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The map label for this gene is dxr [H]

Identifier: 197105237

GI number: 197105237

Start: 1985317

End: 1986507

Strand: Reverse

Name: dxr [H]

Synonym: PHZ_c1774

Alternate gene names: 197105237

Gene position: 1986507-1985317 (Counterclockwise)

Preceding gene: 197105238

Following gene: 197105236

Centisome position: 49.71

GC content: 70.03

Gene sequence:

>1191_bases
ATGGCATTGAATCTGCCGCGTAAGGTCAGCGTCCTGGGATCCACGGGCTCGGTGGGGGTTTCGACCCTCGACCTGTTCCA
ACAGGCCGGCGTCGAGGTCGACGTCGTCGCCCTGACCGCCGGGCGAAACGTCGAACGGCTGGCCGACCAGGCTCTGAAGT
GGCGGCCGCAAGTCGCTGTCATTCAAGATGAAAGCGCGTTGCCGAGGCTTCGAGAGCGGCTGCAGGGCTCGGGGATCGAG
GCCGCCGCCGGCGAGACGGCGGTGACCGATGTGGCGGCGGCCGACGCCCAGTGGGTGATGTCGGCCATCGTGGGGTTTGC
GGGGCTGGCCCCGACCCTGGCGGCGGCGAAGGCCGGGGCGGTGATCGCGCTGGCCAACAAGGAGAGCCTAGTCTGCGCGG
GCCCCTCCCTGCTGCGCACGGCCAAGCTCGCCGGCGGCGCCGTGGTGCCGGTCGATTCCGAGCATTCGGCGATCTTCCAG
GTGCTGGACCCGGCCGTCGCCGAACAGGTCTCGCGCCTGATCCTGACGTCCTCGGGCGGCCCGTTCCGCAATGCGAGCCG
GGACGAGATGGCCGCCGCGACGCCCGAGCGGGCGCTCAACCATCCGAACTTCTCGATGGGCGCCAAGATTTCGATCGATT
CCGCGACGATGATGAACAAGGGCCTGGAGGTCATCGAGGCCGCCTACCTTTTCTCAATGCCGCCCGAGCGGATCGAAGTC
CTGGTTCATCCCCAGCAGATCATTCACAGCCTGGTCGAGTACGCCGACGGATCGACGCTGGCCCAGCTCGGCCCGCCCGA
CATGCGCCCGCCGATCGCCTGCGCGTTCGCCTGGCCCGACCGGCTGCCCTGGCCCGCGCCCAAGCTGGACCTCGTCACGG
CCGGCCCGCTGACGTTCCAGCACCCGGACCTCGACCGGTTCCCGGCGCTGCGGATCGCCAAGGAGGCGCTGGGCGCCGGC
GGCTATGCGCCCGCGGCGATGAATGCGGCCAACGAGCGCGCGGTCTCGGCGTTCCTTGACCGCCGGATCGGCTTCCTCGA
CATCAGTGCGGTCGTCTCCGAGACGCTCGAGCGGCTGGACGGCATGGATTTCGCAGCGGACAACGGCGACGCTGTCGAAA
GCGCCAGGACGACCGACGCGCAGGCGCGTCGCGTGGCGGACGACGTCGTGAGCGGCCTGGCCCGGGCCTGA

Upstream 100 bases:

>100_bases
GCGACCTCATTCCGGGTCACGGGGGCCTGCTCGACCGCGTGGACGGCCTCATGTTCGCCGTGGTCGTGATGGCTGTGGTG
CGTCTCGCCAACATCTGGGG

Downstream 100 bases:

>100_bases
TGGAGTAGATCGCCTGATGCAGTTCCTGCAGACCGTCTTGCTCTACGTGATCCCGTTCCTGCTGGTGCTGGGCGTGGTGG
TCACGGTTCACGAGCTGGGC

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MALNLPRKVSVLGSTGSVGVSTLDLFQQAGVEVDVVALTAGRNVERLADQALKWRPQVAVIQDESALPRLRERLQGSGIE
AAAGETAVTDVAAADAQWVMSAIVGFAGLAPTLAAAKAGAVIALANKESLVCAGPSLLRTAKLAGGAVVPVDSEHSAIFQ
VLDPAVAEQVSRLILTSSGGPFRNASRDEMAAATPERALNHPNFSMGAKISIDSATMMNKGLEVIEAAYLFSMPPERIEV
LVHPQQIIHSLVEYADGSTLAQLGPPDMRPPIACAFAWPDRLPWPAPKLDLVTAGPLTFQHPDLDRFPALRIAKEALGAG
GYAPAAMNAANERAVSAFLDRRIGFLDISAVVSETLERLDGMDFAADNGDAVESARTTDAQARRVADDVVSGLARA

Sequences:

>Translated_396_residues
MALNLPRKVSVLGSTGSVGVSTLDLFQQAGVEVDVVALTAGRNVERLADQALKWRPQVAVIQDESALPRLRERLQGSGIE
AAAGETAVTDVAAADAQWVMSAIVGFAGLAPTLAAAKAGAVIALANKESLVCAGPSLLRTAKLAGGAVVPVDSEHSAIFQ
VLDPAVAEQVSRLILTSSGGPFRNASRDEMAAATPERALNHPNFSMGAKISIDSATMMNKGLEVIEAAYLFSMPPERIEV
LVHPQQIIHSLVEYADGSTLAQLGPPDMRPPIACAFAWPDRLPWPAPKLDLVTAGPLTFQHPDLDRFPALRIAKEALGAG
GYAPAAMNAANERAVSAFLDRRIGFLDISAVVSETLERLDGMDFAADNGDAVESARTTDAQARRVADDVVSGLARA
>Mature_395_residues
ALNLPRKVSVLGSTGSVGVSTLDLFQQAGVEVDVVALTAGRNVERLADQALKWRPQVAVIQDESALPRLRERLQGSGIEA
AAGETAVTDVAAADAQWVMSAIVGFAGLAPTLAAAKAGAVIALANKESLVCAGPSLLRTAKLAGGAVVPVDSEHSAIFQV
LDPAVAEQVSRLILTSSGGPFRNASRDEMAAATPERALNHPNFSMGAKISIDSATMMNKGLEVIEAAYLFSMPPERIEVL
VHPQQIIHSLVEYADGSTLAQLGPPDMRPPIACAFAWPDRLPWPAPKLDLVTAGPLTFQHPDLDRFPALRIAKEALGAGG
YAPAAMNAANERAVSAFLDRRIGFLDISAVVSETLERLDGMDFAADNGDAVESARTTDAQARRVADDVVSGLARA

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=401, Percent_Identity=47.1321695760599, Blast_Score=326, Evalue=1e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 41494; Mature: 41362

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALNLPRKVSVLGSTGSVGVSTLDLFQQAGVEVDVVALTAGRNVERLADQALKWRPQVAV
CCCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHCCCCEEE
IQDESALPRLRERLQGSGIEAAAGETAVTDVAAADAQWVMSAIVGFAGLAPTLAAAKAGA
EECCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VIALANKESLVCAGPSLLRTAKLAGGAVVPVDSEHSAIFQVLDPAVAEQVSRLILTSSGG
EEEEECCCCEEECCHHHHHHHHHCCCEEEECCCCHHHHHHHHCHHHHHHHHHHEEECCCC
PFRNASRDEMAAATPERALNHPNFSMGAKISIDSATMMNKGLEVIEAAYLFSMPPERIEV
CCCCCCHHHHHHCCHHHHCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCHHHHEE
LVHPQQIIHSLVEYADGSTLAQLGPPDMRPPIACAFAWPDRLPWPAPKLDLVTAGPLTFQ
EECHHHHHHHHHHHCCCCEEHHCCCCCCCCCEEEEEECCCCCCCCCCCEEEEECCCCEEC
HPDLDRFPALRIAKEALGAGGYAPAAMNAANERAVSAFLDRRIGFLDISAVVSETLERLD
CCCCCCCHHHHHHHHHHCCCCCCCHHHCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
GMDFAADNGDAVESARTTDAQARRVADDVVSGLARA
CCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ALNLPRKVSVLGSTGSVGVSTLDLFQQAGVEVDVVALTAGRNVERLADQALKWRPQVAV
CCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHCCCCEEE
IQDESALPRLRERLQGSGIEAAAGETAVTDVAAADAQWVMSAIVGFAGLAPTLAAAKAGA
EECCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VIALANKESLVCAGPSLLRTAKLAGGAVVPVDSEHSAIFQVLDPAVAEQVSRLILTSSGG
EEEEECCCCEEECCHHHHHHHHHCCCEEEECCCCHHHHHHHHCHHHHHHHHHHEEECCCC
PFRNASRDEMAAATPERALNHPNFSMGAKISIDSATMMNKGLEVIEAAYLFSMPPERIEV
CCCCCCHHHHHHCCHHHHCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCHHHHEE
LVHPQQIIHSLVEYADGSTLAQLGPPDMRPPIACAFAWPDRLPWPAPKLDLVTAGPLTFQ
EECHHHHHHHHHHHCCCCEEHHCCCCCCCCCEEEEEECCCCCCCCCCCEEEEECCCCEEC
HPDLDRFPALRIAKEALGAGGYAPAAMNAANERAVSAFLDRRIGFLDISAVVSETLERLD
CCCCCCCHHHHHHHHHHCCCCCCCHHHCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
GMDFAADNGDAVESARTTDAQARRVADDVVSGLARA
CCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA