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The map label for this gene is atoC [H]

Identifier: 197116683

GI number: 197116683

Start: 341194

End: 342564

Strand: Direct

Name: atoC [H]

Synonym: Gbem_0283

Alternate gene names: 197116683

Gene position: 341194-342564 (Clockwise)

Preceding gene: 197116682

Following gene: 197116684

Centisome position: 7.39

GC content: 59.59

Gene sequence:

>1371_bases
ATGCGCAAGATAAAGATTATGGTCGTCGATGACGAGCACCTGATCCGCTGGTCTTTGGAGCAAAACCTGAAGAAGCAGGG
ATACGAAGTGGTCACCGCGGGGACCGGCGAAGACGCGCTCCGTCTGGCCCGCGAGGAGCAGCCCGACCTAGTGCTTCTGG
ATTACCATCTTCCCGGGATCAACGGTCTGGAGGTCCTGCAGCGGATCAAGGAGCTCGACGAGGACATCCTGGTCATCATG
GTGACGGCGCAGGGGGGGCTGGAGACGGCCGTCAACACCATGCGCCACGGCGCCTATGATTACATCAACAAGCCGTTCAA
CCTGGACGAGATGGCGCTGGTGATCCGCAAGGCGCTGGAGACCTCGGAGCTGCGCCGCGAGGTGGTGCAGTTAAGGAGCG
AGCACAAGAAGCAGGGACCGCCCACAATCCTGGGTAATTCCAAGCACATGAAAAACGTGCTGGAGATGATGGCCAAGGTC
GCCAAGAGCGACGCCTCCACCGTGCTGGTGCAGGGGGAATCGGGAACCGGGAAGGAGTTGGTGGCGAAGTACATCCACTA
CGAGTCAGCCCGGGCCGAAAAGCCGTTCGTGGCCATCAACTGTGCGGCCGTACCTGCCACCCTTCTGGAGAGCGAGCTTT
TCGGCCACGAGAAGGGGGCCTTTACCGATGCGAAGAACTCCAAGAAGGGTCTTTTCGAGCTGGCCGACGGCGGGACCGTG
TTCCTTGATGAGATCGGGGACATGGAAATCGGGATGCAGGCGAAGCTGCTCCGCTTCCTGGAGGACCGGACCTTCCGGCG
CATCGGCGGCTCGAAGATGATCCCGGTCGACGTCAGGATCGTCTCAGCGACCAACAAGGACCTCCTGAAGGCGATCGAGG
ACAAGAGCTTCAGGAACGACCTCTACTACCGGCTCCAGGTGATTCCGATCTTCCTCCCCTCGCTGCGCGAGCGCAAGGAG
GACATCCTGGTGTTGGCCAACTACTTCATCGAGGTCTTCTCCAAGGAGTTCGGCAAGCCGACCAAAGGGATCTCCAGCAT
GGCGGAGAAGCTCCTGGTGGAATACAACTGGCCCGGCAACATCCGCGAGTTGAAGAACGTCATCGAGCGCGCCATCATCC
TGGGTAACGACGAGAACCTCCTTTTGGAGAACCTGCCGCTGGAGATCGTCGCCAAGGCGAGTCAAGTCACCGTGCCGCTC
ACCACCTTCAAGCTCCCCCCCGAGGGGATCGACATCGAAGAGGTGGAGCGCGAGTTGATCAAGCAGTCGCTGGAGATGAC
CGACTATAACCAGTCCAAAGCCGCCAAGAAGCTGAACCTGGGCATCGACGCCTTCCGTTACCGGATGAAGAAATTCGGGT
TCCTTAAGTAG

Upstream 100 bases:

>100_bases
CCCCCCCCGACGGTGTGCCAGTAAAGAGCGCCAGCAGAAACGACAACAACCGGTCCGCCACCGGATCAGTTGCAGCGGGA
AATAACCTTAAGGAGCCGGA

Downstream 100 bases:

>100_bases
TTAGCCGATAAACTTCGATCTATCGCTGCTCTGCTACCGTTGAGCTTCGGCGGAAAGTCCCCCTTTACACGTCCCCGCCC
CCGGAGGGGGAGGGTCAGGG

Product: sigma-54-dependent transcriptional response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MRKIKIMVVDDEHLIRWSLEQNLKKQGYEVVTAGTGEDALRLAREEQPDLVLLDYHLPGINGLEVLQRIKELDEDILVIM
VTAQGGLETAVNTMRHGAYDYINKPFNLDEMALVIRKALETSELRREVVQLRSEHKKQGPPTILGNSKHMKNVLEMMAKV
AKSDASTVLVQGESGTGKELVAKYIHYESARAEKPFVAINCAAVPATLLESELFGHEKGAFTDAKNSKKGLFELADGGTV
FLDEIGDMEIGMQAKLLRFLEDRTFRRIGGSKMIPVDVRIVSATNKDLLKAIEDKSFRNDLYYRLQVIPIFLPSLRERKE
DILVLANYFIEVFSKEFGKPTKGISSMAEKLLVEYNWPGNIRELKNVIERAIILGNDENLLLENLPLEIVAKASQVTVPL
TTFKLPPEGIDIEEVERELIKQSLEMTDYNQSKAAKKLNLGIDAFRYRMKKFGFLK

Sequences:

>Translated_456_residues
MRKIKIMVVDDEHLIRWSLEQNLKKQGYEVVTAGTGEDALRLAREEQPDLVLLDYHLPGINGLEVLQRIKELDEDILVIM
VTAQGGLETAVNTMRHGAYDYINKPFNLDEMALVIRKALETSELRREVVQLRSEHKKQGPPTILGNSKHMKNVLEMMAKV
AKSDASTVLVQGESGTGKELVAKYIHYESARAEKPFVAINCAAVPATLLESELFGHEKGAFTDAKNSKKGLFELADGGTV
FLDEIGDMEIGMQAKLLRFLEDRTFRRIGGSKMIPVDVRIVSATNKDLLKAIEDKSFRNDLYYRLQVIPIFLPSLRERKE
DILVLANYFIEVFSKEFGKPTKGISSMAEKLLVEYNWPGNIRELKNVIERAIILGNDENLLLENLPLEIVAKASQVTVPL
TTFKLPPEGIDIEEVERELIKQSLEMTDYNQSKAAKKLNLGIDAFRYRMKKFGFLK
>Mature_456_residues
MRKIKIMVVDDEHLIRWSLEQNLKKQGYEVVTAGTGEDALRLAREEQPDLVLLDYHLPGINGLEVLQRIKELDEDILVIM
VTAQGGLETAVNTMRHGAYDYINKPFNLDEMALVIRKALETSELRREVVQLRSEHKKQGPPTILGNSKHMKNVLEMMAKV
AKSDASTVLVQGESGTGKELVAKYIHYESARAEKPFVAINCAAVPATLLESELFGHEKGAFTDAKNSKKGLFELADGGTV
FLDEIGDMEIGMQAKLLRFLEDRTFRRIGGSKMIPVDVRIVSATNKDLLKAIEDKSFRNDLYYRLQVIPIFLPSLRERKE
DILVLANYFIEVFSKEFGKPTKGISSMAEKLLVEYNWPGNIRELKNVIERAIILGNDENLLLENLPLEIVAKASQVTVPL
TTFKLPPEGIDIEEVERELIKQSLEMTDYNQSKAAKKLNLGIDAFRYRMKKFGFLK

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=457, Percent_Identity=44.4201312910284, Blast_Score=385, Evalue=1e-108,
Organism=Escherichia coli, GI1790437, Length=441, Percent_Identity=43.5374149659864, Blast_Score=343, Evalue=2e-95,
Organism=Escherichia coli, GI1790299, Length=475, Percent_Identity=38.3157894736842, Blast_Score=333, Evalue=1e-92,
Organism=Escherichia coli, GI1788905, Length=374, Percent_Identity=41.9786096256684, Blast_Score=286, Evalue=3e-78,
Organism=Escherichia coli, GI87082117, Length=319, Percent_Identity=45.7680250783699, Blast_Score=281, Evalue=5e-77,
Organism=Escherichia coli, GI1789087, Length=317, Percent_Identity=46.3722397476341, Blast_Score=255, Evalue=3e-69,
Organism=Escherichia coli, GI1789233, Length=321, Percent_Identity=44.2367601246106, Blast_Score=248, Evalue=4e-67,
Organism=Escherichia coli, GI87081872, Length=318, Percent_Identity=42.1383647798742, Blast_Score=234, Evalue=6e-63,
Organism=Escherichia coli, GI87082152, Length=322, Percent_Identity=39.4409937888199, Blast_Score=230, Evalue=2e-61,
Organism=Escherichia coli, GI1786524, Length=322, Percent_Identity=39.1304347826087, Blast_Score=219, Evalue=2e-58,
Organism=Escherichia coli, GI1787583, Length=230, Percent_Identity=46.9565217391304, Blast_Score=213, Evalue=1e-56,
Organism=Escherichia coli, GI87081858, Length=286, Percent_Identity=31.4685314685315, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1789828, Length=255, Percent_Identity=32.5490196078431, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI1789809, Length=178, Percent_Identity=33.1460674157303, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1786599, Length=117, Percent_Identity=36.7521367521368, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082012, Length=116, Percent_Identity=31.0344827586207, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1788222, Length=115, Percent_Identity=33.9130434782609, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1788394, Length=130, Percent_Identity=31.5384615384615, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1786784, Length=116, Percent_Identity=30.1724137931034, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1787375, Length=108, Percent_Identity=28.7037037037037, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI145693157, Length=114, Percent_Identity=35.0877192982456, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51579; Mature: 51579

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKIKIMVVDDEHLIRWSLEQNLKKQGYEVVTAGTGEDALRLAREEQPDLVLLDYHLPGI
CCEEEEEEECCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCCEEEEEECCCCC
NGLEVLQRIKELDEDILVIMVTAQGGLETAVNTMRHGAYDYINKPFNLDEMALVIRKALE
CHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHH
TSELRREVVQLRSEHKKQGPPTILGNSKHMKNVLEMMAKVAKSDASTVLVQGESGTGKEL
HHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHH
VAKYIHYESARAEKPFVAINCAAVPATLLESELFGHEKGAFTDAKNSKKGLFELADGGTV
HHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCEE
FLDEIGDMEIGMQAKLLRFLEDRTFRRIGGSKMIPVDVRIVSATNKDLLKAIEDKSFRND
EEECCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCHHHHHHHHCCHHHCC
LYYRLQVIPIFLPSLRERKEDILVLANYFIEVFSKEFGKPTKGISSMAEKLLVEYNWPGN
CEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEEECCCCC
IRELKNVIERAIILGNDENLLLENLPLEIVAKASQVTVPLTTFKLPPEGIDIEEVERELI
HHHHHHHHHHHHEECCCCCEEEECCCHHHEECCCEEEEEEEEEECCCCCCCHHHHHHHHH
KQSLEMTDYNQSKAAKKLNLGIDAFRYRMKKFGFLK
HHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRKIKIMVVDDEHLIRWSLEQNLKKQGYEVVTAGTGEDALRLAREEQPDLVLLDYHLPGI
CCEEEEEEECCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCCEEEEEECCCCC
NGLEVLQRIKELDEDILVIMVTAQGGLETAVNTMRHGAYDYINKPFNLDEMALVIRKALE
CHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHH
TSELRREVVQLRSEHKKQGPPTILGNSKHMKNVLEMMAKVAKSDASTVLVQGESGTGKEL
HHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHH
VAKYIHYESARAEKPFVAINCAAVPATLLESELFGHEKGAFTDAKNSKKGLFELADGGTV
HHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCEE
FLDEIGDMEIGMQAKLLRFLEDRTFRRIGGSKMIPVDVRIVSATNKDLLKAIEDKSFRND
EEECCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCHHHHHHHHCCHHHCC
LYYRLQVIPIFLPSLRERKEDILVLANYFIEVFSKEFGKPTKGISSMAEKLLVEYNWPGN
CEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEEECCCCC
IRELKNVIERAIILGNDENLLLENLPLEIVAKASQVTVPLTTFKLPPEGIDIEEVERELI
HHHHHHHHHHHHEECCCCCEEEECCCHHHEECCCEEEEEEEEEECCCCCCCHHHHHHHHH
KQSLEMTDYNQSKAAKKLNLGIDAFRYRMKKFGFLK
HHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]