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The map label for this gene is eph [H]

Identifier: 197105739

GI number: 197105739

Start: 2579512

End: 2580471

Strand: Direct

Name: eph [H]

Synonym: PHZ_c2277

Alternate gene names: 197105739

Gene position: 2579512-2580471 (Clockwise)

Preceding gene: 197105737

Following gene: 197105740

Centisome position: 64.55

GC content: 70.0

Gene sequence:

>960_bases
ATGCCTGAGCCGAACCGCGTTCGGGTGAACGGGGTGGAGATCGGCTACTACGAAGCCGGCCCGCGGCAAGGCGTTCCCGT
CGTCCTGTGCCACGGATTTCCCGAGCTGGCCTTCTCGTGGCGGCACCAGATCAAGGCCCTGGCCGCCGCCGGCCGCTGGG
TGATCGCCCCGGACCAGCGCGGCTATGGGCTGTCGTCCAAGCCCGACGCCGTCCCCGACTACGACATGGCGCACCTGACG
GGCGACCTCGTGGGGCTGCTGGACCACCTGGGCGTGGAGAAGGCGATCTTCTGCGGCCACGACTGGGGCGGCATCGTCGT
GTGGCAGATGCCGCTGATGCACCCGGAGCGGGTGGCGGGCGTGATCGGCCTCAACACCCCGTTCCTGCCGCGCGCGCCAG
CCGATCCCATCGCCATCTTCCGGCACAGGTTCGGCCCCGACATGTACATCGTCTGGTTCCAGACCCCGGACGAGCCCGAG
GCGGTGCTGGGCGAGGACGTCGCCAAGACCATGCGCTTCTTCATGCGCCGGCCCTCGGCCCTGCGCACGGCCGCGGCCCA
GCCGGAGGGCGGCTCGTCGTTCGCCTTCCGCGACCTGCTGCGGGCCTGGGATGGGGCGGACGGCGGCGACCAGCTGCTCA
GCCCCGACGAACTCGCGGTCTTTGTCGAGACGTTCGAGGCCGGCGGCTTCTTCGGCCCGGTGAGCTGGTATCGCAACTTC
ACCCGGAACTGGGAGCGGGCCGAGGGACTTCCGGGCAGGGTCGACGGCCTGCCCTGCCTGATGATCACGGCCGAGCTCGA
TGCCGTGCTCACCCCCGAGATGGCCGAGCCGATGAAGGGCCTGGTCGGCGACCTGGAGACGCACATGGTGAAGGGCTCGG
GCCACTGGACACAGCAGGAGAAGCCGGGCGAGGTGAACGTGCTGATCCTCGACTGGCTGGACCGGCGCTTCCCGAAGTAG

Upstream 100 bases:

>100_bases
CCTACTGGCGCCGCCCGCTTCCGGGAAAGCGGTTTTGCGGCGATGCTGGCCGCAACGCCGAAAATGAGGGGGAAAAGCCG
TGTCTGCGCTCGAAACCATG

Downstream 100 bases:

>100_bases
ACTGAGGCCCATGGAACGCAACACGCCGGCGCCCGCCGTATCGTCCCCCCAGCACCGGCGCGGCCTGTTCGCCGACAACG
AGCCCTTCGCCTCGGGCTGG

Product: epoxide hydrolase

Products: glycol

Alternate protein names: NA

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MPEPNRVRVNGVEIGYYEAGPRQGVPVVLCHGFPELAFSWRHQIKALAAAGRWVIAPDQRGYGLSSKPDAVPDYDMAHLT
GDLVGLLDHLGVEKAIFCGHDWGGIVVWQMPLMHPERVAGVIGLNTPFLPRAPADPIAIFRHRFGPDMYIVWFQTPDEPE
AVLGEDVAKTMRFFMRRPSALRTAAAQPEGGSSFAFRDLLRAWDGADGGDQLLSPDELAVFVETFEAGGFFGPVSWYRNF
TRNWERAEGLPGRVDGLPCLMITAELDAVLTPEMAEPMKGLVGDLETHMVKGSGHWTQQEKPGEVNVLILDWLDRRFPK

Sequences:

>Translated_319_residues
MPEPNRVRVNGVEIGYYEAGPRQGVPVVLCHGFPELAFSWRHQIKALAAAGRWVIAPDQRGYGLSSKPDAVPDYDMAHLT
GDLVGLLDHLGVEKAIFCGHDWGGIVVWQMPLMHPERVAGVIGLNTPFLPRAPADPIAIFRHRFGPDMYIVWFQTPDEPE
AVLGEDVAKTMRFFMRRPSALRTAAAQPEGGSSFAFRDLLRAWDGADGGDQLLSPDELAVFVETFEAGGFFGPVSWYRNF
TRNWERAEGLPGRVDGLPCLMITAELDAVLTPEMAEPMKGLVGDLETHMVKGSGHWTQQEKPGEVNVLILDWLDRRFPK
>Mature_318_residues
PEPNRVRVNGVEIGYYEAGPRQGVPVVLCHGFPELAFSWRHQIKALAAAGRWVIAPDQRGYGLSSKPDAVPDYDMAHLTG
DLVGLLDHLGVEKAIFCGHDWGGIVVWQMPLMHPERVAGVIGLNTPFLPRAPADPIAIFRHRFGPDMYIVWFQTPDEPEA
VLGEDVAKTMRFFMRRPSALRTAAAQPEGGSSFAFRDLLRAWDGADGGDQLLSPDELAVFVETFEAGGFFGPVSWYRNFT
RNWERAEGLPGRVDGLPCLMITAELDAVLTPEMAEPMKGLVGDLETHMVKGSGHWTQQEKPGEVNVLILDWLDRRFPK

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily. Epoxide hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI27597073, Length=312, Percent_Identity=40.3846153846154, Blast_Score=224, Evalue=9e-59,
Organism=Homo sapiens, GI218777837, Length=314, Percent_Identity=28.6624203821656, Blast_Score=128, Evalue=5e-30,
Organism=Homo sapiens, GI218777840, Length=311, Percent_Identity=27.3311897106109, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI13376164, Length=311, Percent_Identity=27.3311897106109, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17554012, Length=309, Percent_Identity=28.4789644012945, Blast_Score=134, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI17562298, Length=310, Percent_Identity=25.8064516129032, Blast_Score=132, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR000639 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: 3.3.2.3

Molecular weight: Translated: 35399; Mature: 35268

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEPNRVRVNGVEIGYYEAGPRQGVPVVLCHGFPELAFSWRHQIKALAAAGRWVIAPDQR
CCCCCEEEEEEEEEEEEECCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCEEECCCCC
GYGLSSKPDAVPDYDMAHLTGDLVGLLDHLGVEKAIFCGHDWGGIVVWQMPLMHPERVAG
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCCHHHHHE
VIGLNTPFLPRAPADPIAIFRHRFGPDMYIVWFQTPDEPEAVLGEDVAKTMRFFMRRPSA
EEECCCCCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCHH
LRTAAAQPEGGSSFAFRDLLRAWDGADGGDQLLSPDELAVFVETFEAGGFFGPVSWYRNF
HHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHEEEEEEHHCCCCCCHHHHHHHH
TRNWERAEGLPGRVDGLPCLMITAELDAVLTPEMAEPMKGLVGDLETHMVKGSGHWTQQE
HCCHHHHCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHEEEECCCCCCCCC
KPGEVNVLILDWLDRRFPK
CCCCEEEEEEEHHHHCCCC
>Mature Secondary Structure 
PEPNRVRVNGVEIGYYEAGPRQGVPVVLCHGFPELAFSWRHQIKALAAAGRWVIAPDQR
CCCCEEEEEEEEEEEEECCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCEEECCCCC
GYGLSSKPDAVPDYDMAHLTGDLVGLLDHLGVEKAIFCGHDWGGIVVWQMPLMHPERVAG
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCCHHHHHE
VIGLNTPFLPRAPADPIAIFRHRFGPDMYIVWFQTPDEPEAVLGEDVAKTMRFFMRRPSA
EEECCCCCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCHH
LRTAAAQPEGGSSFAFRDLLRAWDGADGGDQLLSPDELAVFVETFEAGGFFGPVSWYRNF
HHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHEEEEEEHHCCCCCCHHHHHHHH
TRNWERAEGLPGRVDGLPCLMITAELDAVLTPEMAEPMKGLVGDLETHMVKGSGHWTQQE
HCCHHHHCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHEEEECCCCCCCCC
KPGEVNVLILDWLDRRFPK
CCCCEEEEEEEHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O; epoxide

Specific reaction: H2O + an epoxide = a glycol

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]