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The map label for this gene is nat [H]

Identifier: 197105331

GI number: 197105331

Start: 2096120

End: 2096923

Strand: Reverse

Name: nat [H]

Synonym: PHZ_c1868

Alternate gene names: 197105331

Gene position: 2096923-2096120 (Counterclockwise)

Preceding gene: 197105332

Following gene: 197105330

Centisome position: 52.47

GC content: 72.64

Gene sequence:

>804_bases
ATGGTCGACCTCGACGCCTACTTCGCCCGCATCGGCTACGCCGGCTCTCGCGAGCCGACGCTTCAGACCCTGCGCGAGCT
GCACGCCCTGCATCCCGCGGCTATCCCGTTCGAGGCTGTCGACTGCCTGCTGGACCGCGGGATCGACATCTCGCCCCAGG
CCGTGGACGCCAAGCTGATCCACGCCCGCCGGGGCGGCTACTGCTTCGAGCACAACGGCCTCTTCCGGCGGGTCCTGGCG
GCCCTCGGCTACGAGGTGGAGGGCCTCGCGGCCCGCGTCCGCTGGAACATGCCGCCGGGCGCGCCGGACCAGCCGCGCAC
CCACATGGTCCTGAAGGTGCTGGCCGAGGGCGAGCCCTGGCTGGTGGACGTGGGCTTCGGCGGCTGCGTGCTGACGGCGC
CGCTCCGCTACGAGGCCGGCGTCGAACAGGCGACCGACCACGACCGCTACCGCCTGGCGCCGGTGGTCGAGGACCTGCGT
CTGGAGGTGCTGCGAGAGGCCGGCTGGGTCCCGGCCTACGACATCGGGCCCAGCCCCTGCGTCCCGCGCGACTACGAGAT
GGCCAACTGGTTCACCTCCACCCATCCGACCAGCCATTTCCGCCACAACCTCCTGGCCGCCCGCACGACGCCCGAGGCGC
GTTACGGGCTGCTGTTCAACCGCTTCACCGTCCGGCCGCGCGGGGGCGAGACGGCCCACGAGATCCTGGACGCCGGCGGG
ATCGAACGGGTCCTGCGCGAGGTGTTCGGCCTGCCGGTCGAACCGTCGTGGCGGCCGCTCATCGAAGCGGCCGCGGCCCG
CTGA

Upstream 100 bases:

>100_bases
CTTCCTGCACGTGGCCGTGGACGAGCGCTGGGCCGACAAGCGCGAGTTCTACGGCCCGCTGGGCCTGGACTACGACGTGT
GAGAGCCTAGCTCTCACCAG

Downstream 100 bases:

>100_bases
TGGAATTCGAGGACGACGCCTTCGTGCTGGCCGCCCGCGCCCACGGCGAGACGGGCGCCATCGTCGAGCTGCTCACCTCG
GCCCACGGCAGGTACGCCGC

Product: N-hydroxyarylamine O-acetyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MVDLDAYFARIGYAGSREPTLQTLRELHALHPAAIPFEAVDCLLDRGIDISPQAVDAKLIHARRGGYCFEHNGLFRRVLA
ALGYEVEGLAARVRWNMPPGAPDQPRTHMVLKVLAEGEPWLVDVGFGGCVLTAPLRYEAGVEQATDHDRYRLAPVVEDLR
LEVLREAGWVPAYDIGPSPCVPRDYEMANWFTSTHPTSHFRHNLLAARTTPEARYGLLFNRFTVRPRGGETAHEILDAGG
IERVLREVFGLPVEPSWRPLIEAAAAR

Sequences:

>Translated_267_residues
MVDLDAYFARIGYAGSREPTLQTLRELHALHPAAIPFEAVDCLLDRGIDISPQAVDAKLIHARRGGYCFEHNGLFRRVLA
ALGYEVEGLAARVRWNMPPGAPDQPRTHMVLKVLAEGEPWLVDVGFGGCVLTAPLRYEAGVEQATDHDRYRLAPVVEDLR
LEVLREAGWVPAYDIGPSPCVPRDYEMANWFTSTHPTSHFRHNLLAARTTPEARYGLLFNRFTVRPRGGETAHEILDAGG
IERVLREVFGLPVEPSWRPLIEAAAAR
>Mature_267_residues
MVDLDAYFARIGYAGSREPTLQTLRELHALHPAAIPFEAVDCLLDRGIDISPQAVDAKLIHARRGGYCFEHNGLFRRVLA
ALGYEVEGLAARVRWNMPPGAPDQPRTHMVLKVLAEGEPWLVDVGFGGCVLTAPLRYEAGVEQATDHDRYRLAPVVEDLR
LEVLREAGWVPAYDIGPSPCVPRDYEMANWFTSTHPTSHFRHNLLAARTTPEARYGLLFNRFTVRPRGGETAHEILDAGG
IERVLREVFGLPVEPSWRPLIEAAAAR

Specific function: Could have a role in acetylating, and hence inactivating, the antitubercular drug isoniazid [H]

COG id: COG2162

COG function: function code Q; Arylamine N-acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the arylamine N-acetyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI237649132, Length=283, Percent_Identity=24.7349823321555, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI237649130, Length=283, Percent_Identity=24.7349823321555, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI237649128, Length=282, Percent_Identity=24.822695035461, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI237649126, Length=282, Percent_Identity=24.822695035461, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI237649124, Length=282, Percent_Identity=24.822695035461, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI237649122, Length=282, Percent_Identity=24.822695035461, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI237649119, Length=282, Percent_Identity=24.822695035461, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI42741671, Length=282, Percent_Identity=24.822695035461, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI237649009, Length=282, Percent_Identity=24.822695035461, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI116295260, Length=237, Percent_Identity=24.8945147679325, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1787736, Length=253, Percent_Identity=41.897233201581, Blast_Score=174, Evalue=6e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001447 [H]

Pfam domain/function: PF00797 Acetyltransf_2 [H]

EC number: =2.3.1.5 [H]

Molecular weight: Translated: 29764; Mature: 29764

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDLDAYFARIGYAGSREPTLQTLRELHALHPAAIPFEAVDCLLDRGIDISPQAVDAKLI
CCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHH
HARRGGYCFEHNGLFRRVLAALGYEVEGLAARVRWNMPPGAPDQPRTHMVLKVLAEGEPW
HHCCCCEEEECCCHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCE
LVDVGFGGCVLTAPLRYEAGVEQATDHDRYRLAPVVEDLRLEVLREAGWVPAYDIGPSPC
EEEECCCCEEEECCHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
VPRDYEMANWFTSTHPTSHFRHNLLAARTTPEARYGLLFNRFTVRPRGGETAHEILDAGG
CCCCCHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHEEHEEEECCCCCCHHHHHHCCCC
IERVLREVFGLPVEPSWRPLIEAAAAR
HHHHHHHHHCCCCCCCHHHHHHHHCCC
>Mature Secondary Structure
MVDLDAYFARIGYAGSREPTLQTLRELHALHPAAIPFEAVDCLLDRGIDISPQAVDAKLI
CCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHH
HARRGGYCFEHNGLFRRVLAALGYEVEGLAARVRWNMPPGAPDQPRTHMVLKVLAEGEPW
HHCCCCEEEECCCHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCE
LVDVGFGGCVLTAPLRYEAGVEQATDHDRYRLAPVVEDLRLEVLREAGWVPAYDIGPSPC
EEEECCCCEEEECCHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
VPRDYEMANWFTSTHPTSHFRHNLLAARTTPEARYGLLFNRFTVRPRGGETAHEILDAGG
CCCCCHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHEEHEEEECCCCCCHHHHHHCCCC
IERVLREVFGLPVEPSWRPLIEAAAAR
HHHHHHHHHCCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]