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The map label for this gene is tktA [C]

Identifier: 197116679

GI number: 197116679

Start: 337047

End: 337871

Strand: Direct

Name: tktA [C]

Synonym: Gbem_0279

Alternate gene names: 197116679

Gene position: 337047-337871 (Clockwise)

Preceding gene: 197116678

Following gene: 197116680

Centisome position: 7.3

GC content: 64.24

Gene sequence:

>825_bases
GTGAAAGAAAAGATTGCAGATCTGGAGGAAAAGGCGAGGCGCCTGCGCGTCGCCATCGTGAAGACGCTGCACAAATCGCA
GTCCGGCCACACCGGCGGGTCGCTCTCGGCCATCGACATGGTGTGCGCCCTGTACTTCCACAAGATGCGCCATAACCCGC
AGGACCCGTCCTGGGAGGGTAGGGACCGCTTCGTGCTCAGCAAGGGGCACGCGGCGCCGGCGCTTTACGTCACCTTGGCG
GAGTGCGGCTACTTCCCGGCCGAGGATCTGATGATGCTGCGCCGCCTGGGGAGCCACCTCCAGGGGCACCCGGACAGCAA
GGGAACTCCCGGCGTCGACGTCTGCACCGGCTCGCTCGGGCAGGGGCTTTCCATGGCCAACGGCATGGCGCTCGGCTTCA
AGCTCGACGGCAAGGACAACCGCGTCTATGCGGTCCTGGGCGACGGCGAGCTCCAGGAAGGGCAGATCTGGGAAGCCGCC
ATGGCCGCCGGTCACTACAAGAGCGACAACCTCTGCGCCCTGATCGACTCCAACGGCCTGCAGATCGACGGCGACGTCTC
CAAGGTCATGAACGTGGCCTCCATCGGCGATAAGTTCAAGGCCTTCGGCTGGAACGTGATCGAGATCGACGGGCACGACA
TGGGTCAGATCATCTCCGCTTTGGATAAGGCCGAGGCGCACAAGGGGGCACCCACCGCCATCATCGCCAAGACGGTCAAG
GGCAAGGGGGTTCACCTGTTCGAGAACAAGGCTTCCTACCACGGCGTCACCCCGAACGACGAGGAGCTTCCCGAGGCGCT
CAGGTGCCTTGGCTGCTGCGACTAA

Upstream 100 bases:

>100_bases
ATACCCCCGGCACAATCAGCCAACCGTAGCCTGGACGAGGTGATCCTCGATTACCTCATCACGGGCGAAGACAAATAAAG
CCAGCCTGAAAGGAACCTTC

Downstream 100 bases:

>100_bases
ACTTCATCGGCATGCTGCCGGGACAGGAAACAGCCCCCTCCCTGACCCTCCCCTTCCGGGGGCGGGGACGTTGGGCGGCA
GACCACATACCAGAAAGGGA

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MKEKIADLEEKARRLRVAIVKTLHKSQSGHTGGSLSAIDMVCALYFHKMRHNPQDPSWEGRDRFVLSKGHAAPALYVTLA
ECGYFPAEDLMMLRRLGSHLQGHPDSKGTPGVDVCTGSLGQGLSMANGMALGFKLDGKDNRVYAVLGDGELQEGQIWEAA
MAAGHYKSDNLCALIDSNGLQIDGDVSKVMNVASIGDKFKAFGWNVIEIDGHDMGQIISALDKAEAHKGAPTAIIAKTVK
GKGVHLFENKASYHGVTPNDEELPEALRCLGCCD

Sequences:

>Translated_274_residues
MKEKIADLEEKARRLRVAIVKTLHKSQSGHTGGSLSAIDMVCALYFHKMRHNPQDPSWEGRDRFVLSKGHAAPALYVTLA
ECGYFPAEDLMMLRRLGSHLQGHPDSKGTPGVDVCTGSLGQGLSMANGMALGFKLDGKDNRVYAVLGDGELQEGQIWEAA
MAAGHYKSDNLCALIDSNGLQIDGDVSKVMNVASIGDKFKAFGWNVIEIDGHDMGQIISALDKAEAHKGAPTAIIAKTVK
GKGVHLFENKASYHGVTPNDEELPEALRCLGCCD
>Mature_274_residues
MKEKIADLEEKARRLRVAIVKTLHKSQSGHTGGSLSAIDMVCALYFHKMRHNPQDPSWEGRDRFVLSKGHAAPALYVTLA
ECGYFPAEDLMMLRRLGSHLQGHPDSKGTPGVDVCTGSLGQGLSMANGMALGFKLDGKDNRVYAVLGDGELQEGQIWEAA
MAAGHYKSDNLCALIDSNGLQIDGDVSKVMNVASIGDKFKAFGWNVIEIDGHDMGQIISALDKAEAHKGAPTAIIAKTVK
GKGVHLFENKASYHGVTPNDEELPEALRCLGCCD

Specific function: Unknown

COG id: COG3959

COG function: function code G; Transketolase, N-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=256, Percent_Identity=44.921875, Blast_Score=200, Evalue=1e-51,
Organism=Homo sapiens, GI4507521, Length=256, Percent_Identity=44.921875, Blast_Score=200, Evalue=1e-51,
Organism=Homo sapiens, GI133778974, Length=261, Percent_Identity=41.7624521072797, Blast_Score=191, Evalue=7e-49,
Organism=Homo sapiens, GI225637459, Length=261, Percent_Identity=32.183908045977, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI225637461, Length=261, Percent_Identity=31.8007662835249, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI225637463, Length=225, Percent_Identity=33.3333333333333, Blast_Score=111, Evalue=8e-25,
Organism=Escherichia coli, GI48994911, Length=262, Percent_Identity=37.7862595419847, Blast_Score=157, Evalue=6e-40,
Organism=Escherichia coli, GI1788808, Length=272, Percent_Identity=36.7647058823529, Blast_Score=155, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17539652, Length=250, Percent_Identity=43.2, Blast_Score=208, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6325331, Length=256, Percent_Identity=39.84375, Blast_Score=158, Evalue=9e-40,
Organism=Saccharomyces cerevisiae, GI6319593, Length=266, Percent_Identity=37.593984962406, Blast_Score=150, Evalue=2e-37,
Organism=Drosophila melanogaster, GI45551847, Length=254, Percent_Identity=42.1259842519685, Blast_Score=199, Evalue=1e-51,
Organism=Drosophila melanogaster, GI45550715, Length=254, Percent_Identity=42.1259842519685, Blast_Score=199, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24666278, Length=239, Percent_Identity=42.6778242677824, Blast_Score=194, Evalue=5e-50,
Organism=Drosophila melanogaster, GI24645119, Length=214, Percent_Identity=45.3271028037383, Blast_Score=180, Evalue=9e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 29516; Mature: 29516

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEKIADLEEKARRLRVAIVKTLHKSQSGHTGGSLSAIDMVCALYFHKMRHNPQDPSWEG
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
RDRFVLSKGHAAPALYVTLAECGYFPAEDLMMLRRLGSHLQGHPDSKGTPGVDVCTGSLG
CCEEEEECCCCCCEEEEEHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHEECCCCC
QGLSMANGMALGFKLDGKDNRVYAVLGDGELQEGQIWEAAMAAGHYKSDNLCALIDSNGL
CCCHHCCCEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCC
QIDGDVSKVMNVASIGDKFKAFGWNVIEIDGHDMGQIISALDKAEAHKGAPTAIIAKTVK
EECCCHHHHHHHHHHCCHHHHCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEECCC
GKGVHLFENKASYHGVTPNDEELPEALRCLGCCD
CCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKEKIADLEEKARRLRVAIVKTLHKSQSGHTGGSLSAIDMVCALYFHKMRHNPQDPSWEG
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
RDRFVLSKGHAAPALYVTLAECGYFPAEDLMMLRRLGSHLQGHPDSKGTPGVDVCTGSLG
CCEEEEECCCCCCEEEEEHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHEECCCCC
QGLSMANGMALGFKLDGKDNRVYAVLGDGELQEGQIWEAAMAAGHYKSDNLCALIDSNGL
CCCHHCCCEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCC
QIDGDVSKVMNVASIGDKFKAFGWNVIEIDGHDMGQIISALDKAEAHKGAPTAIIAKTVK
EECCCHHHHHHHHHHCCHHHHCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEECCC
GKGVHLFENKASYHGVTPNDEELPEALRCLGCCD
CCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]