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The map label for this gene is lysA [H]

Identifier: 197104100

GI number: 197104100

Start: 682580

End: 683848

Strand: Reverse

Name: lysA [H]

Synonym: PHZ_c0634

Alternate gene names: 197104100

Gene position: 683848-682580 (Counterclockwise)

Preceding gene: 197104101

Following gene: 197104096

Centisome position: 17.11

GC content: 72.81

Gene sequence:

>1269_bases
ATGAACCATTTCGAGCTCCGCGGGGGCGAGCTCTTCTGCGAGGACGTGCCGCTGGCGCGCATTGCGCAGGCGGTCGGCAC
GCCGGTCTACGTCTATTCGTCCGCCACGCTAGAGCGGCACTACACCGTGCTGCGCGACGCCCTCGTGGCGCACGGGGTGA
AGGATCCGCTGATCGCCTTCGCCGTGAAGGCCAACTCCAACGTCGCCGTGCTGCGCACCCTCGCGCGCCTGGGCGCCGGG
GCGGACGTCGTCTCCGAGGGCGAGGTGCGGCGGGCGCTCGCCGCGGGCGTGCCGCCCGAGCGCATCGTCTTCTCCGGCGT
CGGCAAGACCGAGGCCGAGGTGGCCTTCGCGCTGCAGGCCGGGGTGGCCGAGATCAACGTCGAATCCGAGCCCGAGCTCG
ACCTCGTCGACCGGGTCGCCCAGCGCCTGGGCGTGCGGGCGCAGATCGCCATCCGGGTGAACCCCGACGTGCAGGCCGGC
GGGCACGAGAAGATCTCAACCGGCAAGTCCGAGAACAAGTTCGGCGTCTCGTTCTCCGAGGCCGAGCGCCTCTACGCCAA
GGCCTCGAACCTGGCCGGCGTCCGCCCCGTGGGCGTGGCCTGCCACATCGGCAGCCAGATCACCGACCTTGCGCCCATGG
CCGAGGCCTTCGCCAAGATGCGCGGCCTCGTCGAGCGCCTCCAGCGCGAGGGCCTGCGGGTCGAGCGCCTGGACCTCGGC
GGCGGCCTCGGCGTGCCCTACTTCAACCAGCCCGAACCGCCGTCCCCCGACGACTACGCCGCCATGATCGCCGAGACGGT
GGGCGGTCTGGACGTCGGCCTCGCCTTCGAGCCCGGGCGGATGATCGCCGCCAACGCCGGCGTGCTGATCGCCGGCGTGA
CCCACGTCCACGAGCGGCCCGAGGGGCGGCGCTTCCTGGTGCTCGACGCGGCCATGAACGACCTGATCCGGCCGGCCATG
TACGACGCCTACCACGACATCCGGGCGGTGCGGCCGCGCGAGGGCGAGGCGCGTCCCTACGACGTGGTGGGCCCGGTCTG
CGAGACCGGCGACACCTTCACCCGCGACCGGGCCCTGCCGCCGCTGGAGCCGGGCGACCTCGTGGCGTTCATGACCGCCG
GGGCCTACGGGGCGGCGATGGCCAGCGAGTACAACTCGCGCCTGCTGGTCCCCGAAGTGCTGGTGAAGGGCGCCGAGTTC
GCCGTGGTCCGCCCGCGGCCGACCTATGACGACATGCTGGCGCGCGAGCGGCCCGCGCCCTGGCTGTGA

Upstream 100 bases:

>100_bases
CGGCGCCGCCGCGCACCCTGCCGATCGAGGGCACCTCGCCGAACCCCGGCCGCACCGCGCCCCAGGGCGCCCTGCCCGAC
CCGTACGCCAACCCGCGCCG

Downstream 100 bases:

>100_bases
GGCGCCGTCACAGGTCCCCTTTCAAAGGTCGAGGTGCATGAACTGGCTGAAGGCGTTCGGCCGGTAGTCGGCGAACGCCT
CGCCCGGCGCGAAGCCGCGC

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MNHFELRGGELFCEDVPLARIAQAVGTPVYVYSSATLERHYTVLRDALVAHGVKDPLIAFAVKANSNVAVLRTLARLGAG
ADVVSEGEVRRALAAGVPPERIVFSGVGKTEAEVAFALQAGVAEINVESEPELDLVDRVAQRLGVRAQIAIRVNPDVQAG
GHEKISTGKSENKFGVSFSEAERLYAKASNLAGVRPVGVACHIGSQITDLAPMAEAFAKMRGLVERLQREGLRVERLDLG
GGLGVPYFNQPEPPSPDDYAAMIAETVGGLDVGLAFEPGRMIAANAGVLIAGVTHVHERPEGRRFLVLDAAMNDLIRPAM
YDAYHDIRAVRPREGEARPYDVVGPVCETGDTFTRDRALPPLEPGDLVAFMTAGAYGAAMASEYNSRLLVPEVLVKGAEF
AVVRPRPTYDDMLARERPAPWL

Sequences:

>Translated_422_residues
MNHFELRGGELFCEDVPLARIAQAVGTPVYVYSSATLERHYTVLRDALVAHGVKDPLIAFAVKANSNVAVLRTLARLGAG
ADVVSEGEVRRALAAGVPPERIVFSGVGKTEAEVAFALQAGVAEINVESEPELDLVDRVAQRLGVRAQIAIRVNPDVQAG
GHEKISTGKSENKFGVSFSEAERLYAKASNLAGVRPVGVACHIGSQITDLAPMAEAFAKMRGLVERLQREGLRVERLDLG
GGLGVPYFNQPEPPSPDDYAAMIAETVGGLDVGLAFEPGRMIAANAGVLIAGVTHVHERPEGRRFLVLDAAMNDLIRPAM
YDAYHDIRAVRPREGEARPYDVVGPVCETGDTFTRDRALPPLEPGDLVAFMTAGAYGAAMASEYNSRLLVPEVLVKGAEF
AVVRPRPTYDDMLARERPAPWL
>Mature_422_residues
MNHFELRGGELFCEDVPLARIAQAVGTPVYVYSSATLERHYTVLRDALVAHGVKDPLIAFAVKANSNVAVLRTLARLGAG
ADVVSEGEVRRALAAGVPPERIVFSGVGKTEAEVAFALQAGVAEINVESEPELDLVDRVAQRLGVRAQIAIRVNPDVQAG
GHEKISTGKSENKFGVSFSEAERLYAKASNLAGVRPVGVACHIGSQITDLAPMAEAFAKMRGLVERLQREGLRVERLDLG
GGLGVPYFNQPEPPSPDDYAAMIAETVGGLDVGLAFEPGRMIAANAGVLIAGVTHVHERPEGRRFLVLDAAMNDLIRPAM
YDAYHDIRAVRPREGEARPYDVVGPVCETGDTFTRDRALPPLEPGDLVAFMTAGAYGAAMASEYNSRLLVPEVLVKGAEF
AVVRPRPTYDDMLARERPAPWL

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=354, Percent_Identity=25.9887005649718, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI16506287, Length=350, Percent_Identity=25.4285714285714, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI22538418, Length=348, Percent_Identity=25.8620689655172, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI21361583, Length=348, Percent_Identity=25.8620689655172, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1789203, Length=430, Percent_Identity=33.4883720930233, Blast_Score=183, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17562780, Length=341, Percent_Identity=23.7536656891496, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6322664, Length=352, Percent_Identity=24.4318181818182, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45323; Mature: 45323

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHFELRGGELFCEDVPLARIAQAVGTPVYVYSSATLERHYTVLRDALVAHGVKDPLIAF
CCCCCCCCCEEEECCCCHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCEEEE
AVKANSNVAVLRTLARLGAGADVVSEGEVRRALAAGVPPERIVFSGVGKTEAEVAFALQA
EEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHEEEECCCCCHHHHHHHHHC
GVAEINVESEPELDLVDRVAQRLGVRAQIAIRVNPDVQAGGHEKISTGKSENKFGVSFSE
CCEEEECCCCCCHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHH
AERLYAKASNLAGVRPVGVACHIGSQITDLAPMAEAFAKMRGLVERLQREGLRVERLDLG
HHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
GGLGVPYFNQPEPPSPDDYAAMIAETVGGLDVGLAFEPGRMIAANAGVLIAGVTHVHERP
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCEEEECCCEEEEEHHHHHCCC
EGRRFLVLDAAMNDLIRPAMYDAYHDIRAVRPREGEARPYDVVGPVCETGDTFTRDRALP
CCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCCCCCHHCCCCC
PLEPGDLVAFMTAGAYGAAMASEYNSRLLVPEVLVKGAEFAVVRPRPTYDDMLARERPAP
CCCCCCEEEEEECCCHHHHHHHHHCCEEEHHHHHHCCCCEEEECCCCCHHHHHHHCCCCC
WL
CC
>Mature Secondary Structure
MNHFELRGGELFCEDVPLARIAQAVGTPVYVYSSATLERHYTVLRDALVAHGVKDPLIAF
CCCCCCCCCEEEECCCCHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCEEEE
AVKANSNVAVLRTLARLGAGADVVSEGEVRRALAAGVPPERIVFSGVGKTEAEVAFALQA
EEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHEEEECCCCCHHHHHHHHHC
GVAEINVESEPELDLVDRVAQRLGVRAQIAIRVNPDVQAGGHEKISTGKSENKFGVSFSE
CCEEEECCCCCCHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHH
AERLYAKASNLAGVRPVGVACHIGSQITDLAPMAEAFAKMRGLVERLQREGLRVERLDLG
HHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
GGLGVPYFNQPEPPSPDDYAAMIAETVGGLDVGLAFEPGRMIAANAGVLIAGVTHVHERP
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCEEEECCCEEEEEHHHHHCCC
EGRRFLVLDAAMNDLIRPAMYDAYHDIRAVRPREGEARPYDVVGPVCETGDTFTRDRALP
CCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCCCCCHHCCCCC
PLEPGDLVAFMTAGAYGAAMASEYNSRLLVPEVLVKGAEFAVVRPRPTYDDMLARERPAP
CCCCCCEEEEEECCCHHHHHHHHHCCEEEHHHHHHCCCCEEEECCCCCHHHHHHHCCCCC
WL
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA