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The map label for this gene is mvaB [H]

Identifier: 197103891

GI number: 197103891

Start: 433560

End: 434489

Strand: Reverse

Name: mvaB [H]

Synonym: PHZ_c0425

Alternate gene names: 197103891

Gene position: 434489-433560 (Counterclockwise)

Preceding gene: 197103892

Following gene: 197103883

Centisome position: 10.87

GC content: 72.47

Gene sequence:

>930_bases
ATGAGCCGGCGTATCGAGATCGTGGAAGTCGGGCCCCGCGACGGGCTGCAGAACGAGAAGACCCTGCTCGAGGTCGACCA
GAAGCTCGAGATGATCCGCCGGCTCGAGGACGCCGGCGCCCGCCGCATGGAGGTGGTCTCCTTCGTCAATCCGCGCCGCG
TGCCGCAGATGGCCGGCGCCGAGGAGATCATGGCCGCCCTGAACACGCCGGGCGCCAAGCCGGCCGGCCGCTCGCGCATC
GGCCTCGTGCTGAACCAGAAGGGCTGGGAACGCTGCGTCGCCGCCGCCTGCGACGAGGCCAACGTGGTGGTCTGCGCCTC
GGACGGCTTCGGCATCCGCAACCAGGGCGCCTCGGTGGCCGAGCAGATCGACGCCCTGGGCGCGATCATGCAGGCCCGCC
GCCTGGAGGATCCGCCGGTCACGGTGACCGTCTCGGTGGCCTTCGGCTGCCCCTTCGACGGCGAGGTGCCCGAGGAGCGG
GTCGTCGACATCGTCAGGACCGCCGCCGACATGCGGGTGGCCGAGATCGCCCTGGCCGACACCATCGGCGTGGCCGACCC
CTGGACCGTCCGCCGCCGGGTCGAAGCGGCGCGCAAGGCCGCCGGCCGCATCCCGCTGCGCCTGCACTTCCACGACACCC
GCAACACGGGCCTGGCCAACGCCTACGCCGGCGTCGAGGCCGGGGTCGACATCCTGGACGCCAGCGTCGGCGGCCTGGGC
GGCTGTCCGTTCGCCCCAAACGCCACCGGCAACATCGGCACGGAAGACCTCGTCTACATGCTGGAGCGCGGCGGCTTCGA
GACCGGCTACGACCTCGACAAGCTCATCGAGATCGGCCGCTGGGTCTCCGGCCTCCTCGGCAAGCCCCCCGCCAGCTCCC
TCGCCCGCGCCGGCTCGTTCCCGGTCAAGCGCGAAGAGGCGGCGGCGTAG

Upstream 100 bases:

>100_bases
GCGAGGTGGCCCGGATCCGCGGCCTCAACTATTCCAAGGGCGACGAGGTGACCCTCGGCGTCTATGTCAGTCCCCAGACC
GTGGTGCGGGAGGTCAGGCC

Downstream 100 bases:

>100_bases
TTTCTCCGTCTCCTCTCCCCCCGCGAAGCGGAGAGGGAGAGGGCAGGGTGAGGGCCCGAGCGGAGCGAGGGATGGGGCAA
GGGTGAGGGCCCGAGCGCAG

Product: 3-hydroxy-3-methylglutarate-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MSRRIEIVEVGPRDGLQNEKTLLEVDQKLEMIRRLEDAGARRMEVVSFVNPRRVPQMAGAEEIMAALNTPGAKPAGRSRI
GLVLNQKGWERCVAAACDEANVVVCASDGFGIRNQGASVAEQIDALGAIMQARRLEDPPVTVTVSVAFGCPFDGEVPEER
VVDIVRTAADMRVAEIALADTIGVADPWTVRRRVEAARKAAGRIPLRLHFHDTRNTGLANAYAGVEAGVDILDASVGGLG
GCPFAPNATGNIGTEDLVYMLERGGFETGYDLDKLIEIGRWVSGLLGKPPASSLARAGSFPVKREEAAA

Sequences:

>Translated_309_residues
MSRRIEIVEVGPRDGLQNEKTLLEVDQKLEMIRRLEDAGARRMEVVSFVNPRRVPQMAGAEEIMAALNTPGAKPAGRSRI
GLVLNQKGWERCVAAACDEANVVVCASDGFGIRNQGASVAEQIDALGAIMQARRLEDPPVTVTVSVAFGCPFDGEVPEER
VVDIVRTAADMRVAEIALADTIGVADPWTVRRRVEAARKAAGRIPLRLHFHDTRNTGLANAYAGVEAGVDILDASVGGLG
GCPFAPNATGNIGTEDLVYMLERGGFETGYDLDKLIEIGRWVSGLLGKPPASSLARAGSFPVKREEAAA
>Mature_308_residues
SRRIEIVEVGPRDGLQNEKTLLEVDQKLEMIRRLEDAGARRMEVVSFVNPRRVPQMAGAEEIMAALNTPGAKPAGRSRIG
LVLNQKGWERCVAAACDEANVVVCASDGFGIRNQGASVAEQIDALGAIMQARRLEDPPVTVTVSVAFGCPFDGEVPEERV
VDIVRTAADMRVAEIALADTIGVADPWTVRRRVEAARKAAGRIPLRLHFHDTRNTGLANAYAGVEAGVDILDASVGGLGG
CPFAPNATGNIGTEDLVYMLERGGFETGYDLDKLIEIGRWVSGLLGKPPASSLARAGSFPVKREEAAA

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=297, Percent_Identity=38.3838383838384, Blast_Score=214, Evalue=7e-56,
Organism=Homo sapiens, GI109150422, Length=293, Percent_Identity=38.2252559726962, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI109150427, Length=293, Percent_Identity=38.2252559726962, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI260654708, Length=134, Percent_Identity=41.044776119403, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17510563, Length=281, Percent_Identity=37.7224199288256, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24582381, Length=303, Percent_Identity=39.2739273927393, Blast_Score=217, Evalue=9e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 32998; Mature: 32867

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRIEIVEVGPRDGLQNEKTLLEVDQKLEMIRRLEDAGARRMEVVSFVNPRRVPQMAGA
CCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHCCH
EEIMAALNTPGAKPAGRSRIGLVLNQKGWERCVAAACDEANVVVCASDGFGIRNQGASVA
HHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHH
EQIDALGAIMQARRLEDPPVTVTVSVAFGCPFDGEVPEERVVDIVRTAADMRVAEIALAD
HHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TIGVADPWTVRRRVEAARKAAGRIPLRLHFHDTRNTGLANAYAGVEAGVDILDASVGGLG
HCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHCHHHHHHCCCCCC
GCPFAPNATGNIGTEDLVYMLERGGFETGYDLDKLIEIGRWVSGLLGKPPASSLARAGSF
CCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCC
PVKREEAAA
CCCHHHCCC
>Mature Secondary Structure 
SRRIEIVEVGPRDGLQNEKTLLEVDQKLEMIRRLEDAGARRMEVVSFVNPRRVPQMAGA
CCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHCCH
EEIMAALNTPGAKPAGRSRIGLVLNQKGWERCVAAACDEANVVVCASDGFGIRNQGASVA
HHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHH
EQIDALGAIMQARRLEDPPVTVTVSVAFGCPFDGEVPEERVVDIVRTAADMRVAEIALAD
HHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TIGVADPWTVRRRVEAARKAAGRIPLRLHFHDTRNTGLANAYAGVEAGVDILDASVGGLG
HCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHCHHHHHHCCCCCC
GCPFAPNATGNIGTEDLVYMLERGGFETGYDLDKLIEIGRWVSGLLGKPPASSLARAGSF
CCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCC
PVKREEAAA
CCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]