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The map label for this gene is gltT [H]

Identifier: 197103817

GI number: 197103817

Start: 355318

End: 356538

Strand: Direct

Name: gltT [H]

Synonym: PHZ_c0351

Alternate gene names: 197103817

Gene position: 355318-356538 (Clockwise)

Preceding gene: 197103812

Following gene: 197103819

Centisome position: 8.89

GC content: 72.15

Gene sequence:

>1221_bases
GTGCTGTGGAAGCGGATTCTGGGGGCGCTGGTCCTGGGGATCGTCGCCGGCCTCGTCCTGGGCGAGGCGGCCGAGGGCCT
GAAGTGGCTGGGCGACCTGTTCGTGCGGCTGATCCGGATGATCGTCGTGCCGCTGGTGTTCGTCTCGATCGTCTCGGCGG
TGGCGGCCATGCGCGAGGTCCGCCGCCTGGGCTCGATCGGCGGGCGCACCCTGCTGCTCTACCTCGGGACCACGGCCTGC
GCGGTGGCGATCGGCCAGGCGGTCGGAGCGCTGTTCCGGCCCGGCGTCGGCGTGGATTTCGCCGGCACGACGCCGCGGGT
GGTGGGCGAGGCGCCCTCGGTGGCCGACCAGCTGCTGGGGATCGTGCCGCTCAACCCCTTCGAGGCCCTGGCCGAGGGCG
ACATGCTGGGGGTGATCTTCTTCGCCATCCTGGTGGGGGCGGCGGTGCTGGTGCAAGGCGAGGACGCCGCGCCCGTCCGG
CGCCTGTTCGACGCGGGCGCCTCGCTTATGCTGTTCATCACCCGGGTGGTGATGGAGGCGGCGCCCTTCGGCGTCTTCGC
GCTGATCGCCTGGGTGACGGGCACGGTGGGTCTGGGCGTCTTCGGCCACGTGGCGCTGATCGCCGCCGCGCTGGTGACCG
GCAGCCTGCTGCAGGTGCTGGTCGTCCACGGAGGGCTGCTGCGGCTGGCGGCCAGGCTGCCGGTCGTGCCGTTCTTCCGC
GACATCGGCGAGGCGGTGCTGGTGGCGTTCTCCACCTCCTCGTCGGCCGCCACCCTGCCGGTGGCCATGCGGGTGGCGCA
GAAGAACCTCGGCGTCGGCCGGACCGTGGCGGCCACGGCCCTGCCGATCGGCGCCACCGTCTCGATGGACGGCACGGCGC
TCTACATCGGCATCCTGACGATGTTCTCGGCCCAGGCCTTCGGCCTCGAGCTCACCCTGGCGCAGATGATCTTCGCCGGG
GTCACGACGGTGCTGGTGGCGGTCGGCACCGCGCCGGTGCCCTCGGCCTCGCTGTTCATGCTGGCCGCCGTGCTCAGCAC
CCTGGGCGTGAGCGCCGAGCAGACGGCCCTGGTGGTCGGCTTCATGCTGCCGTTCGACCGGCCGCTGGACATGACCCGGA
CCATCCCGAACAACACCGCCGACCTGGCGGTGGCGGTCACGGTGGCCAAGTGGGAAGGCGAGCTGGACGCGGAGGTCTAC
CGCGCCCGCCCTTCCGAATAA

Upstream 100 bases:

>100_bases
AACGCCCGCCAAGGACCGGAGGCCCGCATTGCCGCCAACCCGCCCCGCGCCGCCGCCGGCCGCCCGCCCCAGCCTGCTGC
GGCGCTGGTGGTTCGACATC

Downstream 100 bases:

>100_bases
CGGCCCGCCGAATAGCCGCCCCACTTAGTAGGGCGTCCGGACGGCCTACTCGGCCGGCGCCCCCGCGGCCCGGGCTTCGG
GCTCGGTGATCTGCCCTTCC

Product: proton/glutamate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MLWKRILGALVLGIVAGLVLGEAAEGLKWLGDLFVRLIRMIVVPLVFVSIVSAVAAMREVRRLGSIGGRTLLLYLGTTAC
AVAIGQAVGALFRPGVGVDFAGTTPRVVGEAPSVADQLLGIVPLNPFEALAEGDMLGVIFFAILVGAAVLVQGEDAAPVR
RLFDAGASLMLFITRVVMEAAPFGVFALIAWVTGTVGLGVFGHVALIAAALVTGSLLQVLVVHGGLLRLAARLPVVPFFR
DIGEAVLVAFSTSSSAATLPVAMRVAQKNLGVGRTVAATALPIGATVSMDGTALYIGILTMFSAQAFGLELTLAQMIFAG
VTTVLVAVGTAPVPSASLFMLAAVLSTLGVSAEQTALVVGFMLPFDRPLDMTRTIPNNTADLAVAVTVAKWEGELDAEVY
RARPSE

Sequences:

>Translated_406_residues
MLWKRILGALVLGIVAGLVLGEAAEGLKWLGDLFVRLIRMIVVPLVFVSIVSAVAAMREVRRLGSIGGRTLLLYLGTTAC
AVAIGQAVGALFRPGVGVDFAGTTPRVVGEAPSVADQLLGIVPLNPFEALAEGDMLGVIFFAILVGAAVLVQGEDAAPVR
RLFDAGASLMLFITRVVMEAAPFGVFALIAWVTGTVGLGVFGHVALIAAALVTGSLLQVLVVHGGLLRLAARLPVVPFFR
DIGEAVLVAFSTSSSAATLPVAMRVAQKNLGVGRTVAATALPIGATVSMDGTALYIGILTMFSAQAFGLELTLAQMIFAG
VTTVLVAVGTAPVPSASLFMLAAVLSTLGVSAEQTALVVGFMLPFDRPLDMTRTIPNNTADLAVAVTVAKWEGELDAEVY
RARPSE
>Mature_406_residues
MLWKRILGALVLGIVAGLVLGEAAEGLKWLGDLFVRLIRMIVVPLVFVSIVSAVAAMREVRRLGSIGGRTLLLYLGTTAC
AVAIGQAVGALFRPGVGVDFAGTTPRVVGEAPSVADQLLGIVPLNPFEALAEGDMLGVIFFAILVGAAVLVQGEDAAPVR
RLFDAGASLMLFITRVVMEAAPFGVFALIAWVTGTVGLGVFGHVALIAAALVTGSLLQVLVVHGGLLRLAARLPVVPFFR
DIGEAVLVAFSTSSSAATLPVAMRVAQKNLGVGRTVAATALPIGATVSMDGTALYIGILTMFSAQAFGLELTLAQMIFAG
VTTVLVAVGTAPVPSASLFMLAAVLSTLGVSAEQTALVVGFMLPFDRPLDMTRTIPNNTADLAVAVTVAKWEGELDAEVY
RARPSE

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=408, Percent_Identity=27.2058823529412, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI66773030, Length=455, Percent_Identity=26.8131868131868, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI4827012, Length=337, Percent_Identity=29.3768545994065, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI194239697, Length=256, Percent_Identity=30.46875, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI262359914, Length=344, Percent_Identity=27.3255813953488, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI21314632, Length=408, Percent_Identity=26.4705882352941, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI40254478, Length=170, Percent_Identity=36.4705882352941, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI223468564, Length=251, Percent_Identity=29.4820717131474, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI223468566, Length=251, Percent_Identity=29.4820717131474, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI5032093, Length=251, Percent_Identity=29.4820717131474, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI301601644, Length=144, Percent_Identity=34.0277777777778, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1790514, Length=424, Percent_Identity=31.8396226415094, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1789947, Length=406, Percent_Identity=28.8177339901478, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI1788024, Length=408, Percent_Identity=29.1666666666667, Blast_Score=108, Evalue=9e-25,
Organism=Escherichia coli, GI1789473, Length=389, Percent_Identity=27.2493573264781, Blast_Score=95, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17537407, Length=460, Percent_Identity=30.2173913043478, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71983106, Length=454, Percent_Identity=26.8722466960352, Blast_Score=131, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI71983099, Length=454, Percent_Identity=27.5330396475771, Blast_Score=131, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI71996953, Length=452, Percent_Identity=26.3274336283186, Blast_Score=130, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI193206505, Length=426, Percent_Identity=26.2910798122066, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17541374, Length=404, Percent_Identity=25.2475247524752, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI193206654, Length=424, Percent_Identity=25.9433962264151, Blast_Score=94, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24583025, Length=464, Percent_Identity=25.2155172413793, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI17137668, Length=464, Percent_Identity=25.2155172413793, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24583023, Length=464, Percent_Identity=25.2155172413793, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI281360481, Length=375, Percent_Identity=25.6, Blast_Score=85, Evalue=9e-17,
Organism=Drosophila melanogaster, GI281360483, Length=375, Percent_Identity=25.6, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17137666, Length=375, Percent_Identity=25.6, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 41929; Mature: 41929

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHCCCCCCCCHHHCCCCCCCCEEEEEEEEECCCCCCHHHHHCCCCC
>Mature Secondary Structure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HHCCCCCCCCHHHCCCCCCCCEEEEEEEEECCCCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]