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The map label for this gene is mutB [H]

Identifier: 197104561

GI number: 197104561

Start: 1242789

End: 1244945

Strand: Reverse

Name: mutB [H]

Synonym: PHZ_c1095

Alternate gene names: 197104561

Gene position: 1244945-1242789 (Counterclockwise)

Preceding gene: 197104562

Following gene: 197104558

Centisome position: 31.15

GC content: 70.51

Gene sequence:

>2157_bases
ATGTCCTCGTTCCCCGATTTCGCCGCCCTGCCGTTCGACGCCGAGCTTGCGTCCGCCCCGCCCGCGACCGGCGAGGCCTG
GGCCACGCCCGAGGGCATTCCCGTCAAGCCGGCCTATGACGCGTCCGACGCCCACGGCCTGACGGAGCTGTCCGGCTATC
CCGGCCTCGCGCCCTTCGTCCGGGGCCCCTACCCCACGATGTACGCGACCAATCCGTGGACCATCCGCCAGTACGCGGGC
TTCTCCACGGCCGAGGACTCCAACGCCTTCTACCGCCGCAACCTGGCGGCCGGTCAGATGGGCCTGTCCATCGCCTTCGA
CCTGGCCACCCACCGCGGCTACGATTCCGACCATCCGCGCGTGCCCGGCGACGTCGGCATGGCGGGCGTGGCCATCGATT
CCATCCTCGACATGCGCACGCTGTTCGACGGCATCCCGCTCGACAAGATGAGCGTGTCGATGACCATGAACGGCGCCGTG
CTGCCGATCATGGCGCTCTACATCGTGGCGGCCGAGGAGCAGGGCGTCCCGCACGAGAAGCTGTCGGGCACCATCCAGAA
CGACATCCTCAAGGAGTTCCTGACCCGGAACACCTACATCTACCCGCCCGGTCCCTCGATGCGGATCATCGCGGACATCT
TCGCCTACACCTCGAAGGAGATGCCGCGGTTCAACTCGATCTCGATCAGCGGCTACCACATGCAGGAAGCCGGGGCGACG
CTCGACCTGGAGCTGGCCTACACCCTGGCCGACGGCATCGAGTACGTCCGCGCCGGCGTCGCCGCCGGCATGAGCGTGGA
CCAGTTCGCCCCGCGCCTGTCGTTCTTCTGGAACGCCGGCATGAACGTCTTCATGGAGATCGCCAAGCAGCGGGCCGCGC
GCCTGCTGTGGGCCAAGCTCATGAAGCAGGAGTTCGACCCCAAGGACGCTCGCTCGCTGTCGCTTAGGGCCCACACCCAG
ACCTCGGGCTGGTCGCTGGCCGCCCAGGACGTGTTCAACAACGTCGCGCGGACGGCCATCGAGGCCATGGCCGCCACCGG
CGGCCAGACCCAGAGCCTGCACACCAACAGCCTCGACGAGGCCCTGGCCCTGCCGACCGACTTCTCGGCCCGCATCAGCC
GCAACACCCAGCTCTTCCTGCAGATCGAAAGCGGCCAGACCCGGGTGATCGATCCCTGGGGCGGCAGCTACTACGTCGAG
GCCCTGACGGCCCAGCTCGCCGAGCGCGCCCTGGCCCATATCGCCGAGGTGGAGGCGCTCGGCGGCATGGCCAAGGCGAT
CGAGGACGGCCTGCCCAAGCGGCGCATCGAGGAGGCCTCGGCCCGCACCCAGGCGCGGATCGATTCGGGCCAGCAGAGCG
TCGTCGGCGTGAACCGCTACAAGCCCGACGTCGCCGACGACATCCCGGTGCTGAAGGTCGACAACACCGCGGTCCGCACC
GCCCAGATCGCCAAGCTGAACCGGCTGAAGGCCGAGCGCGATCCCGAGGCCGTGGCCGCCGCGCTCGACGCGCTCTCGGC
CGGCGCCGCCGGCGACGGCAACCTGCTGGAGCTGTCGGTGAACGCCGCCCGCGCCAAGGCCACCGTGGGCGAGATCTCCT
ACGCGCTCGAGAAGGTGTTCGGCCGCCACAAGGCCCACGCCGACGCGGTGAAGGGCGTCTACCTGCGCGAGGCGGGCGCC
ACGCCGGCCGCCGACCGCGCCCGCGCCATGGCCGAGGCCTTCCGCCAGGCCGACGGGCGCAGGCCCCGCGTCCTGATCGC
CAAGATGGGCCAGGACGGCCACGACCGCGGCCAGAAGGTGATCGCCTCCGGCTTCGCCGACCTCGGCTTCGACGTAGACA
TCGGCGACCTCTTCCAGACCCCGGCCGAGACCGCCGCCCAGGCGGTGCGCGACGGCGTCCATGCGGTGGGCGCGAGCTCC
CTGGCCGCCGGCCACCTGACGCTCGTTCCCGAGCTGAGGGCCGAGCTGGCCAAGCTGGGCCGGCCCGACATCGTGGTCTT
CGTCGGCGGCGTCATCCCGCCCGAGGACTTCAAGGCGCTGGAGGAGATGGGCGTGGCGGCGATCTTCCCGCCCGGCACCG
TCGTGCCCGAGGCCGCCATCGAGGTCCTGGACCGCCTGAACGAACAGCTCGGCTACGCCCAGGAGGCGGCGCAGTAG

Upstream 100 bases:

>100_bases
CAGGGCGATCCGGGGGACCCAAGCCGCCTCGCCACAACGACGCCGTCAGCATGGGTCGCCCGGACATGCCGGGCGATGAC
GAACTTTGGGATCTGCGTTG

Downstream 100 bases:

>100_bases
GCGGCTACTCCGCCGCCTGCGGCGCGGCCTTCGCGGGGACGGGCCTGCGCCGCGTCTGCTTGATTAGGAACGACCAGAGG
CCGAAGCCGCCCAGGGCCGC

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM-alpha [H]

Number of amino acids: Translated: 718; Mature: 717

Protein sequence:

>718_residues
MSSFPDFAALPFDAELASAPPATGEAWATPEGIPVKPAYDASDAHGLTELSGYPGLAPFVRGPYPTMYATNPWTIRQYAG
FSTAEDSNAFYRRNLAAGQMGLSIAFDLATHRGYDSDHPRVPGDVGMAGVAIDSILDMRTLFDGIPLDKMSVSMTMNGAV
LPIMALYIVAAEEQGVPHEKLSGTIQNDILKEFLTRNTYIYPPGPSMRIIADIFAYTSKEMPRFNSISISGYHMQEAGAT
LDLELAYTLADGIEYVRAGVAAGMSVDQFAPRLSFFWNAGMNVFMEIAKQRAARLLWAKLMKQEFDPKDARSLSLRAHTQ
TSGWSLAAQDVFNNVARTAIEAMAATGGQTQSLHTNSLDEALALPTDFSARISRNTQLFLQIESGQTRVIDPWGGSYYVE
ALTAQLAERALAHIAEVEALGGMAKAIEDGLPKRRIEEASARTQARIDSGQQSVVGVNRYKPDVADDIPVLKVDNTAVRT
AQIAKLNRLKAERDPEAVAAALDALSAGAAGDGNLLELSVNAARAKATVGEISYALEKVFGRHKAHADAVKGVYLREAGA
TPAADRARAMAEAFRQADGRRPRVLIAKMGQDGHDRGQKVIASGFADLGFDVDIGDLFQTPAETAAQAVRDGVHAVGASS
LAAGHLTLVPELRAELAKLGRPDIVVFVGGVIPPEDFKALEEMGVAAIFPPGTVVPEAAIEVLDRLNEQLGYAQEAAQ

Sequences:

>Translated_718_residues
MSSFPDFAALPFDAELASAPPATGEAWATPEGIPVKPAYDASDAHGLTELSGYPGLAPFVRGPYPTMYATNPWTIRQYAG
FSTAEDSNAFYRRNLAAGQMGLSIAFDLATHRGYDSDHPRVPGDVGMAGVAIDSILDMRTLFDGIPLDKMSVSMTMNGAV
LPIMALYIVAAEEQGVPHEKLSGTIQNDILKEFLTRNTYIYPPGPSMRIIADIFAYTSKEMPRFNSISISGYHMQEAGAT
LDLELAYTLADGIEYVRAGVAAGMSVDQFAPRLSFFWNAGMNVFMEIAKQRAARLLWAKLMKQEFDPKDARSLSLRAHTQ
TSGWSLAAQDVFNNVARTAIEAMAATGGQTQSLHTNSLDEALALPTDFSARISRNTQLFLQIESGQTRVIDPWGGSYYVE
ALTAQLAERALAHIAEVEALGGMAKAIEDGLPKRRIEEASARTQARIDSGQQSVVGVNRYKPDVADDIPVLKVDNTAVRT
AQIAKLNRLKAERDPEAVAAALDALSAGAAGDGNLLELSVNAARAKATVGEISYALEKVFGRHKAHADAVKGVYLREAGA
TPAADRARAMAEAFRQADGRRPRVLIAKMGQDGHDRGQKVIASGFADLGFDVDIGDLFQTPAETAAQAVRDGVHAVGASS
LAAGHLTLVPELRAELAKLGRPDIVVFVGGVIPPEDFKALEEMGVAAIFPPGTVVPEAAIEVLDRLNEQLGYAQEAAQ
>Mature_717_residues
SSFPDFAALPFDAELASAPPATGEAWATPEGIPVKPAYDASDAHGLTELSGYPGLAPFVRGPYPTMYATNPWTIRQYAGF
STAEDSNAFYRRNLAAGQMGLSIAFDLATHRGYDSDHPRVPGDVGMAGVAIDSILDMRTLFDGIPLDKMSVSMTMNGAVL
PIMALYIVAAEEQGVPHEKLSGTIQNDILKEFLTRNTYIYPPGPSMRIIADIFAYTSKEMPRFNSISISGYHMQEAGATL
DLELAYTLADGIEYVRAGVAAGMSVDQFAPRLSFFWNAGMNVFMEIAKQRAARLLWAKLMKQEFDPKDARSLSLRAHTQT
SGWSLAAQDVFNNVARTAIEAMAATGGQTQSLHTNSLDEALALPTDFSARISRNTQLFLQIESGQTRVIDPWGGSYYVEA
LTAQLAERALAHIAEVEALGGMAKAIEDGLPKRRIEEASARTQARIDSGQQSVVGVNRYKPDVADDIPVLKVDNTAVRTA
QIAKLNRLKAERDPEAVAAALDALSAGAAGDGNLLELSVNAARAKATVGEISYALEKVFGRHKAHADAVKGVYLREAGAT
PAADRARAMAEAFRQADGRRPRVLIAKMGQDGHDRGQKVIASGFADLGFDVDIGDLFQTPAETAAQAVRDGVHAVGASSL
AAGHLTLVPELRAELAKLGRPDIVVFVGGVIPPEDFKALEEMGVAAIFPPGTVVPEAAIEVLDRLNEQLGYAQEAAQ

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. This conversion most likely represents an important source of building blocks for polyketide antibiotic biosynthes

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=691, Percent_Identity=63.5311143270622, Blast_Score=912, Evalue=0.0,
Organism=Escherichia coli, GI1789284, Length=685, Percent_Identity=61.3138686131387, Blast_Score=823, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25144500, Length=685, Percent_Identity=63.5036496350365, Blast_Score=912, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 76861; Mature: 76730

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSFPDFAALPFDAELASAPPATGEAWATPEGIPVKPAYDASDAHGLTELSGYPGLAPFV
CCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCHHH
RGPYPTMYATNPWTIRQYAGFSTAEDSNAFYRRNLAAGQMGLSIAFDLATHRGYDSDHPR
CCCCCCEEECCCEEEHHHCCCCCCCCCCHHHHHCCCCCCCCCEEEEEHHHCCCCCCCCCC
VPGDVGMAGVAIDSILDMRTLFDGIPLDKMSVSMTMNGAVLPIMALYIVAAEEQGVPHEK
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCHHH
LSGTIQNDILKEFLTRNTYIYPPGPSMRIIADIFAYTSKEMPRFNSISISGYHMQEAGAT
HCCHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHCCCCCCCCEEEECEEECCCCCE
LDLELAYTLADGIEYVRAGVAAGMSVDQFAPRLSFFWNAGMNVFMEIAKQRAARLLWAKL
EEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKQEFDPKDARSLSLRAHTQTSGWSLAAQDVFNNVARTAIEAMAATGGQTQSLHTNSLDE
HHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
ALALPTDFSARISRNTQLFLQIESGQTRVIDPWGGSYYVEALTAQLAERALAHIAEVEAL
HHCCCCCCHHHHCCCCEEEEEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GGMAKAIEDGLPKRRIEEASARTQARIDSGQQSVVGVNRYKPDVADDIPVLKVDNTAVRT
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCEEEECCCHHHH
AQIAKLNRLKAERDPEAVAAALDALSAGAAGDGNLLELSVNAARAKATVGEISYALEKVF
HHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHH
GRHKAHADAVKGVYLREAGATPAADRARAMAEAFRQADGRRPRVLIAKMGQDGHDRGQKV
HHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHH
IASGFADLGFDVDIGDLFQTPAETAAQAVRDGVHAVGASSLAAGHLTLVPELRAELAKLG
HHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHCCHHHCCCCEEECHHHHHHHHHCC
RPDIVVFVGGVIPPEDFKALEEMGVAAIFPPGTVVPEAAIEVLDRLNEQLGYAQEAAQ
CCCEEEEECCCCCCHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHCCHHHHCC
>Mature Secondary Structure 
SSFPDFAALPFDAELASAPPATGEAWATPEGIPVKPAYDASDAHGLTELSGYPGLAPFV
CCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCHHH
RGPYPTMYATNPWTIRQYAGFSTAEDSNAFYRRNLAAGQMGLSIAFDLATHRGYDSDHPR
CCCCCCEEECCCEEEHHHCCCCCCCCCCHHHHHCCCCCCCCCEEEEEHHHCCCCCCCCCC
VPGDVGMAGVAIDSILDMRTLFDGIPLDKMSVSMTMNGAVLPIMALYIVAAEEQGVPHEK
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCHHH
LSGTIQNDILKEFLTRNTYIYPPGPSMRIIADIFAYTSKEMPRFNSISISGYHMQEAGAT
HCCHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHCCCCCCCCEEEECEEECCCCCE
LDLELAYTLADGIEYVRAGVAAGMSVDQFAPRLSFFWNAGMNVFMEIAKQRAARLLWAKL
EEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKQEFDPKDARSLSLRAHTQTSGWSLAAQDVFNNVARTAIEAMAATGGQTQSLHTNSLDE
HHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
ALALPTDFSARISRNTQLFLQIESGQTRVIDPWGGSYYVEALTAQLAERALAHIAEVEAL
HHCCCCCCHHHHCCCCEEEEEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GGMAKAIEDGLPKRRIEEASARTQARIDSGQQSVVGVNRYKPDVADDIPVLKVDNTAVRT
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCEEEECCCHHHH
AQIAKLNRLKAERDPEAVAAALDALSAGAAGDGNLLELSVNAARAKATVGEISYALEKVF
HHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHH
GRHKAHADAVKGVYLREAGATPAADRARAMAEAFRQADGRRPRVLIAKMGQDGHDRGQKV
HHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHH
IASGFADLGFDVDIGDLFQTPAETAAQAVRDGVHAVGASSLAAGHLTLVPELRAELAKLG
HHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHCCHHHCCCCEEECHHHHHHHHHCC
RPDIVVFVGGVIPPEDFKALEEMGVAAIFPPGTVVPEAAIEVLDRLNEQLGYAQEAAQ
CCCEEEEECCCCCCHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8099072 [H]