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The map label for this gene is yycG [H]

Identifier: 197116409

GI number: 197116409

Start: 12272

End: 14536

Strand: Direct

Name: yycG [H]

Synonym: Gbem_0009

Alternate gene names: 197116409

Gene position: 12272-14536 (Clockwise)

Preceding gene: 197116408

Following gene: 197116410

Centisome position: 0.27

GC content: 60.79

Gene sequence:

>2265_bases
ATGCAACTTCGTTTTGGCATAAGAACAAAATTGCTCCTGTCCATACTCGCCATCCTCTTCGTATCATACTCAACCCTGCT
GTACTCCTCCATGAAGACCCTCAACGCGTCGCTGCAGACCGAGCTGGACCGGAACCTGGCGACCAACCTGAAGTACGCAC
GCAGCCAGTACCTGGATCAAGCTGAGATCGCCAAGTTTTCCATGATGCAGGCGGTGGTTTCGCAGACGGTGCAGCAGCGC
CTGCGCGAGCGGGACAGCGCCTGGTTCTCCACGCGCATCAAGCGCTGGCACGACGTGCTCCCCTTCGTGGACCTGGTGGT
CGTGGTAGATCCCCAGGAAAAGGTCCTGGCCACCCTCCAGGGTCCCGAAAAAAATGGGCCGATGGAGCTGCCGGCGATGG
TGAAACAGGCCCTCGCCAGCAAGAGGGCCATCTTGTCGACCGAGCTGCTCAGCGGTGAGTTCATGTGCCGCGCAGGGGTG
CCAGGATACTGCGAGCGCCCCGGCAGCGAGGCCTTAGTCGCCACGGTGGCGGTCCCGGTCATCGGAACGGACGGCAGCGT
GCTCGGTTGCGTGGTGACCGGGGACATCCTGAACCACCACCCGAATCTCCCCGGCAAGCTGCAGGAGGTCACCGGGAACA
ACGTGGAGGTGACCCTGACCCAGCGCGGGCTTCGGGTCGCCAGCAGCCTTCCGGCGCGGGTGCGGGAATCGTACATCCTC
TCTCCCAAGGTGCTCGACGTGCTGGAGCGCGGCGAAGTGTACCGCGGCCGGACGGACATGGGCGCCAAGAGCTACGAAAC
CATCATCGACCCGCTTTTGAACAGCAGGGGGGAGTTCGTCGGCTCGCTTTCGGTGGCGATATCGACGGAAACGGTGACCA
ACAGCAGGCGGGAAAATCTGCAGTACATACTCGCCTCGGCTTTCCTGGGCATCATCTGCTCCTTCGCCATGGCCTACTTC
GCCTCGCGTCACCTGACGGGGCCGCTGCGGCAGTTAGCGATGAGCGCGCGCCGTATCGAGGAAGGGGACCTCGACCAGAG
GGTAGTCGGCCACCAGCGGGACGAGGTGGGGATGCTGGCCTCTTCCTTCAACAACATGGCCGAATCGCTCAAGGAACGGG
ACGGCATCATCAACAAGAAGACCGGCGACCTCCAGGAGCTGAACGAACAGCTGGAGAAAATGGTCGAGCAGCGGACCTCC
GCCCTCAGCATGGAGATGGGGAGGCTGGAGGCGGTGTTGACGAGCCTTGCCGAAGGGGTGGTGGTGACCGACCGCGACAA
CCTCGTGGTGCTCTTCAACCCGGCGGCTCAGCAGCTCTTCGAACTGGTTCCGCATCGCGTTGTCGGGCAGTCTGTCGAGC
GCCTGTGCGAGATGACCGGGTTTTGCAATGTCCTGGAACAGGTCAGCGATAAGGCGCAACGGGAGCCCCGCTGCGGTAAA
AAAGAGGTCACCGTGAAAGGGAAGCGGCTGCACGTGAACACGGCCACCCTCCAGGACGAGGCAGGGGAGTTCGCCGGAAT
GGTCATGTCGCTGCGCGACGTCACCAAGGAGGAGCAGGTGGACCGGATGAAGACCGAGTTCATATCCACCGTCTCCCACG
AGTTGAAGACGCCGCTTACTTCGATCAAGGGGTCGCTGCAACTGCTGTTGACGCGCAGCAAGTGGCTCACGGATACCGAG
AGGCAGCTTTTGACCGTCTGCTTCCGCAACACGCAGCGGCTGATCCGGCTGATCAGCGAGATCCTCGACATCTCCGGCAT
CGAATCCGGCGGGATGATCTTCAACTTCAAGCCCCTTTGCATCGGTGAACTTGCGGTGTACGCGGTCGAGGAGATCAAGT
CCTTAGCCATGGGACGGGAGATCACCATCGTCAACACCGTGGGCGAGCATCTTCCCATGGTATTCGGCGACAGCGATCGC
CTGATCCAGGTGATGACCAACCTCCTCTCCAACGCGGTGAAGTTTTCCCCCGAGGGAAAGGTGGTCATGGTCACCGCGGA
GCAGGAAGGAAACTACGTGGTGGTCTCGGTGGCCGACAGAGGAAGGGTGATACAGTGGTCCGACCGGGACAAGCTTTTCA
AGAAGTTCCAACAAATTGAATCAACCGAACGCAACAAGATCGGCGGGACCGGGTTGGGGCTCGCCATCTGCAAGGAGATA
GTCGAGCGGCATCACGGCAGGATCTTCTACACCGCCGCCAAGGAATACGGCAATACCTTCAGCTTCACGGTGCCGATAAT
AGGGGAGACAGATGCAAAAGGATAA

Upstream 100 bases:

>100_bases
GTTGAGGTCGAGATTGAGACAAGAAGAACCGGCAATCACGCGGGTTTTGAATTTTCTCAATCTTAATCTTAATCTTTATC
TGATTTACAAAGGATAGGTG

Downstream 100 bases:

>100_bases
GATTCTCATCGTGGACGACGAGGCGGACATCGCGCTCATCCTCAAGCTGCAACTGGAGGACGCCGGCTACGAGACGGTCC
GGGCCCGCGATGGTGTAGAG

Product: HAMP/PAS domain-containing sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 754; Mature: 754

Protein sequence:

>754_residues
MQLRFGIRTKLLLSILAILFVSYSTLLYSSMKTLNASLQTELDRNLATNLKYARSQYLDQAEIAKFSMMQAVVSQTVQQR
LRERDSAWFSTRIKRWHDVLPFVDLVVVVDPQEKVLATLQGPEKNGPMELPAMVKQALASKRAILSTELLSGEFMCRAGV
PGYCERPGSEALVATVAVPVIGTDGSVLGCVVTGDILNHHPNLPGKLQEVTGNNVEVTLTQRGLRVASSLPARVRESYIL
SPKVLDVLERGEVYRGRTDMGAKSYETIIDPLLNSRGEFVGSLSVAISTETVTNSRRENLQYILASAFLGIICSFAMAYF
ASRHLTGPLRQLAMSARRIEEGDLDQRVVGHQRDEVGMLASSFNNMAESLKERDGIINKKTGDLQELNEQLEKMVEQRTS
ALSMEMGRLEAVLTSLAEGVVVTDRDNLVVLFNPAAQQLFELVPHRVVGQSVERLCEMTGFCNVLEQVSDKAQREPRCGK
KEVTVKGKRLHVNTATLQDEAGEFAGMVMSLRDVTKEEQVDRMKTEFISTVSHELKTPLTSIKGSLQLLLTRSKWLTDTE
RQLLTVCFRNTQRLIRLISEILDISGIESGGMIFNFKPLCIGELAVYAVEEIKSLAMGREITIVNTVGEHLPMVFGDSDR
LIQVMTNLLSNAVKFSPEGKVVMVTAEQEGNYVVVSVADRGRVIQWSDRDKLFKKFQQIESTERNKIGGTGLGLAICKEI
VERHHGRIFYTAAKEYGNTFSFTVPIIGETDAKG

Sequences:

>Translated_754_residues
MQLRFGIRTKLLLSILAILFVSYSTLLYSSMKTLNASLQTELDRNLATNLKYARSQYLDQAEIAKFSMMQAVVSQTVQQR
LRERDSAWFSTRIKRWHDVLPFVDLVVVVDPQEKVLATLQGPEKNGPMELPAMVKQALASKRAILSTELLSGEFMCRAGV
PGYCERPGSEALVATVAVPVIGTDGSVLGCVVTGDILNHHPNLPGKLQEVTGNNVEVTLTQRGLRVASSLPARVRESYIL
SPKVLDVLERGEVYRGRTDMGAKSYETIIDPLLNSRGEFVGSLSVAISTETVTNSRRENLQYILASAFLGIICSFAMAYF
ASRHLTGPLRQLAMSARRIEEGDLDQRVVGHQRDEVGMLASSFNNMAESLKERDGIINKKTGDLQELNEQLEKMVEQRTS
ALSMEMGRLEAVLTSLAEGVVVTDRDNLVVLFNPAAQQLFELVPHRVVGQSVERLCEMTGFCNVLEQVSDKAQREPRCGK
KEVTVKGKRLHVNTATLQDEAGEFAGMVMSLRDVTKEEQVDRMKTEFISTVSHELKTPLTSIKGSLQLLLTRSKWLTDTE
RQLLTVCFRNTQRLIRLISEILDISGIESGGMIFNFKPLCIGELAVYAVEEIKSLAMGREITIVNTVGEHLPMVFGDSDR
LIQVMTNLLSNAVKFSPEGKVVMVTAEQEGNYVVVSVADRGRVIQWSDRDKLFKKFQQIESTERNKIGGTGLGLAICKEI
VERHHGRIFYTAAKEYGNTFSFTVPIIGETDAKG
>Mature_754_residues
MQLRFGIRTKLLLSILAILFVSYSTLLYSSMKTLNASLQTELDRNLATNLKYARSQYLDQAEIAKFSMMQAVVSQTVQQR
LRERDSAWFSTRIKRWHDVLPFVDLVVVVDPQEKVLATLQGPEKNGPMELPAMVKQALASKRAILSTELLSGEFMCRAGV
PGYCERPGSEALVATVAVPVIGTDGSVLGCVVTGDILNHHPNLPGKLQEVTGNNVEVTLTQRGLRVASSLPARVRESYIL
SPKVLDVLERGEVYRGRTDMGAKSYETIIDPLLNSRGEFVGSLSVAISTETVTNSRRENLQYILASAFLGIICSFAMAYF
ASRHLTGPLRQLAMSARRIEEGDLDQRVVGHQRDEVGMLASSFNNMAESLKERDGIINKKTGDLQELNEQLEKMVEQRTS
ALSMEMGRLEAVLTSLAEGVVVTDRDNLVVLFNPAAQQLFELVPHRVVGQSVERLCEMTGFCNVLEQVSDKAQREPRCGK
KEVTVKGKRLHVNTATLQDEAGEFAGMVMSLRDVTKEEQVDRMKTEFISTVSHELKTPLTSIKGSLQLLLTRSKWLTDTE
RQLLTVCFRNTQRLIRLISEILDISGIESGGMIFNFKPLCIGELAVYAVEEIKSLAMGREITIVNTVGEHLPMVFGDSDR
LIQVMTNLLSNAVKFSPEGKVVMVTAEQEGNYVVVSVADRGRVIQWSDRDKLFKKFQQIESTERNKIGGTGLGLAICKEI
VERHHGRIFYTAAKEYGNTFSFTVPIIGETDAKG

Specific function: Member of the two-component regulatory system YycG/YycF involved in the regulation of the ftsAZ operon, the yocH and ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Probably phosphorylates YycF [H]

COG id: COG5002

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=232, Percent_Identity=32.7586206896552, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI1788549, Length=406, Percent_Identity=24.8768472906404, Blast_Score=118, Evalue=2e-27,
Organism=Escherichia coli, GI1789149, Length=234, Percent_Identity=30.7692307692308, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1788713, Length=230, Percent_Identity=32.1739130434783, Blast_Score=114, Evalue=3e-26,
Organism=Escherichia coli, GI87081816, Length=261, Percent_Identity=29.5019157088123, Blast_Score=110, Evalue=4e-25,
Organism=Escherichia coli, GI1788393, Length=257, Percent_Identity=27.6264591439689, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI1786600, Length=357, Percent_Identity=26.0504201680672, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1790436, Length=225, Percent_Identity=31.5555555555556, Blast_Score=102, Evalue=1e-22,
Organism=Escherichia coli, GI48994928, Length=264, Percent_Identity=29.9242424242424, Blast_Score=102, Evalue=1e-22,
Organism=Escherichia coli, GI1786783, Length=247, Percent_Identity=26.3157894736842, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI1786912, Length=240, Percent_Identity=28.3333333333333, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI1790300, Length=357, Percent_Identity=25.7703081232493, Blast_Score=80, Evalue=6e-16,
Organism=Escherichia coli, GI87082128, Length=239, Percent_Identity=23.0125523012552, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788279, Length=222, Percent_Identity=23.8738738738739, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1790551, Length=254, Percent_Identity=25.5905511811024, Blast_Score=73, Evalue=8e-14,
Organism=Escherichia coli, GI1790346, Length=217, Percent_Identity=26.2672811059908, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1787374, Length=228, Percent_Identity=25, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1787894, Length=260, Percent_Identity=24.6153846153846, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 83749; Mature: 83749

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: PS50885 HAMP ; PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLRFGIRTKLLLSILAILFVSYSTLLYSSMKTLNASLQTELDRNLATNLKYARSQYLDQ
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
AEIAKFSMMQAVVSQTVQQRLRERDSAWFSTRIKRWHDVLPFVDLVVVVDPQEKVLATLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHC
GPEKNGPMELPAMVKQALASKRAILSTELLSGEFMCRAGVPGYCERPGSEALVATVAVPV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCEEEEEEEEE
IGTDGSVLGCVVTGDILNHHPNLPGKLQEVTGNNVEVTLTQRGLRVASSLPARVRESYIL
ECCCCCEEEEEEECHHHHCCCCCCCHHHHCCCCCEEEEEECCCHHHHHCCCHHHHHHHCC
SPKVLDVLERGEVYRGRTDMGAKSYETIIDPLLNSRGEFVGSLSVAISTETVTNSRRENL
CHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEEEEHHHHCCHHHHH
QYILASAFLGIICSFAMAYFASRHLTGPLRQLAMSARRIEEGDLDQRVVGHQRDEVGMLA
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHH
SSFNNMAESLKERDGIINKKTGDLQELNEQLEKMVEQRTSALSMEMGRLEAVLTSLAEGV
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCE
VVTDRDNLVVLFNPAAQQLFELVPHRVVGQSVERLCEMTGFCNVLEQVSDKAQREPRCGK
EEECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
KEVTVKGKRLHVNTATLQDEAGEFAGMVMSLRDVTKEEQVDRMKTEFISTVSHELKTPLT
CCEEEECCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
SIKGSLQLLLTRSKWLTDTERQLLTVCFRNTQRLIRLISEILDISGIESGGMIFNFKPLC
HHCCHHHHEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHH
IGELAVYAVEEIKSLAMGREITIVNTVGEHLPMVFGDSDRLIQVMTNLLSNAVKFSPEGK
HHHHHHHHHHHHHHHHCCCEEEEEECHHHHCCEEECCCHHHHHHHHHHHHHHHEECCCCC
VVMVTAEQEGNYVVVSVADRGRVIQWSDRDKLFKKFQQIESTERNKIGGTGLGLAICKEI
EEEEEECCCCCEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
VERHHGRIFYTAAKEYGNTFSFTVPIIGETDAKG
HHHHCCEEEEEEHHHHCCEEEEEEEEECCCCCCC
>Mature Secondary Structure
MQLRFGIRTKLLLSILAILFVSYSTLLYSSMKTLNASLQTELDRNLATNLKYARSQYLDQ
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
AEIAKFSMMQAVVSQTVQQRLRERDSAWFSTRIKRWHDVLPFVDLVVVVDPQEKVLATLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHC
GPEKNGPMELPAMVKQALASKRAILSTELLSGEFMCRAGVPGYCERPGSEALVATVAVPV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCEEEEEEEEE
IGTDGSVLGCVVTGDILNHHPNLPGKLQEVTGNNVEVTLTQRGLRVASSLPARVRESYIL
ECCCCCEEEEEEECHHHHCCCCCCCHHHHCCCCCEEEEEECCCHHHHHCCCHHHHHHHCC
SPKVLDVLERGEVYRGRTDMGAKSYETIIDPLLNSRGEFVGSLSVAISTETVTNSRRENL
CHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEEEEHHHHCCHHHHH
QYILASAFLGIICSFAMAYFASRHLTGPLRQLAMSARRIEEGDLDQRVVGHQRDEVGMLA
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHH
SSFNNMAESLKERDGIINKKTGDLQELNEQLEKMVEQRTSALSMEMGRLEAVLTSLAEGV
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCE
VVTDRDNLVVLFNPAAQQLFELVPHRVVGQSVERLCEMTGFCNVLEQVSDKAQREPRCGK
EEECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
KEVTVKGKRLHVNTATLQDEAGEFAGMVMSLRDVTKEEQVDRMKTEFISTVSHELKTPLT
CCEEEECCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
SIKGSLQLLLTRSKWLTDTERQLLTVCFRNTQRLIRLISEILDISGIESGGMIFNFKPLC
HHCCHHHHEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHH
IGELAVYAVEEIKSLAMGREITIVNTVGEHLPMVFGDSDRLIQVMTNLLSNAVKFSPEGK
HHHHHHHHHHHHHHHHCCCEEEEEECHHHHCCEEECCCHHHHHHHHHHHHHHHEECCCCC
VVMVTAEQEGNYVVVSVADRGRVIQWSDRDKLFKKFQQIESTERNKIGGTGLGLAICKEI
EEEEEECCCCCEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
VERHHGRIFYTAAKEYGNTFSFTVPIIGETDAKG
HHHHCCEEEEEEHHHHCCEEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9829949; 10878122; 11758928 [H]