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The map label for this gene is mutA [H]

Identifier: 197104562

GI number: 197104562

Start: 1245073

End: 1246494

Strand: Reverse

Name: mutA [H]

Synonym: PHZ_c1096

Alternate gene names: 197104562

Gene position: 1246494-1245073 (Counterclockwise)

Preceding gene: 197104564

Following gene: 197104561

Centisome position: 31.19

GC content: 75.88

Gene sequence:

>1422_bases
ATGTCGGACGCACGCCTCCTGGACCCTGGAATCACGCCCGCGGGCGAGGACGCCTGGCGCGCCCTGGTCGCCAAGACCCT
GGGCGAGAAGCCCTTCGAGAGCCTGCTGAAGCAGACCGCCGAGGGCCTGCCGATCCAGCCGCTCTACGCCCAGGCCCCGC
AGGGTCCGGCCTTCCCGCCCCGTCCCTTCGACGCCGAGCGGCCGTGGGACGTGCGCACGCTCACCGCCCATCCCGATCCC
GCCCGCGCCAACGCCGAGCTGCTGGCCGACCTGGAGGGCGGCGCGGCCTCGGTGACGGTGAGGATCGACCCGACCGGCCA
GGCCGGCGTCGCCGTGGGCTCGGCCGAGGGGCTCGCCCGCGCGCTCAAGGACGTGGTCGTCGAGCTGGCGCCGGTCGGCC
TCGACGCCGGCTTCCTGGGCCCCAAGGCCGCCGACTGGCTGCACGCGGTCGCCAAGTCCTCGCCGGGCGCGAAGCTGGCG
TTCAACCTCGATCCGCTGAGCGCCTTCGCCGAGGCCGGCGAGAGCCCCGGCCCGGTCCAGAGCCATCTGGTCAGCGCCGC
CACCGTCGGCGTGCGCCTCGCCCAGCCCTACCCGCACGCTCGGCTGTTCCTGGCCTCGGGCCGGGTGGTCCACGAGGCCG
GCGGCGGCGAGGCCCTCGAGGTCGCCTTCGCGGCGGCCGCGGCGGTGGCCTACGCCAAGGCGCTGGTCCGTGCGGGCCTT
CCGATGAACGAGGCGTTCGCGCGCATCGCCCTCGGCCTCTGCGTCGACGCGGACTATTTCGTCGGCATCGCCAAGCTGCG
CGCCGCCCGGGCGGTGTGGGCGCGGATCGCCACCGCCTGCGGCGCCGATCCCCTGGCGCGGATCGAGGCCCGGTCCTCGC
GCCGGATGCTGGCGGCAAGGGACGTCTACACCAACATGATCCGGCTCACCGCCGCGGGCTTCGCCGGCGCGGTCGGCGGC
GCCGATACGGTCCAGCTCGGCCATTTCACCGACGCGCTGGGCCTGCCCACCGCCTTCGCCCGCCGCGAAAGCCGCAACAC
CCAGCTCGTGCTGATGGAAGAGGCCAGCGTCGGCCGCGTCGCCGACCCCGCCGCCGGCTCGGGCTACATCGAGGCGCTGA
CCGACGAGATCGCCCGCGCCGCCTGGGCCCGGTTCCAGGCCATCGAGGCCGCCGGCGGCCTGGTCGCCGCGCTCGAGAAG
GGCGACGTCGCCCGCGAGGTCGAGGCCGCGAACGCCGCCCGCGGCGAGCTGAAGATCCTCGGCGTCAACGCCTTCCCGCC
CGCCGACGAGGCGCCCGCCCAGGTCGAGCGGCCCACGCCCGTCCCGGTGGACGCGCCCTCGCCCCGCCTGCCCGGCCCCG
ACGGCCGCTGCCCGCCGCTCAAGCCCATGCGGCTGTCCGAAAAGTACGAGGCCCTGGCATGA

Upstream 100 bases:

>100_bases
GTCCTCCCGGTCTCGGCCGGCGAGCTTAAGGCCGAATCGGGCCCCCGCGATGCCGCTGGGTGAACTTGACGCGATCGTGC
GCGGCGGCCCATCTGCCCCC

Downstream 100 bases:

>100_bases
ACACCCTCGTCTTCCTCCGGTCGTCCGCAGGGCGATCCGGGGGACCCAAGCCGCCTCGCCACAACGACGCCGTCAGCATG
GGTCGCCCGGACATGCCGGG

Product: methylmalonyl-CoA mutase, beta subunit

Products: NA

Alternate protein names: MCM-beta [H]

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MSDARLLDPGITPAGEDAWRALVAKTLGEKPFESLLKQTAEGLPIQPLYAQAPQGPAFPPRPFDAERPWDVRTLTAHPDP
ARANAELLADLEGGAASVTVRIDPTGQAGVAVGSAEGLARALKDVVVELAPVGLDAGFLGPKAADWLHAVAKSSPGAKLA
FNLDPLSAFAEAGESPGPVQSHLVSAATVGVRLAQPYPHARLFLASGRVVHEAGGGEALEVAFAAAAAVAYAKALVRAGL
PMNEAFARIALGLCVDADYFVGIAKLRAARAVWARIATACGADPLARIEARSSRRMLAARDVYTNMIRLTAAGFAGAVGG
ADTVQLGHFTDALGLPTAFARRESRNTQLVLMEEASVGRVADPAAGSGYIEALTDEIARAAWARFQAIEAAGGLVAALEK
GDVAREVEAANAARGELKILGVNAFPPADEAPAQVERPTPVPVDAPSPRLPGPDGRCPPLKPMRLSEKYEALA

Sequences:

>Translated_473_residues
MSDARLLDPGITPAGEDAWRALVAKTLGEKPFESLLKQTAEGLPIQPLYAQAPQGPAFPPRPFDAERPWDVRTLTAHPDP
ARANAELLADLEGGAASVTVRIDPTGQAGVAVGSAEGLARALKDVVVELAPVGLDAGFLGPKAADWLHAVAKSSPGAKLA
FNLDPLSAFAEAGESPGPVQSHLVSAATVGVRLAQPYPHARLFLASGRVVHEAGGGEALEVAFAAAAAVAYAKALVRAGL
PMNEAFARIALGLCVDADYFVGIAKLRAARAVWARIATACGADPLARIEARSSRRMLAARDVYTNMIRLTAAGFAGAVGG
ADTVQLGHFTDALGLPTAFARRESRNTQLVLMEEASVGRVADPAAGSGYIEALTDEIARAAWARFQAIEAAGGLVAALEK
GDVAREVEAANAARGELKILGVNAFPPADEAPAQVERPTPVPVDAPSPRLPGPDGRCPPLKPMRLSEKYEALA
>Mature_472_residues
SDARLLDPGITPAGEDAWRALVAKTLGEKPFESLLKQTAEGLPIQPLYAQAPQGPAFPPRPFDAERPWDVRTLTAHPDPA
RANAELLADLEGGAASVTVRIDPTGQAGVAVGSAEGLARALKDVVVELAPVGLDAGFLGPKAADWLHAVAKSSPGAKLAF
NLDPLSAFAEAGESPGPVQSHLVSAATVGVRLAQPYPHARLFLASGRVVHEAGGGEALEVAFAAAAAVAYAKALVRAGLP
MNEAFARIALGLCVDADYFVGIAKLRAARAVWARIATACGADPLARIEARSSRRMLAARDVYTNMIRLTAAGFAGAVGGA
DTVQLGHFTDALGLPTAFARRESRNTQLVLMEEASVGRVADPAAGSGYIEALTDEIARAAWARFQAIEAAGGLVAALEKG
DVAREVEAANAARGELKILGVNAFPPADEAPAQVERPTPVPVDAPSPRLPGPDGRCPPLKPMRLSEKYEALA

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. This conversion most likely represents an important source of building blocks for polyketide antibiotic biosynthes

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methylmalonyl-CoA mutase family [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=460, Percent_Identity=26.5217391304348, Blast_Score=147, Evalue=2e-35,
Organism=Escherichia coli, GI1789284, Length=465, Percent_Identity=30.1075268817204, Blast_Score=177, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI25144500, Length=496, Percent_Identity=27.0161290322581, Blast_Score=166, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR004608 [H]

Pfam domain/function: PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 48975; Mature: 48844

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS00583 PFKB_KINASES_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDARLLDPGITPAGEDAWRALVAKTLGEKPFESLLKQTAEGLPIQPLYAQAPQGPAFPP
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHCCCCCCCCCC
RPFDAERPWDVRTLTAHPDPARANAELLADLEGGAASVTVRIDPTGQAGVAVGSAEGLAR
CCCCCCCCCCEEEEECCCCCCCCCHHHEEECCCCCEEEEEEECCCCCCCEEECCHHHHHH
ALKDVVVELAPVGLDAGFLGPKAADWLHAVAKSSPGAKLAFNLDPLSAFAEAGESPGPVQ
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCHHHHHHHCCCCCCHHH
SHLVSAATVGVRLAQPYPHARLFLASGRVVHEAGGGEALEVAFAAAAAVAYAKALVRAGL
HHHHHHHHHCEEECCCCCCEEEEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCC
PMNEAFARIALGLCVDADYFVGIAKLRAARAVWARIATACGADPLARIEARSSRRMLAAR
CHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
DVYTNMIRLTAAGFAGAVGGADTVQLGHFTDALGLPTAFARRESRNTQLVLMEEASVGRV
HHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHCCCHHHHHHCCCCCEEEEEECCCCCCC
ADPAAGSGYIEALTDEIARAAWARFQAIEAAGGLVAALEKGDVAREVEAANAARGELKIL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHCCCHHHHHHHHCCCCCCEEEE
GVNAFPPADEAPAQVERPTPVPVDAPSPRLPGPDGRCPPLKPMRLSEKYEALA
EECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCC
>Mature Secondary Structure 
SDARLLDPGITPAGEDAWRALVAKTLGEKPFESLLKQTAEGLPIQPLYAQAPQGPAFPP
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHCCCCCCCCCC
RPFDAERPWDVRTLTAHPDPARANAELLADLEGGAASVTVRIDPTGQAGVAVGSAEGLAR
CCCCCCCCCCEEEEECCCCCCCCCHHHEEECCCCCEEEEEEECCCCCCCEEECCHHHHHH
ALKDVVVELAPVGLDAGFLGPKAADWLHAVAKSSPGAKLAFNLDPLSAFAEAGESPGPVQ
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCHHHHHHHCCCCCCHHH
SHLVSAATVGVRLAQPYPHARLFLASGRVVHEAGGGEALEVAFAAAAAVAYAKALVRAGL
HHHHHHHHHCEEECCCCCCEEEEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCC
PMNEAFARIALGLCVDADYFVGIAKLRAARAVWARIATACGADPLARIEARSSRRMLAAR
CHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
DVYTNMIRLTAAGFAGAVGGADTVQLGHFTDALGLPTAFARRESRNTQLVLMEEASVGRV
HHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHCCCHHHHHHCCCCCEEEEEECCCCCCC
ADPAAGSGYIEALTDEIARAAWARFQAIEAAGGLVAALEKGDVAREVEAANAARGELKIL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHCCCHHHHHHHHCCCCCCEEEE
GVNAFPPADEAPAQVERPTPVPVDAPSPRLPGPDGRCPPLKPMRLSEKYEALA
EECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8099072 [H]