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The map label for this gene is dxs [C]

Identifier: 197116680

GI number: 197116680

Start: 337978

End: 338910

Strand: Direct

Name: dxs [C]

Synonym: Gbem_0280

Alternate gene names: 197116680

Gene position: 337978-338910 (Clockwise)

Preceding gene: 197116679

Following gene: 197116681

Centisome position: 7.32

GC content: 63.99

Gene sequence:

>933_bases
ATGATCGCAACGAGGGACGCCTACGGCGAGGCGCTGGCCGAGCTGGGAGGCGAGAACGATAAGATAGTGGCGCTGGACGC
GGACCTCTCCGGGTCCACCAAGACCGGCGTCTTCGCCAAGAAATTCCCCAACCGCTTCTTCAACATGGGAATCGCCGAGG
CCAACATGGTGGGAACCGCCGCAGGCTTAGCCTCGGTAGGGAAGATCCCTTTCCTCTCCACCTTCGCCATCTTCGCCGCC
GGCCGCGCCTGGGAGCAGATCCGCCAGTCGCTCGCCTACCCGAAGGCCAACGTTAAGGTCGTCGCCACCCACGGCGGCGT
CACCGTGGGCGAGGACGGGGGGAGCCACCAGTCGGTCGAGGATATCGCCATCATGCGCGCCATCCCCAACATGACCGTTA
TCGTCCCCGCCGACGGCGAGGAGACCAAGGGGGCCATCCGCGCCGCCGCGGCCTACAAGGGGCCGGTCTACGTGCGCCTT
GGGCGCAACAAGGTCGCCAACGTCTTCCCGGCAGGTCACAAGTTCGAGATCGGCAAGGGGAACGTCGTTGCCGAAGGGAA
GGACTTAACCTTCATCACCACCGGCCTCATGACCGCCCAGGCGGTAATCGCCGCGGAGAAGCTGAAGGAAGAAGGGATCT
CGGCGCGGGTGCTGCACCTGGGGACCATCAAGCCTCTCGACAAGGAGCTGGTGCTTAAAGCAGCACAGGAAACCGGAGCC
ATCGTCACCGCCGAAGAGCATTCCGTCGTTGGCGGGCTCGGCGGCGCCGTAGCCGAGTTCCTGGGCGAGGAATGCCCGAC
CCTGATGAAGCGGGTCGGCATCTACGACCGGTTCGGGCTTTCCGGCAAATCCGACGAACTCCTCAAGTATTTCGGGCTGA
ACGCCGAGACGCTGATCGAGCAGGCGAGGGAGATCGTTTCGAGGAAGAAATGA

Upstream 100 bases:

>100_bases
TCGGCATGCTGCCGGGACAGGAAACAGCCCCCTCCCTGACCCTCCCCTTCCGGGGGCGGGGACGTTGGGCGGCAGACCAC
ATACCAGAAAGGGAATCGAT

Downstream 100 bases:

>100_bases
TGCGCAGGGTGCTTGCGTCCAGCGGCGGCTTCACCTACATGACGGTTCTCGTCATCGTGGTCGTGGTCGGCATCGCGGCG
TCGCGTGGCGCCATCGTCTG

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MIATRDAYGEALAELGGENDKIVALDADLSGSTKTGVFAKKFPNRFFNMGIAEANMVGTAAGLASVGKIPFLSTFAIFAA
GRAWEQIRQSLAYPKANVKVVATHGGVTVGEDGGSHQSVEDIAIMRAIPNMTVIVPADGEETKGAIRAAAAYKGPVYVRL
GRNKVANVFPAGHKFEIGKGNVVAEGKDLTFITTGLMTAQAVIAAEKLKEEGISARVLHLGTIKPLDKELVLKAAQETGA
IVTAEEHSVVGGLGGAVAEFLGEECPTLMKRVGIYDRFGLSGKSDELLKYFGLNAETLIEQAREIVSRKK

Sequences:

>Translated_310_residues
MIATRDAYGEALAELGGENDKIVALDADLSGSTKTGVFAKKFPNRFFNMGIAEANMVGTAAGLASVGKIPFLSTFAIFAA
GRAWEQIRQSLAYPKANVKVVATHGGVTVGEDGGSHQSVEDIAIMRAIPNMTVIVPADGEETKGAIRAAAAYKGPVYVRL
GRNKVANVFPAGHKFEIGKGNVVAEGKDLTFITTGLMTAQAVIAAEKLKEEGISARVLHLGTIKPLDKELVLKAAQETGA
IVTAEEHSVVGGLGGAVAEFLGEECPTLMKRVGIYDRFGLSGKSDELLKYFGLNAETLIEQAREIVSRKK
>Mature_310_residues
MIATRDAYGEALAELGGENDKIVALDADLSGSTKTGVFAKKFPNRFFNMGIAEANMVGTAAGLASVGKIPFLSTFAIFAA
GRAWEQIRQSLAYPKANVKVVATHGGVTVGEDGGSHQSVEDIAIMRAIPNMTVIVPADGEETKGAIRAAAAYKGPVYVRL
GRNKVANVFPAGHKFEIGKGNVVAEGKDLTFITTGLMTAQAVIAAEKLKEEGISARVLHLGTIKPLDKELVLKAAQETGA
IVTAEEHSVVGGLGGAVAEFLGEECPTLMKRVGIYDRFGLSGKSDELLKYFGLNAETLIEQAREIVSRKK

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=311, Percent_Identity=40.8360128617363, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI4507521, Length=311, Percent_Identity=40.8360128617363, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI225637461, Length=302, Percent_Identity=38.4105960264901, Blast_Score=191, Evalue=7e-49,
Organism=Homo sapiens, GI225637459, Length=302, Percent_Identity=38.4105960264901, Blast_Score=191, Evalue=8e-49,
Organism=Homo sapiens, GI225637463, Length=302, Percent_Identity=38.4105960264901, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI133778974, Length=304, Percent_Identity=37.171052631579, Blast_Score=184, Evalue=1e-46,
Organism=Escherichia coli, GI1786622, Length=291, Percent_Identity=31.9587628865979, Blast_Score=141, Evalue=6e-35,
Organism=Escherichia coli, GI1788808, Length=335, Percent_Identity=29.8507462686567, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI48994911, Length=320, Percent_Identity=28.125, Blast_Score=88, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17539652, Length=302, Percent_Identity=38.4105960264901, Blast_Score=183, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI17538422, Length=274, Percent_Identity=25.1824817518248, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6325331, Length=282, Percent_Identity=30.1418439716312, Blast_Score=89, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6319593, Length=279, Percent_Identity=28.673835125448, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319698, Length=285, Percent_Identity=25.2631578947368, Blast_Score=62, Evalue=8e-11,
Organism=Drosophila melanogaster, GI45551847, Length=309, Percent_Identity=36.2459546925566, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI45550715, Length=309, Percent_Identity=36.2459546925566, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24645119, Length=309, Percent_Identity=36.2459546925566, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24666278, Length=311, Percent_Identity=34.4051446945338, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI21358145, Length=280, Percent_Identity=25.7142857142857, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24650940, Length=280, Percent_Identity=25.7142857142857, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 32691; Mature: 32691

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIATRDAYGEALAELGGENDKIVALDADLSGSTKTGVFAKKFPNRFFNMGIAEANMVGTA
CCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHCHHHHHCCCCHHHHHHHH
AGLASVGKIPFLSTFAIFAAGRAWEQIRQSLAYPKANVKVVATHGGVTVGEDGGSHQSVE
HHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEEECCCEEECCCCCCCCHHH
DIAIMRAIPNMTVIVPADGEETKGAIRAAAAYKGPVYVRLGRNKVANVFPAGHKFEIGKG
HHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCEEEEECCCCHHHCCCCCCEEECCCC
NVVAEGKDLTFITTGLMTAQAVIAAEKLKEEGISARVLHLGTIKPLDKELVLKAAQETGA
CEEECCCCEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHCCC
IVTAEEHSVVGGLGGAVAEFLGEECPTLMKRVGIYDRFGLSGKSDELLKYFGLNAETLIE
EEEECCCCHHHCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHCCCHHHHHH
QAREIVSRKK
HHHHHHHCCC
>Mature Secondary Structure
MIATRDAYGEALAELGGENDKIVALDADLSGSTKTGVFAKKFPNRFFNMGIAEANMVGTA
CCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHCHHHHHCCCCHHHHHHHH
AGLASVGKIPFLSTFAIFAAGRAWEQIRQSLAYPKANVKVVATHGGVTVGEDGGSHQSVE
HHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEEECCCEEECCCCCCCCHHH
DIAIMRAIPNMTVIVPADGEETKGAIRAAAAYKGPVYVRLGRNKVANVFPAGHKFEIGKG
HHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCEEEEECCCCHHHCCCCCCEEECCCC
NVVAEGKDLTFITTGLMTAQAVIAAEKLKEEGISARVLHLGTIKPLDKELVLKAAQETGA
CEEECCCCEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHCCC
IVTAEEHSVVGGLGGAVAEFLGEECPTLMKRVGIYDRFGLSGKSDELLKYFGLNAETLIE
EEEECCCCHHHCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHCCCHHHHHH
QAREIVSRKK
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]