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The map label for this gene is acdA [H]

Identifier: 197106236

GI number: 197106236

Start: 3184179

End: 3185279

Strand: Direct

Name: acdA [H]

Synonym: PHZ_c2775

Alternate gene names: 197106236

Gene position: 3184179-3185279 (Clockwise)

Preceding gene: 197106235

Following gene: 197106237

Centisome position: 79.68

GC content: 69.48

Gene sequence:

>1101_bases
ATGGCCGTTCTGACCGAAGAACAGAACATGCTGCGCGATGCGGCGAAGAGCTGGGTGCAGGAGAAGAGCCCGGTCACCGC
CTTCCGCAAGATGCGCGATAGCGGCGCCGAGCTGGGCTACGAGGTCGCCGCCTGGAACGAGATGGCCGAGATGGGCTGGG
CCGGGGTGATCGTCCCCGAGGAATACGGCGGCTCGGCCTTCGGCTACCTCTCGATGGGCCTGATCCTGGAGGAGACCGGC
CGCACCCTCACCGCCTCGCCGCTGCTGGCCTCGGCCCTGGGCGCGGCCTCGGCCCTGATCCTGGGCGGCTCGGACGAACA
GAAGTCCGAATGGCTGCCGAAGATCGCGGCCGGCGAGGTCGTGGCGACCCTGGCCATCGACGAGGGCGCGCACCACCATC
CCGAAAAGGCCGAGGCGAAGGTCTCGGGCGGCAAGCTGACGGGCAAGAAGACCTTCGTGCTGGAAGGCATGGCCGCCGAC
CTGTTCGTGGTCTCTGCCCAAGGGGACGGGGTCGGGGACGGGGGCGTCGGCCTCTATCTCGTGAAGGCGAGCGATCCGGG
CGTGAAGCGCCAGCGGCTGTCGCTGGCCGACAGCCGCGGCGCGGCCAACGTCACCTTCGACGGCGCGGCGGCCGAGCCGC
TGTCGGGCGGCTTCGAAACCCTCGAGAAGACCCTCGACCGCGCCCGCGCCGGGATCTGCGCCGAGATGCTGGGCGCGGCG
ACCCAGGCCTTCGAGACCACCCTCGACTACCTGAAGACCCGCGTGCAGTTCGGCCAGGTGATCGGCAGCTTCCAGGCGCT
GCAGCACCGCGCGGCCAAGATGTTCACCGAGCTGGAGCTGTCGCGCTCCACCGTCGAGGCGGCGCTGACCGCCATCGACA
ACGACAGCCCCGACGTGCCCGAGCTGGTGTCGCTGGCCAAGGCCAAGATGGGCGACACCTTCCACCTCGTCTCGAACGAG
ATGGTCCAGATGCACGGCGGCATCGGCATGACCGACGCCCACGAGGCCGGCTTCTACCTCAAGCGCGCCCGCGCCTGCGA
AGCGGCCTTCGGCAACCAAGCCTACCACCGCGACCGGTACGCGAAGATCCAGGGGTACTAG

Upstream 100 bases:

>100_bases
AAGCCGAACGGGCCGCGAAGGCCGCTTGGGTCCCCCGGATCGCCGCGCGACCGGGGGATGACGACCAAACGACACACGAG
ATTTCACGAGGACAACCGAC

Downstream 100 bases:

>100_bases
ACGGCGTCGCGCCGCCTCGCTTCGCGGGCTGTTCTCGCTTCGCTCGCCCTCTCCTTAGGTCCTCTCCCTCTCGCTTCGCG
GGGGAAAGGAAGGGGGCGAT

Product: acyl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 366; Mature: 365

Protein sequence:

>366_residues
MAVLTEEQNMLRDAAKSWVQEKSPVTAFRKMRDSGAELGYEVAAWNEMAEMGWAGVIVPEEYGGSAFGYLSMGLILEETG
RTLTASPLLASALGAASALILGGSDEQKSEWLPKIAAGEVVATLAIDEGAHHHPEKAEAKVSGGKLTGKKTFVLEGMAAD
LFVVSAQGDGVGDGGVGLYLVKASDPGVKRQRLSLADSRGAANVTFDGAAAEPLSGGFETLEKTLDRARAGICAEMLGAA
TQAFETTLDYLKTRVQFGQVIGSFQALQHRAAKMFTELELSRSTVEAALTAIDNDSPDVPELVSLAKAKMGDTFHLVSNE
MVQMHGGIGMTDAHEAGFYLKRARACEAAFGNQAYHRDRYAKIQGY

Sequences:

>Translated_366_residues
MAVLTEEQNMLRDAAKSWVQEKSPVTAFRKMRDSGAELGYEVAAWNEMAEMGWAGVIVPEEYGGSAFGYLSMGLILEETG
RTLTASPLLASALGAASALILGGSDEQKSEWLPKIAAGEVVATLAIDEGAHHHPEKAEAKVSGGKLTGKKTFVLEGMAAD
LFVVSAQGDGVGDGGVGLYLVKASDPGVKRQRLSLADSRGAANVTFDGAAAEPLSGGFETLEKTLDRARAGICAEMLGAA
TQAFETTLDYLKTRVQFGQVIGSFQALQHRAAKMFTELELSRSTVEAALTAIDNDSPDVPELVSLAKAKMGDTFHLVSNE
MVQMHGGIGMTDAHEAGFYLKRARACEAAFGNQAYHRDRYAKIQGY
>Mature_365_residues
AVLTEEQNMLRDAAKSWVQEKSPVTAFRKMRDSGAELGYEVAAWNEMAEMGWAGVIVPEEYGGSAFGYLSMGLILEETGR
TLTASPLLASALGAASALILGGSDEQKSEWLPKIAAGEVVATLAIDEGAHHHPEKAEAKVSGGKLTGKKTFVLEGMAADL
FVVSAQGDGVGDGGVGLYLVKASDPGVKRQRLSLADSRGAANVTFDGAAAEPLSGGFETLEKTLDRARAGICAEMLGAAT
QAFETTLDYLKTRVQFGQVIGSFQALQHRAAKMFTELELSRSTVEAALTAIDNDSPDVPELVSLAKAKMGDTFHLVSNEM
VQMHGGIGMTDAHEAGFYLKRARACEAAFGNQAYHRDRYAKIQGY

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501859, Length=362, Percent_Identity=25.6906077348066, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI226958412, Length=378, Percent_Identity=28.5714285714286, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI7656849, Length=321, Percent_Identity=27.1028037383178, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI4557233, Length=377, Percent_Identity=26.790450928382, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI226958414, Length=337, Percent_Identity=28.7833827893175, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI4501857, Length=346, Percent_Identity=25.7225433526012, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI4503943, Length=388, Percent_Identity=27.0618556701031, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI7669494, Length=359, Percent_Identity=27.0194986072423, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI4557231, Length=375, Percent_Identity=24.5333333333333, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI187960098, Length=375, Percent_Identity=24.5333333333333, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI21361497, Length=326, Percent_Identity=26.3803680981595, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI4557235, Length=363, Percent_Identity=25.6198347107438, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI76496475, Length=363, Percent_Identity=25.6198347107438, Blast_Score=72, Evalue=6e-13,
Organism=Escherichia coli, GI1786223, Length=312, Percent_Identity=25.3205128205128, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI87081958, Length=360, Percent_Identity=24.7222222222222, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17538396, Length=377, Percent_Identity=28.9124668435013, Blast_Score=114, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17508101, Length=300, Percent_Identity=29.3333333333333, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17506239, Length=335, Percent_Identity=28.6567164179104, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI71985184, Length=316, Percent_Identity=28.4810126582279, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17533517, Length=314, Percent_Identity=24.8407643312102, Blast_Score=88, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI71990804, Length=276, Percent_Identity=27.8985507246377, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17569725, Length=379, Percent_Identity=26.3852242744063, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71985192, Length=279, Percent_Identity=29.3906810035842, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17534899, Length=326, Percent_Identity=27.6073619631902, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI32563615, Length=234, Percent_Identity=28.6324786324786, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17570075, Length=326, Percent_Identity=27.3006134969325, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17534353, Length=353, Percent_Identity=24.3626062322946, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24646207, Length=382, Percent_Identity=26.9633507853403, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI21355753, Length=389, Percent_Identity=28.0205655526992, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21356377, Length=378, Percent_Identity=24.8677248677249, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24666513, Length=362, Percent_Identity=26.2430939226519, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI19920834, Length=356, Percent_Identity=26.4044943820225, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24660351, Length=380, Percent_Identity=25, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI281363737, Length=368, Percent_Identity=26.0869565217391, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 38858; Mature: 38727

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVLTEEQNMLRDAAKSWVQEKSPVTAFRKMRDSGAELGYEVAAWNEMAEMGWAGVIVPE
CCEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHCCEEHHHHHHHHHCCCCEEEEEC
EYGGSAFGYLSMGLILEETGRTLTASPLLASALGAASALILGGSDEQKSEWLPKIAAGEV
CCCCCCHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHEEEECCCCCHHHHHCCCHHCCCE
VATLAIDEGAHHHPEKAEAKVSGGKLTGKKTFVLEGMAADLFVVSAQGDGVGDGGVGLYL
EEEEEECCCCCCCCCHHCCCCCCCEECCCEEEEEECCCEEEEEEEECCCCCCCCCCEEEE
VKASDPGVKRQRLSLADSRGAANVTFDGAAAEPLSGGFETLEKTLDRARAGICAEMLGAA
EECCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
TQAFETTLDYLKTRVQFGQVIGSFQALQHRAAKMFTELELSRSTVEAALTAIDNDSPDVP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
ELVSLAKAKMGDTFHLVSNEMVQMHGGIGMTDAHEAGFYLKRARACEAAFGNQAYHRDRY
HHHHHHHHHCCCEEEHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCC
AKIQGY
EEECCC
>Mature Secondary Structure 
AVLTEEQNMLRDAAKSWVQEKSPVTAFRKMRDSGAELGYEVAAWNEMAEMGWAGVIVPE
CEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHCCEEHHHHHHHHHCCCCEEEEEC
EYGGSAFGYLSMGLILEETGRTLTASPLLASALGAASALILGGSDEQKSEWLPKIAAGEV
CCCCCCHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHEEEECCCCCHHHHHCCCHHCCCE
VATLAIDEGAHHHPEKAEAKVSGGKLTGKKTFVLEGMAADLFVVSAQGDGVGDGGVGLYL
EEEEEECCCCCCCCCHHCCCCCCCEECCCEEEEEECCCEEEEEEEECCCCCCCCCCEEEE
VKASDPGVKRQRLSLADSRGAANVTFDGAAAEPLSGGFETLEKTLDRARAGICAEMLGAA
EECCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
TQAFETTLDYLKTRVQFGQVIGSFQALQHRAAKMFTELELSRSTVEAALTAIDNDSPDVP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
ELVSLAKAKMGDTFHLVSNEMVQMHGGIGMTDAHEAGFYLKRARACEAAFGNQAYHRDRY
HHHHHHHHHCCCEEEHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCC
AKIQGY
EEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]