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The map label for this gene is coxA [H]

Identifier: 197116443

GI number: 197116443

Start: 52879

End: 54498

Strand: Direct

Name: coxA [H]

Synonym: Gbem_0043

Alternate gene names: 197116443

Gene position: 52879-54498 (Clockwise)

Preceding gene: 197116442

Following gene: 197116444

Centisome position: 1.15

GC content: 61.85

Gene sequence:

>1620_bases
ATGAGTCAAGATACGGCAATGGCGCAGGGCGGTTTCTGGCGGGATACCAGGAGGAGCGGGATAGGCTCCTGGATCTTCTC
AACCGACCACAAGCGGATAGGGATGATGTACCTCTACTGCGTACTGAGCTTCTTCCTGGTCGGGGTCGTCCTCGGGTTCC
TGATCCGGCTGGAGCTGATCGCGCCCGGCCCGACCATCGTCACCGCCCAGACCTACAACGCCCTCTTTACGGTGCACGGG
GTGGTGATGATCTTTCTCTTCATCATCCCGGGGATACCGGCCTCCTTCGGCAACCTGGTGCTCCCCATCCAGTTGGGCGC
CCGCGACGTCGCCTTTCCCAGGGTGAATCTTTTATCCTGGTGGCTCTACGCCATCGGCGCCGTCATCGTGCTGGTTTCCC
TCTTCACAGGCGGAGGCGCGCCCGACACCGGGTGGACCTTCTACGTCCCCTTCAGCGCCAGGACCAGCACCAACGTCTCC
CTGGCTGTCTTCGGCGTATTCGTCCTCGGCTTTTCCTCCATCCTCACCGGGATCAACTTCATCACCACCATCCACCGCAT
GCGCGCACCGGGGATGACCTGGACCCGGATCCCGCTATTCACCTGGAGCCTATACGCGACAGCCTGGGTGCAGGTGCTCG
CCACCCCGATCATCGCCATCACGCTCCTATTGGTGGTGACCGAGCGGATCCTGGGCCTCGGGCTTTTCGACCCCAACCGC
GGCGGGGACCCGGTAATGTACCAGCACATGTTCTGGATCTACTCGCACCCCGCCGTGTACATCATGATCCTGCCGGGCAT
GGGGGTGATCTCGGACATCATCCCGGTCTTCTCCAGAAAGCCCATCTTCGGCTACAAGATGATCGCCTTTTCCAGCCTCG
CCATCGCCGCGGCCGGCTCCGCCGTCTGGGGGCACCACATGTACACCTCGGGGATGAGCGACCTGGGCGTACTAGTCTTC
TCGTTCCTGACCTTCATCGTGGCGATCCCCTCGGCCATCAAGGTGTTCAACTGGGTCTCCACCATGTACAAGGGCTCCAT
CTCGCTTGAGGCCCCCATGCTCTTCGCGCTCTCCTTCATCCTGCTTTTCTCCATCGGCGGCTTGTCCGGGCTGATCCTCG
GCGCCGCCGCCACCGACATCCACGTGCACGACACCCATTTCGTGGTCGGGCATTTCCGCTACGTCATGTTCGGCGGCACC
GGTTTCGCCTTCTTCGCGGCGGCGCATTACTGGCTCCCCAAATACTACGGGCGCAGATATAAGGAAAAGCCCGCCATCGT
CGGCTGGATCCTCATGTTCGTAGGCTTCAACGTCATGTACTTCACCATGCAGGTGCTGGGGATGGAGGGGATGCCCAGGC
GTTATTACGACTACCTCCCGGAATTCACCCGGCTGAACGTCGTCGCCACCGTCGGGAGCTGGATCCTGGTGGCCGGAATC
GTCATAGTGGTCTGGAACCTCTGGCGCGGCCTGTTCAGGGGCGAGCCGTTCACCGGCAACCCCTGGGGAGGCGCGACGCT
TGAGTGGAGCATCGCGACGCCTCCTCCCACCGAAAATTTTGATGAGGACCCGGTGGTGACCCACGGGCCGTACGAGTTCA
AGGGGGCAGGCATTCCATGA

Upstream 100 bases:

>100_bases
CGGAGGCAAAAAACCGCCGGCGGGTAAAGGGCAGTAAAGGGAATAACAGCGACAAGATCACTGGCGCCTGTGACAGGGTG
CCGGTTCGTTCGGAGGGAAA

Downstream 100 bases:

>100_bases
GTCATGCGGAAAAGGACAGTTTTGGTGCAAAGCTCGGCATGTGGTTGTTCCTGTTCACAGAGATGCTTCTCTTTGGCGGG
GTCTTCATCCTCTACTCGGT

Product: cytochrome c oxidase subunit I

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1; Cytochrome c oxidase polypeptide I; Oxidase aa(3) subunit 1 [H]

Number of amino acids: Translated: 539; Mature: 538

Protein sequence:

>539_residues
MSQDTAMAQGGFWRDTRRSGIGSWIFSTDHKRIGMMYLYCVLSFFLVGVVLGFLIRLELIAPGPTIVTAQTYNALFTVHG
VVMIFLFIIPGIPASFGNLVLPIQLGARDVAFPRVNLLSWWLYAIGAVIVLVSLFTGGGAPDTGWTFYVPFSARTSTNVS
LAVFGVFVLGFSSILTGINFITTIHRMRAPGMTWTRIPLFTWSLYATAWVQVLATPIIAITLLLVVTERILGLGLFDPNR
GGDPVMYQHMFWIYSHPAVYIMILPGMGVISDIIPVFSRKPIFGYKMIAFSSLAIAAAGSAVWGHHMYTSGMSDLGVLVF
SFLTFIVAIPSAIKVFNWVSTMYKGSISLEAPMLFALSFILLFSIGGLSGLILGAAATDIHVHDTHFVVGHFRYVMFGGT
GFAFFAAAHYWLPKYYGRRYKEKPAIVGWILMFVGFNVMYFTMQVLGMEGMPRRYYDYLPEFTRLNVVATVGSWILVAGI
VIVVWNLWRGLFRGEPFTGNPWGGATLEWSIATPPPTENFDEDPVVTHGPYEFKGAGIP

Sequences:

>Translated_539_residues
MSQDTAMAQGGFWRDTRRSGIGSWIFSTDHKRIGMMYLYCVLSFFLVGVVLGFLIRLELIAPGPTIVTAQTYNALFTVHG
VVMIFLFIIPGIPASFGNLVLPIQLGARDVAFPRVNLLSWWLYAIGAVIVLVSLFTGGGAPDTGWTFYVPFSARTSTNVS
LAVFGVFVLGFSSILTGINFITTIHRMRAPGMTWTRIPLFTWSLYATAWVQVLATPIIAITLLLVVTERILGLGLFDPNR
GGDPVMYQHMFWIYSHPAVYIMILPGMGVISDIIPVFSRKPIFGYKMIAFSSLAIAAAGSAVWGHHMYTSGMSDLGVLVF
SFLTFIVAIPSAIKVFNWVSTMYKGSISLEAPMLFALSFILLFSIGGLSGLILGAAATDIHVHDTHFVVGHFRYVMFGGT
GFAFFAAAHYWLPKYYGRRYKEKPAIVGWILMFVGFNVMYFTMQVLGMEGMPRRYYDYLPEFTRLNVVATVGSWILVAGI
VIVVWNLWRGLFRGEPFTGNPWGGATLEWSIATPPPTENFDEDPVVTHGPYEFKGAGIP
>Mature_538_residues
SQDTAMAQGGFWRDTRRSGIGSWIFSTDHKRIGMMYLYCVLSFFLVGVVLGFLIRLELIAPGPTIVTAQTYNALFTVHGV
VMIFLFIIPGIPASFGNLVLPIQLGARDVAFPRVNLLSWWLYAIGAVIVLVSLFTGGGAPDTGWTFYVPFSARTSTNVSL
AVFGVFVLGFSSILTGINFITTIHRMRAPGMTWTRIPLFTWSLYATAWVQVLATPIIAITLLLVVTERILGLGLFDPNRG
GDPVMYQHMFWIYSHPAVYIMILPGMGVISDIIPVFSRKPIFGYKMIAFSSLAIAAAGSAVWGHHMYTSGMSDLGVLVFS
FLTFIVAIPSAIKVFNWVSTMYKGSISLEAPMLFALSFILLFSIGGLSGLILGAAATDIHVHDTHFVVGHFRYVMFGGTG
FAFFAAAHYWLPKYYGRRYKEKPAIVGWILMFVGFNVMYFTMQVLGMEGMPRRYYDYLPEFTRLNVVATVGSWILVAGIV
IVVWNLWRGLFRGEPFTGNPWGGATLEWSIATPPPTENFDEDPVVTHGPYEFKGAGIP

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=503, Percent_Identity=39.3638170974155, Blast_Score=353, Evalue=2e-97,
Organism=Escherichia coli, GI1786634, Length=530, Percent_Identity=37.1698113207547, Blast_Score=330, Evalue=1e-91,
Organism=Saccharomyces cerevisiae, GI6226519, Length=532, Percent_Identity=36.8421052631579, Blast_Score=368, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6226524, Length=324, Percent_Identity=37.6543209876543, Blast_Score=238, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6226523, Length=248, Percent_Identity=33.8709677419355, Blast_Score=151, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 59646; Mature: 59515

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQDTAMAQGGFWRDTRRSGIGSWIFSTDHKRIGMMYLYCVLSFFLVGVVLGFLIRLELI
CCCCCCCCCCCCCCHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
APGPTIVTAQTYNALFTVHGVVMIFLFIIPGIPASFGNLVLPIQLGARDVAFPRVNLLSW
CCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCHHHHHHH
WLYAIGAVIVLVSLFTGGGAPDTGWTFYVPFSARTSTNVSLAVFGVFVLGFSSILTGINF
HHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ITTIHRMRAPGMTWTRIPLFTWSLYATAWVQVLATPIIAITLLLVVTERILGLGLFDPNR
HHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GGDPVMYQHMFWIYSHPAVYIMILPGMGVISDIIPVFSRKPIFGYKMIAFSSLAIAAAGS
CCCCHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCC
AVWGHHMYTSGMSDLGVLVFSFLTFIVAIPSAIKVFNWVSTMYKGSISLEAPMLFALSFI
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
LLFSIGGLSGLILGAAATDIHVHDTHFVVGHFRYVMFGGTGFAFFAAAHYWLPKYYGRRY
HHHHHCCHHHHHEEEEECEEEEECCEEEEEEEEEEEECCCHHHHHHHHHHHHHHHHCCCC
KEKPAIVGWILMFVGFNVMYFTMQVLGMEGMPRRYYDYLPEFTRLNVVATVGSWILVAGI
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHH
VIVVWNLWRGLFRGEPFTGNPWGGATLEWSIATPPPTENFDEDPVVTHGPYEFKGAGIP
HHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEECCCCCCCCCCCC
>Mature Secondary Structure 
SQDTAMAQGGFWRDTRRSGIGSWIFSTDHKRIGMMYLYCVLSFFLVGVVLGFLIRLELI
CCCCCCCCCCCCCHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
APGPTIVTAQTYNALFTVHGVVMIFLFIIPGIPASFGNLVLPIQLGARDVAFPRVNLLSW
CCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCHHHHHHH
WLYAIGAVIVLVSLFTGGGAPDTGWTFYVPFSARTSTNVSLAVFGVFVLGFSSILTGINF
HHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ITTIHRMRAPGMTWTRIPLFTWSLYATAWVQVLATPIIAITLLLVVTERILGLGLFDPNR
HHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GGDPVMYQHMFWIYSHPAVYIMILPGMGVISDIIPVFSRKPIFGYKMIAFSSLAIAAAGS
CCCCHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCC
AVWGHHMYTSGMSDLGVLVFSFLTFIVAIPSAIKVFNWVSTMYKGSISLEAPMLFALSFI
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
LLFSIGGLSGLILGAAATDIHVHDTHFVVGHFRYVMFGGTGFAFFAAAHYWLPKYYGRRY
HHHHHCCHHHHHEEEEECEEEEECCEEEEEEEEEEEECCCHHHHHHHHHHHHHHHHCCCC
KEKPAIVGWILMFVGFNVMYFTMQVLGMEGMPRRYYDYLPEFTRLNVVATVGSWILVAGI
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHH
VIVVWNLWRGLFRGEPFTGNPWGGATLEWSIATPPPTENFDEDPVVTHGPYEFKGAGIP
HHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8387368; 8905231 [H]