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The map label for this gene is gpsA

Identifier: 197116408

GI number: 197116408

Start: 11070

End: 12077

Strand: Direct

Name: gpsA

Synonym: Gbem_0008

Alternate gene names: 197116408

Gene position: 11070-12077 (Clockwise)

Preceding gene: 308535144

Following gene: 197116409

Centisome position: 0.24

GC content: 63.39

Gene sequence:

>1008_bases
ATGGCAGAAAAAATAGCCGTTATCGGTGCAGGGAGCTGGGGCACGACCCTCGCCGACCTGCTCGCCAAGAAAGGGCACGA
GGTCACGCTTTGGGCCTACGAGCCCGAACTCGTACTGGAGATGCGCGACAACAGGGAGAACAGCCTGTTCCTTCCCGGCA
TCAAGCTGAACGAGCGTCTCGCCTTCACCAACGACCTGGCGGAGGCCTACCGCGGCTGCAGCATGGTGCTCTGCGTGGTC
CCCTCGCAACTGGTGCGCCGGGTGATGACCAACTCGCTCCCTTTCCTCCCCAAGGAAGCGATCATCGTCAGCGCCTCCAA
GGGGATCGAGGTCGACACCCTGGCCACCGTTTCCGAGATCTACCAGGAGATCCTCCCCCCCGAGCAGTTCCAGGTGCTGG
CTGCCCTTTCCGGCCCTAGCTTCGCGCGCGAGGTCGCGCTGGAGATGCCGACCGCGGTCACTGCGGCCGCGAGCTCAGAG
GCTGTCGCCCGCCGGGTGCAAGAGGCGTTTACCACCGACTACTTCCGGGTCTACCGCAACTCCGACGTGGTAGGGGTGGA
ACTTGGCGGGGCCATCAAGAACGTAATTGCCATCGCCGCCGGCATCTCCGACGGTCTTGGTTTCGGCAGCAATACGAGAG
CTGCCCTCATCACCCGCGGCCTGGCCGAGATGACCCGCCTGGGAGTCGCCATGGGGGCGCAACCCTCCACCTTCGCGGGG
CTCGCCGGGATGGGGGACCTGGTGCTCACCTGCACCGGCGACCTATCGCGAAACCGCAGCGTCGGCATCCAGATCGGCCA
GGGGAGGACGCTCTCCGAGATTCTGGGAGAGATGCGGATGGTCGCCGAAGGGGTGAAGACCACCGAATCGGCCTACAACC
TGGCCAAGAAGCTTGGCGTGGAGATGCCCATCATCGAGCAGATGTACCAGATGCTATACCAGAACAAGTCCGCCCGGGAA
GCGGTTCTGGAGCTGATGACCAGAAACCTGAAAGCTGAAGGAGTTTAA

Upstream 100 bases:

>100_bases
GCGGGGCGACGATGCGCCGCTTCGGGCGGCCGAGGAATTTTAACGACCCTACCCTTCTCCCTCCGGGGGGAAGCGGGATT
ACCATAAAAAGAGAGATCGG

Downstream 100 bases:

>100_bases
AAGCAGGAAAAACAGATTGAGATTAAGATTAAGAAAACCTTGAACCAACCTCGATCCAGGTCTTCCTCAATCTTGATGTC
TTTCTGATGCAAAGGTTGAG

Product: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MAEKIAVIGAGSWGTTLADLLAKKGHEVTLWAYEPELVLEMRDNRENSLFLPGIKLNERLAFTNDLAEAYRGCSMVLCVV
PSQLVRRVMTNSLPFLPKEAIIVSASKGIEVDTLATVSEIYQEILPPEQFQVLAALSGPSFAREVALEMPTAVTAAASSE
AVARRVQEAFTTDYFRVYRNSDVVGVELGGAIKNVIAIAAGISDGLGFGSNTRAALITRGLAEMTRLGVAMGAQPSTFAG
LAGMGDLVLTCTGDLSRNRSVGIQIGQGRTLSEILGEMRMVAEGVKTTESAYNLAKKLGVEMPIIEQMYQMLYQNKSARE
AVLELMTRNLKAEGV

Sequences:

>Translated_335_residues
MAEKIAVIGAGSWGTTLADLLAKKGHEVTLWAYEPELVLEMRDNRENSLFLPGIKLNERLAFTNDLAEAYRGCSMVLCVV
PSQLVRRVMTNSLPFLPKEAIIVSASKGIEVDTLATVSEIYQEILPPEQFQVLAALSGPSFAREVALEMPTAVTAAASSE
AVARRVQEAFTTDYFRVYRNSDVVGVELGGAIKNVIAIAAGISDGLGFGSNTRAALITRGLAEMTRLGVAMGAQPSTFAG
LAGMGDLVLTCTGDLSRNRSVGIQIGQGRTLSEILGEMRMVAEGVKTTESAYNLAKKLGVEMPIIEQMYQMLYQNKSARE
AVLELMTRNLKAEGV
>Mature_334_residues
AEKIAVIGAGSWGTTLADLLAKKGHEVTLWAYEPELVLEMRDNRENSLFLPGIKLNERLAFTNDLAEAYRGCSMVLCVVP
SQLVRRVMTNSLPFLPKEAIIVSASKGIEVDTLATVSEIYQEILPPEQFQVLAALSGPSFAREVALEMPTAVTAAASSEA
VARRVQEAFTTDYFRVYRNSDVVGVELGGAIKNVIAIAAGISDGLGFGSNTRAALITRGLAEMTRLGVAMGAQPSTFAGL
AGMGDLVLTCTGDLSRNRSVGIQIGQGRTLSEILGEMRMVAEGVKTTESAYNLAKKLGVEMPIIEQMYQMLYQNKSAREA
VLELMTRNLKAEGV

Specific function: De novo phospholipid biosynthesis; glycerol-3 phosphate formation. [C]

COG id: COG0240

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI24307999, Length=339, Percent_Identity=29.7935103244838, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI33695088, Length=351, Percent_Identity=28.4900284900285, Blast_Score=134, Evalue=1e-31,
Organism=Escherichia coli, GI1790037, Length=330, Percent_Identity=46.969696969697, Blast_Score=298, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI32564399, Length=333, Percent_Identity=31.2312312312312, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI193210136, Length=342, Percent_Identity=30.9941520467836, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI32564403, Length=342, Percent_Identity=30.9941520467836, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17507425, Length=347, Percent_Identity=27.0893371757925, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI193210134, Length=330, Percent_Identity=28.1818181818182, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320181, Length=342, Percent_Identity=29.5321637426901, Blast_Score=127, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6324513, Length=342, Percent_Identity=27.1929824561404, Blast_Score=119, Evalue=6e-28,
Organism=Drosophila melanogaster, GI17136204, Length=338, Percent_Identity=28.9940828402367, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI17136202, Length=338, Percent_Identity=28.9940828402367, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI17136200, Length=338, Percent_Identity=28.9940828402367, Blast_Score=114, Evalue=7e-26,
Organism=Drosophila melanogaster, GI22026922, Length=329, Percent_Identity=26.7477203647416, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI45551945, Length=343, Percent_Identity=26.2390670553936, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI281362270, Length=287, Percent_Identity=28.9198606271777, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24648969, Length=290, Percent_Identity=26.2068965517241, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPDA_GEOBB (B5E7Q3)

Other databases:

- EMBL:   CP001124
- RefSeq:   YP_002136835.1
- ProteinModelPortal:   B5E7Q3
- GeneID:   6782826
- GenomeReviews:   CP001124_GR
- KEGG:   gbm:Gbem_0008
- HOGENOM:   HBG586392
- OMA:   NVAKGIE
- ProtClustDB:   PRK00094
- HAMAP:   MF_00394
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR006168
- InterPro:   IPR006109
- InterPro:   IPR011128
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR11728
- PIRSF:   PIRSF000114
- PRINTS:   PR00077

Pfam domain/function: PF07479 NAD_Gly3P_dh_C; PF01210 NAD_Gly3P_dh_N; SSF48179 6DGDH_C_like

EC number: =1.1.1.94

Molecular weight: Translated: 36012; Mature: 35881

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00957 NAD_G3PDH

Important sites: ACT_SITE 193-193 BINDING 107-107 BINDING 107-107 BINDING 142-142 BINDING 257-257 BINDING 283-283

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEKIAVIGAGSWGTTLADLLAKKGHEVTLWAYEPELVLEMRDNRENSLFLPGIKLNERL
CCCEEEEEECCCHHHHHHHHHHHCCCEEEEEEECCEEEEEECCCCCCCEEECCCCCCCCH
AFTNDLAEAYRGCSMVLCVVPSQLVRRVMTNSLPFLPKEAIIVSASKGIEVDTLATVSEI
HHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHH
YQEILPPEQFQVLAALSGPSFAREVALEMPTAVTAAASSEAVARRVQEAFTTDYFRVYRN
HHHHCCCHHHHHHHHHCCCHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
SDVVGVELGGAIKNVIAIAAGISDGLGFGSNTRAALITRGLAEMTRLGVAMGAQPSTFAG
CCEEEEECCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LAGMGDLVLTCTGDLSRNRSVGIQIGQGRTLSEILGEMRMVAEGVKTTESAYNLAKKLGV
HCCCCCEEEEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EMPIIEQMYQMLYQNKSAREAVLELMTRNLKAEGV
CCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AEKIAVIGAGSWGTTLADLLAKKGHEVTLWAYEPELVLEMRDNRENSLFLPGIKLNERL
CCEEEEEECCCHHHHHHHHHHHCCCEEEEEEECCEEEEEECCCCCCCEEECCCCCCCCH
AFTNDLAEAYRGCSMVLCVVPSQLVRRVMTNSLPFLPKEAIIVSASKGIEVDTLATVSEI
HHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHH
YQEILPPEQFQVLAALSGPSFAREVALEMPTAVTAAASSEAVARRVQEAFTTDYFRVYRN
HHHHCCCHHHHHHHHHCCCHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
SDVVGVELGGAIKNVIAIAAGISDGLGFGSNTRAALITRGLAEMTRLGVAMGAQPSTFAG
CCEEEEECCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LAGMGDLVLTCTGDLSRNRSVGIQIGQGRTLSEILGEMRMVAEGVKTTESAYNLAKKLGV
HCCCCCEEEEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EMPIIEQMYQMLYQNKSAREAVLELMTRNLKAEGV
CCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA