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The map label for this gene is mmpA [H]

Identifier: 197105236

GI number: 197105236

Start: 1984086

End: 1985300

Strand: Reverse

Name: mmpA [H]

Synonym: PHZ_c1773

Alternate gene names: 197105236

Gene position: 1985300-1984086 (Counterclockwise)

Preceding gene: 197105237

Following gene: 197105235

Centisome position: 49.68

GC content: 69.63

Gene sequence:

>1215_bases
ATGCAGTTCCTGCAGACCGTCTTGCTCTACGTGATCCCGTTCCTGCTGGTGCTGGGCGTGGTGGTCACGGTTCACGAGCT
GGGCCACTTCCTGGCCGCCAAGTGGCTGGGCACCAAGATCGACCGCTTCTCCATCGGGTTCGGCAAGGCGCTGGCCAGCT
GGCGGGACCGGCAGGGCGTGGAGTGGCGCGTCGCCTGGCTGCCGCTCGGCGGCTACGTCCGCTTCGCCGGCGACGAGAAC
ATGGCCTCCATCCCCGACGCCGACGACCTGGCCGCGATGCGCAAGGACCTGGTGAAGCGGGAAGGGGAGGGCGCGCTCAC
CCAATACTTCCACTTCAAGCCGCTGTGGGAGCGGGCGATCATCGTCGCGGCGGGCCCGTTCGCGAACTTCGCCCTGGCGA
TCGTGATCTTCGCGGCCCTGCTGATGTCGTTCGGCGAGATGGTGCTGCCGTTCCGGGTGGCCCAGGTGAACCCCGACAGC
GCCGCCGCCGCGGCCGGCTTCCGGCCCGGCGACCTGATCGTCGAGGCCAACGGCCGGCCCGTGCGCCGCTTCGACGAGGT
GCAGCAGCTCGTCCGCGTCCGGGCCGAGGTGCCGACCCGCTTCGTGGTCGAGCGCGGCGGCGAGCGGGTGGCCCTGACGG
CGACGCCGCGCTGGGAGACCCAGACCGACGCCGTGGCCGGTGAGCAGCGCGTCGGCGTGCTGGGCCTCGTTCCGGCTCAG
CGGCCCGAGGACTTCGTCCGCGTCCGGTACGACCCGATCAAGGCCCTGGCCGGGGGCGTGCAGCGCACCTGGAACGTCCT
GGAGACCAGCGTCTACTACCTGGGGCGCATGGTGACCGGCCAGGTGGGGACCGACCAGCTGCGCGGCCCGCTGGGAATCG
CCAGCGTCACCAAGAACGTCGCCCAGCTCGGCGCCGAGAACGCCCCCTCGCTCGGCCACATGCTGATGGGCGTGGGCCTC
AACCTCGTGCAGCTCGCGGCGCTGATCTCGGTCAGCATCGGCTTCATGAACCTGCTGCCGGTGCCGGTGCTCGACGGCGG
CCACCTGCTGTTCTACGCCTACGAAGCGGTCGCAAGGCGCCCTCTTGCCGCCAAGGTTCAAGCTGCAGGGTACCGGGTGG
GCCTTGCGCTCGTCCTCGGTTTGATGTTGTTCGCGACTTGGAACGATTTGCAGCGCCTGCGTGTGTTCAATCTGTTCGGC
GGCCTATTCTCCTAG

Upstream 100 bases:

>100_bases
GACGCTGTCGAAAGCGCCAGGACGACCGACGCGCAGGCGCGTCGCGTGGCGGACGACGTCGTGAGCGGCCTGGCCCGGGC
CTGATGGAGTAGATCGCCTG

Downstream 100 bases:

>100_bases
GCCCTCGGTCTCACAAAACGGCTGATTCGATGCTCAAGACCCGCGCCCGCAGCGCCGCGCTCGCCTCCGGCCTTGCCCTG
CTTCTGGGCTCGACCGCCCT

Product: membrane-associated zinc metalloprotease

Products: NA

Alternate protein names: Membrane metalloprotease A [H]

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MQFLQTVLLYVIPFLLVLGVVVTVHELGHFLAAKWLGTKIDRFSIGFGKALASWRDRQGVEWRVAWLPLGGYVRFAGDEN
MASIPDADDLAAMRKDLVKREGEGALTQYFHFKPLWERAIIVAAGPFANFALAIVIFAALLMSFGEMVLPFRVAQVNPDS
AAAAAGFRPGDLIVEANGRPVRRFDEVQQLVRVRAEVPTRFVVERGGERVALTATPRWETQTDAVAGEQRVGVLGLVPAQ
RPEDFVRVRYDPIKALAGGVQRTWNVLETSVYYLGRMVTGQVGTDQLRGPLGIASVTKNVAQLGAENAPSLGHMLMGVGL
NLVQLAALISVSIGFMNLLPVPVLDGGHLLFYAYEAVARRPLAAKVQAAGYRVGLALVLGLMLFATWNDLQRLRVFNLFG
GLFS

Sequences:

>Translated_404_residues
MQFLQTVLLYVIPFLLVLGVVVTVHELGHFLAAKWLGTKIDRFSIGFGKALASWRDRQGVEWRVAWLPLGGYVRFAGDEN
MASIPDADDLAAMRKDLVKREGEGALTQYFHFKPLWERAIIVAAGPFANFALAIVIFAALLMSFGEMVLPFRVAQVNPDS
AAAAAGFRPGDLIVEANGRPVRRFDEVQQLVRVRAEVPTRFVVERGGERVALTATPRWETQTDAVAGEQRVGVLGLVPAQ
RPEDFVRVRYDPIKALAGGVQRTWNVLETSVYYLGRMVTGQVGTDQLRGPLGIASVTKNVAQLGAENAPSLGHMLMGVGL
NLVQLAALISVSIGFMNLLPVPVLDGGHLLFYAYEAVARRPLAAKVQAAGYRVGLALVLGLMLFATWNDLQRLRVFNLFG
GLFS
>Mature_404_residues
MQFLQTVLLYVIPFLLVLGVVVTVHELGHFLAAKWLGTKIDRFSIGFGKALASWRDRQGVEWRVAWLPLGGYVRFAGDEN
MASIPDADDLAAMRKDLVKREGEGALTQYFHFKPLWERAIIVAAGPFANFALAIVIFAALLMSFGEMVLPFRVAQVNPDS
AAAAAGFRPGDLIVEANGRPVRRFDEVQQLVRVRAEVPTRFVVERGGERVALTATPRWETQTDAVAGEQRVGVLGLVPAQ
RPEDFVRVRYDPIKALAGGVQRTWNVLETSVYYLGRMVTGQVGTDQLRGPLGIASVTKNVAQLGAENAPSLGHMLMGVGL
NLVQLAALISVSIGFMNLLPVPVLDGGHLLFYAYEAVARRPLAAKVQAAGYRVGLALVLGLMLFATWNDLQRLRVFNLFG
GLFS

Specific function: Involved in the regulated intramembrane proteolysis (RIP) of the short isoform of podJ protein (podJS), during the swarmer-to-stalked transition. The cleavage occurs near or within the single transmembrane of podJS thereby releasing the N-terminal segment

COG id: COG0750

COG function: function code M; Predicted membrane-associated Zn-dependent proteases 1

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Escherichia coli, GI1786373, Length=459, Percent_Identity=29.6296296296296, Blast_Score=129, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR004387
- InterPro:   IPR008915 [H]

Pfam domain/function: PF00595 PDZ; PF02163 Peptidase_M50 [H]

EC number: NA

Molecular weight: Translated: 44152; Mature: 44152

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: PS50106 PDZ ; PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFLQTVLLYVIPFLLVLGVVVTVHELGHFLAAKWLGTKIDRFSIGFGKALASWRDRQGV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEECCHHHHHHHHHCCCCC
EWRVAWLPLGGYVRFAGDENMASIPDADDLAAMRKDLVKREGEGALTQYFHFKPLWERAI
EEEEEEEECCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHCEE
IVAAGPFANFALAIVIFAALLMSFGEMVLPFRVAQVNPDSAAAAAGFRPGDLIVEANGRP
EEEECCHHHHHHHHHHHHHHHHHHCHHHHCEEEEEECCCHHHHHCCCCCCCEEEECCCCC
VRRFDEVQQLVRVRAEVPTRFVVERGGERVALTATPRWETQTDAVAGEQRVGVLGLVPAQ
CHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEEEECCCCCCCHHHHCCCCCCCEEEECCCC
RPEDFVRVRYDPIKALAGGVQRTWNVLETSVYYLGRMVTGQVGTDQLRGPLGIASVTKNV
CCCHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHH
AQLGAENAPSLGHMLMGVGLNLVQLAALISVSIGFMNLLPVPVLDGGHLLFYAYEAVARR
HHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEECCCCCEEHHHHHHHCC
PLAAKVQAAGYRVGLALVLGLMLFATWNDLQRLRVFNLFGGLFS
CCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQFLQTVLLYVIPFLLVLGVVVTVHELGHFLAAKWLGTKIDRFSIGFGKALASWRDRQGV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEECCHHHHHHHHHCCCCC
EWRVAWLPLGGYVRFAGDENMASIPDADDLAAMRKDLVKREGEGALTQYFHFKPLWERAI
EEEEEEEECCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHCEE
IVAAGPFANFALAIVIFAALLMSFGEMVLPFRVAQVNPDSAAAAAGFRPGDLIVEANGRP
EEEECCHHHHHHHHHHHHHHHHHHCHHHHCEEEEEECCCHHHHHCCCCCCCEEEECCCCC
VRRFDEVQQLVRVRAEVPTRFVVERGGERVALTATPRWETQTDAVAGEQRVGVLGLVPAQ
CHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEEEECCCCCCCHHHHCCCCCCCEEEECCCC
RPEDFVRVRYDPIKALAGGVQRTWNVLETSVYYLGRMVTGQVGTDQLRGPLGIASVTKNV
CCCHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHH
AQLGAENAPSLGHMLMGVGLNLVQLAALISVSIGFMNLLPVPVLDGGHLLFYAYEAVARR
HHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEECCCCCEEHHHHHHHCC
PLAAKVQAAGYRVGLALVLGLMLFATWNDLQRLRVFNLFGGLFS
CCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]