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The map label for this gene is deoA [C]

Identifier: 197103927

GI number: 197103927

Start: 476349

End: 477785

Strand: Direct

Name: deoA [C]

Synonym: PHZ_c0461

Alternate gene names: 197103927

Gene position: 476349-477785 (Clockwise)

Preceding gene: 197103926

Following gene: 197103928

Centisome position: 11.92

GC content: 73.56

Gene sequence:

>1437_bases
GTGATCCTGCCGCGGTCGAGCCCGGCCGTGCGGCCGGAGCGGCTGGCGGGCGTGCGCAAGGTCGAGGTGCGGGCCGGCGA
GGTGACCATCCTCGCCACGCCGATGATCTCGGAGGACGGCCTGCTGCAGCCTGGCGAGCTGGGCCTGCCGCAACCGGCGT
TCCGGCGCCTGGGCGTGCGGCCCGGCGATCCGGTGCACGTCGCGCCCGCCCGCTCGCCGCGCACCCTCGAGGCGGTCCGG
GCGAAGATCGCCGGCGCCAGCCTGACGCCGGACGACTACGAGGCCATCACCGGGGACCTGGCGGCGCACCGCTGGTCCGA
CATGGAGATCGCCGCCTTCCTCGTGGCCTGCGCCGCGTTCATGACGCCGGAGGAGGTGCTGTCGCTGACCAAAGCGATGG
TGACAGCCGGCCGGCGGCTGAGCTGGAACCGCGACCTGGTGGTGGACAAGCACTGCATCGGCGGCATCCCCGGCAACCGC
ACGACGCTGATCGTCACGCCCATCGTGGCGGCGCACGGCCTGACCATGCCCAAGACCTCGTCGCGGGCCATCACCTCGCC
CGCGGGGACCGCCGACACCATGGAGGTCTTCGCCCGGGTCGACCTCAGCGAGGCCGAGATGCGGCAGGTGGTGGAGACCT
GCGGGGCCTGCGTCTCGTGGGGCGGGCGGGTGAACCTGTCCCCCGCCGACGACGTGCTGATCTCGGTGGAGCGCCCGCTG
TCCATCGACACGCCCGAGCAGATGGTCGCCTCGATCGTCTCGAAGAAGCTGGCGGCGGGCTCGACCCACCTCGTGCTCGA
CGTGCCGGTCGGTCCCACGGCCAAGGTCCGCGACAGGCGCCAGGCGCTGCGGCTGAAGAAGCTGTTCGAATACGTCGCCG
ACGGGACCGGGCTGTCCATCGAGGTGCTGCTGACCGACGCTATCGAGCCGATCGGCCGCGGCGTCGGCCCGGTGCTGGAG
GCGCGCGACGTCACCGCCGTGCTGGAGAACCGCGCCGACGCGCCCGAGGACCTGAGGGAGAAGTCGATCCGGCTGGCCGG
CCGGGTGCTGGAGGTGGATCCCGCCCTGCGCGGCGGGGCCGGCGAGCGCCGGGCGCGCGAGCTGCTGGAGAGCGGGGCGG
CGGCCGAGAAGATGGCCCAGATCTGCGAAGCCCAGGGCGCCTCGCCGCTGAAGAACGCCACCGGCGACCTGATCCACGAG
GTGCGGGCGGCCGGCTCGGGCCGGGTGGCCGCCATCGACTGCCTGCGGATCGCCACCATCGCCCGGCTGGCGGGCGCCCC
GACGGATCCCGGCGCGGGGCTGGAGCTGCTGCGCAAGACCGGCGAGACGGTGCGCACGGGCGAGCCGCTCTACCGGATCT
ACGGCTCGGAGATCTCGGACTTCGGCTTCGCCTGCGAGGCCACGGGCGAGGACCCCGGCGTGCGGATCGAATCATGA

Upstream 100 bases:

>100_bases
GCCTGCGGCCCCTCCCGTCCGTGAGCCGGAAGCCCGCCTGGGCCCCGCCGCGCCGCTGACCGCGCGGCCGGTGGCCCTCA
ACACCTTCCGCGAGAACGTG

Downstream 100 bases:

>100_bases
GGCTCGTCGTCCACGCCTTCGCCGACGAGGAGGCGCCGGCCAGCCGCCTGGCCGCGGCCCTGGGCGTCCCTCTCAGGCTG
GTGGACGTCCACGCCTTCCC

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase [H]

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MILPRSSPAVRPERLAGVRKVEVRAGEVTILATPMISEDGLLQPGELGLPQPAFRRLGVRPGDPVHVAPARSPRTLEAVR
AKIAGASLTPDDYEAITGDLAAHRWSDMEIAAFLVACAAFMTPEEVLSLTKAMVTAGRRLSWNRDLVVDKHCIGGIPGNR
TTLIVTPIVAAHGLTMPKTSSRAITSPAGTADTMEVFARVDLSEAEMRQVVETCGACVSWGGRVNLSPADDVLISVERPL
SIDTPEQMVASIVSKKLAAGSTHLVLDVPVGPTAKVRDRRQALRLKKLFEYVADGTGLSIEVLLTDAIEPIGRGVGPVLE
ARDVTAVLENRADAPEDLREKSIRLAGRVLEVDPALRGGAGERRARELLESGAAAEKMAQICEAQGASPLKNATGDLIHE
VRAAGSGRVAAIDCLRIATIARLAGAPTDPGAGLELLRKTGETVRTGEPLYRIYGSEISDFGFACEATGEDPGVRIES

Sequences:

>Translated_478_residues
MILPRSSPAVRPERLAGVRKVEVRAGEVTILATPMISEDGLLQPGELGLPQPAFRRLGVRPGDPVHVAPARSPRTLEAVR
AKIAGASLTPDDYEAITGDLAAHRWSDMEIAAFLVACAAFMTPEEVLSLTKAMVTAGRRLSWNRDLVVDKHCIGGIPGNR
TTLIVTPIVAAHGLTMPKTSSRAITSPAGTADTMEVFARVDLSEAEMRQVVETCGACVSWGGRVNLSPADDVLISVERPL
SIDTPEQMVASIVSKKLAAGSTHLVLDVPVGPTAKVRDRRQALRLKKLFEYVADGTGLSIEVLLTDAIEPIGRGVGPVLE
ARDVTAVLENRADAPEDLREKSIRLAGRVLEVDPALRGGAGERRARELLESGAAAEKMAQICEAQGASPLKNATGDLIHE
VRAAGSGRVAAIDCLRIATIARLAGAPTDPGAGLELLRKTGETVRTGEPLYRIYGSEISDFGFACEATGEDPGVRIES
>Mature_478_residues
MILPRSSPAVRPERLAGVRKVEVRAGEVTILATPMISEDGLLQPGELGLPQPAFRRLGVRPGDPVHVAPARSPRTLEAVR
AKIAGASLTPDDYEAITGDLAAHRWSDMEIAAFLVACAAFMTPEEVLSLTKAMVTAGRRLSWNRDLVVDKHCIGGIPGNR
TTLIVTPIVAAHGLTMPKTSSRAITSPAGTADTMEVFARVDLSEAEMRQVVETCGACVSWGGRVNLSPADDVLISVERPL
SIDTPEQMVASIVSKKLAAGSTHLVLDVPVGPTAKVRDRRQALRLKKLFEYVADGTGLSIEVLLTDAIEPIGRGVGPVLE
ARDVTAVLENRADAPEDLREKSIRLAGRVLEVDPALRGGAGERRARELLESGAAAEKMAQICEAQGASPLKNATGDLIHE
VRAAGSGRVAAIDCLRIATIARLAGAPTDPGAGLELLRKTGETVRTGEPLYRIYGSEISDFGFACEATGEDPGVRIES

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=421, Percent_Identity=29.9287410926366, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI4503445, Length=421, Percent_Identity=29.9287410926366, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI166158922, Length=421, Percent_Identity=29.9287410926366, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI1790842, Length=411, Percent_Identity=27.9805352798054, Blast_Score=100, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013466 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.4 [H]

Molecular weight: Translated: 50615; Mature: 50615

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILPRSSPAVRPERLAGVRKVEVRAGEVTILATPMISEDGLLQPGELGLPQPAFRRLGVR
CCCCCCCCCCCHHHHCCCEEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHCCCC
PGDPVHVAPARSPRTLEAVRAKIAGASLTPDDYEAITGDLAAHRWSDMEIAAFLVACAAF
CCCCEEECCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
MTPEEVLSLTKAMVTAGRRLSWNRDLVVDKHCIGGIPGNRTTLIVTPIVAAHGLTMPKTS
CCHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHCCCCCCCEEEEEECHHHHCCCCCCCCC
SRAITSPAGTADTMEVFARVDLSEAEMRQVVETCGACVSWGGRVNLSPADDVLISVERPL
CCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEEECCCC
SIDTPEQMVASIVSKKLAAGSTHLVLDVPVGPTAKVRDRRQALRLKKLFEYVADGTGLSI
CCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEE
EVLLTDAIEPIGRGVGPVLEARDVTAVLENRADAPEDLREKSIRLAGRVLEVDPALRGGA
EEEEHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCEEEEECCCCCCCC
GERRARELLESGAAAEKMAQICEAQGASPLKNATGDLIHEVRAAGSGRVAAIDCLRIATI
CHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHH
ARLAGAPTDPGAGLELLRKTGETVRTGEPLYRIYGSEISDFGFACEATGEDPGVRIES
HHHHCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHCCCHHCCCCEEECCCCCCCCEECC
>Mature Secondary Structure
MILPRSSPAVRPERLAGVRKVEVRAGEVTILATPMISEDGLLQPGELGLPQPAFRRLGVR
CCCCCCCCCCCHHHHCCCEEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHCCCC
PGDPVHVAPARSPRTLEAVRAKIAGASLTPDDYEAITGDLAAHRWSDMEIAAFLVACAAF
CCCCEEECCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
MTPEEVLSLTKAMVTAGRRLSWNRDLVVDKHCIGGIPGNRTTLIVTPIVAAHGLTMPKTS
CCHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHCCCCCCCEEEEEECHHHHCCCCCCCCC
SRAITSPAGTADTMEVFARVDLSEAEMRQVVETCGACVSWGGRVNLSPADDVLISVERPL
CCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEEECCCC
SIDTPEQMVASIVSKKLAAGSTHLVLDVPVGPTAKVRDRRQALRLKKLFEYVADGTGLSI
CCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEE
EVLLTDAIEPIGRGVGPVLEARDVTAVLENRADAPEDLREKSIRLAGRVLEVDPALRGGA
EEEEHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCEEEEECCCCCCCC
GERRARELLESGAAAEKMAQICEAQGASPLKNATGDLIHEVRAAGSGRVAAIDCLRIATI
CHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHH
ARLAGAPTDPGAGLELLRKTGETVRTGEPLYRIYGSEISDFGFACEATGEDPGVRIES
HHHHCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHCCCHHCCCCEEECCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA