMGKSIDHVVSLSVDKGELLKRLTGRRACANCGAGYHVDFAPSKVAGVCDACSGQLVQR
EDDKEETILNRLAVYEAQTAPLIAYYQAAGLLRSVDGLGTVEGVQSGILAAIRA
>Mature_214_residues
MNLILLGPPGVGKGTQAKLLIDRFGIPQISTGDILRAAVKELTPMGAKAKGYMDSGALVPDEVVIGIVEERLAQADCQKG
FILDGFPRTVPQADALGQVLSGMGKSIDHVVSLSVDKGELLKRLTGRRACANCGAGYHVDFAPSKVAGVCDACSGQLVQR
EDDKEETILNRLAVYEAQTAPLIAYYQAAGLLRSVDGLGTVEGVQSGILAAIRA

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=209, Percent_Identity=41.1483253588517, Blast_Score=170, Evalue=9e-43,
Organism=Homo sapiens, GI4502013, Length=209, Percent_Identity=41.1483253588517, Blast_Score=170, Evalue=1e-42,
Organism=Homo sapiens, GI19923437, Length=197, Percent_Identity=38.5786802030457, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI310110345, Length=197, Percent_Identity=37.0558375634518, Blast_Score=130, Evalue=9e-31,
Organism=Homo sapiens, GI53832003, Length=197, Percent_Identity=37.0558375634518, Blast_Score=130, Evalue=9e-31,
Organism=Homo sapiens, GI8051579, Length=197, Percent_Identity=37.0558375634518, Blast_Score=130, Evalue=9e-31,
Organism=Homo sapiens, GI53832001, Length=197, Percent_Identity=37.0558375634518, Blast_Score=130, Evalue=9e-31,
Organism=Homo sapiens, GI4502011, Length=213, Percent_Identity=30.9859154929577, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI22749187, Length=212, Percent_Identity=29.7169811320755, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI28144897, Length=217, Percent_Identity=27.1889400921659, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI28144899, Length=217, Percent_Identity=27.1889400921659, Blast_Score=86, Evalue=2e-17,
Organism=Escherichia coli, GI1786680, Length=186, Percent_Identity=52.1505376344086, Blast_Score=200, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI17552384, Length=205, Percent_Identity=40, Blast_Score=161, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17567503, Length=212, Percent_Identity=32.0754716981132, Blast_Score=106, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17533833, Length=194, Percent_Identity=28.3505154639175, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17537943, Length=188, Percent_Identity=27.1276595744681, Blast_Score=80, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17550688, Length=213, Percent_Identity=25.3521126760563, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320432, Length=213, Percent_Identity=39.4366197183099, Blast_Score=165, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6321018, Length=209, Percent_Identity=36.3636363636364, Blast_Score=125, Evalue=5e-30,
Organism=Drosophila melanogaster, GI22026816, Length=208, Percent_Identity=41.8269230769231, Blast_Score=171, Evalue=2e-43,
Organism=Drosophila melanogaster, GI17737899, Length=199, Percent_Identity=37.6884422110553, Blast_Score=134, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24645822, Length=199, Percent_Identity=37.6884422110553, Blast_Score=134, Evalue=4e-32,
Organism=Drosophila melanogaster, GI221459597, Length=205, Percent_Identity=28.2926829268293, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21356893, Length=205, Percent_Identity=28.2926829268293, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24663208, Length=201, Percent_Identity=25.8706467661692, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17647141, Length=201, Percent_Identity=25.8706467661692, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_GEOBB (B5EFS1)

Other databases:

- EMBL:   CP001124
- RefSeq:   YP_002137771.1
- ProteinModelPortal:   B5EFS1
- SMR:   B5EFS1
- GeneID:   6783796
- GenomeReviews:   CP001124_GR
- KEGG:   gbm:Gbem_0954
- HOGENOM:   HBG630208
- OMA:   CGEGYHD
- ProtClustDB:   PRK00279
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 22404; Mature: 22404

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLILLGPPGVGKGTQAKLLIDRFGIPQISTGDILRAAVKELTPMGAKAKGYMDSGALVP
CCEEEECCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCH
DEVVIGIVEERLAQADCQKGFILDGFPRTVPQADALGQVLSGMGKSIDHVVSLSVDKGEL
HHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHHHHHCCCHHHHEEECCCHHHH
LKRLTGRRACANCGAGYHVDFAPSKVAGVCDACSGQLVQREDDKEETILNRLAVYEAQTA
HHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHCCCC
PLIAYYQAAGLLRSVDGLGTVEGVQSGILAAIRA
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNLILLGPPGVGKGTQAKLLIDRFGIPQISTGDILRAAVKELTPMGAKAKGYMDSGALVP
CCEEEECCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCH
DEVVIGIVEERLAQADCQKGFILDGFPRTVPQADALGQVLSGMGKSIDHVVSLSVDKGEL
HHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHHHHHCCCHHHHEEECCCHHHH
LKRLTGRRACANCGAGYHVDFAPSKVAGVCDACSGQLVQREDDKEETILNRLAVYEAQTA
HHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHCCCC
PLIAYYQAAGLLRSVDGLGTVEGVQSGILAAIRA
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA