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The map label for this gene is argH [H]

Identifier: 197104101

GI number: 197104101

Start: 684156

End: 685484

Strand: Reverse

Name: argH [H]

Synonym: PHZ_c0635

Alternate gene names: 197104101

Gene position: 685484-684156 (Counterclockwise)

Preceding gene: 197104103

Following gene: 197104100

Centisome position: 17.15

GC content: 70.73

Gene sequence:

>1329_bases
ATGCAGGCGATCAACGTCTCCATCGGGTTCGACAAGCGCCTTGCGGCGCAGGACCTGGCGGGGTCCCGCGCGCACGCGGC
GATGTTGCTCAAGGCGGGAGTCATTTCAAGCGAGGACGAGGCGCAGATCCAGGAGGGCCTGGCCGCCATCGAGCGCGAGA
TGGCCGAGGGGACCTTCCCCTTCCGCGACGAGTTCGAGGACATCCACATGAACGTGGAGGCCCGGCTGCGCGAGCTGATC
GGGCCCGCCGCCGGCCGGCTGCACACCGCCCGCTCGCGCAACGACCAGGTGGCGCTCGACTTCCGCATGTGGGTCCGCGA
CGCCTGCGACCGGACGATCGGGCAGCTCAGGGCTCTGCAGGGCGCCCTGCTCGCCAAGGCCGAGGCCCACGCCGACGCGA
TCATGCCCGGCTTCACCCACCTGCAGCCGGCCCAGCCGGTGACCGTCGGCCACCACCTGATGGCCTATGTGGAGATGTTC
GGCCGCGACGCCGCGCGCTTCGCCGACGCCCGGGCGCGGATGAACGAGAGCCCGCTGGGCGCCGCCGCCCTGGCCGGTTC
GCCCTTCCCGATCGACCGCCAGATGACGGCCGCCGCGCTGGGCTTCGACCGGCCCACGGCCAACTCCCTGGACAGCGTCT
CCGACCGCGACTTCGCCCTGGAGAGCCTGGCCGCCGGCTCGATCTGCGCCATCCACCTGTCGCGGCTGGCCGAGGAGATC
GTGATCTGGATGACGCCGCAGTTCGGCTTCGTGAGGCTGTCCGACGCCTTCACGACCGGCTCGTCGATCATGCCGCAGAA
GAAGAACCCCGACGCCGCCGAACTGGTCCGGGCCAAGGCCGGCCGGCTGCTCGCCAGCTTCCAGCAGCTGGCGGTGGTGA
TGAAGGGGCTGCCGCTGACCTATTCGAAGGACATGCAGGAGGACAAGGTCCCCACCTTCGAGGCCTTCGACGCGCTCGAG
CTGTCGCTGCGCGCCATGGCCGGCATGGTCGCCGACCTGCAGCCGAACGTGGCGGCGATGGCCCGGGCGGCCGGCTCGGG
CTTCTCGACCGCCACCGACCTCGCCGACTGGCTGGTGCGCGAGCTGAACCTGCCCTTCCGCGACGCCCACCACGTGACCG
GCGCGGCCGTGAAGCGGGCCGAGGAGCTGGGCCAGGAGCTTTCGCAACTTTCTCTGGACGAGCTGCAGAAGCTGGACCCC
AGGATCACGGCTTCGGTCTACGATGTGCTGACGCCCGAGGCCTCGGCGCGCAGCCGCCGCAGCTACGGCGGAACCGCGCC
CGACCAGGTGCGGGCCCAGATCAAGCGTTGGAAGGACCTCCTGGCATGA

Upstream 100 bases:

>100_bases
GCCCGGCGGGACCGCTCCGGCGGGCCAGACGCCTACGGGACAGGCGCCCACGGGACAAGCCATGTGGGGCGGTCGGTTTA
CGGACAAGCCCGCCGAATTG

Downstream 100 bases:

>100_bases
GCCGCAAAATCCAAACCGGCGCCGCGGCGCTCGTCCTGATCCTGGCCGCCGGCCTCGCCGGCTGCGGCAAGATGGGCCAG
CTGGAGCGCCCCGGCCCGCT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MQAINVSIGFDKRLAAQDLAGSRAHAAMLLKAGVISSEDEAQIQEGLAAIEREMAEGTFPFRDEFEDIHMNVEARLRELI
GPAAGRLHTARSRNDQVALDFRMWVRDACDRTIGQLRALQGALLAKAEAHADAIMPGFTHLQPAQPVTVGHHLMAYVEMF
GRDAARFADARARMNESPLGAAALAGSPFPIDRQMTAAALGFDRPTANSLDSVSDRDFALESLAAGSICAIHLSRLAEEI
VIWMTPQFGFVRLSDAFTTGSSIMPQKKNPDAAELVRAKAGRLLASFQQLAVVMKGLPLTYSKDMQEDKVPTFEAFDALE
LSLRAMAGMVADLQPNVAAMARAAGSGFSTATDLADWLVRELNLPFRDAHHVTGAAVKRAEELGQELSQLSLDELQKLDP
RITASVYDVLTPEASARSRRSYGGTAPDQVRAQIKRWKDLLA

Sequences:

>Translated_442_residues
MQAINVSIGFDKRLAAQDLAGSRAHAAMLLKAGVISSEDEAQIQEGLAAIEREMAEGTFPFRDEFEDIHMNVEARLRELI
GPAAGRLHTARSRNDQVALDFRMWVRDACDRTIGQLRALQGALLAKAEAHADAIMPGFTHLQPAQPVTVGHHLMAYVEMF
GRDAARFADARARMNESPLGAAALAGSPFPIDRQMTAAALGFDRPTANSLDSVSDRDFALESLAAGSICAIHLSRLAEEI
VIWMTPQFGFVRLSDAFTTGSSIMPQKKNPDAAELVRAKAGRLLASFQQLAVVMKGLPLTYSKDMQEDKVPTFEAFDALE
LSLRAMAGMVADLQPNVAAMARAAGSGFSTATDLADWLVRELNLPFRDAHHVTGAAVKRAEELGQELSQLSLDELQKLDP
RITASVYDVLTPEASARSRRSYGGTAPDQVRAQIKRWKDLLA
>Mature_442_residues
MQAINVSIGFDKRLAAQDLAGSRAHAAMLLKAGVISSEDEAQIQEGLAAIEREMAEGTFPFRDEFEDIHMNVEARLRELI
GPAAGRLHTARSRNDQVALDFRMWVRDACDRTIGQLRALQGALLAKAEAHADAIMPGFTHLQPAQPVTVGHHLMAYVEMF
GRDAARFADARARMNESPLGAAALAGSPFPIDRQMTAAALGFDRPTANSLDSVSDRDFALESLAAGSICAIHLSRLAEEI
VIWMTPQFGFVRLSDAFTTGSSIMPQKKNPDAAELVRAKAGRLLASFQQLAVVMKGLPLTYSKDMQEDKVPTFEAFDALE
LSLRAMAGMVADLQPNVAAMARAAGSGFSTATDLADWLVRELNLPFRDAHHVTGAAVKRAEELGQELSQLSLDELQKLDP
RITASVYDVLTPEASARSRRSYGGTAPDQVRAQIKRWKDLLA

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=441, Percent_Identity=43.7641723356009, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI68303542, Length=441, Percent_Identity=43.7641723356009, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI68303549, Length=441, Percent_Identity=41.7233560090703, Blast_Score=338, Evalue=7e-93,
Organism=Homo sapiens, GI68303547, Length=441, Percent_Identity=41.4965986394558, Blast_Score=338, Evalue=8e-93,
Organism=Escherichia coli, GI1790398, Length=429, Percent_Identity=46.1538461538462, Blast_Score=369, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6321806, Length=444, Percent_Identity=42.5675675675676, Blast_Score=358, Evalue=1e-99,
Organism=Drosophila melanogaster, GI221473854, Length=438, Percent_Identity=39.041095890411, Blast_Score=319, Evalue=2e-87,
Organism=Drosophila melanogaster, GI78706858, Length=438, Percent_Identity=39.041095890411, Blast_Score=319, Evalue=2e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 48020; Mature: 48020

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAINVSIGFDKRLAAQDLAGSRAHAAMLLKAGVISSEDEAQIQEGLAAIEREMAEGTFP
CCEEEEECCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCC
FRDEFEDIHMNVEARLRELIGPAAGRLHTARSRNDQVALDFRMWVRDACDRTIGQLRALQ
CHHCHHHHHCCHHHHHHHHHCHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHH
GALLAKAEAHADAIMPGFTHLQPAQPVTVGHHLMAYVEMFGRDAARFADARARMNESPLG
HHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCC
AAALAGSPFPIDRQMTAAALGFDRPTANSLDSVSDRDFALESLAAGSICAIHLSRLAEEI
HHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHH
VIWMTPQFGFVRLSDAFTTGSSIMPQKKNPDAAELVRAKAGRLLASFQQLAVVMKGLPLT
EEEECCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
YSKDMQEDKVPTFEAFDALELSLRAMAGMVADLQPNVAAMARAAGSGFSTATDLADWLVR
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHH
ELNLPFRDAHHVTGAAVKRAEELGQELSQLSLDELQKLDPRITASVYDVLTPEASARSRR
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHCCCHHHHHHH
SYGGTAPDQVRAQIKRWKDLLA
CCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQAINVSIGFDKRLAAQDLAGSRAHAAMLLKAGVISSEDEAQIQEGLAAIEREMAEGTFP
CCEEEEECCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCC
FRDEFEDIHMNVEARLRELIGPAAGRLHTARSRNDQVALDFRMWVRDACDRTIGQLRALQ
CHHCHHHHHCCHHHHHHHHHCHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHH
GALLAKAEAHADAIMPGFTHLQPAQPVTVGHHLMAYVEMFGRDAARFADARARMNESPLG
HHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCC
AAALAGSPFPIDRQMTAAALGFDRPTANSLDSVSDRDFALESLAAGSICAIHLSRLAEEI
HHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHH
VIWMTPQFGFVRLSDAFTTGSSIMPQKKNPDAAELVRAKAGRLLASFQQLAVVMKGLPLT
EEEECCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
YSKDMQEDKVPTFEAFDALELSLRAMAGMVADLQPNVAAMARAAGSGFSTATDLADWLVR
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHH
ELNLPFRDAHHVTGAAVKRAEELGQELSQLSLDELQKLDPRITASVYDVLTPEASARSRR
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHCCCHHHHHHH
SYGGTAPDQVRAQIKRWKDLLA
CCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]