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The map label for this gene is prs [H]

Identifier: 197103928

GI number: 197103928

Start: 477782

End: 478696

Strand: Direct

Name: prs [H]

Synonym: PHZ_c0462

Alternate gene names: 197103928

Gene position: 477782-478696 (Clockwise)

Preceding gene: 197103927

Following gene: 197103931

Centisome position: 11.96

GC content: 75.63

Gene sequence:

>915_bases
ATGAGGCTCGTCGTCCACGCCTTCGCCGACGAGGAGGCGCCGGCCAGCCGCCTGGCCGCGGCCCTGGGCGTCCCTCTCAG
GCTGGTGGACGTCCACGCCTTCCCGGACGGCGAGACGCTGCCGAGGGTGCCCGAGACGGCGCCCACGGTGATCGTCTACC
GCTCGCTGGACCGGCCGAACCCCAAGCTCATGCCGCTGATGCTGGCGTGCGACGCCTGGCGGCGCGCGGGCGCCCAGCGG
CTGGTGCTGGTCGCGCCCTACCTCTGCTACATGCGCCAGGACACCGTCTTCGAGCCGGGGCAGTCGCTGAGCCGCGACGT
CATCGGGGCGCTGCTGGGCGCGCGCTTCGACCGGATCGTCACCGTCAATCCGCACCTGCACCGCACCAGCGACCTGTCGG
CCGTGTTCGGCTGCGACGCCGACGCGCTGTCGGCGGCCGAGGACCTCGCCCGCACCCTCGGCGGGGACGGCGAGCCGGTC
GTGGTCGGACCCGACGTGGAGTCCGCGCCCTGGGCCGCGGACGTGGCGGGGTTCCTGGGCGCGCCCAGCCTGACGCTGGC
CAAGCGCCGGCGGGGCGATCGGGAGGTGGAGCTCAGCGTGCCCGATCCGGCGATGGTGGCCGGCCGCCGGGCGATCCTGG
TGGACGACATCTGCTCGTCGGGCGCGACCCTGGCCCTTGCGGCCCGGCGGCTCGTCGCCGCCGGCGCGGCCTCGGTGGAG
ATCGCCGTGACCCACGCGCTGTTCGAGCCGTCGGCCGACGCCCGGCTGCGGGCGGCCGGTGTGCAGCGGATCGTCTCGAC
GGACTCCTGTCCCCATCCCACCAACGCCGTGGCCCTGGCGCCGCTGCTGGCCGTCGCCCTGGCGGGCGAGGGCGCTCAGC
CGCGCGAGGGCGTGAAGCGGGCGATCAGGTCGTAG

Upstream 100 bases:

>100_bases
GCACGGGCGAGCCGCTCTACCGGATCTACGGCTCGGAGATCTCGGACTTCGGCTTCGCCTGCGAGGCCACGGGCGAGGAC
CCCGGCGTGCGGATCGAATC

Downstream 100 bases:

>100_bases
GCCTCCCCCGGGAAGGTCAGCCGCACGTCCGTGATCCGGTCGGCGCCGCGCCAGGTGCGGCGCTCGAGCACCAGGCAGGC
GGTCCCGGCGGGGATGGCCA

Product: phosphoribosylpyrophosphate synthetase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MRLVVHAFADEEAPASRLAAALGVPLRLVDVHAFPDGETLPRVPETAPTVIVYRSLDRPNPKLMPLMLACDAWRRAGAQR
LVLVAPYLCYMRQDTVFEPGQSLSRDVIGALLGARFDRIVTVNPHLHRTSDLSAVFGCDADALSAAEDLARTLGGDGEPV
VVGPDVESAPWAADVAGFLGAPSLTLAKRRRGDREVELSVPDPAMVAGRRAILVDDICSSGATLALAARRLVAAGAASVE
IAVTHALFEPSADARLRAAGVQRIVSTDSCPHPTNAVALAPLLAVALAGEGAQPREGVKRAIRS

Sequences:

>Translated_304_residues
MRLVVHAFADEEAPASRLAAALGVPLRLVDVHAFPDGETLPRVPETAPTVIVYRSLDRPNPKLMPLMLACDAWRRAGAQR
LVLVAPYLCYMRQDTVFEPGQSLSRDVIGALLGARFDRIVTVNPHLHRTSDLSAVFGCDADALSAAEDLARTLGGDGEPV
VVGPDVESAPWAADVAGFLGAPSLTLAKRRRGDREVELSVPDPAMVAGRRAILVDDICSSGATLALAARRLVAAGAASVE
IAVTHALFEPSADARLRAAGVQRIVSTDSCPHPTNAVALAPLLAVALAGEGAQPREGVKRAIRS
>Mature_304_residues
MRLVVHAFADEEAPASRLAAALGVPLRLVDVHAFPDGETLPRVPETAPTVIVYRSLDRPNPKLMPLMLACDAWRRAGAQR
LVLVAPYLCYMRQDTVFEPGQSLSRDVIGALLGARFDRIVTVNPHLHRTSDLSAVFGCDADALSAAEDLARTLGGDGEPV
VVGPDVESAPWAADVAGFLGAPSLTLAKRRRGDREVELSVPDPAMVAGRRAILVDDICSSGATLALAARRLVAAGAASVE
IAVTHALFEPSADARLRAAGVQRIVSTDSCPHPTNAVALAPLLAVALAGEGAQPREGVKRAIRS

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI28557709, Length=266, Percent_Identity=27.8195488721804, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI84875539, Length=282, Percent_Identity=26.5957446808511, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI4506129, Length=279, Percent_Identity=26.1648745519713, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI4506127, Length=266, Percent_Identity=27.4436090225564, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1787458, Length=297, Percent_Identity=29.2929292929293, Blast_Score=92, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17554702, Length=282, Percent_Identity=24.822695035461, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI25149168, Length=294, Percent_Identity=24.4897959183673, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17554704, Length=282, Percent_Identity=24.822695035461, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71989924, Length=282, Percent_Identity=24.822695035461, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320946, Length=268, Percent_Identity=29.1044776119403, Blast_Score=83, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6319403, Length=268, Percent_Identity=28.3582089552239, Blast_Score=79, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6321776, Length=230, Percent_Identity=26.0869565217391, Blast_Score=62, Evalue=8e-11,
Organism=Drosophila melanogaster, GI21355239, Length=278, Percent_Identity=27.6978417266187, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45551540, Length=289, Percent_Identity=26.2975778546713, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 31957; Mature: 31957

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLVVHAFADEEAPASRLAAALGVPLRLVDVHAFPDGETLPRVPETAPTVIVYRSLDRPN
CEEEEEECCCCCCCHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCC
PKLMPLMLACDAWRRAGAQRLVLVAPYLCYMRQDTVFEPGQSLSRDVIGALLGARFDRIV
CCHHHHHHHHHHHHHCCCCEEEHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEE
TVNPHLHRTSDLSAVFGCDADALSAAEDLARTLGGDGEPVVVGPDVESAPWAADVAGFLG
EECCCCCCCCCCCCEECCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHC
APSLTLAKRRRGDREVELSVPDPAMVAGRRAILVDDICSSGATLALAARRLVAAGAASVE
CCCHHHHHHHCCCCEEEEECCCHHHHHCCCEEEEHHHHCCCCHHHHHHHHHHHCCCCEEE
IAVTHALFEPSADARLRAAGVQRIVSTDSCPHPTNAVALAPLLAVALAGEGAQPREGVKR
EEEEEHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHH
AIRS
HHCC
>Mature Secondary Structure
MRLVVHAFADEEAPASRLAAALGVPLRLVDVHAFPDGETLPRVPETAPTVIVYRSLDRPN
CEEEEEECCCCCCCHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCC
PKLMPLMLACDAWRRAGAQRLVLVAPYLCYMRQDTVFEPGQSLSRDVIGALLGARFDRIV
CCHHHHHHHHHHHHHCCCCEEEHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEE
TVNPHLHRTSDLSAVFGCDADALSAAEDLARTLGGDGEPVVVGPDVESAPWAADVAGFLG
EECCCCCCCCCCCCEECCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHC
APSLTLAKRRRGDREVELSVPDPAMVAGRRAILVDDICSSGATLALAARRLVAAGAASVE
CCCHHHHHHHCCCCEEEEECCCHHHHHCCCEEEEHHHHCCCCHHHHHHHHHHHCCCCEEE
IAVTHALFEPSADARLRAAGVQRIVSTDSCPHPTNAVALAPLLAVALAGEGAQPREGVKR
EEEEEHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHH
AIRS
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014 [H]